CN103649031A - 异戊烯化羟基二苯乙烯 - Google Patents

异戊烯化羟基二苯乙烯 Download PDF

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CN103649031A
CN103649031A CN201280033556.XA CN201280033556A CN103649031A CN 103649031 A CN103649031 A CN 103649031A CN 201280033556 A CN201280033556 A CN 201280033556A CN 103649031 A CN103649031 A CN 103649031A
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och
compound
chc
cancer
chch
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Chinese (zh)
Inventor
科林·查尔斯·杜克
范·霍安·德兰
鲁吉·基卡吉·杜克
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University of Sydney
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University of Sydney
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Priority claimed from AU2011901663A external-priority patent/AU2011901663A0/en
Application filed by University of Sydney filed Critical University of Sydney
Priority to CN201710431414.3A priority Critical patent/CN107266297B/zh
Publication of CN103649031A publication Critical patent/CN103649031A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/235—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/253—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
    • C07C39/215—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring containing, e.g. diethylstilbestrol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/293—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/297—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201280033556.XA 2011-05-04 2012-05-04 异戊烯化羟基二苯乙烯 Pending CN103649031A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710431414.3A CN107266297B (zh) 2011-05-04 2012-05-04 异戊烯化羟基二苯乙烯、包含其的药物组合物、用途及其制备方法

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Application Number Priority Date Filing Date Title
AU2011901663A AU2011901663A0 (en) 2011-05-04 Prenylated Hydroxystilbenes
AU2011901663 2011-05-04
PCT/AU2012/000482 WO2012149608A1 (en) 2011-05-04 2012-05-04 Prenylated hydroxystilbenes

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US (4) US10196335B2 (enExample)
EP (1) EP2709975B1 (enExample)
JP (2) JP6297485B2 (enExample)
KR (1) KR101907716B1 (enExample)
CN (2) CN103649031A (enExample)
AU (1) AU2012250497C1 (enExample)
CA (1) CA2833780C (enExample)
DK (1) DK2709975T3 (enExample)
ES (1) ES2909403T3 (enExample)
IL (1) IL229204A (enExample)
PT (1) PT2709975T (enExample)
SG (2) SG194582A1 (enExample)
WO (1) WO2012149608A1 (enExample)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN115485259A (zh) * 2019-12-23 2022-12-16 凯楠公爵Ip有限责任公司 被取代的羟基均二苯乙烯化合物和衍生物、合成及其用途

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CA2833780C (en) * 2011-05-04 2020-10-06 Colin Charles Duke Prenylated hydroxystilbenes
US9642829B2 (en) * 2012-12-04 2017-05-09 The University Of Hong Kong Antifungal compound and uses thereof
FR3030511B1 (fr) * 2014-12-22 2018-04-06 L'oreal Composes 1-phenyl (3,4,5-trisubstitues), 2-phenyl (3,5-disubstitues) ethylene et leur utilisation.
FR3030508B1 (fr) * 2014-12-22 2017-06-23 Oreal Composes 1-phenyl (3,4-disubstitues) 2-phenyl (3,5-disubstitues) ethylene et leur utilisation
FR3030510B1 (fr) 2014-12-22 2017-02-03 Oreal Composes 1-phenyl (3,4-disubstitues), 2-phenyl (3,4-disubstitues) ethane et leur utilisation
RU2762568C2 (ru) * 2016-09-07 2021-12-21 Кайнан Дьюк АйПи, ЭлЭлСи Применение в медицине серрулатановых дитерпенов
CN110183311B (zh) * 2019-07-25 2019-10-29 江西中医药大学 一种异戊烯基芪及其在制备治疗炎症性疾病药物中的用途
CN110183414B (zh) * 2019-07-25 2019-10-25 江西中医药大学 二色波罗蜜中的一种异戊烯基二苯乙烯及其在制备治疗炎症性疾病药物中的用途
CN111579682A (zh) * 2020-05-29 2020-08-25 山东师范大学 一种针对不同蜂胶产品差异性代谢物的分析方法及其应用
CN114573430B (zh) * 2022-03-10 2022-09-06 中国科学院华南植物园 一种甘草抗炎物质及其制备方法
JP7614652B2 (ja) * 2022-08-12 2025-01-16 株式会社山田養蜂場本社 ステロイド－５α－リダクターゼ阻害剤
WO2024249297A2 (en) * 2023-05-26 2024-12-05 Cambium Biomaterials, Inc. Polymeric compositions with prenylated stilbenes

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115485259A (zh) * 2019-12-23 2022-12-16 凯楠公爵Ip有限责任公司 被取代的羟基均二苯乙烯化合物和衍生物、合成及其用途
US12459883B2 (en) 2019-12-23 2025-11-04 Kynan Duke IP, LLC Substituted hydroxystilbene compounds and derivatives synthesis and uses thereof

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SG10201603776RA (en) 2016-07-28
EP2709975A4 (en) 2014-12-17
US20150307429A1 (en) 2015-10-29
AU2012250497C1 (en) 2016-09-29
KR20140043369A (ko) 2014-04-09
ES2909403T3 (es) 2022-05-06
AU2012250497A1 (en) 2013-11-28
AU2012250497B2 (en) 2016-04-14
US20220380285A1 (en) 2022-12-01
US20200331833A1 (en) 2020-10-22
SG194582A1 (en) 2013-12-30
JP6297485B2 (ja) 2018-03-20
IL229204A0 (en) 2014-01-30
KR101907716B1 (ko) 2018-10-12
CA2833780C (en) 2020-10-06
CN107266297B (zh) 2020-10-16
NZ616960A (en) 2016-01-29
US11352310B2 (en) 2022-06-07
PT2709975T (pt) 2022-03-31
JP2018127454A (ja) 2018-08-16
US20190194105A1 (en) 2019-06-27
WO2012149608A8 (en) 2013-11-14
IL229204A (en) 2016-11-30
EP2709975A1 (en) 2014-03-26
EP2709975B1 (en) 2022-01-12
CN107266297A (zh) 2017-10-20
JP2014519488A (ja) 2014-08-14
DK2709975T3 (da) 2022-03-21
US11634375B2 (en) 2023-04-25
US10696615B2 (en) 2020-06-30
US10196335B2 (en) 2019-02-05
CA2833780A1 (en) 2012-11-08
JP6461398B2 (ja) 2019-01-30
WO2012149608A1 (en) 2012-11-08

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Application publication date: 20140319