ES2891473T3 - Composiciones y métodos para reducir los niveles de alta sensibilidad (hs-CRP) en un sujeto - Google Patents
Composiciones y métodos para reducir los niveles de alta sensibilidad (hs-CRP) en un sujeto Download PDFInfo
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Applications Claiming Priority (4)
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| US201261584013P | 2012-01-06 | 2012-01-06 | |
| US201261656347P | 2012-06-06 | 2012-06-06 | |
| US201261670408P | 2012-07-11 | 2012-07-11 | |
| PCT/US2013/020526 WO2013103958A1 (en) | 2012-01-06 | 2013-01-07 | Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject |
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| ES2891473T3 true ES2891473T3 (es) | 2022-01-28 |
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| ES13733751T Active ES2891473T3 (es) | 2012-01-06 | 2013-01-07 | Composiciones y métodos para reducir los niveles de alta sensibilidad (hs-CRP) en un sujeto |
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| US (3) | US9827219B2 (OSRAM) |
| EP (1) | EP2800469B1 (OSRAM) |
| JP (2) | JP6307442B2 (OSRAM) |
| AU (4) | AU2013207368A1 (OSRAM) |
| ES (1) | ES2891473T3 (OSRAM) |
| WO (1) | WO2013103958A1 (OSRAM) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3578177A1 (en) | 2008-09-02 | 2019-12-11 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same |
| CN102458109B (zh) | 2009-04-29 | 2015-02-11 | 阿马里纳制药公司 | 稳定的药物组合物和使用其的方法 |
| MX2011011517A (es) | 2009-04-29 | 2012-06-19 | Amarin Corp Plc | Composiciones farmaceuticas que comprenden epa y un agente cardiovascular y metodos para utilizar el mismo. |
| LT2443246T (lt) | 2009-06-15 | 2018-03-26 | Amarin Pharmaceuticals Ireland Limited | Kompozicijos ir būdai, skirti trigliceridų sumažinimui, nepakeliant ldl-c lygio subjekte, kartu taikant statino terapiją |
| US20110071176A1 (en) | 2009-09-23 | 2011-03-24 | Amarin Pharma, Inc. | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
| US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| AU2011336856A1 (en) | 2010-11-29 | 2013-07-04 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| US20130131170A1 (en) | 2011-11-07 | 2013-05-23 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| WO2013103958A1 (en) | 2012-01-06 | 2013-07-11 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject |
| BR112014032905B1 (pt) | 2012-06-29 | 2022-02-22 | Amarin Pharmaceuticals Ireland Limited | Uso de éster etílico do ácido eicosapentaenóico para redução do risco de morte cardiovascular, revascularização coronária e/ou angina instável em um indivíduo em terapia com estatina |
| US20150265566A1 (en) | 2012-11-06 | 2015-09-24 | Amarin Pharmaceuticals Ireland Limited | Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy |
| US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
| US9814733B2 (en) | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
| US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
| US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
| US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
| US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
| US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
| US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
| US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
| WO2015066512A1 (en) * | 2013-10-31 | 2015-05-07 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
| US10172818B2 (en) | 2014-06-16 | 2019-01-08 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
| US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
| WO2018213663A1 (en) * | 2017-05-19 | 2018-11-22 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject having reduced kidney function |
| US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
| CN109125311A (zh) * | 2018-06-26 | 2019-01-04 | 东南大学 | 预防或治疗阿尔茨海默症的药物组合物及其应用 |
| MA51766A (fr) | 2018-09-24 | 2020-12-16 | Amarin Pharmaceuticals Ie Ltd | Procédés de réduction du risque d'événements cardiovasculaires chez un sujet |
| CN114980973A (zh) | 2019-11-12 | 2022-08-30 | 阿马里纳药物爱尔兰有限公司 | 降低心房纤颤和/或心房扑动受试者心血管事件风险的方法 |
| AU2022263358A1 (en) | 2021-04-21 | 2023-11-30 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of heart failure |
Family Cites Families (309)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU527784B2 (en) | 1978-05-26 | 1983-03-24 | Bang, Hans Olaf Dr. | Treatment of thromboembolic conditions withall-z)-5, 8, 11, 14, 17-eicosapentaenoic acid |
| US4377526A (en) | 1981-05-15 | 1983-03-22 | Nippon Suisan Kaisha, Ltd. | Method of purifying eicosapentaenoic acid and its esters |
| CA1239587A (en) | 1983-10-24 | 1988-07-26 | David Rubin | Combined fatty acid composition for lowering blood cholestrol and triglyceride levels |
| US4526902A (en) | 1983-10-24 | 1985-07-02 | Century Laboratories, Inc. | Combined fatty acid composition for treatment or prophylaxis of thrombo-embolic conditions |
| JPS6135356A (ja) | 1984-07-27 | 1986-02-19 | Nippon Oil & Fats Co Ltd | 血液脂質脂肪酸の分析方法 |
| EP0347509A1 (en) | 1988-06-21 | 1989-12-27 | Century Laboratories Inc. | A process of extraction and purification of polyunsaturated fatty acids from natural sources |
| US4920098A (en) | 1986-09-17 | 1990-04-24 | Baxter International Inc. | Nutritional support or therapy for individuals at risk or under treatment for atherosclerotic vascular, cardiovascular, and/or thrombotic diseases |
| AU602376B2 (en) | 1986-12-26 | 1990-10-11 | Sagami Chemical Research Center | Process for production of eicosapentaenoic acid |
| JPS63185390A (ja) | 1987-01-27 | 1988-07-30 | Suntory Ltd | 藻類によるエイコサペンタエン酸の製造方法 |
| US5252333A (en) | 1987-04-27 | 1993-10-12 | Scotia Holdings Plc | Lithium salt-containing pharmaceutical compositions |
