ES2763237T3 - Conjugados de péptidos de RGD y fotosensibilizantes de (bacterio)clorofila y sus usos - Google Patents

Conjugados de péptidos de RGD y fotosensibilizantes de (bacterio)clorofila y sus usos Download PDF

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Publication number
ES2763237T3
ES2763237T3 ES07805515T ES07805515T ES2763237T3 ES 2763237 T3 ES2763237 T3 ES 2763237T3 ES 07805515 T ES07805515 T ES 07805515T ES 07805515 T ES07805515 T ES 07805515T ES 2763237 T3 ES2763237 T3 ES 2763237T3
Authority
ES
Spain
Prior art keywords
conjugate
rgd
amide
peptide
bacteriochlorophyll
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07805515T
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English (en)
Spanish (es)
Inventor
Avigdor Scherz
Yoram Salomon
Efrat Rubinstein
Alexander Brandis
Doron Eren
Karin Neimann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Application granted granted Critical
Publication of ES2763237T3 publication Critical patent/ES2763237T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES07805515T 2006-08-23 2007-08-23 Conjugados de péptidos de RGD y fotosensibilizantes de (bacterio)clorofila y sus usos Active ES2763237T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83940906P 2006-08-23 2006-08-23
PCT/IL2007/001055 WO2008023378A1 (en) 2006-08-23 2007-08-23 Conjugates of rgd peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses

Publications (1)

Publication Number Publication Date
ES2763237T3 true ES2763237T3 (es) 2020-05-27

Family

ID=38896083

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07805515T Active ES2763237T3 (es) 2006-08-23 2007-08-23 Conjugados de péptidos de RGD y fotosensibilizantes de (bacterio)clorofila y sus usos

Country Status (12)

Country Link
US (1) US20080138278A1 (cg-RX-API-DMAC7.html)
EP (1) EP2061512B1 (cg-RX-API-DMAC7.html)
JP (3) JP2010502574A (cg-RX-API-DMAC7.html)
AU (1) AU2007287205B8 (cg-RX-API-DMAC7.html)
CA (1) CA2661319C (cg-RX-API-DMAC7.html)
DK (1) DK2061512T3 (cg-RX-API-DMAC7.html)
ES (1) ES2763237T3 (cg-RX-API-DMAC7.html)
HU (1) HUE047789T2 (cg-RX-API-DMAC7.html)
IL (1) IL197195A (cg-RX-API-DMAC7.html)
PT (1) PT2061512T (cg-RX-API-DMAC7.html)
RU (1) RU2450018C2 (cg-RX-API-DMAC7.html)
WO (1) WO2008023378A1 (cg-RX-API-DMAC7.html)

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CA2717060C (en) 2008-02-27 2016-11-01 Avigdor Scherz Rgd-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors
LT5567B (lt) 2008-08-06 2009-04-27 Vilniaus Universitetas Maisto ir su maistu susietų paviršių nukenksminimo būdas
ES2627377T3 (es) * 2008-10-23 2017-07-27 Steba Biotech S.A. Peptidomiméticos que contienen RGD y sus usos
US8263133B2 (en) * 2009-02-18 2012-09-11 The Regents Of The University Of California Multivalent clustering targeting strategy for drug carriers
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WO2012166792A1 (en) 2011-05-31 2012-12-06 North Carolina State University Bacteriochlorin imides
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US9436645B2 (en) 2011-10-13 2016-09-06 Masimo Corporation Medical monitoring hub
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TWI568747B (zh) * 2012-09-05 2017-02-01 上海晟順生物科技有限公司 同時具溶血栓、清除自由基和血栓靶向功能的新穎化合物及其製備方法和用途
US9749232B2 (en) 2012-09-20 2017-08-29 Masimo Corporation Intelligent medical network edge router
RU2548675C9 (ru) * 2013-05-29 2015-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет тонких химических технологий имени М.В. Ломоносова" (МИТХТ им. М.В. Ломоносова) Аминоамиды в ряду бактериохлорофилла a, обладающие фотодинамической активностью, и способ их получения
JP6263716B2 (ja) * 2013-07-31 2018-01-24 国立大学法人 筑波大学 悪性腫瘍のｐｅｔ診断用トレーサー
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Also Published As

Publication number Publication date
AU2007287205A1 (en) 2008-02-28
WO2008023378A1 (en) 2008-02-28
RU2450018C2 (ru) 2012-05-10
DK2061512T3 (da) 2020-01-20
EP2061512A1 (en) 2009-05-27
WO2008023378A9 (en) 2008-04-10
US20080138278A1 (en) 2008-06-12
IL197195A (en) 2015-10-29
EP2061512B1 (en) 2019-10-02
IL197195A0 (en) 2009-12-24
RU2009110226A (ru) 2010-09-27
JP6177013B2 (ja) 2017-08-09
CA2661319C (en) 2015-12-01
JP2013231039A (ja) 2013-11-14
JP2017039700A (ja) 2017-02-23
HUE047789T2 (hu) 2020-05-28
AU2007287205B8 (en) 2013-08-15
PT2061512T (pt) 2020-01-14
JP2010502574A (ja) 2010-01-28
CA2661319A1 (en) 2008-02-28
AU2007287205B2 (en) 2013-04-18

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