MX2019002313A - Estimuladores de guanilato ciclasa soluble (sgc) biciclicos fusionados. - Google Patents

Estimuladores de guanilato ciclasa soluble (sgc) biciclicos fusionados.

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Publication number
MX2019002313A
MX2019002313A MX2019002313A MX2019002313A MX2019002313A MX 2019002313 A MX2019002313 A MX 2019002313A MX 2019002313 A MX2019002313 A MX 2019002313A MX 2019002313 A MX2019002313 A MX 2019002313A MX 2019002313 A MX2019002313 A MX 2019002313A
Authority
MX
Mexico
Prior art keywords
fused bicyclic
sgc stimulators
concentration
increase
sgc
Prior art date
Application number
MX2019002313A
Other languages
English (en)
Inventor
Mermerian Ara
Nakai Takashi
Robert Rennie Glen
Claude Barden Timothy
Iyer Karthik
Jung Joon
Allan RENHOWE Paul
Yoon Jamie Im G-
R Iyengar Rajesh
Wai- Ho Lee Thomas
Germano Peter
Tang Kim
Jia James
Original Assignee
Cyclerion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyclerion Therapeutics Inc filed Critical Cyclerion Therapeutics Inc
Publication of MX2019002313A publication Critical patent/MX2019002313A/es

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

La presente invención se relaciona con estimuladores de la guanilato ciclasa soluble (sGC), formulaciones farmacéuticas que los comprenden y sus usos, sólo o en combinación con uno o más agentes adicionales, para el tratamiento de varias enfermedades, en donde sea conveniente un aumento de la concentración de óxido nítrico (NO) y/o un aumento de la concentración de monofosfato de guanosina cíclico (cGMP), o una regulación positiva de la vía de NO. Los compuestos son de Fórmula I: (ver Fórmula).
MX2019002313A 2016-09-02 2017-09-01 Estimuladores de guanilato ciclasa soluble (sgc) biciclicos fusionados. MX2019002313A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662382942P 2016-09-02 2016-09-02
US201662423445P 2016-11-17 2016-11-17
US201762468598P 2017-03-08 2017-03-08
US201762482486P 2017-04-06 2017-04-06
PCT/US2017/049834 WO2018045276A1 (en) 2016-09-02 2017-09-01 Fused bicyclic sgc stimulators

Publications (1)

Publication Number Publication Date
MX2019002313A true MX2019002313A (es) 2019-07-08

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MX2019002313A MX2019002313A (es) 2016-09-02 2017-09-01 Estimuladores de guanilato ciclasa soluble (sgc) biciclicos fusionados.
MX2021007580A MX2021007580A (es) 2016-09-02 2017-09-01 Estimuladores de guanilato ciclasa soluble (sgc) biciclicos fusionados.
MX2021007579A MX2021007579A (es) 2016-09-02 2019-02-26 Estimuladores de guanilato ciclasa soluble (sgc) biciclicos fusionados.

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MX2021007580A MX2021007580A (es) 2016-09-02 2017-09-01 Estimuladores de guanilato ciclasa soluble (sgc) biciclicos fusionados.
MX2021007579A MX2021007579A (es) 2016-09-02 2019-02-26 Estimuladores de guanilato ciclasa soluble (sgc) biciclicos fusionados.

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US (4) US10472363B2 (es)
EP (2) EP3872080B1 (es)
JP (2) JP7050759B2 (es)
KR (2) KR20230124760A (es)
CN (2) CN109790167B (es)
AU (2) AU2017321810B2 (es)
BR (1) BR112019004468A2 (es)
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