ES2909403T3 - Hidroxiestilbenos prenilados - Google Patents
Hidroxiestilbenos prenilados Download PDFInfo
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- ES2909403T3 ES2909403T3 ES12779889T ES12779889T ES2909403T3 ES 2909403 T3 ES2909403 T3 ES 2909403T3 ES 12779889 T ES12779889 T ES 12779889T ES 12779889 T ES12779889 T ES 12779889T ES 2909403 T3 ES2909403 T3 ES 2909403T3
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- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- XTDKVQYWANHUFS-UHFFFAOYSA-N trans-Arachidin 3 Natural products C1=C(O)C(C=CC(C)C)=C(O)C=C1C=CC1=CC=C(O)C=C1 XTDKVQYWANHUFS-UHFFFAOYSA-N 0.000 description 1
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- 239000012581 transferrin Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 238000004724 ultra fast liquid chromatography Methods 0.000 description 1
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- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
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- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- 230000035899 viability Effects 0.000 description 1
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- 238000012447 xenograft mouse model Methods 0.000 description 1
Classifications
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- C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
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- A61P17/00—Drugs for dermatological disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/235—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring
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- A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
- C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
- C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
- C07C39/215—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring containing, e.g. diethylstilbestrol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C07C67/293—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C07C67/297—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2011901663A AU2011901663A0 (en) | 2011-05-04 | Prenylated Hydroxystilbenes | |
| PCT/AU2012/000482 WO2012149608A1 (en) | 2011-05-04 | 2012-05-04 | Prenylated hydroxystilbenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2909403T3 true ES2909403T3 (es) | 2022-05-06 |
Family
ID=47107689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12779889T Active ES2909403T3 (es) | 2011-05-04 | 2012-05-04 | Hidroxiestilbenos prenilados |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10196335B2 (enExample) |
| EP (1) | EP2709975B1 (enExample) |
| JP (2) | JP6297485B2 (enExample) |
| KR (1) | KR101907716B1 (enExample) |
| CN (2) | CN107266297B (enExample) |
| AU (1) | AU2012250497C1 (enExample) |
| CA (1) | CA2833780C (enExample) |
| DK (1) | DK2709975T3 (enExample) |
| ES (1) | ES2909403T3 (enExample) |
| IL (1) | IL229204A (enExample) |
| PT (1) | PT2709975T (enExample) |
| SG (2) | SG194582A1 (enExample) |
| WO (1) | WO2012149608A1 (enExample) |
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| SG194582A1 (en) * | 2011-05-04 | 2013-12-30 | Univ Sydney | Prenylated hydroxystilbenes |
| US9642829B2 (en) * | 2012-12-04 | 2017-05-09 | The University Of Hong Kong | Antifungal compound and uses thereof |
| FR3030511B1 (fr) * | 2014-12-22 | 2018-04-06 | L'oreal | Composes 1-phenyl (3,4,5-trisubstitues), 2-phenyl (3,5-disubstitues) ethylene et leur utilisation. |
| FR3030508B1 (fr) * | 2014-12-22 | 2017-06-23 | Oreal | Composes 1-phenyl (3,4-disubstitues) 2-phenyl (3,5-disubstitues) ethylene et leur utilisation |
| FR3030510B1 (fr) | 2014-12-22 | 2017-02-03 | Oreal | Composes 1-phenyl (3,4-disubstitues), 2-phenyl (3,4-disubstitues) ethane et leur utilisation |