| US5198468A (en) | 1987-06-24 | 1993-03-30 | Efamol Holdings Plc | Essential fatty acid composition |
| US4843095A (en) | 1987-08-07 | 1989-06-27 | Century Laboratories, Inc. | Free fatty acids for treatment or propyhlaxis of rheumatoid arthritis arthritis |
| GB8819110D0 (en) | 1988-08-11 | 1988-09-14 | Norsk Hydro As | Antihypertensive drug & method for production |
| CA1338683C (en) | 1988-09-13 | 1996-10-29 | Efamol Holdings Plc | Fatty acid therapy and compositions |
| GB2223943A (en) | 1988-10-21 | 1990-04-25 | Tillotts Pharma Ag | Oral disage forms of omega-3 polyunsaturated acids |
| US4935243A (en) | 1988-12-19 | 1990-06-19 | Pharmacaps, Inc. | Chewable, edible soft gelatin capsule |
| JP2839276B2 (ja) | 1989-01-23 | 1998-12-16 | 日本分光工業株式会社 | 超臨界流体抽出・分離方法及び装置 |
| US5457130A (en) | 1989-03-20 | 1995-10-10 | Cancer Research Campaign Technology Limited | Eicosapentaenoic acid used to treat cachexia |
| GB8906369D0 (en) | 1989-03-20 | 1989-05-04 | Tisdale Michael J | Eicosapentaenoic acid |
| CA2043615C (en) | 1990-06-04 | 2001-08-14 | Kazuhiko Hata | Method of producing eicosapentaenoic acid or the ester derivative thereof |
| GB9012651D0 (en) | 1990-06-06 | 1990-07-25 | Efamol Holdings | Essential fatty acid treatment |
| JP3103588B2 (ja) | 1990-11-16 | 2000-10-30 | 持田製薬株式会社 | リポプロテイン(a)低下剤 |
| SE9101642D0 (sv) | 1991-05-30 | 1991-05-30 | Kabi Pharmacia Ab | Phospholipids |
| US5215630A (en) | 1991-06-04 | 1993-06-01 | Nippon Suisan Kaisha, Ltd. | Method of purifying eicosapentaenoic acid or the ester derivative thereof by fractional distillation |
| WO1993003450A1 (en) | 1991-07-30 | 1993-02-18 | North Carolina State University | Method and apparatus for measuring blood lipoprotein levels by nmr spectroscopy |
| DE4133694C2 (de) | 1991-10-11 | 1993-10-07 | Fresenius Ag | Verwendung einer Emulsion mit mehrfach ungesättigten Fettsären zur i.v.-Verabreichung zur Behandlung von Hauterkrankungen |
| JP3400466B2 (ja) | 1991-10-28 | 2003-04-28 | 日本水産株式会社 | 高純度エイコサペンタエン酸またはそのエステルの製造方法 |
| JPH0649479A (ja) | 1992-07-28 | 1994-02-22 | Maruha Corp | ω−3不飽和脂肪酸系化合物の安定化法 |
| GB9217780D0 (en) | 1992-08-21 | 1992-10-07 | Efamol Holdings | Fatty acid treatment |
| US5888541A (en) | 1992-08-21 | 1999-03-30 | Scotia Holdings Plc | Fatty acid treatment |
| JPH0692847A (ja) | 1992-09-11 | 1994-04-05 | Mochida Pharmaceut Co Ltd | 骨粗鬆症治療剤 |
| GB9300125D0 (en) | 1993-01-06 | 1993-03-03 | Scotia Holdings Plc | Compositions containing esters of unsaturated fatty acids |
| WO1994028891A1 (en) | 1993-06-04 | 1994-12-22 | Martek Biosciences Corporation | Method of treating coronary vascular disease using docosahexaenoic acid |
| GB9318611D0 (en) | 1993-09-08 | 1993-10-27 | Sandoz Nutrition Ltd | Improvements in or relating to organic compounds |
| JP3325995B2 (ja) | 1994-02-28 | 2002-09-17 | ミサワホーム株式会社 | パネル接合構造 |
| GB9403857D0 (en) | 1994-03-01 | 1994-04-20 | Scotia Holdings Plc | Fatty acid derivatives |
| GB9404483D0 (en) | 1994-03-08 | 1994-04-20 | Norsk Hydro As | Refining marine oil compositions |
| US5385929A (en) | 1994-05-04 | 1995-01-31 | Warner-Lambert Company | [(Hydroxyphenylamino) carbonyl] pyrroles |
| US5760081A (en) | 1994-05-10 | 1998-06-02 | The General Hospital Corporation | Omega 3 fatty acids in the prevention of ventricular fibrillation |
| JP3368100B2 (ja) | 1994-06-02 | 2003-01-20 | キヤノン株式会社 | 静電荷像現像用トナー |
| AU711482B2 (en) | 1994-06-28 | 1999-10-14 | Scotia Holdings Plc | Compositions for treatment of diabetic complications |
| IT1274734B (it) | 1994-08-25 | 1997-07-24 | Prospa Bv | Composizioni farmaceutiche contenenti acidi grassi poliinsaturi, loro esteri o sali, unitamente a vitamine o provitamine antiossidanti |
| JP2780154B2 (ja) | 1995-02-17 | 1998-07-30 | 株式会社ヤクルト本社 | ヨーグルト |
| MY118354A (en) | 1995-05-01 | 2004-10-30 | Scarista Ltd | 1,3-propane diol derivatives as bioactive compounds |
| GB9509764D0 (en) | 1995-05-15 | 1995-07-05 | Tillotts Pharma Ag | Treatment of inflammatory bowel disease using oral dosage forms of omega-3 polyunsaturated acids |
| JPH0959206A (ja) | 1995-08-25 | 1997-03-04 | Nippon Oil & Fats Co Ltd | エイコサペンタエン酸およびエイコサペンタエン酸エステルの製造方法 |
| GB9519661D0 (en) | 1995-09-27 | 1995-11-29 | Scotia Holdings Plc | Fatty acid treatment |
| US5763496A (en) | 1995-11-27 | 1998-06-09 | The Research Foundation Of State University Of New York | Prevention of atherosclerosis using NADPH oxidase inhibitors |
| AU2738497A (en) | 1996-04-24 | 1997-11-12 | Brigham And Women's Hospital | Omega-3 fatty acids and omega-3 phosphatidylcholine in the treatment of bipolar disorder |
| US6077828A (en) | 1996-04-25 | 2000-06-20 | Abbott Laboratories | Method for the prevention and treatment of cachexia and anorexia |
| US6248398B1 (en) | 1996-05-22 | 2001-06-19 | Applied Materials, Inc. | Coater having a controllable pressurized process chamber for semiconductor processing |
| TW425285B (en) | 1996-06-10 | 2001-03-11 | Viva America Marketing Inc | Fish oil and garlic nutritive supplement |
| US5861399A (en) | 1996-07-17 | 1999-01-19 | Heart Care Partners | Methods and compositions for the rapid and enduring relief of inadequate myocardial function |
| US20020055539A1 (en) | 1996-10-02 | 2002-05-09 | Bockow Barry I. | Compositions and methods for treating cardiovascular conditions |
| DK0956013T3 (da) | 1996-10-11 | 2003-08-04 | Scarista Ltd | Farmaceutisk præparat indeholdende eicosapentaensyre og/eller stearidonsyre |
| DE69622722T2 (de) | 1996-11-20 | 2003-02-27 | N.V. Nutricia, Zoetermeer | Fette enthaltende Ernährungszusammensetzung zur Behandlung des Stoffwechselsyndroms |
| US20010006644A1 (en) | 1997-07-31 | 2001-07-05 | David J. Bova | Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night |
