ES2862224T3 - Preparación de muestras para tipos de muestra difíciles - Google Patents
Preparación de muestras para tipos de muestra difíciles Download PDFInfo
- Publication number
- ES2862224T3 ES2862224T3 ES16862803T ES16862803T ES2862224T3 ES 2862224 T3 ES2862224 T3 ES 2862224T3 ES 16862803 T ES16862803 T ES 16862803T ES 16862803 T ES16862803 T ES 16862803T ES 2862224 T3 ES2862224 T3 ES 2862224T3
- Authority
- ES
- Spain
- Prior art keywords
- sample
- vial
- illustratively
- buffer
- sample buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/50—Other enzymatic activities
- C12Q2521/537—Protease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/153—Viscosity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N2001/028—Sampling from a surface, swabbing, vaporising
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562249592P | 2015-11-02 | 2015-11-02 | |
| PCT/US2016/059928 WO2017079167A1 (en) | 2015-11-02 | 2016-11-01 | Sample preparation for difficult sample types |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2862224T3 true ES2862224T3 (es) | 2021-10-07 |
Family
ID=58635347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16862803T Active ES2862224T3 (es) | 2015-11-02 | 2016-11-01 | Preparación de muestras para tipos de muestra difíciles |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11175205B2 (enExample) |
| EP (2) | EP3353278B1 (enExample) |
| JP (3) | JP7126445B2 (enExample) |
| KR (2) | KR20250108762A (enExample) |
| CN (2) | CN115181781A (enExample) |
| AU (1) | AU2016350734B2 (enExample) |
| BR (1) | BR112018008331B1 (enExample) |
| CA (1) | CA3003172A1 (enExample) |
| CL (1) | CL2018001156A1 (enExample) |
| ES (1) | ES2862224T3 (enExample) |
| SG (1) | SG11201802946WA (enExample) |
| WO (1) | WO2017079167A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9522396B2 (en) | 2010-12-29 | 2016-12-20 | S.D. Sight Diagnostics Ltd. | Apparatus and method for automatic detection of pathogens |
| CN104169719B (zh) | 2011-12-29 | 2017-03-08 | 思迪赛特诊断有限公司 | 用于检测生物样品中病原体的方法和系统 |
| US20160299132A1 (en) | 2013-03-15 | 2016-10-13 | Ancera, Inc. | Systems and methods for bead-based assays in ferrofluids |
| US20160296945A1 (en) | 2013-03-15 | 2016-10-13 | Ancera, Inc. | Systems and methods for active particle separation |
| WO2014144340A1 (en) | 2013-03-15 | 2014-09-18 | Ancera, Inc. | Systems and methods for three-dimensional extraction of target particles ferrofluids |
| IL227276A0 (en) | 2013-07-01 | 2014-03-06 | Parasight Ltd | A method and system for preparing a monolayer of cells, particularly suitable for diagnosis |
| US11285490B2 (en) | 2015-06-26 | 2022-03-29 | Ancera, Llc | Background defocusing and clearing in ferrofluid-based capture assays |
| US9933445B1 (en) | 2016-05-16 | 2018-04-03 | Hound Labs, Inc. | System and method for target substance identification |
| CN109963640A (zh) * | 2016-07-31 | 2019-07-02 | 安测络有限责任公司 | 用于基于铁磁流体的测定的多层一次性盒及其使用方法 |
