ES2934507T3 - Anillos fusionados en 5-5 como inhibidores de C5a - Google Patents

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Publication number

ES2934507T3

ES2934507T3 ES18809125T ES18809125T ES2934507T3 ES 2934507 T3 ES2934507 T3 ES 2934507T3 ES 18809125 T ES18809125 T ES 18809125T ES 18809125 T ES18809125 T ES 18809125T ES 2934507 T3 ES2934507 T3 ES 2934507T3

Authority

ES

Spain

Prior art keywords

alkyl

group

compound

ring

pharmaceutically acceptable

Prior art date

2017-05-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 108010073240 complement C5a-inhibitors Proteins 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 190
• 102100031506 Complement C5 Human genes 0.000 claims abstract description 62
• 101000941598 Homo sapiens Complement C5 Proteins 0.000 claims abstract description 62
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 48
• 150000003839 salts Chemical class 0.000 claims abstract description 37
• 201000010099 disease Diseases 0.000 claims abstract description 35
• 238000000034 method Methods 0.000 claims abstract description 30
• 238000011282 treatment Methods 0.000 claims abstract description 25
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 16
• 230000004913 activation Effects 0.000 claims abstract description 13
• 208000035475 disorder Diseases 0.000 claims abstract description 12
• 230000001575 pathological effect Effects 0.000 claims abstract description 4
• 125000000217 alkyl group Chemical group 0.000 claims description 58
• -1 cyano, hydroxyl Chemical group 0.000 claims description 54
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 48
• 239000000203 mixture Substances 0.000 claims description 45
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• 229910052757 nitrogen Inorganic materials 0.000 claims description 24
• 229910052736 halogen Inorganic materials 0.000 claims description 23
• 150000002367 halogens Chemical class 0.000 claims description 23
• 229910052760 oxygen Inorganic materials 0.000 claims description 22
• 125000001424 substituent group Chemical group 0.000 claims description 22
• 239000003814 drug Substances 0.000 claims description 21
• 229910052717 sulfur Inorganic materials 0.000 claims description 20
• 230000035605 chemotaxis Effects 0.000 claims description 19
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 18
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• 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 17
• 125000003545 alkoxy group Chemical group 0.000 claims description 17
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• 229910052739 hydrogen Inorganic materials 0.000 claims description 15
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 13
• 125000003118 aryl group Chemical group 0.000 claims description 13
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• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 9
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