| KR100569319B1 (ko) | 1997-10-30 | 2006-04-07 | 모리시타 진탄 가부시키가이샤 | 불포화 지방산 또는 이들의 유도체를 내용물로 하는 캡슐제제 및 그의 제조방법 |
| WO1999026583A2 (en) | 1997-11-25 | 1999-06-03 | Warner-Lambert Company | Inhibtion of lipoprotein oxidation |
| ATE497384T1 (de) | 1997-12-10 | 2011-02-15 | Cyclosporine Therapeutics Ltd | Omega-3 fettsäure enthaltende pharmazeutische zusammensetzungen |
| NZ500703A (en) | 1998-11-04 | 2001-06-29 | F | Preparation of food-grade marine edible oils by treatment with silica, vacuum steam deodorisation and addition of a herb extract |
| US20020055529A1 (en) | 1998-12-02 | 2002-05-09 | Bisgaier Charles Larry | Method for treating alzheimer's disease |
| GB9901809D0 (en) | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
| CA2260397A1 (en) | 1999-01-29 | 2000-07-29 | Atlantis Marine Inc. | Method of converting rendered triglyceride oil from marine sources into bland, stable food oil |
| US20030104048A1 (en) | 1999-02-26 | 2003-06-05 | Lipocine, Inc. | Pharmaceutical dosage forms for highly hydrophilic materials |
| US6193999B1 (en) | 1999-03-01 | 2001-02-27 | Banner Pharmacaps, Inc. | Gum acacia substituted soft gelatin capsules |
| DE60005152T2 (de) | 1999-03-03 | 2004-07-08 | Eurovita A/S | Arzneimittel, nahrungszusätze und kosmetische zubereitung enthaltend eine fettsäure und ingwer |
| ES2286999T5 (es) | 1999-03-04 | 2016-11-17 | Suntory Holdings Limited | Utilización de un material que contiene ácido docosapentaenoico |
| US20020054871A1 (en) | 1999-04-12 | 2002-05-09 | Yadong Huang | Methods and compositions for use in the treatment of hyperlipidemia |
| US7112609B2 (en) | 1999-06-01 | 2006-09-26 | Drugtech Corporation | Nutritional supplements |
| US6207699B1 (en) | 1999-06-18 | 2001-03-27 | Richard Brian Rothman | Pharmaceutical combinations for treating obesity and food craving |
| CA2311974A1 (en) | 1999-06-28 | 2000-12-28 | Nisshin Flour Milling Co., Ltd. | Processes of selectively separating and purifying eicosapentaenoic and docosahexaenoic acids or their esters |
| GB9916536D0 (en) | 1999-07-14 | 1999-09-15 | Scarista Limited | Nutritional or pharmaceutical compositions |
| ATE394941T1 (de) | 1999-07-28 | 2008-05-15 | Swiss Caps Rechte & Lizenzen | Präparat zur verwendung als medikament und/oder nahrungsmittelergänzung |
| EP1211955A1 (en) | 1999-08-30 | 2002-06-12 | Ocean Nutrition Canada Ltd. | A nutritional supplement for lowering serum triglyceride and cholesterol levels |
| JP4170542B2 (ja) | 1999-11-18 | 2008-10-22 | 日油株式会社 | 高度不飽和脂肪酸誘導体の製造方法及び高純度エイコサペンタエン酸誘導体 |
| EP1125914A1 (en) | 2000-02-14 | 2001-08-22 | Nisshin Flour Milling Co., Ltd. | Process for separating and purifying eicosapentaenoic acid or its ester |
| ES2246769T3 (es) | 2000-05-22 | 2006-03-01 | Pro Aparts - Investimentos E Consultoria Lda | Composicion de acidos grasos que contiene al menos 80% en peso de epa y dha o sus derivados y su uso farmaceutico. |
| US6620821B2 (en) | 2000-06-15 | 2003-09-16 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
| GB0016045D0 (en) | 2000-06-29 | 2000-08-23 | Laxdale Limited | Therapeutic combinations of fatty acids |
| GB0016452D0 (en) | 2000-07-04 | 2000-08-23 | Kilgowan Limited | Vitamin K and essential fatty acids |
| JP4391673B2 (ja) | 2000-08-08 | 2009-12-24 | 花王株式会社 | 油脂組成物 |
| CA2419406A1 (en) | 2000-08-15 | 2002-02-21 | Pfizer Products Inc. | Pharmaceutical combinations of torcetrapib and atorvastatin or hydroxy derivatives for the treatment of atherosclerosis, angina and low hdl levels |
| GB0101198D0 (en) | 2001-01-17 | 2001-02-28 | Scherer Technologies Inc R P | Ingestible compositions containing an odoriferous oil |
| ITMI20010129A1 (it) | 2001-01-25 | 2002-07-25 | Pharmacia & Upjohn Spa | Acidi grassi essenziali nella terapia di insufficienza cardiaca e scompenso cardiaco |
| GB0111282D0 (en) | 2001-05-09 | 2001-06-27 | Laxdale Ltd | Potentiation of therapeutic effects of fatty acids |
| MXPA03010888A (es) | 2001-05-30 | 2004-02-27 | Laxdale Ltd | Coenzimas q y acido eicosapentaenoico (epa). |
| US20120214771A1 (en) | 2001-07-27 | 2012-08-23 | Fontini Sampalis | Compositions for treatment of cardiometabolic disorders |
| ITMI20012384A1 (it) | 2001-11-12 | 2003-05-12 | Quatex Nv | Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori |
| WO2003043570A2 (en) * | 2001-11-15 | 2003-05-30 | Galileo Laboratories, Inc. | Formulations and methods for treatment or amelioration of inflammatory conditions |
| ITMI20020269A1 (it) | 2002-02-12 | 2003-08-12 | Victorix Assets Ltd | Uso di steri etilici di acidi poliinsaturi omega-3 in pazienti con insufficienza cardiaca |
| JP2003306690A (ja) | 2002-02-18 | 2003-10-31 | Nooburu:Kk | 多価不飽和脂肪酸含有油脂組成物 |
| US20030166614A1 (en) | 2002-03-01 | 2003-09-04 | Harrison Stanley F. | Method for reducing cholesterol and triglycerides |
| EP1501493B1 (en) | 2002-05-03 | 2009-10-07 | Pronova BioPharma Norge AS | Use of epa and dha in secondary prevention of strokes |
| WO2003103582A2 (en) | 2002-06-05 | 2003-12-18 | Ivax Corporation | Reduction of gelatin cross-linking |
| US7157235B2 (en) | 2002-06-17 | 2007-01-02 | St. Vincent's Hospital Sydney Limited | Methods of diagnosis, prognosis and treatment of cardiovascular disease |
| US20040001874A1 (en) | 2002-06-24 | 2004-01-01 | Vital Living, Inc. | Safe and effective nutritional supplement formulations and associated regimens adapted to prevent and/or treat targeted diseases or medical or health conditions, and related methods |
| JP2005532394A (ja) * | 2002-07-02 | 2005-10-27 | ガリレオ ファーマシューティカルズ, インコーポレイティド | 雌性被験体における炎症性症状および/またはバイオマーカーの低減のための組成物および方法 |
| US20060211761A1 (en) | 2002-07-08 | 2006-09-21 | Yatendra Kumar | Hmg-coa-reductase inhibitors |
| US20080200453A1 (en) | 2002-07-29 | 2008-08-21 | Cincotta Anthony H | Methods of treating metabolic syndrome using dopamine receptor agonists |
