ES2871483T3 - Sal hemisulfato del ácido 5,10-metilen-(6r)-tetrahidrofólico - Google Patents
Sal hemisulfato del ácido 5,10-metilen-(6r)-tetrahidrofólico Download PDFInfo
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- ES2871483T3 ES2871483T3 ES17190279T ES17190279T ES2871483T3 ES 2871483 T3 ES2871483 T3 ES 2871483T3 ES 17190279 T ES17190279 T ES 17190279T ES 17190279 T ES17190279 T ES 17190279T ES 2871483 T3 ES2871483 T3 ES 2871483T3
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- hemisulfate salt
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- hemisulfate
- water
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07—ORGANIC CHEMISTRY
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- C07D475/12—Heterocyclic compounds containing pteridine ring systems containing pteridine ring systems condensed with carbocyclic rings or ring systems
- C07D475/14—Benz [g] pteridines, e.g. riboflavin
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
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- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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- Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
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- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13004050.4A EP2837631A1 (en) | 2013-08-14 | 2013-08-14 | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2871483T3 true ES2871483T3 (es) | 2021-10-29 |
Family
ID=48998397
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17190279T Active ES2871483T3 (es) | 2013-08-14 | 2014-08-14 | Sal hemisulfato del ácido 5,10-metilen-(6r)-tetrahidrofólico |
| ES14758102.9T Active ES2654474T3 (es) | 2013-08-14 | 2014-08-14 | Nueva sal estable del ácido 5,10-metilen-(6R)-tetrahidrofólico |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14758102.9T Active ES2654474T3 (es) | 2013-08-14 | 2014-08-14 | Nueva sal estable del ácido 5,10-metilen-(6R)-tetrahidrofólico |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US20160185787A1 (https=) |
| EP (3) | EP2837631A1 (https=) |
| JP (5) | JP6617104B2 (https=) |
| KR (2) | KR102410373B1 (https=) |
| CN (2) | CN108096200A (https=) |
| AU (2) | AU2014307872B2 (https=) |
| BR (2) | BR122020002802B1 (https=) |
| CA (1) | CA2921178C (https=) |
| CY (2) | CY1119694T1 (https=) |
| DK (2) | DK3033344T3 (https=) |
| EA (3) | EA202091271A3 (https=) |
| ES (2) | ES2871483T3 (https=) |
| HK (1) | HK1256262A1 (https=) |
| HR (2) | HRP20171895T1 (https=) |
| HU (2) | HUE037615T2 (https=) |
| IL (2) | IL244069B (https=) |
| LT (2) | LT3287460T (https=) |
| MX (2) | MX382578B (https=) |
| NO (1) | NO3033344T3 (https=) |
| NZ (2) | NZ745811A (https=) |
| PL (2) | PL3287460T3 (https=) |
| PT (2) | PT3287460T (https=) |
| RS (2) | RS61986B1 (https=) |
| SG (2) | SG11201601016PA (https=) |
| SI (2) | SI3033344T1 (https=) |
| WO (1) | WO2015022407A1 (https=) |
| ZA (1) | ZA201509204B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2837631A1 (en) * | 2013-08-14 | 2015-02-18 | Merck & Cie | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
| US10059710B2 (en) | 2016-02-17 | 2018-08-28 | Merck & Cie | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid |
| EP3446704A1 (en) * | 2017-08-24 | 2019-02-27 | Isofol Medical AB | [6r]-mthf - an efficient folate alternative in 5-fluorouracil based chemotherapy |
| EP3446703A1 (en) * | 2017-08-24 | 2019-02-27 | Isofol Medical AB | 6r]-mthf multiple bolus administration in 5-fluorouracil based chemotherapy |
| DK3668516T3 (da) | 2017-08-16 | 2021-12-13 | Merck Patent Gmbh | Stabile lyofilisater omfattende 5,10-methylen-(6r)-tetrahydrofolsyre og en dicarboxylsyre |
| JP7258759B2 (ja) * | 2018-01-05 | 2023-04-17 | アイソフォル・メディカル・エービー | 大腸癌及び転移性大腸癌を治療する方法 |
| CN115335740A (zh) * | 2020-03-30 | 2022-11-11 | 住友化学株式会社 | 层叠体 |
| CN119343131A (zh) | 2022-06-08 | 2025-01-21 | 默克专利股份有限公司 | 包含5,10-亚甲基-(6r)-四氢叶酸钠的浓缩溶液 |
| CN119325374A (zh) | 2022-06-08 | 2025-01-17 | 默克专利股份有限公司 | 包含5,10-亚甲基-(6r)-四氢叶酸的稳定的冻干物 |
