ES2757648T3 - Agentes de quimiodenervación dirigida postsinápticamente y sus procedimientos de uso - Google Patents
Agentes de quimiodenervación dirigida postsinápticamente y sus procedimientos de uso Download PDFInfo
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- ES2757648T3 ES2757648T3 ES09713319T ES09713319T ES2757648T3 ES 2757648 T3 ES2757648 T3 ES 2757648T3 ES 09713319 T ES09713319 T ES 09713319T ES 09713319 T ES09713319 T ES 09713319T ES 2757648 T3 ES2757648 T3 ES 2757648T3
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000001260 vocal cord Anatomy 0.000 description 1
- 230000021542 voluntary musculoskeletal movement Effects 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229920001221 xylan Polymers 0.000 description 1
- 150000004823 xylans Chemical class 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 210000000216 zygoma Anatomy 0.000 description 1
- BVGLZNQZEYAYBJ-QWZQWHGGSA-N α-cobratoxin Chemical compound NC(=O)C[C@@H](C(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)CC1=CC=C(O)C=C1 BVGLZNQZEYAYBJ-QWZQWHGGSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6634708P | 2008-02-19 | 2008-02-19 | |
| PCT/US2009/034578 WO2009105585A2 (en) | 2008-02-19 | 2009-02-19 | Postsynaptically targeted chemodenervation agents and their methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2757648T3 true ES2757648T3 (es) | 2020-04-29 |
Family
ID=40986187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09713319T Active ES2757648T3 (es) | 2008-02-19 | 2009-02-19 | Agentes de quimiodenervación dirigida postsinápticamente y sus procedimientos de uso |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9815875B2 (enExample) |
| EP (1) | EP2250193B1 (enExample) |
| JP (1) | JP2011523935A (enExample) |
| CN (1) | CN102007142A (enExample) |
| AU (1) | AU2009215436A1 (enExample) |
| CA (1) | CA2754352A1 (enExample) |
| ES (1) | ES2757648T3 (enExample) |
| IL (1) | IL207631A0 (enExample) |
| WO (1) | WO2009105585A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7259237B1 (en) | 2006-12-29 | 2007-08-21 | Miller Kent D | Pan-antiviral peptides |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| KR20120093312A (ko) * | 2009-10-30 | 2012-08-22 | 바이엘 헬스케어 엘엘씨 | 항체 모방체 스캐폴드 |
| US9220743B2 (en) | 2010-01-22 | 2015-12-29 | Nuovo Biologics, Llc | Pan-antiviral peptides for protein kinase inhibition |
| CN103145799B (zh) * | 2013-02-18 | 2014-04-16 | 大连理工大学 | 一组具有促进经皮和跨膜渗透作用的多肽及其应用 |
| CN104232653B (zh) * | 2014-09-19 | 2017-04-05 | 中南大学湘雅医院 | 重组α‑银环蛇毒素αBtx的制备方法 |
| JP2020518653A (ja) * | 2017-02-07 | 2020-06-25 | マイオセプト インコーポレイティド | 局所製剤及び方法 |
| CN110090296A (zh) * | 2018-09-21 | 2019-08-06 | 祁展楷 | 一组与烟碱乙酰胆碱受体具有高度亲和力能快速起效的眼镜蛇神经毒素分子在镇痛上的应用 |
| CN118561963A (zh) | 2018-10-16 | 2024-08-30 | 格罗制药公司 | 烟碱乙酰胆碱受体肽拮抗剂芋螺毒素组合物及相关方法 |
| AU2019408420B2 (en) * | 2018-12-21 | 2025-04-17 | Vib Vzw | Fusion protein with a toxin and scaffold protein |
| EP3753568A1 (en) * | 2019-06-21 | 2020-12-23 | Fastox Pharma SA | Composition modulating botulinum neurotoxin effect |
| CN110478473B (zh) * | 2019-07-14 | 2025-08-12 | 江苏毫末医药生物科技有限公司 | 眼镜蛇神经毒素多肽对鸦片类药品痛觉过敏和耐受的抑制及对其镇痛的协同增效作用 |
| EP4046648A4 (en) * | 2019-10-11 | 2023-10-18 | Qi, Zhankai | Application of elapidae snake postsynaptic neurotoxin monomer molecule in treatment of alzheimer's disease |
| EP4093378A1 (en) * | 2020-01-24 | 2022-11-30 | W.L. Gore & Associates, Inc. | Sustained-release matrices for adventitial or periadventitial neural ablation and uses thereof |
| CN111544571A (zh) * | 2020-06-02 | 2020-08-18 | 沈喆景 | 眼镜蛇科蛇突触后神经毒素在治疗与炎性细胞因子过度表达相关疾病的应用 |
| CN114409757B (zh) * | 2022-01-26 | 2023-07-18 | 云南南诏药业有限公司 | 一种蛇毒神经毒素及应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447356A (en) * | 1981-04-17 | 1984-05-08 | Olivera Baldomero M | Conotoxins |
| FR2762009B1 (fr) * | 1997-04-10 | 1999-06-04 | Commissariat Energie Atomique | Enzymes recombinantes purifiees a activite prolylpeptidasique, leur procede de preparation et leurs applications |
| IL143379A (en) * | 2001-05-24 | 2013-11-28 | Yissum Res Dev Co | Oligonucleotide against human ache isoform r and its uses |
| US7964630B2 (en) | 2004-11-02 | 2011-06-21 | Dsm Ip Assets B.V. | Topical application agents against mimic and age-related wrinkles |
| WO2007035474A2 (en) | 2005-09-15 | 2007-03-29 | Novomed Technologies, Inc. (Shanghai) | Transdermal delivery peptides and method of use thereof |
| US7659252B2 (en) * | 2005-09-15 | 2010-02-09 | Novomed Technologies, Inc. (Shanghai) | Transdermal delivery peptides and method of use thereof |
-
2009
- 2009-02-19 AU AU2009215436A patent/AU2009215436A1/en not_active Abandoned
- 2009-02-19 US US12/867,975 patent/US9815875B2/en not_active Expired - Fee Related
- 2009-02-19 CA CA2754352A patent/CA2754352A1/en not_active Abandoned
- 2009-02-19 JP JP2010547761A patent/JP2011523935A/ja active Pending
- 2009-02-19 ES ES09713319T patent/ES2757648T3/es active Active
- 2009-02-19 EP EP09713319.3A patent/EP2250193B1/en active Active
- 2009-02-19 CN CN2009801144924A patent/CN102007142A/zh active Pending
- 2009-02-19 WO PCT/US2009/034578 patent/WO2009105585A2/en not_active Ceased
-
2010
- 2010-08-16 IL IL207631A patent/IL207631A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011523935A (ja) | 2011-08-25 |
| CA2754352A1 (en) | 2009-08-27 |
| AU2009215436A1 (en) | 2009-08-27 |
| IL207631A0 (en) | 2010-12-30 |
| EP2250193A2 (en) | 2010-11-17 |
| US20110118190A1 (en) | 2011-05-19 |
| EP2250193B1 (en) | 2019-09-18 |
| US9815875B2 (en) | 2017-11-14 |
| CN102007142A (zh) | 2011-04-06 |
| WO2009105585A3 (en) | 2009-12-23 |
| WO2009105585A2 (en) | 2009-08-27 |
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