CN102007142A - 突触后靶向化学去神经剂及它们的使用方法 - Google Patents

突触后靶向化学去神经剂及它们的使用方法 Download PDF

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Publication number
CN102007142A
CN102007142A CN2009801144924A CN200980114492A CN102007142A CN 102007142 A CN102007142 A CN 102007142A CN 2009801144924 A CN2009801144924 A CN 2009801144924A CN 200980114492 A CN200980114492 A CN 200980114492A CN 102007142 A CN102007142 A CN 102007142A
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CN
China
Prior art keywords
polypeptide
chemodenervation
muscle
postsynaptic
polypeptides
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CN2009801144924A
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English (en)
Chinese (zh)
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L·E·彼得斯
T·劳伦斯
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MYOCEPT Inc
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MYOCEPT Inc
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Publication of CN102007142A publication Critical patent/CN102007142A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN2009801144924A 2008-02-19 2009-02-19 突触后靶向化学去神经剂及它们的使用方法 Pending CN102007142A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6634708P 2008-02-19 2008-02-19
US61/066,347 2008-02-19
PCT/US2009/034578 WO2009105585A2 (en) 2008-02-19 2009-02-19 Postsynaptically targeted chemodenervation agents and their methods of use

Publications (1)

Publication Number Publication Date
CN102007142A true CN102007142A (zh) 2011-04-06

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ID=40986187

Family Applications (1)

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CN2009801144924A Pending CN102007142A (zh) 2008-02-19 2009-02-19 突触后靶向化学去神经剂及它们的使用方法

Country Status (9)

Country Link
US (1) US9815875B2 (enExample)
EP (1) EP2250193B1 (enExample)
JP (1) JP2011523935A (enExample)
CN (1) CN102007142A (enExample)
AU (1) AU2009215436A1 (enExample)
CA (1) CA2754352A1 (enExample)
ES (1) ES2757648T3 (enExample)
IL (1) IL207631A0 (enExample)
WO (1) WO2009105585A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104232653A (zh) * 2014-09-19 2014-12-24 中南大学湘雅医院 重组α-银环蛇毒素αBtx的制备方法
WO2020057012A1 (zh) * 2018-09-21 2020-03-26 祁展楷 一组与烟碱乙酰胆碱受体具有高度亲和力能快速起效的眼镜蛇神经毒素分子在镇痛上的应用
WO2021008100A1 (zh) * 2019-07-14 2021-01-21 祁展楷 眼镜蛇神经毒素多肽对鸦片类药品痛觉过敏和耐受的抑制及对其镇痛的协同增效作用
WO2021068432A1 (zh) * 2019-10-11 2021-04-15 祁展楷 眼镜蛇科蛇突触后神经毒素单体分子在治疗老年痴呆上的应用
CN113474357A (zh) * 2018-12-21 2021-10-01 非营利性组织佛兰芒综合大学生物技术研究所 具有毒素和支架蛋白的融合蛋白
WO2021244027A1 (zh) * 2020-06-02 2021-12-09 沈喆景 眼镜蛇科蛇突触后神经毒素在治疗与炎性细胞因子过度表达相关疾病的应用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7259237B1 (en) 2006-12-29 2007-08-21 Miller Kent D Pan-antiviral peptides
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
KR20120093312A (ko) * 2009-10-30 2012-08-22 바이엘 헬스케어 엘엘씨 항체 모방체 스캐폴드
US9220743B2 (en) 2010-01-22 2015-12-29 Nuovo Biologics, Llc Pan-antiviral peptides for protein kinase inhibition
CN103145799B (zh) * 2013-02-18 2014-04-16 大连理工大学 一组具有促进经皮和跨膜渗透作用的多肽及其应用
JP2020518653A (ja) * 2017-02-07 2020-06-25 マイオセプト インコーポレイティド 局所製剤及び方法
CN118561963A (zh) 2018-10-16 2024-08-30 格罗制药公司 烟碱乙酰胆碱受体肽拮抗剂芋螺毒素组合物及相关方法
EP3753568A1 (en) * 2019-06-21 2020-12-23 Fastox Pharma SA Composition modulating botulinum neurotoxin effect
EP4093378A1 (en) * 2020-01-24 2022-11-30 W.L. Gore & Associates, Inc. Sustained-release matrices for adventitial or periadventitial neural ablation and uses thereof
CN114409757B (zh) * 2022-01-26 2023-07-18 云南南诏药业有限公司 一种蛇毒神经毒素及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003002739A1 (en) * 2001-05-24 2003-01-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Antisense oligonucleotide against human acetylcholinesterase (ache) and uses thereof
WO2006047900A2 (de) * 2004-11-02 2006-05-11 Pentapharm Ag Neue topisch anwendbare wirkstoffe gegen mimische und alterabedingt falten

