ES2959692T3 - Cerdulatinib y venetoclax para tratar linfoma no Hodgkin - Google Patents
Cerdulatinib y venetoclax para tratar linfoma no Hodgkin Download PDFInfo
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- ES2959692T3 ES2959692T3 ES16819235T ES16819235T ES2959692T3 ES 2959692 T3 ES2959692 T3 ES 2959692T3 ES 16819235 T ES16819235 T ES 16819235T ES 16819235 T ES16819235 T ES 16819235T ES 2959692 T3 ES2959692 T3 ES 2959692T3
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- Prior art keywords
- cerdulatinib
- pharmaceutically acceptable
- acceptable salt
- venetoclax
- patient
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201562263582P | 2015-12-04 | 2015-12-04 | |
| US201662342727P | 2016-05-27 | 2016-05-27 | |
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| US201662371145P | 2016-08-04 | 2016-08-04 | |
| PCT/US2016/064824 WO2017096303A2 (en) | 2015-12-04 | 2016-12-02 | Cerdulatinib for treating hematological cancers |
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| US20170042896A1 (en) | 2015-08-12 | 2017-02-16 | Portola Pharmaceuticals, Inc. | Cerdulatinib for treating myeloma |
| WO2019138291A2 (en) * | 2018-01-09 | 2019-07-18 | Dermavant Sciences GmbH | Cerdulatinib-containing topical skin pharmaceutical compositions and uses thereof |
| CN112074271B (zh) * | 2018-05-04 | 2023-10-20 | 博尔托拉制药公司 | 用于治疗淋巴瘤的方法 |
| JP7324778B2 (ja) | 2018-05-04 | 2023-08-10 | ポートラ ファーマシューティカルズ， エルエルシー | セルデュラチニブ（ｃｅｒｄｕｌａｔｉｎｉｂ）の固体形態 |
| TWI805751B (zh) | 2018-05-04 | 2023-06-21 | 美商普托拉製藥有限公司 | 賽度替尼(cerdulatinib)之合成 |
| WO2020165861A1 (en) * | 2019-02-15 | 2020-08-20 | Janssen Biotech, Inc. | Combination therapy for treatment of b-cell malignancies |
| US20230181581A1 (en) * | 2020-05-26 | 2023-06-15 | Alexion Pharmaceuticals, Inc. | Circulating b cell subpopulations in indolent b cell lymphoma |
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| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| CN1665789A (zh) | 2002-06-28 | 2005-09-07 | 山之内制药株式会社 | 二氨基嘧啶酰胺衍生物 |
| WO2008009458A1 (en) | 2006-07-21 | 2008-01-24 | Novartis Ag | 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors |
| PT2201840E (pt) | 2006-09-22 | 2012-02-14 | Pharmacyclics Inc | Inibidores da tirosina quinase de bruton |
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| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| US8367689B2 (en) | 2009-05-06 | 2013-02-05 | Portola Pharmaceuticals, Inc. | Inhibitors of JAK |
| BR122019016429B1 (pt) | 2009-05-26 | 2020-03-24 | Abbvie Ireland Unlimited Company | Compostos inibidores da atividade de proteínas bcl-2 antiapoptótica e composição farmacêutica compreendendo ditos compostos |
| CA2780759A1 (en) | 2009-12-01 | 2011-06-09 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
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| WO2012045010A1 (en) | 2010-09-30 | 2012-04-05 | Portola Pharmaceuticals, Inc. | Combinations of 4-(3-(2h-1,2,3-triazo-2-yl) phenylamino)-2-((1r,2s)-2-aminocyclohexylamino) pyrimidine-5-carboxamide and fludarabine |
| AU2011332043C1 (en) | 2010-11-23 | 2016-11-10 | Abbvie Inc. | Salts and crystalline forms of an apoptosis-inducing agent |
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| CA2890111A1 (en) | 2012-11-02 | 2014-05-08 | Pharmacyclics, Inc. | Tec family kinase inhibitor adjuvant therapy |
| WO2016040858A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| EP3302485B1 (en) | 2015-05-29 | 2023-07-12 | Alexion Pharmaceuticals, Inc. | Cerdulatinib for the treatment of b-cell malignancies |
| US20170042896A1 (en) | 2015-08-12 | 2017-02-16 | Portola Pharmaceuticals, Inc. | Cerdulatinib for treating myeloma |
| JP7324778B2 (ja) | 2018-05-04 | 2023-08-10 | ポートラ ファーマシューティカルズ， エルエルシー | セルデュラチニブ（ｃｅｒｄｕｌａｔｉｎｉｂ）の固体形態 |
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| CN108367006B (zh) | 2021-12-31 |
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| EP3383396A2 (en) | 2018-10-10 |
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| US10736895B2 (en) | 2020-08-11 |
| CN108367006A (zh) | 2018-08-03 |
| EP3383396B1 (en) | 2023-07-12 |
| JP6944936B2 (ja) | 2021-10-06 |
| CA2950640A1 (en) | 2017-06-04 |
| US20180353506A1 (en) | 2018-12-13 |
| WO2017096303A2 (en) | 2017-06-08 |
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