ES2819374T3 - Métodos de síntesis del hidrocloruro de (1R,2R,5R)-5-amino-2-metilciclohexanol e intermedios útiles en los mismos - Google Patents

Métodos de síntesis del hidrocloruro de (1R,2R,5R)-5-amino-2-metilciclohexanol e intermedios útiles en los mismos Download PDF

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Publication number
ES2819374T3
ES2819374T3 ES16831114T ES16831114T ES2819374T3 ES 2819374 T3 ES2819374 T3 ES 2819374T3 ES 16831114 T ES16831114 T ES 16831114T ES 16831114 T ES16831114 T ES 16831114T ES 2819374 T3 ES2819374 T3 ES 2819374T3
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formula
compound
solvent
contacting
base
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Spanish (es)
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Terrence Joseph Connolly
Hon-Wah Man
Periyandi Nagarajan
Chinnapillai Rajendiran
Jasti Venkateswarlu
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Celgene Corp
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Celgene Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
    • C07C209/58—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from or via amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES16831114T 2015-07-24 2016-07-22 Métodos de síntesis del hidrocloruro de (1R,2R,5R)-5-amino-2-metilciclohexanol e intermedios útiles en los mismos Active ES2819374T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562196363P 2015-07-24 2015-07-24
PCT/US2016/043511 WO2017019487A1 (en) 2015-07-24 2016-07-22 Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein

Publications (1)

Publication Number Publication Date
ES2819374T3 true ES2819374T3 (es) 2021-04-15

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
ES20193348T Active ES2994877T3 (en) 2015-07-24 2016-07-22 Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
ES16831114T Active ES2819374T3 (es) 2015-07-24 2016-07-22 Métodos de síntesis del hidrocloruro de (1R,2R,5R)-5-amino-2-metilciclohexanol e intermedios útiles en los mismos

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ES20193348T Active ES2994877T3 (en) 2015-07-24 2016-07-22 Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein

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Country Link
US (4) US10252981B2 (enExample)
EP (2) EP3325432B1 (enExample)
JP (2) JP6805232B2 (enExample)
CN (1) CN107922287B (enExample)
AU (2) AU2016297784B2 (enExample)
CA (2) CA3208587A1 (enExample)
ES (2) ES2994877T3 (enExample)
MX (2) MX2018001004A (enExample)
WO (1) WO2017019487A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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CN111848423B (zh) * 2019-04-30 2022-10-14 尚科生物医药（上海）有限公司 3-氧代环丁基氨基甲酸叔丁酯的制备方法

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JP2021046426A (ja) 2021-03-25
EP3795553B1 (en) 2024-05-15
CN107922287A (zh) 2018-04-17
ES2994877T3 (en) 2025-02-03
CA2993173A1 (en) 2017-02-02
CN107922287B (zh) 2021-04-09
JP2018521085A (ja) 2018-08-02
MX2018001004A (es) 2018-06-07
EP3325432A1 (en) 2018-05-30
US10252981B2 (en) 2019-04-09
AU2021201493B2 (en) 2022-07-14
AU2021201493A1 (en) 2021-03-25
US11192847B2 (en) 2021-12-07
HK1255553A1 (en) 2019-08-23
US20220234990A1 (en) 2022-07-28
JP7165178B2 (ja) 2022-11-02
EP3795553A1 (en) 2021-03-24
AU2016297784A1 (en) 2018-02-08
US10774033B2 (en) 2020-09-15
MX385379B (es) 2025-03-18
AU2016297784B2 (en) 2020-12-24
EP3325432B1 (en) 2020-09-02
CA3208587A1 (en) 2017-02-02
US20190152893A1 (en) 2019-05-23
JP6805232B2 (ja) 2020-12-23
MX2020001720A (es) 2021-08-13
EP3325432A4 (en) 2019-04-24
CA2993173C (en) 2023-10-03
US20180215700A1 (en) 2018-08-02
US11780801B2 (en) 2023-10-10
WO2017019487A1 (en) 2017-02-02
US20200369600A1 (en) 2020-11-26

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