| CN109952095B (zh) * | 2016-09-07 | 2022-05-03 | 凯楠公爵Ip有限责任公司 | 细齿烷二萜类的药物用途 |
| CN110183414B (zh) * | 2019-07-25 | 2019-10-25 | 江西中医药大学 | 二色波罗蜜中的一种异戊烯基二苯乙烯及其在制备治疗炎症性疾病药物中的用途 |
| CN110183311B (zh) * | 2019-07-25 | 2019-10-29 | 江西中医药大学 | 一种异戊烯基芪及其在制备治疗炎症性疾病药物中的用途 |
| IL294179B2 (en) * | 2019-12-23 | 2026-04-01 | Kynan Duke Ip Llc | Modified hydroxystilbene compounds, their derivatives, method for their preparation and use. |
| CN111579682A (zh) * | 2020-05-29 | 2020-08-25 | 山东师范大学 | 一种针对不同蜂胶产品差异性代谢物的分析方法及其应用 |
| CN114573430B (zh) * | 2022-03-10 | 2022-09-06 | 中国科学院华南植物园 | 一种甘草抗炎物质及其制备方法 |
| JP7614652B2 (ja) * | 2022-08-12 | 2025-01-16 | 株式会社山田養蜂場本社 | ステロイド－５α－リダクターゼ阻害剤 |
| JP7849021B2 (ja) * | 2022-09-14 | 2026-04-21 | 株式会社山田養蜂場本社 | Ｓｉｒｔ１活性化剤 |
| WO2024249297A2 (en) * | 2023-05-26 | 2024-12-05 | Cambium Biomaterials, Inc. | Polymeric compositions with prenylated stilbenes |
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| JPH0717859A (ja) | 1993-06-30 | 1995-01-20 | Tsumura & Co | アラキドン酸代謝異常疾患治療剤 |
| KR20030011980A (ko) | 2001-07-23 | 2003-02-12 | 주식회사 태평양 | 스틸벤 유도체를 유효성분으로 포함하는 과색소 침착치료용 의약 조성물 |
| WO2003009807A2 (en) | 2001-07-23 | 2003-02-06 | Galileo Laboratories, Inc. | Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods |
| WO2003010121A1 (en) | 2001-07-23 | 2003-02-06 | Pacific Corporation | Stilbene derivatives, a method for preparation thereof, and its use |
| US6737439B2 (en) | 2001-08-07 | 2004-05-18 | The Board Of Trustees Of The University Of Illinois | Aromatase inhibitors from Broussonetia papyrifera |
| CN100342862C (zh) * | 2003-06-27 | 2007-10-17 | 中国医学科学院药物研究所 | 白藜芦醇低聚茋类化合物及其制法和其药物组合物与用途 |
| GB2411353A (en) | 2004-02-25 | 2005-08-31 | Univ Hertfordshire | Resveratrol Analogues |
| CN1331856C (zh) * | 2005-08-05 | 2007-08-15 | 大连理工大学 | 多羟基茋类化合物的制备和抑制sars病毒药物的用途 |
| US7781580B2 (en) * | 2007-04-23 | 2010-08-24 | Virginia Commonwealth University | Stilbene derivatives as new cancer therapeutic agents |
| CN100503539C (zh) * | 2007-06-14 | 2009-06-24 | 复旦大学 | 一种具有抗肿瘤活性的二苯乙烯类化合物及其制备方法 |
| WO2009012910A1 (en) | 2007-07-20 | 2009-01-29 | Universita'degli Studi Di Milano | Biologically-active stilbene derivatives and compositions thereof |
| JP2012503595A (ja) * | 2008-07-28 | 2012-02-09 | シダンスク ユニバーシティ | 代謝病の治療用の化合物 |
| US20130310611A1 (en) * | 2010-10-28 | 2013-11-21 | Uha Mikakuto Co., Ltd. | Process for production of phenolic polymerizable compound having physiological activity |
| US9340477B2 (en) * | 2010-11-26 | 2016-05-17 | Uha Mikakuto Co., Ltd. | Process for production of hydroxystilbene derivative having physiological activity |
| SG194582A1 (en) * | 2011-05-04 | 2013-12-30 | Univ Sydney | Prenylated hydroxystilbenes |
| JP7017859B2 (ja) | 2017-03-21 | 2022-02-09 | 日鉄鋼板株式会社 | 建築パネル |
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- 2012-05-04 CN CN201710431414.3A patent/CN107266297B/zh active Active
- 2012-05-04 CN CN201280033556.XA patent/CN103649031A/zh active Pending
- 2012-05-04 PT PT127798890T patent/PT2709975T/pt unknown
- 2012-05-04 ES ES12779889T patent/ES2909403T3/es active Active
- 2012-05-04 WO PCT/AU2012/000482 patent/WO2012149608A1/en not_active Ceased
- 2012-05-04 EP EP12779889.0A patent/EP2709975B1/en active Active
- 2012-05-04 AU AU2012250497A patent/AU2012250497C1/en active Active
- 2012-05-04 CA CA2833780A patent/CA2833780C/en active Active
- 2012-05-04 US US14/115,574 patent/US10196335B2/en active Active
- 2012-05-04 KR KR1020137032115A patent/KR101907716B1/ko active Active
- 2012-05-04 DK DK12779889.0T patent/DK2709975T3/da active
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2013
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2018
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2020
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2022
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