| US7314643B2 (en) | 2002-08-20 | 2008-01-01 | Nikken Chemicals Co., Ltd. | Soft capsule preparation |
| US7511131B2 (en) | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
| KR20110053281A (ko) | 2002-11-22 | 2011-05-19 | 니폰스이산가부시키가이샤 | 산화 안정성이 향상된 이중결합을 가진 유기물을 함유하는 조성물 |
| US8017651B2 (en) | 2002-11-22 | 2011-09-13 | Bionexus, Ltd. | Compositions and methods for the treatment of HIV-associated fat maldistribution and hyperlipidemia |
| GB0228079D0 (en) | 2002-12-02 | 2003-01-08 | Laxdale Ltd | Huntington's Disease |
| US8124582B2 (en) * | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| GB0301701D0 (en) | 2003-01-24 | 2003-02-26 | Ensay Ltd | Psoriasis and Eicosapentaenoic acid |
| WO2004068970A2 (en) | 2003-01-31 | 2004-08-19 | The Procter & Gamble Company | Means for improving the appearance of mammalian keratinous tissue |
| WO2004069238A1 (ja) | 2003-02-07 | 2004-08-19 | Mochida Pharmaceutical Co., Ltd. | くも膜下出血の予後改善剤 |
| US20060088502A1 (en) | 2003-02-21 | 2006-04-27 | Michio Sata | Drug for reducing side effects in ribavirin interferon combination therapy |
| CA2515328A1 (en) | 2003-03-05 | 2004-09-16 | Solvay Pharmaceuticals Gmbh | Use of omega-3-fatty acids in the treatment of diabetic patients |
| PL377614A1 (pl) | 2003-03-18 | 2006-02-06 | Novartis Ag | Kompozycje zawierające kwasy tłuszczowe i aminokwasy |
| US7598227B2 (en) | 2003-04-16 | 2009-10-06 | Isis Pharmaceuticals Inc. | Modulation of apolipoprotein C-III expression |
| US6846942B2 (en) | 2003-05-20 | 2005-01-25 | David Rubin | Method for preparing pure EPA and pure DHA |
| US7205329B2 (en) | 2003-05-30 | 2007-04-17 | Microbia, Inc. | Modulators of CRTH2 activity |
| JP4870430B2 (ja) | 2003-06-20 | 2012-02-08 | 持田製薬株式会社 | 下肢静脈瘤予防・治療用組成物 |
| WO2005020785A2 (en) | 2003-07-15 | 2005-03-10 | The Regents Of The University Of California | Discovery of the microorganism that causes the human autoimmune disease, primary biliary cirrhosis |
| AU2003249492A1 (en) | 2003-07-24 | 2005-02-14 | Eswaran Krishnan Iyer | Oral compositions for treatment of diseases |
| US20050132441A1 (en) | 2003-11-12 | 2005-06-16 | Damude Howard G. | Delta15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast |
| ITMI20032247A1 (it) | 2003-11-19 | 2005-05-20 | Tiberio Bruzzese | Interazione di derivati polari di composti insaturi con substrati inorganici |
| SE0303513D0 (sv) | 2003-12-19 | 2003-12-19 | Pronova Biocare As | Use of a fatty acid composition comprising at least one of epa and dha or any combinations thereof |
| WO2005063231A2 (en) | 2003-12-31 | 2005-07-14 | Igennus Limited | Formulation containing an eicosapentaenoic acid or an ester thereof and a triterpene or esther thereof |
| IL159729A0 (en) | 2004-01-06 | 2004-06-20 | Doron I Friedman | Non-aqueous composition for oral delivery of insoluble bioactive agents |
| GB0403247D0 (en) | 2004-02-13 | 2004-03-17 | Tillotts Pharma Ag | A pharmaceutical composition |
| US7022713B2 (en) | 2004-02-19 | 2006-04-04 | Kowa Co., Ltd. | Hyperlipemia therapeutic agent |
| EP1591114A1 (en) | 2004-03-12 | 2005-11-02 | Fournier Laboratories Ireland Limited | Use of metformin and orlistat for the treatment or prevention of obesity |
| US20050215640A1 (en) | 2004-03-26 | 2005-09-29 | Baxter Jeffrey H | HMB compositions and uses thereof |
| US7923043B2 (en) | 2004-03-30 | 2011-04-12 | Theta Biomedical Consulting & Development Co., Inc. | Method for protecting humans against superficial vasodilator flush syndrome |
| US20050244367A1 (en) | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
| WO2005114190A2 (en) | 2004-05-19 | 2005-12-01 | Ppd Biomarker Discovery Sciences, Llc | Methods of identifying biomarkers |
| TW200613009A (en) | 2004-06-11 | 2006-05-01 | Ono Pharmaceutical Co | Capsule having chewing stability |
| GB0413729D0 (en) | 2004-06-18 | 2004-07-21 | Tillotts Pharma Ag | A pharmaceutical composition and its use |
| GB0413730D0 (en) | 2004-06-18 | 2004-07-21 | Tillotts Pharma Ag | A pharmaceutical composition and its use |
| JP2007284350A (ja) | 2004-07-27 | 2007-11-01 | Takeda Chem Ind Ltd | 糖尿病治療剤 |
| ITRM20040395A1 (it) | 2004-08-03 | 2004-11-03 | Sigma Tau Ind Farmaceuti | Composizione comprendente statine e acidi grassi omega 3. |
| AU2005271413A1 (en) | 2004-08-06 | 2006-02-16 | Transform Pharmaceuticals, Inc. | Novel statin pharmaceutical compositions and related methods of treatment |
| US20090042979A1 (en) | 2004-08-06 | 2009-02-12 | Transform Pharmaceuticals Inc. | Novel Statin Pharmaceutical Compositions and Related Methods of Treatment |
| WO2006017627A2 (en) | 2004-08-06 | 2006-02-16 | Barry Sears | Dietary compositions comprising docosahexaenoic acid and eicosapentaenoic acid and use thereof for treating insulin resistance |
| CA2577345C (en) | 2004-08-18 | 2013-02-19 | Hiroki Ueshima | Jelly composition |
| US20060051418A1 (en) | 2004-08-25 | 2006-03-09 | Essentialis, Inc. | Pharmaceutical formulations of potassium ATP channel openers and uses thereof |
| CN1759834B (zh) | 2004-09-17 | 2010-06-23 | 中国医学科学院医药生物技术研究所 | 黄连素或其与辛伐他汀联合在制备用于预防或治疗与血脂有关疾病或症状的产品中用途 |
| DE602005010899D1 (de) | 2004-09-27 | 2008-12-18 | Sigmoid Pharma Ltd | Mikrokapseln mit einem methylxanthin und einem kortikosteroid |
| JP5491697B2 (ja) * | 2004-10-15 | 2014-05-14 | フォトンズ コーポレイション リミテッド | 高レベルオメガ−3および低レベル飽和脂肪酸を含む組成物 |
| FR2878747B1 (fr) | 2004-12-03 | 2007-03-30 | Pierre Fabre Medicament Sa | Utilisation d'acide(s) gras omega-3 pour le traitement de l'hypercholesterolemie causee par un traitement anti-retroviral chez les patients infectes par le vih |
| KR101356335B1 (ko) | 2004-12-06 | 2014-02-06 | 릴라이언트 파마슈티컬스 인코퍼레이티드 | 지질 치료를 위한 오메가-3 지방산 및 이상지질혈증 제제 |