| US20250360135A1 (en) | 2022-06-08 | 2025-11-27 | Merck Patent Gmbh | Compositions comprising disodium 5,10-methylene-(6r)-tetrahydrofolate |
| EP4536185A1 (en) | 2022-06-08 | 2025-04-16 | Merck Patent GmbH | Stable pharmaceutical compositions comprising 5,10-methylene-(6r)-tetrahydrofolic acid and nacl |
| US20260000671A1 (en) | 2022-06-08 | 2026-01-01 | Merck Patent Gmbh | Concentrated solutions comprising 5,10-methylene-(6r)-tetrahydrofolic acid |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2300505A (en) * | 1940-10-31 | 1942-11-03 | Bell Telephone Labor Inc | Selective system |
| CA1215945A (en) | 1983-03-20 | 1986-12-30 | Bengt Gustavsson | Fluid transfer system |
| DE3821875C1 (https=) * | 1988-06-29 | 1990-02-15 | Eprova Ag, Forschungsinstitut, Schaffhausen, Ch | |
| CH682664A5 (en) * | 1991-10-15 | 1993-10-29 | Eprova Ag | Stable salts of 5,10-methylene tetrahydrofolate. |
| CH684644A5 (de) | 1992-07-13 | 1994-11-15 | Eprova Ag | 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen. |
| HU226998B1 (en) | 2000-11-23 | 2010-04-28 | Richter Gedeon Nyrt | Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same |
| CH696628A5 (de) * | 2002-02-26 | 2007-08-31 | Eprova Ag | Verwendung von Folaten zur Herstellung einer Zubereitung geeignet zur Vorbeugung und Behandlung von Entzündungen und entzündungsassoziierter Krankheiten, im Speziellen zur Beeinflussung der |
| CH697021A5 (de) | 2003-06-26 | 2008-03-31 | Merck Eprova Ag | Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat. |
| EP1968551A2 (en) | 2005-12-02 | 2008-09-17 | Adventrx Pharmaceuticals, Inc. | Stable pharmaceutical compositions of 5,10 methylenetetrahydrofolate |
| ES2577391T3 (es) | 2006-12-21 | 2016-07-14 | F. Hoffmann-La Roche Ag | Polimorfos de un antagonista del receptor mglur5 |
| JP5294968B2 (ja) | 2009-05-01 | 2013-09-18 | 三星ダイヤモンド工業株式会社 | スクライブヘッド及び該スクライブヘッドを用いたスクライブ装置 |
| CN110200963A (zh) * | 2011-10-19 | 2019-09-06 | 墨卡托医疗系统公司 | 局部调节组织和细胞以提高疗效包括肾去神经支配 |
| EP2837766A1 (de) * | 2013-08-14 | 2015-02-18 | Sika Technology AG | Verfahren zum Ausfüllen einer Fuge mit einem Kleb- und/oder Dichtstoff sowie System zum Ausfüllen einer Fuge mit einem Kleb- und/oder Dichtstoff |
| EP2837631A1 (en) * | 2013-08-14 | 2015-02-18 | Merck & Cie | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
| JP6971761B2 (ja) * | 2017-10-11 | 2021-11-24 | 株式会社Ｉｈｉプラント | タンクの構築方法 |
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2013
- 2013-08-14 EP EP13004050.4A patent/EP2837631A1/en not_active Withdrawn
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2014
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- 2014-08-14 BR BR122020002802-5A patent/BR122020002802B1/pt active IP Right Grant
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- 2014-08-14 SI SI201430529T patent/SI3033344T1/en unknown
- 2014-08-14 NZ NZ745811A patent/NZ745811A/en unknown
- 2014-08-14 CN CN201810160334.3A patent/CN108096200A/zh active Pending
- 2014-08-14 CA CA2921178A patent/CA2921178C/en active Active
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- 2014-08-14 EA EA201892729A patent/EA201892729A1/ru unknown
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2015
- 2015-12-17 ZA ZA2015/09204A patent/ZA201509204B/en unknown
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2016
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2017
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2018
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- 2018-11-29 HK HK18115320.9A patent/HK1256262A1/zh unknown
- 2018-12-06 US US16/212,056 patent/US20190106431A1/en not_active Abandoned
- 2018-12-13 AU AU2018278943A patent/AU2018278943B2/en active Active
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2019
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2020
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2021
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2024
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