ES2778059T3 - Combinaciones farmacéuticas de un inhibidor de CDK4/6 y un inhibidor de B-Raf - Google Patents
Combinaciones farmacéuticas de un inhibidor de CDK4/6 y un inhibidor de B-Raf Download PDFInfo
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- ES2778059T3 ES2778059T3 ES13745540T ES13745540T ES2778059T3 ES 2778059 T3 ES2778059 T3 ES 2778059T3 ES 13745540 T ES13745540 T ES 13745540T ES 13745540 T ES13745540 T ES 13745540T ES 2778059 T3 ES2778059 T3 ES 2778059T3
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| EP2934515B1 (en) * | 2012-12-20 | 2018-04-04 | Novartis AG | A pharmaceutical combination comprising binimetinib |
| US10011874B2 (en) * | 2013-02-25 | 2018-07-03 | Novartis Ag | Androgen receptor mutation |
| MA38522A1 (fr) | 2013-03-21 | 2017-10-31 | Novartis Ag | Thérapie de combinaison comprenant un inhibiteur de b-raf et un second inhibiteur. |
| JP2018502089A (ja) * | 2014-12-23 | 2018-01-25 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｒａｆ阻害剤及びａｕｒｏｒａキナーゼ阻害剤の組み合わせ |
| CN105753869B (zh) * | 2015-04-01 | 2018-09-25 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
| WO2016155670A1 (zh) * | 2015-04-01 | 2016-10-06 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
| US20190365741A1 (en) * | 2015-08-28 | 2019-12-05 | Novartis Ag | Combinations of the cdk4/6 inhibitor lee011 and the mek1/2 inhibitor trametinib, optionally further comprising the pi3k inhibitor byl719 to treat cancer |
| CN105732642B (zh) * | 2015-11-18 | 2018-09-25 | 苏州晶云药物科技有限公司 | 一种cdk抑制剂和mek抑制剂的共晶及其制备方法 |
| AU2017275650B2 (en) * | 2016-06-03 | 2023-06-01 | Array Biopharma Inc. | Pharmaceutical combinations |
| JP7190425B2 (ja) * | 2016-08-23 | 2022-12-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 肝細胞癌の治療のための併用療法 |
| CN109715163B (zh) * | 2016-09-19 | 2022-11-22 | 诺华股份有限公司 | 包含raf抑制剂和erk抑制剂的治疗组合 |
| WO2018081211A1 (en) * | 2016-10-26 | 2018-05-03 | Li George Y | Deuterated 7-cyclopentyl-n, n-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7h-pyrrolo[2,3-d]pyrimdine-6-carboxamide |
| US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
| IL270224B1 (en) * | 2017-05-02 | 2024-04-01 | Novartis Ag | Combination therapy employing trametinib and a defined raf inhibitor |
| WO2018218633A1 (en) | 2017-06-02 | 2018-12-06 | Beijing Percans Oncology Co. Ltd. | Combination therapies for treating cancers |
| CN111837146B (zh) | 2018-01-08 | 2024-10-15 | G1治疗公司 | G1t38优异剂量方案 |
| MX2020008559A (es) | 2018-02-15 | 2021-01-08 | Nuvation Bio Inc | Compuestos heterocíclicos como inhibidores de la quinasa. |
| WO2019195959A1 (en) * | 2018-04-08 | 2019-10-17 | Cothera Biosciences, Inc. | Combination therapy for cancers with braf mutation |
| US11633401B2 (en) | 2018-07-06 | 2023-04-25 | Memorial Sloan Kettering Cancer Center | Combination therapy with MEK inhibitor and CDK4/6 inhibitor to treat pancreatic cancer |
| BR112021011699A2 (pt) * | 2018-12-20 | 2021-09-08 | Novartis Ag | Terapia de combinação com um inibidor de raf e um inibidor de cdk4/6 para uso no tratamento contra câncer |
| CA3138123A1 (en) | 2019-05-13 | 2020-11-19 | Novartis Ag | New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2 (trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer |
| WO2021047573A1 (zh) * | 2019-09-11 | 2021-03-18 | 江苏恒瑞医药股份有限公司 | 一种mek抑制剂与cdk4/6抑制剂联合在制备治疗肿瘤的药物中的用途 |
| KR102836833B1 (ko) | 2019-12-10 | 2025-07-22 | 에프. 호프만-라 로슈 아게 | 신규 메틸퀴나졸리논 유도체 |
| JP2023525100A (ja) * | 2020-05-12 | 2023-06-14 | ノバルティス アーゲー | Ｃｒａｆ阻害剤を含む治療的組み合わせ |
| WO2023230554A1 (en) | 2022-05-25 | 2023-11-30 | Pfizer Inc. | Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer |
| WO2025003956A1 (en) | 2023-06-30 | 2025-01-02 | Pfizer Inc. | High drug loading formulations of encorafenib |
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| KR101830455B1 (ko) * | 2010-04-13 | 2018-02-20 | 노파르티스 아게 | 시클린 의존성 키나제 ４ 또는 시클린 의존성 키나제 （ｃｄｋ４／６） 억제제 및 ｍｔｏｒ 억제제를 포함하는 암 치료를 위한 조합물 |
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| MX2015001122A (es) | 2015-04-08 |
| CN104507474B (zh) | 2018-01-02 |
| JP2015523397A (ja) | 2015-08-13 |
| EP2877174A1 (en) | 2015-06-03 |
| CA2874860A1 (en) | 2014-01-30 |
| TW201412316A (zh) | 2014-04-01 |
| CN104507474A (zh) | 2015-04-08 |
| AU2013295771A1 (en) | 2014-12-11 |
| US9700557B2 (en) | 2017-07-11 |
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| TWI599357B (zh) | 2017-09-21 |
| HK1210721A1 (en) | 2016-05-06 |
| IN2015DN00376A (en, 2012) | 2015-06-12 |
| AU2013295771B2 (en) | 2016-08-11 |
| US20150164897A1 (en) | 2015-06-18 |
| KR20150036146A (ko) | 2015-04-07 |
| AR091876A1 (es) | 2015-03-04 |
| BR112014033118A8 (pt) | 2023-01-31 |
| BR112014033118A2 (pt) | 2017-06-27 |
| KR102113363B1 (ko) | 2020-05-21 |
| CA2874860C (en) | 2020-06-23 |
| MX360045B (es) | 2018-10-19 |
| EP2877174B1 (en) | 2020-01-01 |
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