ES2845473T3 - (Bencil-ciano-metil)-amidas sustituidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico inhibidores de la catepsina- C - Google Patents
(Bencil-ciano-metil)-amidas sustituidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico inhibidores de la catepsina- C Download PDFInfo
- Publication number
- ES2845473T3 ES2845473T3 ES14709652T ES14709652T ES2845473T3 ES 2845473 T3 ES2845473 T3 ES 2845473T3 ES 14709652 T ES14709652 T ES 14709652T ES 14709652 T ES14709652 T ES 14709652T ES 2845473 T3 ES2845473 T3 ES 2845473T3
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- Prior art keywords
- alkylene
- alkyl
- independently
- independently selected
- cycloalkyl
- Prior art date
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- 0 *N([C@]1[C@]2CC1)[C@@]2C(N[C@@](Cc(c(F)c1)ccc1N=[N+]=[N-])C#N)=O Chemical compound *N([C@]1[C@]2CC1)[C@@]2C(N[C@@](Cc(c(F)c1)ccc1N=[N+]=[N-])C#N)=O 0.000 description 3
- WNLXAUXQXSIXJZ-UHFFFAOYSA-N C(C(C1)NCC11C2C(C3NC4)C5CNC2CC5)C1c1c3c4ccc1 Chemical compound C(C(C1)NCC11C2C(C3NC4)C5CNC2CC5)C1c1c3c4ccc1 WNLXAUXQXSIXJZ-UHFFFAOYSA-N 0.000 description 1
- LKDJYZBKCVSODK-UHFFFAOYSA-N C(C1)C2NC1CNC2 Chemical compound C(C1)C2NC1CNC2 LKDJYZBKCVSODK-UHFFFAOYSA-N 0.000 description 1
- DJWDAKFSDBOQJK-UHFFFAOYSA-N C(C1)C2NCC1NC2 Chemical compound C(C1)C2NCC1NC2 DJWDAKFSDBOQJK-UHFFFAOYSA-N 0.000 description 1
- ATNXGUBNSJAEQE-UHFFFAOYSA-N C(C1C2)C3C11C45C67C89C%10%11C2C8C6C4C1CC%10CC%11C9C7C35 Chemical compound C(C1C2)C3C11C45C67C89C%10%11C2C8C6C4C1CC%10CC%11C9C7C35 ATNXGUBNSJAEQE-UHFFFAOYSA-N 0.000 description 1
- UKHJNJFJCGBKSF-UHFFFAOYSA-N C1C2NCC1NC2 Chemical compound C1C2NCC1NC2 UKHJNJFJCGBKSF-UHFFFAOYSA-N 0.000 description 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N C1NCCNC1 Chemical compound C1NCCNC1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 1
- DCTDBKRLYIDBRN-UHFFFAOYSA-N C1OCC2=CC=CCC12 Chemical compound C1OCC2=CC=CCC12 DCTDBKRLYIDBRN-UHFFFAOYSA-N 0.000 description 1
- LPAGFVYQRIESJQ-UHFFFAOYSA-N C1c(cccc2)c2NC1 Chemical compound C1c(cccc2)c2NC1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 description 1
- QXQQOFWCYXYFAE-ZUIVOOLFSA-N CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(NC(Cc(c(OCc1ccccc1)c1)ccc1-c1cc(N(C)C(C2)=O)c2cc1)C#N)=O)O Chemical compound CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(NC(Cc(c(OCc1ccccc1)c1)ccc1-c1cc(N(C)C(C2)=O)c2cc1)C#N)=O)O QXQQOFWCYXYFAE-ZUIVOOLFSA-N 0.000 description 1
