ES2970007T3 - Método para producir un dispositivo médico - Google Patents
Método para producir un dispositivo médico Download PDFInfo
- Publication number
- ES2970007T3 ES2970007T3 ES21740915T ES21740915T ES2970007T3 ES 2970007 T3 ES2970007 T3 ES 2970007T3 ES 21740915 T ES21740915 T ES 21740915T ES 21740915 T ES21740915 T ES 21740915T ES 2970007 T3 ES2970007 T3 ES 2970007T3
- Authority
- ES
- Spain
- Prior art keywords
- substrate
- medical device
- group
- hydrophilic polymer
- acid
- Prior art date
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- 238000004519 manufacturing process Methods 0.000 title description 26
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 112
- 238000000034 method Methods 0.000 claims abstract description 89
- 238000010438 heat treatment Methods 0.000 claims abstract description 83
- 239000000463 material Substances 0.000 claims abstract description 49
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract description 41
- 150000007524 organic acids Chemical class 0.000 claims abstract description 22
- 230000002378 acidificating effect Effects 0.000 claims abstract description 18
- 239000000758 substrate Substances 0.000 claims description 242
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 87
- 239000011248 coating agent Substances 0.000 claims description 64
- 238000000576 coating method Methods 0.000 claims description 64
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 63
- 229920001296 polysiloxane Polymers 0.000 claims description 45
- 239000000017 hydrogel Substances 0.000 claims description 44
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- 235000015165 citric acid Nutrition 0.000 claims description 29
- 239000007788 liquid Substances 0.000 claims description 19
- 239000007779 soft material Substances 0.000 claims description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
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- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 6
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- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 3
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- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 claims description 2
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- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 6
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- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 125000000129 anionic group Chemical group 0.000 description 4
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- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 3
- 239000000920 calcium hydroxide Substances 0.000 description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 3
- 210000004087 cornea Anatomy 0.000 description 3
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 3
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- NLAIHECABDOZBR-UHFFFAOYSA-M sodium 2,2-bis(2-methylprop-2-enoyloxymethyl)butyl 2-methylprop-2-enoate 2-hydroxyethyl 2-methylprop-2-enoate 2-methylprop-2-enoate Chemical compound [Na+].CC(=C)C([O-])=O.CC(=C)C(=O)OCCO.CCC(COC(=O)C(C)=C)(COC(=O)C(C)=C)COC(=O)C(C)=C NLAIHECABDOZBR-UHFFFAOYSA-M 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- IHPYMWDTONKSCO-UHFFFAOYSA-N 2,2'-piperazine-1,4-diylbisethanesulfonic acid Chemical compound OS(=O)(=O)CCN1CCN(CCS(O)(=O)=O)CC1 IHPYMWDTONKSCO-UHFFFAOYSA-N 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- AJTVSSFTXWNIRG-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanesulfonic acid Chemical compound OCC[NH+](CCO)CCS([O-])(=O)=O AJTVSSFTXWNIRG-UHFFFAOYSA-N 0.000 description 2
- KKOWZRLUUCIGQY-UHFFFAOYSA-N 2-hydroxyethyl 2-methylprop-2-enoate 2-methylprop-2-enoic acid 2-(2-methylprop-2-enoyloxy)ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(O)=O.CC(=C)C(=O)OCCO.CC(=C)C(=O)OCCOC(=O)C(C)=C KKOWZRLUUCIGQY-UHFFFAOYSA-N 0.000 description 2
- DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 description 2
