ES2933987T3 - Esteroides neuroactivos sustituidos con 19-alcoxilo-17, útiles en métodos de tratamiento - Google Patents

Esteroides neuroactivos sustituidos con 19-alcoxilo-17, útiles en métodos de tratamiento Download PDF

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Publication number
ES2933987T3
ES2933987T3 ES18162373T ES18162373T ES2933987T3 ES 2933987 T3 ES2933987 T3 ES 2933987T3 ES 18162373 T ES18162373 T ES 18162373T ES 18162373 T ES18162373 T ES 18162373T ES 2933987 T3 ES2933987 T3 ES 2933987T3
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optionally substituted
alkyl
certain embodiments
compound
beta
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Spanish (es)
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Douglas Covey
Albert Robichaud
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Washington University in St Louis WUSTL
Sage Therapeutics Inc
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Washington University in St Louis WUSTL
Sage Therapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
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    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
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    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
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    • C07J—STEROIDS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
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    • C07J—STEROIDS
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    • C—CHEMISTRY; METALLURGY
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    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
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    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
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    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
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    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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ES18162373T 2012-12-18 2013-12-18 Esteroides neuroactivos sustituidos con 19-alcoxilo-17, útiles en métodos de tratamiento Active ES2933987T3 (es)

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US201261738822P 2012-12-18 2012-12-18

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ES2933987T3 true ES2933987T3 (es) 2023-02-15

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ES18162373T Active ES2933987T3 (es) 2012-12-18 2013-12-18 Esteroides neuroactivos sustituidos con 19-alcoxilo-17, útiles en métodos de tratamiento
ES13865411.6T Active ES2680582T3 (es) 2012-12-18 2013-12-18 Esteroides 19-alcoxi-17-sustituidos neuroactivos, profármacos de los mismos y métodos de tratamiento con los mismos

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US (8) US9676812B2 (https=)
EP (3) EP4086270B1 (https=)
JP (5) JP6542127B2 (https=)
KR (3) KR102400891B1 (https=)
CN (3) CN105026415B (https=)
AU (5) AU2013361485B2 (https=)
BR (1) BR112015014397B1 (https=)
CA (1) CA2895513C (https=)
CY (1) CY1121150T1 (https=)
DK (1) DK2935307T3 (https=)
ES (2) ES2933987T3 (https=)
HR (1) HRP20181048T1 (https=)
HU (1) HUE039057T2 (https=)
IL (3) IL278396B2 (https=)
LT (1) LT2935307T (https=)
MX (2) MX365644B (https=)
NZ (2) NZ709211A (https=)
PH (2) PH12018502141A1 (https=)
PL (1) PL2935307T3 (https=)
PT (2) PT3392260T (https=)
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SG (3) SG11201504848QA (https=)
SI (2) SI3392260T1 (https=)
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CN101583620B (zh) 2005-11-28 2016-08-17 马里纳斯医药公司 加奈索酮组合物及其制备和使用方法
HRP20230747T1 (hr) 2011-09-08 2024-01-05 Sage Therapeutics, Inc. Neuroaktivni steroidi, pripravci i njihova uporaba
CN119192266A (zh) 2011-10-14 2024-12-27 萨奇治疗股份有限公司 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途
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