| CN101098690A (zh) | 2004-12-06 | 2008-01-02 | 瑞莱恩特医药品有限公司 | 用于血脂治疗的ω-3脂肪酸和脂血异常剂 |
| US20090239927A1 (en) | 2004-12-06 | 2009-09-24 | George Bobotas | Statin and Omega-3 Fatty Acids For Lipid Therapy |
| US20070191467A1 (en) | 2004-12-06 | 2007-08-16 | Reliant Pharmaceutical, Inc. | Statin and omega-3 fatty acids for lipid therapy |
| US20060135610A1 (en) | 2004-12-22 | 2006-06-22 | Bortz Jonathan D | Cardiovascular compositions |
| GB2421909A (en) | 2004-12-23 | 2006-07-12 | Laxdale Ltd | Pharmaceutical compositions comprising EPA and methods of use |
| US20080200707A1 (en) | 2005-01-04 | 2008-08-21 | Mochida-Pharmaceuticals Pharmaceutical Co., Ltd. | Lipotoxicity Relieving Agent |
| CA2593768C (en) | 2005-01-04 | 2014-02-18 | Mochida Pharmaceutical Co., Ltd. | Use of .omega.3 unsaturated fatty acids for relieving lipotoxicity |
| ATE528005T1 (de) | 2005-01-10 | 2011-10-15 | Cortendo Ab Publ | 2s,4r ketoconazol zur behandlung von diabetes, metabolischem syndrom und anderen erkrankungen |
| US20060172012A1 (en) | 2005-01-28 | 2006-08-03 | Finley John W | Anti-inflammatory supplement compositions and regimens to reduce cardiovascular disease risks |
| US20060189682A1 (en) | 2005-02-02 | 2006-08-24 | Payne Joseph E | Water soluble prodrugs of COX-2 inhibitors |
| US20080139604A1 (en) | 2005-02-17 | 2008-06-12 | Shaun Fitzpatrick | Method of Treating Atherosclerosis, Dyslipidemias and Related Conditions |
| US20100254951A1 (en) | 2005-02-22 | 2010-10-07 | Mochida Pharmaceutical Co., Ltd. | Nerve Regeneration Promoting Agent |
| US20060211763A1 (en) | 2005-03-08 | 2006-09-21 | Abdel Fawzy | Treatment with Statin and Omega-3 Fatty Acids and a Combination Product Thereof |
| EP1790339B1 (en) | 2005-07-08 | 2014-06-04 | Mochida Pharmaceutical Co., Ltd. | Composition for prevention of occurrence of cardiovascular event |
| MX2008000915A (es) | 2005-07-18 | 2008-04-04 | Reliant Pharmaceuticals Inc | Tratamiento con inhibidores de absorcion de colesterol basados en azetidinona y acidos grasos omega-3 y un producto de combinacion de los mismos. |
| RU2290185C1 (ru) | 2005-07-26 | 2006-12-27 | Дмитрий Николаевич Мясников | Композиция для нормализации липидного обмена и снижения массы тела и способ её получения |
| CA2616806A1 (en) | 2005-07-28 | 2007-02-08 | Reliant Pharmaceuticals, Inc. | Treatment with dihydropyridine calcium channel blockers and omega-3 fatty acids and a combination product thereof |
| ITMI20051560A1 (it) | 2005-08-10 | 2007-02-11 | Tiberio Bruzzese | Composizione di acidi grassi n-3 con elevata concentrazione di epa e-o dha e contenente acidi grassi n-6 |
| US7405302B2 (en) | 2005-10-11 | 2008-07-29 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US20090227602A1 (en) | 2005-10-28 | 2009-09-10 | John Griffin | Compositions and treatments for inhibiting kinase and/or hmg-coa reductase |
| US20070105793A1 (en) | 2005-11-04 | 2007-05-10 | Curt Hendrix | Compositions and methods using nicotinic acid for treatment of hypercholesterolemia, hyperlipidemia nd cardiovascular disease |
| US20070104779A1 (en) | 2005-11-07 | 2007-05-10 | Rongen Roelof M | Treatment with omega-3 fatty acids and products thereof |
| BRPI0618455A2 (pt) | 2005-11-11 | 2011-08-30 | Mochida Pharm Co Ltd | composição de geléia |
| WO2007058523A1 (en) | 2005-11-17 | 2007-05-24 | N.V. Nutricia | Composition with docosapentaenoic acid |
| BRPI0520669A2 (pt) | 2005-11-21 | 2009-06-02 | Teva Pharma | dosagem farmacêutica que reduz o efeito do alimento encontrado para administração de atorvastatina |
| CA2634139C (en) | 2005-12-20 | 2015-06-23 | Cenestra, Llc. | Omega 3 fatty acid formulations |
| PL1800675T4 (pl) | 2005-12-23 | 2012-02-29 | Nutricia Nv | Kompozycja zawierająca wielonienasycone kwasy tłuszczowe, białka, mangan, i/lub molibden oraz nukleozydy/nukleotydy do leczenia otępienia |
| US20070265340A1 (en) | 2006-01-05 | 2007-11-15 | Shalwitz Robert A | Treatment of fatty liver |
| EP1905424A3 (en) | 2006-02-02 | 2008-04-30 | Ranbaxy Laboratories Limited | Process for the preparation of a pharmaceutical composition comprising stabilized statin particles |
| CN103751781A (zh) | 2006-02-07 | 2014-04-30 | 持田制药株式会社 | 预防中风复发的组合物 |
| CN101395170A (zh) | 2006-02-14 | 2009-03-25 | 英特塞普特药品公司 | 用于预防或治疗fxr介导的疾病或状态的作为fxr配体的胆汁酸衍生物 |
| US8784886B2 (en) | 2006-03-09 | 2014-07-22 | GlaxoSmithKline, LLC | Coating capsules with active pharmaceutical ingredients |
| WO2007128801A1 (en) | 2006-05-08 | 2007-11-15 | Novartis Ag | Combination of organic compounds |
| EP2022495B1 (en) | 2006-05-31 | 2014-07-23 | Mochida Pharmaceutical Co., Ltd. | Composition for preventing the occurrence of cardiovascular event in multiple risk patient |
| NZ573719A (en) | 2006-07-05 | 2011-08-26 | Photonz Corp Ltd | Production of ultrapure eicosapentaenoic acid and polar lipids from largely heterotrophic culture of nitzschia laevis |
| US20090304784A1 (en) | 2006-07-28 | 2009-12-10 | V. Mane Fils | Seamless capsules containing high amounts of polyunsaturated fatty acids and a flavouring component |
| US20080085911A1 (en) | 2006-10-10 | 2008-04-10 | Reliant Pharmaceuticals, Inc. | Statin and omega-3 fatty acids for reduction of apo-b levels |
| CN101553221A (zh) | 2006-10-10 | 2009-10-07 | 瑞莱恩特医药品有限公司 | 用于降低APO-B水平的抑制素和ω-3脂肪酸 |
| WO2008088415A1 (en) | 2006-10-18 | 2008-07-24 | Reliant Pharmaceuticals, Inc. | Omega-3 fatty acids for reduction of lp-pla2 levels |
| US20080125490A1 (en) | 2006-11-03 | 2008-05-29 | My Svensson | Treatment and prevention of cardiovascular disease in patients with chronic kidney disease by administering Omega-3 Fatty Acids |
| US20080306154A1 (en) | 2006-11-03 | 2008-12-11 | My Svensson | Treatment and prevention of major adverse cardiovascular events or major coronary evens by administering Omega-3 fatty acids |
