ES2885003T3 - Estimuladores de SGC fusionados bicíclicos - Google Patents
Estimuladores de SGC fusionados bicíclicos Download PDFInfo
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- ES2885003T3 ES2885003T3 ES17768311T ES17768311T ES2885003T3 ES 2885003 T3 ES2885003 T3 ES 2885003T3 ES 17768311 T ES17768311 T ES 17768311T ES 17768311 T ES17768311 T ES 17768311T ES 2885003 T3 ES2885003 T3 ES 2885003T3
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- 0 CCC(C*CCC1=CC=CC[C@]1F)*C Chemical compound CCC(C*CCC1=CC=CC[C@]1F)*C 0.000 description 4
- REPBKGOWOSJOSR-UHFFFAOYSA-N C=CN1C(C2=C=CN3C=CNC3C(Cc(cccc3)c3F)=N2)=NNC1 Chemical compound C=CN1C(C2=C=CN3C=CNC3C(Cc(cccc3)c3F)=N2)=NNC1 REPBKGOWOSJOSR-UHFFFAOYSA-N 0.000 description 1
- YRBZVKVAVYKWQV-MDZDMXLPSA-N CC(C)(C)CSc1c(/C=C/C(NC(CCC2)CC2O)=O)cccn1 Chemical compound CC(C)(C)CSc1c(/C=C/C(NC(CCC2)CC2O)=O)cccn1 YRBZVKVAVYKWQV-MDZDMXLPSA-N 0.000 description 1
- GTKNNCQKFKGSHR-UHFFFAOYSA-N FC(c1n[nH]c(-c(nc2Cc(cccc3)c3F)c[n]3c2ncc3)n1)(F)F Chemical compound FC(c1n[nH]c(-c(nc2Cc(cccc3)c3F)c[n]3c2ncc3)n1)(F)F GTKNNCQKFKGSHR-UHFFFAOYSA-N 0.000 description 1
- OQROGDGUIZXGQI-UHFFFAOYSA-N FC(c1n[nH]c(-c(nc2Cc(cccc3F)c3F)c[n]3c2ncc3)n1)(F)F Chemical compound FC(c1n[nH]c(-c(nc2Cc(cccc3F)c3F)c[n]3c2ncc3)n1)(F)F OQROGDGUIZXGQI-UHFFFAOYSA-N 0.000 description 1
- OTMCDVXJSOEDAX-UHFFFAOYSA-O [NH3+]C(c(nc1Cc(cccc2)c2F)c[n]2c1ncc2)=NC(C(F)(F)F)=N Chemical compound [NH3+]C(c(nc1Cc(cccc2)c2F)c[n]2c1ncc2)=NC(C(F)(F)F)=N OTMCDVXJSOEDAX-UHFFFAOYSA-O 0.000 description 1
- SFKJEIIZHJJRBJ-UHFFFAOYSA-O [NH3+]C(c(nc1Cc2cccc(F)c2)c[n]2c1ncc2)=NC(C(F)(F)F)=N Chemical compound [NH3+]C(c(nc1Cc2cccc(F)c2)c[n]2c1ncc2)=NC(C(F)(F)F)=N SFKJEIIZHJJRBJ-UHFFFAOYSA-O 0.000 description 1
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662382942P | 2016-09-02 | 2016-09-02 | |
| US201662423445P | 2016-11-17 | 2016-11-17 | |
| US201762468598P | 2017-03-08 | 2017-03-08 | |
| US201762482486P | 2017-04-06 | 2017-04-06 | |
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