ES2848857T3 - Anticuerpos monoclonales humanos contra EphA4 y su uso - Google Patents
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- ES2848857T3 ES2848857T3 ES15827008T ES15827008T ES2848857T3 ES 2848857 T3 ES2848857 T3 ES 2848857T3 ES 15827008 T ES15827008 T ES 15827008T ES 15827008 T ES15827008 T ES 15827008T ES 2848857 T3 ES2848857 T3 ES 2848857T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
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- Veterinary Medicine (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
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- Hematology (AREA)
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- Oncology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
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- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462031793P | 2014-07-31 | 2014-07-31 | |
| PCT/US2015/043182 WO2016019280A1 (en) | 2014-07-31 | 2015-07-31 | Human monoclonal antibodies against epha4 and their use |
Publications (1)
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| ES2848857T3 true ES2848857T3 (es) | 2021-08-12 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| ES15827008T Active ES2848857T3 (es) | 2014-07-31 | 2015-07-31 | Anticuerpos monoclonales humanos contra EphA4 y su uso |
| ES18209632T Active ES2925224T3 (es) | 2014-07-31 | 2015-07-31 | Anticuerpos monoclonales humanos contra EphA4 y su uso |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18209632T Active ES2925224T3 (es) | 2014-07-31 | 2015-07-31 | Anticuerpos monoclonales humanos contra EphA4 y su uso |
Country Status (6)
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| US (2) | US10934360B2 (enExample) |
| EP (2) | EP3473271B1 (enExample) |
| JP (1) | JP6811706B2 (enExample) |
| CN (1) | CN106999578B (enExample) |
| ES (2) | ES2848857T3 (enExample) |
| WO (1) | WO2016019280A1 (enExample) |
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| ES2882355T3 (es) | 2015-07-10 | 2021-12-01 | Univ Hong Kong Science & Tech | Composiciones para su uso en el tratamiento de afecciones neurodegenerativas y neuroinflamatorias |
| PE20181051A1 (es) * | 2015-09-08 | 2018-07-03 | Eisai Randd Man Co Ltd | Anticuerpo anti-epha4 |
| CN110769828A (zh) | 2017-05-12 | 2020-02-07 | 香港科技大学 | 作为epha4抑制剂的杂环化合物 |
| CN117398459A (zh) | 2019-07-01 | 2024-01-16 | 卫材R&D管理有限公司 | 抗EphA4抗体 |
| JP2023522986A (ja) * | 2020-04-23 | 2023-06-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ｅｐｈａ４標的化合物及びその使用方法 |
| US11732007B2 (en) | 2020-09-28 | 2023-08-22 | The Regents Of The University Of California | Therapeutic compounds and methods |
| WO2022138707A1 (ja) | 2020-12-24 | 2022-06-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 筋萎縮性側索硬化症の治療用医薬組成物 |
| KR20230123923A (ko) * | 2020-12-24 | 2023-08-24 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 항-EphA4 항체 |
| CN119823276A (zh) * | 2023-10-12 | 2025-04-15 | 徕特康(苏州)生物制药有限公司 | 抗her4抗体及其制备方法和用途 |
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2015
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- 2015-07-31 EP EP15827008.2A patent/EP3177320B1/en active Active
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| CN106999578B (zh) | 2022-03-04 |
| EP3473271B1 (en) | 2022-07-20 |
| US12037404B2 (en) | 2024-07-16 |
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| WO2016019280A1 (en) | 2016-02-04 |
| EP3177320A4 (en) | 2018-05-16 |
| JP6811706B2 (ja) | 2021-01-13 |
| EP3177320A1 (en) | 2017-06-14 |
| ES2925224T3 (es) | 2022-10-14 |
| US10934360B2 (en) | 2021-03-02 |
| EP3177320B1 (en) | 2021-01-06 |
| US20210171645A1 (en) | 2021-06-10 |
| EP3473271A1 (en) | 2019-04-24 |
| US20170218075A1 (en) | 2017-08-03 |
| JP2017525352A (ja) | 2017-09-07 |
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