ES2887261T3 - Compuestos de fenoxiquinazolina y su uso para tratar el cáncer - Google Patents
Compuestos de fenoxiquinazolina y su uso para tratar el cáncer Download PDFInfo
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- ES2887261T3 ES2887261T3 ES18724488T ES18724488T ES2887261T3 ES 2887261 T3 ES2887261 T3 ES 2887261T3 ES 18724488 T ES18724488 T ES 18724488T ES 18724488 T ES18724488 T ES 18724488T ES 2887261 T3 ES2887261 T3 ES 2887261T3
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- compound
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- oxy
- isopropyl
- acetamide
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- 201000011510 cancer Diseases 0.000 title claims description 46
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- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 15
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- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 10
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762490865P | 2017-04-27 | 2017-04-27 | |
| PCT/EP2018/060800 WO2018197643A1 (en) | 2017-04-27 | 2018-04-26 | Phenoxyquinazoline compounds and their use in treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2887261T3 true ES2887261T3 (es) | 2021-12-22 |
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|---|---|---|---|
| ES18724488T Active ES2887261T3 (es) | 2017-04-27 | 2018-04-26 | Compuestos de fenoxiquinazolina y su uso para tratar el cáncer |
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| Country | Link |
|---|---|
| US (1) | US11053223B2 (enExample) |
| EP (1) | EP3615526B1 (enExample) |
| JP (1) | JP7117323B2 (enExample) |
| CN (1) | CN110546147B (enExample) |
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| KR102674404B1 (ko) * | 2018-04-20 | 2024-06-13 | 엘지전자 주식회사 | 저온 저장고의 냉각 시스템 |
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| TW200505452A (en) * | 2003-06-17 | 2005-02-16 | Astrazeneca Ab | Chemical compounds |
| EP2210607B1 (en) * | 2003-09-26 | 2011-08-17 | Exelixis Inc. | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer |
| MX2007004403A (es) * | 2004-10-12 | 2007-04-27 | Astrazeneca Ab | Derivados de quinazolina. |
| CN1313449C (zh) * | 2005-07-14 | 2007-05-02 | 沈阳中海生物技术开发有限公司 | 新的喹唑啉类衍生物、含有其的药物组合物以及它们的用途 |
| CN102267952B (zh) * | 2011-06-21 | 2013-12-11 | 天津市汉康医药生物技术有限公司 | 喹唑啉类化合物、其制备方法和用途 |
| CN103254142B (zh) * | 2013-04-26 | 2015-10-28 | 浙江工业大学 | 4-[4-(2-取代氨基乙酰氨基)苯胺基]喹唑啉类衍生物及制备和应用 |
| CN104130200B (zh) * | 2014-07-01 | 2016-04-20 | 中山大学 | 一种2-取代苯基-4-芳胺基喹唑啉衍生物及其制备方法和应用 |
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