| US11982611B2 (en) * | 2017-03-20 | 2024-05-14 | Nanocellect Biomedical, Inc. | Systems, apparatuses, and methods for cell sorting and flow cytometry |
| JP6823204B2 (ja) | 2017-05-24 | 2021-01-27 | バイオファイアー・ディフェンス・エルエルシー | アレイのポイント・オブ・ユース排出のためのシステムおよび方法 |
| US20200245898A1 (en) | 2019-01-31 | 2020-08-06 | Hound Labs, Inc. | Single-use Microfluidic Cartridge for Detection of Target Chemical Presence in Human Breath |
| US11977086B2 (en) | 2019-03-21 | 2024-05-07 | Hound Labs, Inc. | Biomarker detection from breath samples |
| CN110157702A (zh) * | 2019-05-24 | 2019-08-23 | 中国水产科学研究院南海水产研究所深圳试验基地 | 一种用于提取珊瑚rna样品的采集操作台 |
| JP7762166B2 (ja) * | 2020-05-07 | 2025-10-29 | アボット・ラピッド・ダイアグノスティクス・インターナショナル・アンリミテッド・カンパニー | 試料収集および廃棄用スワブ |
| US11933731B1 (en) | 2020-05-13 | 2024-03-19 | Hound Labs, Inc. | Systems and methods using Surface-Enhanced Raman Spectroscopy for detecting tetrahydrocannabinol |
| CN116529371A (zh) * | 2020-05-29 | 2023-08-01 | 洛克菲勒大学 | 从自收集小体积样品中分离rna的方法和系统 |
| KR20230018435A (ko) * | 2020-05-29 | 2023-02-07 | 더 락커펠러 유니버시티 | 자기-수집된 및 작은 부피 샘플로부터의 rna 단리를 위한 방법 및 시스템 |
| EP4168247A4 (en) * | 2020-06-18 | 2024-06-26 | NanoCellect Biomedical, Inc. | Microfluidic systems and methods for sorting particles |
| CN116157076A (zh) * | 2020-07-13 | 2023-05-23 | 哈佛大学校长及研究员协会 | 前鼻孔拭子及其用途 |
| CN111822282B (zh) * | 2020-07-24 | 2021-07-20 | 惠州法路源基因科技有限公司 | 一种取样拭子植绒设备 |
| US20240002916A1 (en) * | 2020-11-23 | 2024-01-04 | Nuclein, Llc | Direct lysis apparatus and methods for molecular diagnostics |
| US12392769B1 (en) | 2021-01-12 | 2025-08-19 | Hound Labs, Inc. | Ambient contamination in breath analyte detection and measurement |
| CN113136412A (zh) * | 2021-04-22 | 2021-07-20 | 浙江珂瑞康生物医疗科技有限公司 | 用于含可溶性蛋白生物医用材料的生物负载测定处理液 |
| EP4469204A1 (en) * | 2022-01-25 | 2024-12-04 | S.D. Sight Diagnostics Ltd. | Sample carrier for use with a bodily sample |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6645758B1 (en) | 1989-02-03 | 2003-11-11 | Johnson & Johnson Clinical Diagnostics, Inc. | Containment cuvette for PCR and method of use |
| JP3784829B2 (ja) | 1994-04-14 | 2006-06-14 | ザ ロックフェラー ユニヴァーシティ | 細胞成分を単離する方法、装置及び試薬 |
| US6780617B2 (en) | 2000-12-29 | 2004-08-24 | Chen & Chen, Llc | Sample processing device and method |
| EP1415113B1 (en) | 2001-07-16 | 2011-08-31 | Idaho Technology, Inc. | Thermal cycling system and method of use |
| EP1436405A4 (en) | 2001-08-20 | 2006-01-04 | Whatman Inc | CLEANING AND OBTAINING DNA FROM HIGH-PARTICLES AND SOLIDS SAMPLES |
| US20030215845A1 (en) * | 2002-02-19 | 2003-11-20 | Bille Todd William | Selective extraction of DNA from groups of cells |
| JP4286157B2 (ja) * | 2003-01-21 | 2009-06-24 | デンカ生研株式会社 | メンブレンアッセイ法 |
| US20040157219A1 (en) * | 2003-02-06 | 2004-08-12 | Jianrong Lou | Chemical treatment of biological samples for nucleic acid extraction and kits therefor |
| EP1654066B1 (en) * | 2003-07-31 | 2014-11-12 | Handylab, Inc. | Processing particle-containing samples |