| EP2119443B1 (en) | 2007-01-17 | 2014-08-20 | Mochida Pharmaceutical Co., Ltd. | Composition for prevention or treatment of disease associated with thrombus or embolus |
| WO2008091338A1 (en) | 2007-01-23 | 2008-07-31 | Reddy Us Therapeutics, Inc. | Methods and compositions for the treatment of insulin resistance, diabetes, and diabetes-associated dyslipidemia |
| US20080185198A1 (en) | 2007-02-02 | 2008-08-07 | Steven Mark Jones | Next generation hybrid III parallel/series hybrid system |
| DK2121576T3 (en) | 2007-02-15 | 2016-02-15 | Ct De Rech Sur Les Biotechnologies Marine | Polyunsaturated fatty acid monoglycerides, derivatives, and uses thereof |
| CA2677036A1 (en) | 2007-03-06 | 2008-09-12 | Bioriginal Food & Science Corp. | Soft gelatin capsule shells containing oil soluble flavoring and methods of making the same |
| WO2008115529A1 (en) | 2007-03-20 | 2008-09-25 | Reliant Pharmaceuticals, Inc. | Compositions comprising omega-3 fatty acids and cetp inhibitors |
| WO2008145170A1 (de) | 2007-05-31 | 2008-12-04 | Siemens Aktiengesellschaft | Verfahren zum konfigurieren einer automatisierungsanlage |
| US20080299187A1 (en) | 2007-06-01 | 2008-12-04 | Joar Opheim | Substances for Reducing Occurence of Major Cardiac Events in Humans |
| KR20100039362A (ko) | 2007-06-29 | 2010-04-15 | 다케다 야쿠힌 고교 가부시키가이샤 | 심리스 캡슐 |
| EP2205231A1 (en) | 2007-10-01 | 2010-07-14 | NeuroSearch A/S | Pharmaceutical compositions of 5-hydr0xytrypt0phan and serotonin-enhancing compound |
| US8361534B2 (en) | 2007-12-20 | 2013-01-29 | Abbott Laboratories | Stable nutritional powder |
| BRPI0820584A2 (pt) | 2007-12-20 | 2015-07-14 | Abbott Lab | Pó nutricional estável |
| UA102477C2 (en) | 2008-01-10 | 2013-07-10 | Такеда Фармасьютикал Компани Лимитед | Capsule composition |
| US20090182049A1 (en) | 2008-01-16 | 2009-07-16 | Joar Arild Opheim | Pharmaceutical Composition and Method for Treating Hypertriglyceridemia and Hypercholesterolemia in Humans |
| MX2010012482A (es) | 2008-05-15 | 2010-12-01 | Pronova Biopharma Norge As | Proceso para aceite de kril. |
| CA2724983A1 (en) | 2008-05-20 | 2009-11-26 | Mochida Pharmaceutical Co., Ltd. | Composition for preventing cardiovascular event in high-risk patient |
| JPWO2009151125A1 (ja) | 2008-06-13 | 2011-11-17 | 持田製薬株式会社 | 肝障害の診断及び治療 |
| JPWO2009151116A1 (ja) | 2008-06-13 | 2011-11-17 | 持田製薬株式会社 | 非アルコール性脂肪肝炎の予防/改善・治療薬 |
| JPWO2009154230A1 (ja) | 2008-06-17 | 2011-12-01 | 持田製薬株式会社 | 非アルコール性脂肪肝炎の予防/改善・治療薬 |
| KR20110039249A (ko) | 2008-07-07 | 2011-04-15 | 모치다 세이야쿠 가부시키가이샤 | 지질 이상증의 개선 또는 치료약 |
| EP3578177A1 (en) * | 2008-09-02 | 2019-12-11 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same |
| JPWO2010038796A1 (ja) | 2008-09-30 | 2012-03-01 | 持田製薬株式会社 | C型肝炎治療剤 |
| US20100130608A1 (en) | 2008-10-01 | 2010-05-27 | Martek Biosciences Corporation | Compositions and methods for reducing triglyceride levels |
| US20120035105A1 (en) | 2009-01-09 | 2012-02-09 | Sdg, Inc. | Insulin Therapies for the Treatment of Diabetes, Diabetes Related Ailments, and/or Diseases or Conditions Other Than Diabetes or Diabetes Related Ailments |
| WO2010083615A1 (en) | 2009-01-26 | 2010-07-29 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing apolipoprotein c-iii expression |
| ES2769926T3 (es) | 2009-02-10 | 2020-06-29 | Amarin Pharmaceuticals Ie Ltd | Ester etílico del ácido eicosapentaenoico para tratar la hipertrigliceridemia |
| US8241672B2 (en) | 2009-03-11 | 2012-08-14 | Stable Solutions Llc | Omega-3 enriched fish oil-in-water parenteral nutrition emulsions |
| WO2010117951A1 (en) | 2009-04-06 | 2010-10-14 | The Regents Of The University Of California | Inhibitors of soluble epoxide hydrolase to inhibit or prevent niacin-induced flushing |
| CN102458109B (zh) | 2009-04-29 | 2015-02-11 | 阿马里纳制药公司 | 稳定的药物组合物和使用其的方法 |
| MX2011011517A (es) | 2009-04-29 | 2012-06-19 | Amarin Corp Plc | Composiciones farmaceuticas que comprenden epa y un agente cardiovascular y metodos para utilizar el mismo. |
| CA3059911C (en) | 2009-05-22 | 2022-01-11 | Mochida Pharmaceutical Co., Ltd. | Self-emulsifying composition of .omega.3 fatty acid |
| LT2443246T (lt) | 2009-06-15 | 2018-03-26 | Amarin Pharmaceuticals Ireland Limited | Kompozicijos ir būdai, skirti trigliceridų sumažinimui, nepakeliant ldl-c lygio subjekte, kartu taikant statino terapiją |
| RU2402326C1 (ru) | 2009-06-22 | 2010-10-27 | Учреждение Российской академии медицинских наук Дальневосточный научный центр физиологии и патологии дыхания Сибирского отделения Российской академии медицинских наук (ДНЦ ФПД СО РАМН) | Способ коррекции инсулинорезистентности при метаболическом синдроме |
| US8557275B2 (en) | 2009-07-23 | 2013-10-15 | U.S. Nutraceuticals, LLC | Composition and method to alleviate joint pain using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA |
| SG178948A1 (en) | 2009-09-01 | 2012-04-27 | Catabasis Pharmaceuticals Inc | Fatty acid niacin conjugates and their uses |
| US20110071176A1 (en) | 2009-09-23 | 2011-03-24 | Amarin Pharma, Inc. | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
| JP5951489B2 (ja) | 2009-10-16 | 2016-07-13 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | 組成物 |
| JP5758298B2 (ja) | 2009-10-16 | 2015-08-05 | 持田製薬株式会社 | 非アルコール性脂肪肝炎関連マーカー |
| EP2521447B1 (en) | 2010-01-08 | 2017-06-14 | Catabasis Pharmaceuticals, Inc. | Fatty acid fumarate derivatives and their uses |
| WO2011087981A2 (en) | 2010-01-15 | 2011-07-21 | E. I. Du Pont De Nemours And Company | Clinical benefits of eicosapentaenoic acid in humans |
| US20110218243A1 (en) | 2010-03-04 | 2011-09-08 | Amarin Pharma, Inc. | Compositions and methods for treating and/or preventing cardiovascular disease |
