AU2017376444B2 - Thiazine derivatives as beta-secretase inhibitors and methods of use - Google Patents

Thiazine derivatives as beta-secretase inhibitors and methods of use Download PDF

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Publication number
AU2017376444B2
AU2017376444B2 AU2017376444A AU2017376444A AU2017376444B2 AU 2017376444 B2 AU2017376444 B2 AU 2017376444B2 AU 2017376444 A AU2017376444 A AU 2017376444A AU 2017376444 A AU2017376444 A AU 2017376444A AU 2017376444 B2 AU2017376444 B2 AU 2017376444B2
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tautomer
compound
amino
dihydro
pharmaceutically acceptable
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AU2017376444A1 (en
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Matthew P. Bourbeau
Paul E. Harrington
Qingyian Liu
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Amgen Inc
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
AU2017376444A 2016-12-15 2017-12-13 Thiazine derivatives as beta-secretase inhibitors and methods of use Active AU2017376444B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662434714P 2016-12-15 2016-12-15
US62/434,714 2016-12-15
PCT/US2017/066179 WO2018112083A1 (en) 2016-12-15 2017-12-13 Thiazine derivatives as beta-secretase inhibitors and methods of use

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AU2017376444A1 AU2017376444A1 (en) 2019-07-04
AU2017376444B2 true AU2017376444B2 (en) 2021-09-30

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AU2017376444A Active AU2017376444B2 (en) 2016-12-15 2017-12-13 Thiazine derivatives as beta-secretase inhibitors and methods of use

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US (1) US10889579B2 (OSRAM)
EP (1) EP3555084B1 (OSRAM)
JP (1) JP7149272B2 (OSRAM)
AU (1) AU2017376444B2 (OSRAM)
CA (1) CA3047288A1 (OSRAM)
ES (1) ES2910791T3 (OSRAM)
MA (1) MA54100A (OSRAM)
MX (1) MX388697B (OSRAM)
WO (1) WO2018112083A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA54100A (fr) 2016-12-15 2021-10-20 Amgen Inc Dérivés de thiazine en tant qu'inhibiteurs de bêta-sécrétase et procédés d'utilisation
JP7177773B2 (ja) * 2016-12-15 2022-11-24 アムジエン・インコーポレーテツド β－セクレターゼ阻害剤としてのオキサジン誘導体および使用方法
JP7149271B2 (ja) 2016-12-15 2022-10-06 アムジエン・インコーポレーテツド β－セクレターゼ阻害剤としての１，４－チアジンジオキシドおよび１，２，４－チアジアジンジオキシド誘導体ならびに使用方法
JP7159161B2 (ja) 2016-12-15 2022-10-24 アムジエン・インコーポレーテツド β－セクレターゼ阻害剤としてのシクロプロピル縮合チアジン誘導体および使用方法
WO2018112084A1 (en) 2016-12-15 2018-06-21 Amgen Inc. Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use

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Patent Citations (1)

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Also Published As

Publication number Publication date
US10889579B2 (en) 2021-01-12
MA54100A (fr) 2021-10-20
EP3555084A1 (en) 2019-10-23
EP3555084B1 (en) 2022-03-16
JP7149272B2 (ja) 2022-10-06
ES2910791T3 (es) 2022-05-13
MX388697B (es) 2025-03-20
MX2019007102A (es) 2019-12-16
JP2020503292A (ja) 2020-01-30
WO2018112083A1 (en) 2018-06-21
AU2017376444A1 (en) 2019-07-04
US20200062743A1 (en) 2020-02-27
CA3047288A1 (en) 2018-06-21

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