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447356A (en) * 1981-04-17 1984-05-08 Olivera Baldomero M Conotoxins
FR2762009B1 (fr) * 1997-04-10 1999-06-04 Commissariat Energie Atomique Enzymes recombinantes purifiees a activite prolylpeptidasique, leur procede de preparation et leurs applications
WO2007035474A2 (en) 2005-09-15 2007-03-29 Novomed Technologies, Inc. (Shanghai) Transdermal delivery peptides and method of use thereof
US7659252B2 (en) * 2005-09-15 2010-02-09 Novomed Technologies, Inc. (Shanghai) Transdermal delivery peptides and method of use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003002739A1 (en) * 2001-05-24 2003-01-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Antisense oligonucleotide against human acetylcholinesterase (ache) and uses thereof
WO2006047900A2 (de) * 2004-11-02 2006-05-11 Pentapharm Ag Neue topisch anwendbare wirkstoffe gegen mimische und alterabedingt falten

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOLOVANOV A.P.ET AL: "Two-dimensional 1H-NMR study of the spatial structure of neurotoxin II from Naja naja oxiana", 《EUR.J.BIOCHEM.》 *
YING, YINGHE.ET AL: "Cloning and purification of α-neurotoxins from king cobra (Ophiophagus hannah)", 《TOXICON》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104232653A (zh) * 2014-09-19 2014-12-24 中南大学湘雅医院 重组α-银环蛇毒素αBtx的制备方法
WO2020057012A1 (zh) * 2018-09-21 2020-03-26 祁展楷 一组与烟碱乙酰胆碱受体具有高度亲和力能快速起效的眼镜蛇神经毒素分子在镇痛上的应用
CN113474357A (zh) * 2018-12-21 2021-10-01 非营利性组织佛兰芒综合大学生物技术研究所 具有毒素和支架蛋白的融合蛋白
WO2021008100A1 (zh) * 2019-07-14 2021-01-21 祁展楷 眼镜蛇神经毒素多肽对鸦片类药品痛觉过敏和耐受的抑制及对其镇痛的协同增效作用
WO2021068432A1 (zh) * 2019-10-11 2021-04-15 祁展楷 眼镜蛇科蛇突触后神经毒素单体分子在治疗老年痴呆上的应用
WO2021244027A1 (zh) * 2020-06-02 2021-12-09 沈喆景 眼镜蛇科蛇突触后神经毒素在治疗与炎性细胞因子过度表达相关疾病的应用

Also Published As

Publication number Publication date
JP2011523935A (ja) 2011-08-25
ES2757648T3 (es) 2020-04-29
CA2754352A1 (en) 2009-08-27
AU2009215436A1 (en) 2009-08-27
IL207631A0 (en) 2010-12-30
EP2250193A2 (en) 2010-11-17
US20110118190A1 (en) 2011-05-19
EP2250193B1 (en) 2019-09-18
US9815875B2 (en) 2017-11-14
WO2009105585A3 (en) 2009-12-23
WO2009105585A2 (en) 2009-08-27

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Application publication date: 20110406