| US8846321B2 (en) | 2010-03-12 | 2014-09-30 | President And Fellows Of Harvard College | Association of levels of HDL-cholesterol apolipoprotein CIII with the risk of coronary heart disease and cardiovascular events |
| US8663704B2 (en) | 2010-04-30 | 2014-03-04 | U.S. Nutraceuticals, LLC | Composition and method to improve blood lipid profiles and optionally reduce low density lipoprotein (LDL) per-oxidation in humans |
| GB2480146A (en) | 2010-05-05 | 2011-11-09 | St Giles Foods Ltd | Fruit or vegetable based edible composition comprising nutritional supplement |
| CA2803558C (en) | 2010-06-30 | 2018-05-29 | Mochida Pharmaceutical Co., Ltd. | .omega.3 fatty acid compound preparation |
| AR082930A1 (es) | 2010-09-08 | 2013-01-16 | Pronova Biopharma Norge As | Composiciones que comprenden una mezcla oleosa de acidos grasos, un tensioactivo y una estatina |
| US20130260403A1 (en) * | 2010-10-20 | 2013-10-03 | GlycoMark Inc. | Identification of pre-diabetes using a combination of mean glucose and 1,5-anhydroglucitol markers |
| WO2012063820A1 (ja) | 2010-11-09 | 2012-05-18 | 持田製薬株式会社 | 血糖値上昇抑制剤 |
| AU2011336856A1 (en) | 2010-11-29 | 2013-07-04 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| KR101310710B1 (ko) | 2011-03-23 | 2013-09-27 | 한미약품 주식회사 | 오메가-3 지방산 에스테르 및 HMG-CoA 환원효소 억제제를 포함하는 경구용 복합 조성물 |
| US20120264824A1 (en) | 2011-04-15 | 2012-10-18 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| KR20190062511A (ko) | 2011-04-27 | 2019-06-05 | 아이오니스 파마수티컬즈, 인코포레이티드 | 아포지방단백질 ciii (apociii) 발현의 조정 |
| WO2013040507A1 (en) | 2011-09-15 | 2013-03-21 | Omthera Pharmaceuticals, Inc. | Methods and compositions for treating, reversing, inhibiting or preventing resistance to antiplatelet therapy |
| US20130131170A1 (en) | 2011-11-07 | 2013-05-23 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| US20140323709A1 (en) | 2011-12-12 | 2014-10-30 | National Cerebral And Cardiovascular Center | Oligonucleotide and therapeutic agent for hyperlipidemia containing same as active ingredient |
| WO2013103958A1 (en) | 2012-01-06 | 2013-07-11 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject |
| AU2013240427B2 (en) | 2012-03-30 | 2017-08-03 | Sancilio & Company, Inc. | Omega-3 fatty acid ester compositions |
| AR095182A1 (es) | 2012-05-07 | 2015-09-30 | Omthera Pharmaceuticals Inc | Composiciones de estatinas y ácidos grasos omega-3 |
| EP2851069B1 (en) | 2012-05-15 | 2019-08-28 | Mochida Pharmaceutical Co., Ltd. | Cardiovascular disease primary prevention agent for patients having high blood levels of high-sensitivity c-reactive protein |
| BR112014029757A2 (pt) | 2012-05-30 | 2017-06-27 | Clariant Finance Bvi Ltd | composição contendo tensoativos do tipo aminoácido, betaínas e n-metil-n-acilglucaminas e tendo qualidade de espuma melhorada e maior viscosidade |
| US20130324607A1 (en) | 2012-06-05 | 2013-12-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypercholesterolemia |
| US20140080850A1 (en) | 2012-06-05 | 2014-03-20 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising an omega-3 fatty acid and a hydroxy-derivative of a statin and methods of using same |
| EP2861227A4 (en) | 2012-06-17 | 2016-01-27 | Matinas Biopharma Inc | OMEGA-3 PENTAIC ACID COMPOSITIONS AND METHODS OF USE |
| EP3682875A3 (en) | 2012-06-29 | 2020-10-21 | Amarin Pharmaceuticals Ireland Limited | Methods of treating pediatric metabolic syndrome |
| US20140005265A1 (en) | 2012-06-29 | 2014-01-02 | Amarin Pharmaceuticals Ireland Limited | Methods for treating hypertriglyceridemia |
| BR112014032905B1 (pt) | 2012-06-29 | 2022-02-22 | Amarin Pharmaceuticals Ireland Limited | Uso de éster etílico do ácido eicosapentaenóico para redução do risco de morte cardiovascular, revascularização coronária e/ou angina instável em um indivíduo em terapia com estatina |
| US20140004183A1 (en) | 2012-06-29 | 2014-01-02 | Amarin Pharmaceuticals Ireland Limited | Methods for treating cardiovascular disease in statin-tolerant subjects |
| US20150157593A1 (en) | 2012-06-29 | 2015-06-11 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing ldl-p |
| JP6196225B2 (ja) | 2012-09-28 | 2017-09-13 | 持田製薬株式会社 | 糖尿病新規発症低減用組成物 |
| US9486433B2 (en) | 2012-10-12 | 2016-11-08 | Mochida Pharmaceuticals Co. Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| EP2719382A1 (en) | 2012-10-12 | 2014-04-16 | Mochida Pharmaceutical Co., Ltd. | Ethyl Eicosapentanoate and Pharmaceutical Compositions Comprising Ethyl Eicosapentanoate as an Active Ingredient for Use in the Treatment of Non-Alcoholic Steatohepatitis |
| US20150265566A1 (en) | 2012-11-06 | 2015-09-24 | Amarin Pharmaceuticals Ireland Limited | Compositions and Methods for Lowering Triglycerides without Raising LDL-C Levels in a Subject on Concomitant Statin Therapy |
| US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
| US20140213648A1 (en) | 2012-12-31 | 2014-07-31 | Amarin Pharmaceuticals Ireland Limited | Methods of increasing epa blood levels |
| US9814733B2 (en) | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
| US20140221358A1 (en) | 2013-02-06 | 2014-08-07 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and diazoxide and methods of use thereof |
| US20140221452A1 (en) | 2013-02-06 | 2014-08-07 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and 5-htp and methods of use thereof |
| US20140221676A1 (en) | 2013-02-06 | 2014-08-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating and/or preventing cardiovascular disease |
| US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
| US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
| US20140242216A1 (en) | 2013-02-24 | 2014-08-28 | Mead Johnson Nutrition Company | Amino Acid And Protein Hydrolysate Based Formulas With A Stable Emulsion System |
