JP7441210B2 - アルギナーゼインヒビタ及びその使用方法 - Google Patents
アルギナーゼインヒビタ及びその使用方法 Download PDFInfo
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- JP7441210B2 JP7441210B2 JP2021509794A JP2021509794A JP7441210B2 JP 7441210 B2 JP7441210 B2 JP 7441210B2 JP 2021509794 A JP2021509794 A JP 2021509794A JP 2021509794 A JP2021509794 A JP 2021509794A JP 7441210 B2 JP7441210 B2 JP 7441210B2
- Authority
- JP
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- Prior art keywords
- hydroxy
- aza
- oxa
- boraspiro
- dodecane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- MVHFGAWLHMAREF-IIYDPXPESA-N (3R,5R)-3-[(4S)-2,2-dimethyl-5-oxo-4-propan-2-ylimidazolidin-1-yl]-10-hydroxy-11-oxa-1-aza-10-boraspiro[4.7]dodecan-12-one Chemical compound OB1OC([C@]2(C[C@H](CN2)N2C(N[C@H](C2=O)C(C)C)(C)C)CCCC1)=O MVHFGAWLHMAREF-IIYDPXPESA-N 0.000 claims description 32
- -1 Amino-N-((3R,5R)-8-hydroxy-6-oxo-7-oxa-1-aza-8-boraspiro[4.7]dodecane-3-yl)-3-methylbutanamide Form Chemical group 0.000 claims description 28
- 150000003839 salts Chemical class 0.000 claims description 27
- 238000000113 differential scanning calorimetry Methods 0.000 claims description 16
- XUXJHBAJZQREDB-UHFFFAOYSA-N 2-methylbutanamide Chemical compound CCC(C)C(N)=O XUXJHBAJZQREDB-UHFFFAOYSA-N 0.000 claims description 15
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- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
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- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US201862721113P | 2018-08-22 | 2018-08-22 | |
| US62/721,113 | 2018-08-22 | ||
| PCT/EP2019/072341 WO2020038983A1 (en) | 2018-08-22 | 2019-08-21 | Arginase inhibitors and methods of use thereof |
Publications (3)
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| JP2021535111A JP2021535111A (ja) | 2021-12-16 |
| JP2021535111A5 JP2021535111A5 (https=) | 2023-08-15 |
| JP7441210B2 true JP7441210B2 (ja) | 2024-02-29 |
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| TWI877770B (zh) | 2018-02-27 | 2025-03-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶 |
| EP3810610A1 (en) | 2018-05-18 | 2021-04-28 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| WO2020010197A1 (en) | 2018-07-05 | 2020-01-09 | Incyte Corporation | Fused pyrazine derivatives as a2a / a2b inhibitors |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| PH12021551902A1 (en) * | 2019-02-08 | 2022-08-01 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013525364A (ja) | 2010-04-22 | 2013-06-20 | マーズ インコーポレイテッド | アルギナーゼ阻害剤およびそれらの治療用途 |
| WO2018119440A1 (en) | 2016-12-22 | 2018-06-28 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
| JP2018520352A (ja) | 2015-06-23 | 2018-07-26 | カリセラ バイオサイエンシズ，インコーポレイテッド | アルギナーゼ活性を阻害するための組成物および方法 |
| JP7317841B2 (ja) | 2018-02-17 | 2023-07-31 | アストラゼネカ・アクチエボラーグ | アルギナーゼインヒビタ及びその使用方法 |
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| JP2020502259A (ja) * | 2016-11-08 | 2020-01-23 | カリセラ バイオサイエンシズ，インコーポレイテッド | アルギナーゼ阻害剤併用療法 |
| EP3765006A4 (en) | 2018-03-13 | 2022-02-23 | Merck Sharp & Dohme Corp. | ARGINASE INHIBITORS AND METHODS OF USE |
| CN111770756B (zh) | 2018-04-27 | 2023-03-31 | 四川科伦博泰生物医药股份有限公司 | 非天然氨基酸类衍生物、包含其的药物组合物及其制备方法和用途 |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013525364A (ja) | 2010-04-22 | 2013-06-20 | マーズ インコーポレイテッド | アルギナーゼ阻害剤およびそれらの治療用途 |
| JP2018520352A (ja) | 2015-06-23 | 2018-07-26 | カリセラ バイオサイエンシズ，インコーポレイテッド | アルギナーゼ活性を阻害するための組成物および方法 |
| WO2018119440A1 (en) | 2016-12-22 | 2018-06-28 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
| JP7317841B2 (ja) | 2018-02-17 | 2023-07-31 | アストラゼネカ・アクチエボラーグ | アルギナーゼインヒビタ及びその使用方法 |
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