| US7387887B2 (en) | 2004-04-20 | 2008-06-17 | University Of Utah Research Foundation | Nucleic acid melting analysis with saturation dyes |
| US8986614B2 (en) * | 2010-02-23 | 2015-03-24 | Rheonix, Inc. | Self-contained biological assay apparatus, methods, and applications |
| CA2607661C (en) | 2005-05-09 | 2017-08-08 | Idaho Technology, Inc. | A device and method for two-stage nucleic acid amplification |
| US8652782B2 (en) * | 2006-09-12 | 2014-02-18 | Longhorn Vaccines & Diagnostics, Llc | Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids |
| US9481912B2 (en) | 2006-09-12 | 2016-11-01 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and identifying nucleic acid sequences in biological samples |
| JP4297148B2 (ja) | 2006-09-22 | 2009-07-15 | ソニー株式会社 | 核酸回収装置及び核酸回収方法 |
| ES2809168T3 (es) | 2006-11-15 | 2021-03-03 | Biofire Diagnostics Llc | Análisis biológico autónomo de alta densidad |
| JP4522434B2 (ja) | 2007-05-31 | 2010-08-11 | キヤノン株式会社 | 血液採取用容器 |
| AU2009281729A1 (en) * | 2008-08-15 | 2010-02-18 | Litmus Rapid-B Llc | Flow cytometry-based systems and methods for detecting microbes |
| EP2210936A1 (en) | 2009-01-27 | 2010-07-28 | Curetis AG | Processing and analysis of viscous liquid biological samples |
| JP5782384B2 (ja) * | 2009-02-03 | 2015-09-24 | ネットバイオ・インコーポレーテッドＮｅｔＢｉｏ， Ｉｎｃ． | 未処理試料から核酸を単離するための自己完結型装置および精製方法 |
| US9347086B2 (en) * | 2009-04-03 | 2016-05-24 | Integrated Nano-Technologies, Llc | Method and system for sample preparation |
| WO2010147989A1 (en) * | 2009-06-15 | 2010-12-23 | Ibis Biosciences, Inc. | Compositions and methods for the isolation of nucleic acid |
| BR112013002064B1 (pt) * | 2010-07-27 | 2020-11-24 | Northwestern University | Dispositivo e metodos para filtragem do plasma sanguíneo |
| WO2012027302A2 (en) * | 2010-08-21 | 2012-03-01 | The Regents Of The University Of California | Systems and methods for detecting antibiotic resistance |
| WO2012050787A1 (en) * | 2010-09-29 | 2012-04-19 | Ibis Biosciences, Inc. | Fungal nucleic acid extraction |
| IT1403618B1 (it) | 2011-01-05 | 2013-10-31 | Copan Italia Spa | Procedimento per realizzare un dispositivo per il prelievo ed il trasferimento di campioni per biologia molecolare |
| US8894946B2 (en) * | 2011-10-21 | 2014-11-25 | Integenx Inc. | Sample preparation, processing and analysis systems |
| US10865440B2 (en) * | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
| CA2854768C (en) | 2011-11-10 | 2021-08-17 | David E. Jones | Loading vials |
| ES2746565T3 (es) | 2012-04-05 | 2020-03-06 | Tauns Co Ltd | Procedimiento y kit para la detección inmunológica de complejo de Mycobacterium tuberculosis |
| WO2013159116A1 (en) * | 2012-04-20 | 2013-10-24 | University Of Chicago | Fluidic devices for biospecimen preservation |
| DK2855692T3 (da) | 2012-05-24 | 2019-10-14 | Univ Utah Res Found | Ekstrem pcr |
| EP2684947A1 (en) * | 2012-07-09 | 2014-01-15 | Biocartis SA | A method for filtering a biological sample |
