ES2910791T3 - Derivados de tiazina como inhibidores de beta-secretasa y métodos de uso - Google Patents
Derivados de tiazina como inhibidores de beta-secretasa y métodos de uso Download PDFInfo
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- ES2910791T3 ES2910791T3 ES17822985T ES17822985T ES2910791T3 ES 2910791 T3 ES2910791 T3 ES 2910791T3 ES 17822985 T ES17822985 T ES 17822985T ES 17822985 T ES17822985 T ES 17822985T ES 2910791 T3 ES2910791 T3 ES 2910791T3
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- -1 2-propynyloxy Chemical group 0.000 claims abstract description 59
- 150000003839 salts Chemical class 0.000 claims abstract description 56
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- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 8
- 125000001153 fluoro group Chemical group F* 0.000 claims abstract description 5
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- OEEHPGXMFVJORU-QHVUTBCBSA-N 6-[(Z)-2-[3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluorophenyl]-1-fluoroethenyl]pyridine-3-carbonitrile Chemical compound C[C@]1(CCSC(N)=N1)C1=C(F)C=CC(\C=C(/F)C2=CC=C(C=N2)C#N)=C1 OEEHPGXMFVJORU-QHVUTBCBSA-N 0.000 claims description 5
- QBRVMFURZXJSCP-PQLPFPTISA-N 6-[(Z)-2-[3-[(4S,6S)-2-amino-4,6-dimethyl-6-(morpholine-4-carbonyl)-5H-1,3-thiazin-4-yl]-4-fluorophenyl]-1-fluoroethenyl]pyridine-3-carbonitrile Chemical compound C[C@]1(C[C@](C)(N=C(N)S1)C1=C(F)C=CC(\C=C(/F)C2=CC=C(C=N2)C#N)=C1)C(=O)N1CCOCC1 QBRVMFURZXJSCP-PQLPFPTISA-N 0.000 claims description 5
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- General Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
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| PCT/US2017/066179 WO2018112083A1 (en) | 2016-12-15 | 2017-12-13 | Thiazine derivatives as beta-secretase inhibitors and methods of use |
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| ES2910791T3 true ES2910791T3 (es) | 2022-05-13 |
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| MX394391B (es) | 2016-12-15 | 2025-03-24 | Amgen Inc | Derivados de tiazina y oxazina biciclicos como inhibidores de beta-secretasa y metodos de uso. |
| AU2017376444B2 (en) | 2016-12-15 | 2021-09-30 | Amgen Inc. | Thiazine derivatives as beta-secretase inhibitors and methods of use |
| WO2018112086A1 (en) | 2016-12-15 | 2018-06-21 | Amgen Inc. | Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use |
| US11021493B2 (en) | 2016-12-15 | 2021-06-01 | Amgen Inc. | 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use |
| AU2017376441B2 (en) * | 2016-12-15 | 2021-10-14 | Amgen Inc. | Oxazine derivatives as beta-secretase inhibitors and methods of use |
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| US5441870A (en) | 1992-04-15 | 1995-08-15 | Athena Neurosciences, Inc. | Methods for monitoring cellular processing of β-amyloid precursor protein |
| SI9300303A (en) | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
| AU6383396A (en) | 1995-06-07 | 1996-12-30 | Athena Neurosciences, Inc. | Beta-secretase, antibodies to beta-secretase, and assays for detecting beta-secretase inhibition |
| HK1042730B (zh) | 1998-09-24 | 2005-11-18 | 法玛西雅厄普约翰美国公司 | 阿尔茨海默氏疾病分泌酶 |
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| JP7149272B2 (ja) | 2022-10-06 |
| AU2017376444A1 (en) | 2019-07-04 |
| MX2019007102A (es) | 2019-12-16 |
| MA54100A (fr) | 2021-10-20 |
| CA3047288A1 (en) | 2018-06-21 |
| AU2017376444B2 (en) | 2021-09-30 |
| MX388697B (es) | 2025-03-20 |
| US20200062743A1 (en) | 2020-02-27 |
| US10889579B2 (en) | 2021-01-12 |
| WO2018112083A1 (en) | 2018-06-21 |
| EP3555084A1 (en) | 2019-10-23 |
| EP3555084B1 (en) | 2022-03-16 |
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