ES2831049T3 - Uso de antagonistas de cxcr4 para tratar síndrome de WHIM, mielocatexis, neutropenia y linfocitopenia - Google Patents
Uso de antagonistas de cxcr4 para tratar síndrome de WHIM, mielocatexis, neutropenia y linfocitopenia Download PDFInfo
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- ES2831049T3 ES2831049T3 ES12786739T ES12786739T ES2831049T3 ES 2831049 T3 ES2831049 T3 ES 2831049T3 ES 12786739 T ES12786739 T ES 12786739T ES 12786739 T ES12786739 T ES 12786739T ES 2831049 T3 ES2831049 T3 ES 2831049T3
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- methylene
- bis
- compound
- cxcr4
- phenylenebis
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
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- Chemical & Material Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
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| US201161486632P | 2011-05-16 | 2011-05-16 | |
| PCT/US2012/037970 WO2012158707A1 (en) | 2011-05-16 | 2012-05-15 | Use of cxcr4 antagonists |
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| ES2831049T3 true ES2831049T3 (es) | 2021-06-07 |
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| AU2006243776A1 (en) | 2005-05-02 | 2006-11-09 | Genzyme Corporation | Gene therapy for neurometabolic disorders |
| US9419667B2 (en) | 2013-04-16 | 2016-08-16 | Skyworks Solutions, Inc. | Apparatus and methods related to conformal coating implemented with surface mount devices |
| US9375406B2 (en) * | 2014-09-30 | 2016-06-28 | Taigen Biotechnology Co., Ltd. | Substituted pyrimidines for mobilizing cells expressing a type 4 CXC chemokine receptor |
| CN109069486A (zh) | 2015-12-14 | 2018-12-21 | X4 制药有限公司 | 治疗癌症的方法 |
| CN109069426B (zh) | 2015-12-14 | 2021-10-29 | X4 制药有限公司 | 治疗癌症的方法 |
| PT3393468T (pt) | 2015-12-22 | 2023-01-19 | X4 Pharmaceuticals Inc | Métodos para tratar imunodeficiências |
| GB201604213D0 (en) * | 2016-03-11 | 2016-04-27 | Proximagen Ltd | Drug combination and its use in therapy |
| US11337969B2 (en) | 2016-04-08 | 2022-05-24 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| CN109641838A (zh) * | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
| WO2017223239A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| US10988465B2 (en) | 2016-06-21 | 2021-04-27 | X4 Pharmaceuticals, Inc. | CXCR4 inhibitors and uses thereof |
| SG11201901718VA (en) * | 2016-09-08 | 2019-03-28 | Centro De Investigaciones Energeticas Medioambientales Y Tecnologicas | Gene therapy for patients with fanconi anemia |
| CN109988153B (zh) * | 2017-12-29 | 2021-11-19 | 深圳夏浠湾医药科技有限公司 | 一种川芎嗪衍生物及其制备方法和应用 |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| WO2021183650A1 (en) | 2020-03-10 | 2021-09-16 | X4 Pharmaceuticals, Inc. | Methods for treating neutropenia |
| US20250276030A1 (en) * | 2020-10-20 | 2025-09-04 | Eom Pharmaceuticals Inc. | Eom613 for treatment of covid-19 |
| CN113662937B (zh) * | 2021-10-09 | 2022-08-23 | 江苏省人民医院（南京医科大学第一附属医院） | Plerixafor在上调EFTUD2表达和抑制HBV药物中的用途 |
| CN116675708A (zh) * | 2023-04-23 | 2023-09-01 | 华南师范大学 | 一类氧化响应的大环化合物、大环配合物及其应用 |
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| US4060598A (en) | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
| US3538214A (en) | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
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| LU88769I2 (fr) | 1982-07-23 | 1996-11-05 | Zeneca Ltd | Bicalutamide et ses sels et esters pharmaceutiquement acceptables (Casodex (R)) |
| US5021409A (en) | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
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| NZ507161A (en) | 1998-03-30 | 2003-12-19 | Northwest Biotherapeutics Inc | Theraupeutic and diagonistic applications based on the role of the CXCR-4 gene in tumorigenesis |
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| US20070160574A1 (en) | 2000-04-12 | 2007-07-12 | Ahmed Merzouk | Design of CXC chemokine analogs for the treatment of human diseases |
| ATE265219T1 (de) | 2000-05-09 | 2004-05-15 | Univ British Columbia | Verwendung von cxcr4 antagonisten zur behandlung von krebs und autoimmunkrankheiten |
| EP1290033B1 (en) | 2000-06-05 | 2012-10-31 | The Trustees of Columbia University in the City of New York | Identification and use of human bone marrow-derived endothelial progenitor cells to improve myocardial function after ischemic injury |
| BR0114246A (pt) | 2000-09-29 | 2003-10-07 | Anormed Inc | Processo para preparação de poliaminas cìclicas contendo n nitrogênios de anel n-1 protegidas e seus produtos |
| US20040157818A1 (en) | 2001-05-24 | 2004-08-12 | Mikiro Yanaka | Cxcr4-antagonistic drugs composed of nitrogen-containing compound |
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| US20090221683A1 (en) * | 2005-10-18 | 2009-09-03 | Caritas St.Elizabeth Medical Center Of Boston, Inc | Combination of CXCR4 Antagonist and Morphogen to Increase Angiogenesis |
| MX2008010895A (es) | 2006-02-24 | 2008-09-03 | Genzyme Corp | Metodos para aumentar el flujo sanguineo y/o promover la regeneracion de tejidos. |
| WO2008008854A2 (en) | 2006-07-11 | 2008-01-17 | Emory University | Cxcr4 antagonists including diazine and triazine structures for the treatment of medical disorders |
| US20100003224A1 (en) | 2006-08-02 | 2010-01-07 | Genzyme Corporation | Combination Therapy |
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| EA017583B1 (ru) | 2007-02-28 | 2013-01-30 | Полифор Лтд. | Закрепленные на матрице пептидомиметики |
| JP2011527534A (ja) | 2008-06-23 | 2011-10-27 | リサーチ イン モーション リミテッド | デバイスおよびサーバ能力の送達方法 |
| WO2010025416A1 (en) | 2008-08-29 | 2010-03-04 | Genzyme Corporation | Cxcr4 antagonists for kidney injury |
| US20110280827A1 (en) | 2009-01-30 | 2011-11-17 | Yanping Hu | Methods and compositions for treating hematological malignancies |
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| MX365242B (es) | 2019-05-28 |
| BR112013029482A2 (pt) | 2016-08-09 |
| PL2709991T3 (pl) | 2021-04-06 |
| EP2709991B1 (en) | 2020-09-02 |
| RU2638802C2 (ru) | 2017-12-15 |
| KR20210094672A (ko) | 2021-07-29 |
| RU2013155601A (ru) | 2015-06-27 |
| WO2012158707A1 (en) | 2012-11-22 |
| KR20140045411A (ko) | 2014-04-16 |
| EP2709991A4 (en) | 2014-10-01 |
| MX2013013308A (es) | 2014-02-27 |
| JP2014513727A (ja) | 2014-06-05 |
| US20150030561A1 (en) | 2015-01-29 |
| CN103596935A (zh) | 2014-02-19 |
| US20210161859A1 (en) | 2021-06-03 |
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