- MEYCZYQDAXBIMG-ADHYTWILSA-N CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(NC(Cc1ccc(-c(ccc(Cl)c2)c2N(C)C2=O)c2c1)C#N)=O)=O Chemical compound CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(NC(Cc1ccc(-c(ccc(Cl)c2)c2N(C)C2=O)c2c1)C#N)=O)=O MEYCZYQDAXBIMG-ADHYTWILSA-N 0.000 description 1
- AXMMETSGAWZDMI-UUSDYUTISA-N CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(NC(Cc1ccc(B2OC(C)(C)C(C)(C)O2)c(C(OC)=O)c1)C#N)=O)=O Chemical compound CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(NC(Cc1ccc(B2OC(C)(C)C(C)(C)O2)c(C(OC)=O)c1)C#N)=O)=O AXMMETSGAWZDMI-UUSDYUTISA-N 0.000 description 1
- WMBWBPLILFWHMI-YVVXQTMVSA-N CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(N[C@@H](Cc(ccc(Br)c1)c1F)C(N)=O)=O)=O Chemical compound CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(N[C@@H](Cc(ccc(Br)c1)c1F)C(N)=O)=O)=O WMBWBPLILFWHMI-YVVXQTMVSA-N 0.000 description 1
- IXOGUGASMMKTED-YVVXQTMVSA-N CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(N[C@@H](Cc(ccc(N=[N+]=[N-])c1)c1F)C(N)=O)=O)=O Chemical compound CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(N[C@@H](Cc(ccc(N=[N+]=[N-])c1)c1F)C(N)=O)=O)=O IXOGUGASMMKTED-YVVXQTMVSA-N 0.000 description 1
- WIISZLORDJSPAF-UHFFFAOYSA-N CC(C)c(cc(C(F)(F)F)cc1)c1[NH+](C)[O-] Chemical compound CC(C)c(cc(C(F)(F)F)cc1)c1[NH+](C)[O-] WIISZLORDJSPAF-UHFFFAOYSA-N 0.000 description 1
- YSHOWEKUVWPFNR-UHFFFAOYSA-O CC[N+](CC)(CC)S(NC(OC)=O)(=O)=O Chemical compound CC[N+](CC)(CC)S(NC(OC)=O)(=O)=O YSHOWEKUVWPFNR-UHFFFAOYSA-O 0.000 description 1
- OMDHOEFLZYLHJH-BLDHOGSXSA-N CN(C(CC1)=O)c2c1ccc(-c1cc(O)c(CC(C#N)NC([C@H]3N[C@H]4C[C@@H]3CC4)=O)cc1)c2 Chemical compound CN(C(CC1)=O)c2c1ccc(-c1cc(O)c(CC(C#N)NC([C@H]3N[C@H]4C[C@@H]3CC4)=O)cc1)c2 OMDHOEFLZYLHJH-BLDHOGSXSA-N 0.000 description 1
- SVARUVQPDCVUTH-UHDBIXDDSA-N CN(c1cc(Cl)ccc1-c1ccc(CC(C#N)NC([C@H]2N[C@H]3C[C@@H]2CC3)=O)cc11)C1=O Chemical compound CN(c1cc(Cl)ccc1-c1ccc(CC(C#N)NC([C@H]2N[C@H]3C[C@@H]2CC3)=O)cc11)C1=O SVARUVQPDCVUTH-UHDBIXDDSA-N 0.000 description 1
- XRTGYBDFAGUWTC-UHFFFAOYSA-N CNC(Nc1cc(Br)ccc1N)=S Chemical compound CNC(Nc1cc(Br)ccc1N)=S XRTGYBDFAGUWTC-UHFFFAOYSA-N 0.000 description 1
- DFRSYVJABDOPAN-UHFFFAOYSA-N CNc([nH]c1c2)nc1ccc2Br Chemical compound CNc([nH]c1c2)nc1ccc2Br DFRSYVJABDOPAN-UHFFFAOYSA-N 0.000 description 1
- UCHNRCLIUNTABE-UHFFFAOYSA-N CNc(cc(cc1)Cl)c1I Chemical compound CNc(cc(cc1)Cl)c1I UCHNRCLIUNTABE-UHFFFAOYSA-N 0.000 description 1
- WIHHVKUARKTSBU-UHFFFAOYSA-N Nc(c(N)c1)ccc1Br Chemical compound Nc(c(N)c1)ccc1Br WIHHVKUARKTSBU-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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