| US20140249214A1 (en) | 2013-03-01 | 2014-09-04 | Amarin Pharmaceuticals Ireland Limited | Co-administration of warfarin and ethyl eicosapentaenoate |
| WO2014134466A1 (en) | 2013-03-01 | 2014-09-04 | Amarin Pharmaceuticals Ireland Limited. | Co-administration of atorvastatin and ethyl eicosapentaenoic acid or a derivative thereof |
| US20140249225A1 (en) | 2013-03-01 | 2014-09-04 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidative modification of membrane polyunsaturated fatty acids |
| US20140249220A1 (en) | 2013-03-01 | 2014-09-04 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for reducing a fatty acid desaturation index in a subject in need thereof |
| US20140255537A1 (en) | 2013-03-11 | 2014-09-11 | Mead Johnson Nutrition Company | Nutritional Compositions Containing an Enriched Lipid Fraction and Uses Thereof |
| US9661874B2 (en) | 2013-03-11 | 2017-05-30 | Mead Johnson Nutrition Company | Nutritional compositions containing structured fat globules and uses thereof |
| US20140275252A1 (en) | 2013-03-14 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Methods of treating traumatic brain injury |
| US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
| US20140271907A1 (en) | 2013-03-14 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and krill oil and methods of use thereof |
| US10441560B2 (en) | 2013-03-15 | 2019-10-15 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
| CN105592846A (zh) | 2013-03-15 | 2016-05-18 | 持田制药株式会社 | 用于治疗非酒精性脂肪性肝炎的组合物和方法 |
| US20140322314A1 (en) | 2013-04-29 | 2014-10-30 | Matinas Biopharma, Inc. | Omega-3 Fatty Acid Formulations for Use as Pharmaceutical Treatment |
| US20140357717A1 (en) | 2013-06-04 | 2014-12-04 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
| JPWO2015008849A1 (ja) | 2013-07-18 | 2017-03-02 | 持田製薬株式会社 | ω3脂肪酸の自己乳化組成物 |
| CN111888343A (zh) | 2013-07-18 | 2020-11-06 | 持田制药株式会社 | ω-3脂肪酸的自乳化组合物 |
| WO2015021141A1 (en) | 2013-08-06 | 2015-02-12 | Amarin Pharmaceuticals Ireland Limited | Methods of treating a cardiovascular disorder in a subject on apo-c3 modulating therapy |
| US20150051282A1 (en) | 2013-08-14 | 2015-02-19 | Amarin Pharmaceuticals Ireland Limited | Methods of treating a cardiovascular disorder and/or joint pain in a subject on glucosamine therapy |
| US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
| US20150073050A1 (en) | 2013-09-09 | 2015-03-12 | Amarin Pharmaceuticals Ireland Limited | Co-administration of omeprazole and eicosapentaenoic acid or a derivative thereof |
| WO2015053379A1 (en) | 2013-10-07 | 2015-04-16 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
| WO2015066512A1 (en) | 2013-10-31 | 2015-05-07 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| HRP20192299T1 (hr) | 2014-04-11 | 2020-03-06 | Cymabay Therapeutics, Inc. | Liječenje nafld i nash |
| US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
| US10172818B2 (en) | 2014-06-16 | 2019-01-08 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
| WO2016117057A1 (ja) | 2015-01-21 | 2016-07-28 | 持田製薬株式会社 | ω3脂肪酸の自己乳化組成物 |
| WO2016117621A1 (ja) | 2015-01-21 | 2016-07-28 | 持田製薬株式会社 | ω3脂肪酸の自己乳化組成物 |
| WO2016140949A1 (en) | 2015-03-02 | 2016-09-09 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidative modification of membrane polyunsaturated fatty acids |
| US20170151202A1 (en) | 2015-09-09 | 2017-06-01 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids |
| US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
| RS61403B1 (sr) | 2016-07-29 | 2021-02-26 | Kowa Co | Postupci prevencije kardiovaskularnih događaja u populacijama sa dislipidemijom sa rezidualnim rizikom |
| WO2018213663A1 (en) | 2017-05-19 | 2018-11-22 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject having reduced kidney function |
| US20190054054A1 (en) | 2017-08-15 | 2019-02-21 | Amarin Pharmaceuticals Ireland Limited | Methods reducing or preventing oxidation of high density lipoprotein (HDL) |
| US20190054058A1 (en) | 2017-08-15 | 2019-02-21 | Amarin Pharmaceuticals Ireland Limited | Methods of Treating or Preventing Bone Loss |
| US20190209506A1 (en) | 2018-01-09 | 2019-07-11 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of ldl or lipid membranes in a subject in need thereof |
| US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
| US20190275057A1 (en) | 2018-03-06 | 2019-09-12 | Amarin Pharmaceuticals Ireland Limited | Compositions and Methods for Lowering Triglycerides in a Subject with Reduced Kidney Function and Diabetes Mellitus |
| EA202190547A1 (ru) | 2018-08-17 | 2021-04-27 | Амарин Фармасьютикалз Айрлэнд Лимитед | Способы снижения потребности в реваскуляризации периферических артерий у субъекта, получающего лечение статинами |
| MA51766A (fr) | 2018-09-24 | 2020-12-16 | Amarin Pharmaceuticals Ie Ltd | Procédés de réduction du risque d'événements cardiovasculaires chez un sujet |
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- 2013-01-07 AU AU2013207368A patent/AU2013207368A1/en not_active Abandoned
- 2013-01-07 US US13/735,660 patent/US9827219B2/en active Active
- 2013-01-07 EP EP13733751.5A patent/EP2800469B1/en not_active Revoked
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2016
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| AU2016256822B2 (en) | 2018-08-09 |
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| AU2018260825B2 (en) | 2020-08-27 |
| AU2020277100A1 (en) | 2020-12-24 |
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| US20190240183A1 (en) | 2019-08-08 |
| AU2013207368A1 (en) | 2014-07-24 |
| EP2800469B1 (en) | 2021-08-25 |
| JP6419927B2 (ja) | 2018-11-07 |
| AU2018260825A1 (en) | 2018-11-22 |
| AU2020277100B2 (en) | 2022-10-06 |
| JP6307442B2 (ja) | 2018-04-04 |
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