ES2959692T3 - Cerdulatinib y venetoclax para tratar linfoma no Hodgkin - Google Patents
Cerdulatinib y venetoclax para tratar linfoma no Hodgkin Download PDFInfo
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- ES2959692T3 ES2959692T3 ES16819235T ES16819235T ES2959692T3 ES 2959692 T3 ES2959692 T3 ES 2959692T3 ES 16819235 T ES16819235 T ES 16819235T ES 16819235 T ES16819235 T ES 16819235T ES 2959692 T3 ES2959692 T3 ES 2959692T3
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- Prior art keywords
- cerdulatinib
- pharmaceutically acceptable
- acceptable salt
- venetoclax
- patient
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
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- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201562263582P | 2015-12-04 | 2015-12-04 | |
| US201662342727P | 2016-05-27 | 2016-05-27 | |
| US201662342755P | 2016-05-27 | 2016-05-27 | |
| US201662371145P | 2016-08-04 | 2016-08-04 | |
| PCT/US2016/064824 WO2017096303A2 (en) | 2015-12-04 | 2016-12-02 | Cerdulatinib for treating hematological cancers |
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| ES2959692T3 true ES2959692T3 (es) | 2024-02-27 |
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| WO2016196385A1 (en) | 2015-05-29 | 2016-12-08 | Portola Pharmaceuticals, Inc. | Cerdulatinib for the treatment of b-cell malignancies |
| ES2913119T3 (es) | 2015-08-12 | 2022-05-31 | Portola Pharm Inc | Cerdulatinib para tratar mieloma |
| BR112020013976A2 (pt) * | 2018-01-09 | 2020-12-08 | Dermavant Sciences GmbH | Composições farmacêuticas para pele tópicas que contêm cerdulatinibe e usos das mesmas |
| KR20210003789A (ko) * | 2018-05-04 | 2021-01-12 | 포톨라 파마슈티컬스, 인코포레이티드 | 림프종을 치료하는 방법 |
| US10851087B2 (en) | 2018-05-04 | 2020-12-01 | Portola Pharmaceuticals, Inc. | Synthesis of cerdulatinib |
| WO2019213606A2 (en) | 2018-05-04 | 2019-11-07 | Portola Pharmaceuticals, Inc. | Solid forms of cerdulatinib |
| US20200262925A1 (en) * | 2019-02-15 | 2020-08-20 | Janssen Biotech, Inc. | Combination Therapy For Treatment Of B-Cell Malignancies |
| WO2021242614A1 (en) * | 2020-05-26 | 2021-12-02 | Alexion Pharmaceuticals, Inc. | Circulating b cell subpopulations in indolent b cell lymphoma |
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| ES2373226T3 (es) | 2002-06-28 | 2012-02-01 | Astellas Pharma Inc. | Derivado de diaminopirimidincarboxamida. |
| WO2008009458A1 (en) | 2006-07-21 | 2008-01-24 | Novartis Ag | 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors |
| EP2529621B1 (en) | 2006-09-22 | 2016-10-05 | Pharmacyclics LLC | Inhibitors of bruton's tyrosine kinase |
| CA2723205C (en) | 2008-04-16 | 2017-03-14 | Portola Pharmaceuticals, Inc. | 2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinase inhibitors |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
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| ES2546294T7 (es) | 2009-05-26 | 2024-06-06 | Abbvie Ireland Unlimited Co | Agentes inductores de la apoptosis para el tratamiento de cáncer y enfermedades inmunitarias y autoinmunitarias |
| US20110130415A1 (en) | 2009-12-01 | 2011-06-02 | Rajinder Singh | Protein kinase c inhibitors and uses thereof |
| US9398308B2 (en) | 2010-07-28 | 2016-07-19 | Qualcomm Incorporated | Coding motion prediction direction in video coding |
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| WO2012071336A1 (en) | 2010-11-23 | 2012-05-31 | Abbott Laboratories | Salts and crystalline forms of an apoptosis-inducing agent |
| WO2013023119A1 (en) | 2011-08-10 | 2013-02-14 | Novartis Pharma Ag | JAK P13K/mTOR COMBINATION THERAPY |
| HK1206073A1 (en) | 2012-07-24 | 2015-12-31 | 药品循环有限责任公司 | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| WO2014058921A2 (en) | 2012-10-08 | 2014-04-17 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
| SG11201503459SA (en) | 2012-11-02 | 2015-06-29 | Pharmacyclics Inc | Tec family kinase inhibitor adjuvant therapy |
| EP3191098A4 (en) | 2014-09-12 | 2018-04-25 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| WO2016196385A1 (en) | 2015-05-29 | 2016-12-08 | Portola Pharmaceuticals, Inc. | Cerdulatinib for the treatment of b-cell malignancies |
| ES2913119T3 (es) | 2015-08-12 | 2022-05-31 | Portola Pharm Inc | Cerdulatinib para tratar mieloma |
| WO2019213606A2 (en) | 2018-05-04 | 2019-11-07 | Portola Pharmaceuticals, Inc. | Solid forms of cerdulatinib |
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| CN108367006B (zh) | 2021-12-31 |
| CN108367006A (zh) | 2018-08-03 |
| WO2017096303A2 (en) | 2017-06-08 |
| CA2950640A1 (en) | 2017-06-04 |
| US20180353506A1 (en) | 2018-12-13 |
| US11446300B2 (en) | 2022-09-20 |
| EP3383396A2 (en) | 2018-10-10 |
| WO2017096303A3 (en) | 2017-08-03 |
| US20210000827A1 (en) | 2021-01-07 |
| EP3383396B1 (en) | 2023-07-12 |
| JP2018535996A (ja) | 2018-12-06 |
| JP6944936B2 (ja) | 2021-10-06 |
| AU2016363005A1 (en) | 2018-07-05 |
| US10736895B2 (en) | 2020-08-11 |
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