| AU2013312191C1 (en) | 2012-09-10 | 2017-10-19 | Biofire Diagnostics, Llc | Multiple amplification cycle detection |
| WO2014144174A1 (en) | 2013-03-15 | 2014-09-18 | Abbott Molecular Inc. | Compositions and methods for nucleic acid extraction |
| US20160376581A1 (en) * | 2013-07-02 | 2016-12-29 | Ibis Biosciences, Inc. | Method for the purification of targeted nucleic acids from background nucleic acids |
| JP6318239B2 (ja) | 2014-04-24 | 2018-04-25 | 株式会社ヤクルト本社 | 真菌核酸の抽出方法 |
| WO2015187849A2 (en) * | 2014-06-04 | 2015-12-10 | Lucigen Corporation | Sample collection and analysis devices |
-
2016
- 2016-11-01 CN CN202210781180.6A patent/CN115181781A/zh active Pending
- 2016-11-01 WO PCT/US2016/059928 patent/WO2017079167A1/en not_active Ceased
- 2016-11-01 ES ES16862803T patent/ES2862224T3/es active Active
- 2016-11-01 CA CA3003172A patent/CA3003172A1/en active Pending
- 2016-11-01 AU AU2016350734A patent/AU2016350734B2/en active Active
- 2016-11-01 KR KR1020257022174A patent/KR20250108762A/ko active Pending
- 2016-11-01 JP JP2018522661A patent/JP7126445B2/ja active Active
- 2016-11-01 CN CN201680077342.0A patent/CN108473931B/zh active Active
- 2016-11-01 EP EP16862803.0A patent/EP3353278B1/en active Active
- 2016-11-01 KR KR1020187013973A patent/KR102830890B1/ko active Active
- 2016-11-01 SG SG11201802946WA patent/SG11201802946WA/en unknown
- 2016-11-01 US US15/340,612 patent/US11175205B2/en active Active
- 2016-11-01 EP EP20203395.7A patent/EP3789503B1/en active Active
- 2016-11-01 BR BR112018008331-3A patent/BR112018008331B1/pt active IP Right Grant
-
2018
- 2018-04-30 CL CL2018001156A patent/CL2018001156A1/es unknown
-
2021
- 2021-10-01 JP JP2021162839A patent/JP2022008815A/ja active Pending
- 2021-10-19 US US17/504,903 patent/US20220034770A1/en active Pending
-
2023
- 2023-03-08 JP JP2023035914A patent/JP7821137B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20170122851A1 (en) | 2017-05-04 |
| JP7821137B2 (ja) | 2026-02-26 |
| EP3353278A1 (en) | 2018-08-01 |
| JP2023085281A (ja) | 2023-06-20 |
| CN108473931B (zh) | 2022-07-19 |
| JP7126445B2 (ja) | 2022-08-26 |
| BR112018008331B1 (pt) | 2022-09-06 |
| SG11201802946WA (en) | 2018-05-30 |
| HK1252952A1 (en) | 2019-06-06 |
| EP3789503B1 (en) | 2024-04-10 |
| JP2022008815A (ja) | 2022-01-14 |
| JP2019502098A (ja) | 2019-01-24 |
| EP3789503C0 (en) | 2024-04-10 |
| EP3789503A1 (en) | 2021-03-10 |
| EP3353278A4 (en) | 2019-03-06 |
| WO2017079167A1 (en) | 2017-05-11 |
| KR102830890B1 (ko) | 2025-07-07 |
| US11175205B2 (en) | 2021-11-16 |
| KR20180080241A (ko) | 2018-07-11 |
| AU2016350734B2 (en) | 2021-04-08 |
| KR20250108762A (ko) | 2025-07-15 |
| AU2016350734A1 (en) | 2018-06-14 |
| CN115181781A (zh) | 2022-10-14 |
| CA3003172A1 (en) | 2017-05-11 |
| US20220034770A1 (en) | 2022-02-03 |
| BR112018008331A2 (pt) | 2018-10-30 |
| EP3353278B1 (en) | 2021-03-10 |
| CN108473931A (zh) | 2018-08-31 |
| CL2018001156A1 (es) | 2018-11-23 |
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