CA3059660A1 - Phenoxyquinazoline compounds and their use in treating cancer - Google Patents
Phenoxyquinazoline compounds and their use in treating cancer Download PDFInfo
- Publication number
- CA3059660A1 CA3059660A1 CA3059660A CA3059660A CA3059660A1 CA 3059660 A1 CA3059660 A1 CA 3059660A1 CA 3059660 A CA3059660 A CA 3059660A CA 3059660 A CA3059660 A CA 3059660A CA 3059660 A1 CA3059660 A1 CA 3059660A1
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- Prior art keywords
- compound
- formula
- oxy
- triazol
- acetamide
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- 201000011510 cancer Diseases 0.000 title claims description 46
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US62/490,865 | 2017-04-27 | ||
| PCT/EP2018/060800 WO2018197643A1 (en) | 2017-04-27 | 2018-04-26 | Phenoxyquinazoline compounds and their use in treating cancer |
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| CA3059660A1 true CA3059660A1 (en) | 2018-11-01 |
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| KR102674404B1 (ko) * | 2018-04-20 | 2024-06-13 | 엘지전자 주식회사 | 저온 저장고의 냉각 시스템 |
| KR20250072243A (ko) * | 2023-11-16 | 2025-05-23 | (주)신테카바이오 | 헤테로아릴 유도체 화합물 및 이의 용도 |
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| GB9707800D0 (en) | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
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| MXPA03009662A (es) * | 2001-04-27 | 2004-12-06 | Kirin Brewery | Derivados de quinolina y derivados de quinazolina que tienen grupos azolilo. |
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| EP2210607B1 (en) * | 2003-09-26 | 2011-08-17 | Exelixis Inc. | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer |
| AU2005293336B2 (en) | 2004-10-12 | 2009-05-28 | Astrazeneca Ab | Quinazoline derivatives |
| CN1313449C (zh) * | 2005-07-14 | 2007-05-02 | 沈阳中海生物技术开发有限公司 | 新的喹唑啉类衍生物、含有其的药物组合物以及它们的用途 |
| CN102267952B (zh) * | 2011-06-21 | 2013-12-11 | 天津市汉康医药生物技术有限公司 | 喹唑啉类化合物、其制备方法和用途 |
| CN103254142B (zh) * | 2013-04-26 | 2015-10-28 | 浙江工业大学 | 4-[4-(2-取代氨基乙酰氨基)苯胺基]喹唑啉类衍生物及制备和应用 |
| CN104130200B (zh) * | 2014-07-01 | 2016-04-20 | 中山大学 | 一种2-取代苯基-4-芳胺基喹唑啉衍生物及其制备方法和应用 |
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- 2018-04-26 US US16/608,212 patent/US11053223B2/en active Active
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- 2018-04-26 CA CA3059660A patent/CA3059660A1/en active Pending
- 2018-04-26 WO PCT/EP2018/060800 patent/WO2018197643A1/en not_active Ceased
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| JP2020517676A (ja) | 2020-06-18 |
| CN110546147B (zh) | 2023-05-23 |
| EP3615526A1 (en) | 2020-03-04 |
| ES2887261T3 (es) | 2021-12-22 |
| WO2018197643A1 (en) | 2018-11-01 |
| US20200223828A1 (en) | 2020-07-16 |
| US11053223B2 (en) | 2021-07-06 |
| JP7117323B2 (ja) | 2022-08-12 |
| EP3615526B1 (en) | 2021-08-04 |
| CN110546147A (zh) | 2019-12-06 |
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