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- DBXNUXBLKRLWFA-UHFFFAOYSA-N N-(2-acetamido)-2-aminoethanesulfonic acid Chemical compound NC(=O)CNCCS(O)(=O)=O DBXNUXBLKRLWFA-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Materials Engineering (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Ophthalmology & Optometry (AREA)
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- General Chemical & Material Sciences (AREA)
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- Inorganic Chemistry (AREA)
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- Manufacturing & Machinery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Materials For Medical Uses (AREA)
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| JP2020004872 | 2020-01-16 | ||
| PCT/JP2021/000185 WO2021145249A1 (ja) | 2020-01-16 | 2021-01-06 | 医療デバイスの製造方法 |
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| ES2970007T3 true ES2970007T3 (es) | 2024-05-23 |
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| ES21740915T Active ES2970007T3 (es) | 2020-01-16 | 2021-01-06 | Método para producir un dispositivo médico |
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| EP (1) | EP4066867B1 (ja) |
| JP (1) | JP6954490B1 (ja) |
| KR (1) | KR102500448B1 (ja) |
| CN (1) | CN114828904B (ja) |
| ES (1) | ES2970007T3 (ja) |
| TW (1) | TWI753743B (ja) |
| WO (1) | WO2021145249A1 (ja) |
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| GB2629236A (en) * | 2024-01-24 | 2024-10-23 | Coopervision Int Ltd | Contact Lens Formulation and Contact Lens |
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| US5702754A (en) * | 1995-02-22 | 1997-12-30 | Meadox Medicals, Inc. | Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings |
| US6039872A (en) * | 1997-10-27 | 2000-03-21 | Pall Corporation | Hydrophilic membrane |
| JP4834916B2 (ja) | 2000-05-10 | 2011-12-14 | 東レ株式会社 | 表面処理プラスチック成形品 |
| US6428839B1 (en) * | 2000-06-02 | 2002-08-06 | Bausch & Lomb Incorporated | Surface treatment of medical device |
| WO2003030940A1 (en) * | 2001-10-09 | 2003-04-17 | University Of Florida | Method for the surface modification of silicone surfaces |
| US7083646B2 (en) * | 2002-06-28 | 2006-08-01 | Bausch & Lomb Incorporated | Surface modification of functional group-containing intraocular lenses |
| JP5332569B2 (ja) | 2008-09-10 | 2013-11-06 | 東レ株式会社 | 医療用材料 |
| CN102754015A (zh) * | 2010-02-16 | 2012-10-24 | 东丽株式会社 | 低含水性软质眼用镜片及其制造方法 |
| CN102255122B (zh) | 2011-04-26 | 2015-04-01 | 中兴通讯股份有限公司 | 带阻滤波器和基站设备 |
| WO2013024801A1 (ja) * | 2011-08-17 | 2013-02-21 | 東レ株式会社 | 医療デバイスおよびその製造方法 |
| CN103733121B (zh) | 2011-08-17 | 2016-06-01 | 东丽株式会社 | 医疗设备、涂布溶液的组合和医疗设备的制造方法 |
| JP6338263B2 (ja) | 2011-08-17 | 2018-06-06 | 東レ株式会社 | 低含水性軟質デバイスおよびその製造方法 |
| US9505184B2 (en) | 2011-11-15 | 2016-11-29 | Novartis Ag | Silicone hydrogel lens with a crosslinked hydrophilic coating |
| JP2013119555A (ja) | 2011-12-06 | 2013-06-17 | Mitsui Chemicals Inc | 親水性膜 |
| MY184247A (en) * | 2012-12-11 | 2021-03-29 | Alcon Inc | Method for applying a coating onto a silicone hydrogel lens |
| JP2015055809A (ja) * | 2013-09-13 | 2015-03-23 | 東レ株式会社 | 低含水性軟質眼用レンズの製造方法 |
| CN108601858B (zh) * | 2016-02-22 | 2021-09-28 | 东丽株式会社 | 设备和其制造方法 |
| JP6856019B2 (ja) * | 2016-02-22 | 2021-04-07 | 東レ株式会社 | 眼用レンズおよびその製造方法 |
| US11358352B2 (en) | 2017-05-11 | 2022-06-14 | Toray Industries, Inc. | Method for producing medical device |
| US11202849B2 (en) | 2017-08-09 | 2021-12-21 | Toray Industries, Inc. | Medical device and method for manufacturing the same |
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| WO2021145249A1 (ja) | 2021-07-22 |
| KR102500448B1 (ko) | 2023-02-20 |
| TW202146050A (zh) | 2021-12-16 |
| CN114828904A (zh) | 2022-07-29 |
| US20230057266A1 (en) | 2023-02-23 |
| JP6954490B1 (ja) | 2021-10-27 |
| TWI753743B (zh) | 2022-01-21 |
| CN114828904B (zh) | 2022-11-29 |
| KR20220098405A (ko) | 2022-07-12 |
| US11613089B2 (en) | 2023-03-28 |
| EP4066867A4 (en) | 2023-05-31 |
| JPWO2021145249A1 (ja) | 2021-07-22 |
| EP4066867A1 (en) | 2022-10-05 |
| EP4066867B1 (en) | 2023-12-06 |
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