ES2747932T3 - Uso de fitoecdisonas en la preparación de una composición para actuar sobre el síndrome metabólico - Google Patents
Uso de fitoecdisonas en la preparación de una composición para actuar sobre el síndrome metabólico Download PDFInfo
- Publication number
- ES2747932T3 ES2747932T3 ES08856497T ES08856497T ES2747932T3 ES 2747932 T3 ES2747932 T3 ES 2747932T3 ES 08856497 T ES08856497 T ES 08856497T ES 08856497 T ES08856497 T ES 08856497T ES 2747932 T3 ES2747932 T3 ES 2747932T3
- Authority
- ES
- Spain
- Prior art keywords
- phytoecdisones
- extract
- quinoa
- food
- diet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 208000001145 Metabolic Syndrome Diseases 0.000 title claims abstract description 28
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title description 7
- 238000011282 treatment Methods 0.000 claims abstract description 25
- 241000124008 Mammalia Species 0.000 claims abstract description 15
- 239000000419 plant extract Substances 0.000 claims abstract description 15
- 230000003187 abdominal effect Effects 0.000 claims abstract description 7
- 230000002265 prevention Effects 0.000 claims abstract 2
- 239000000284 extract Substances 0.000 claims description 40
- 240000006162 Chenopodium quinoa Species 0.000 claims description 37
- 235000013305 food Nutrition 0.000 claims description 34
- 241000196324 Embryophyta Species 0.000 claims description 19
- 230000007423 decrease Effects 0.000 claims description 11
- NKDFYOWSKOHCCO-YPVLXUMRSA-N 20-hydroxyecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@](C)(O)[C@H](O)CCC(C)(O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 NKDFYOWSKOHCCO-YPVLXUMRSA-N 0.000 claims description 9
- HXWZQRICWSADMH-SEHXZECUSA-N 20-hydroxyecdysone Natural products CC(C)(C)CC[C@@H](O)[C@@](C)(O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C HXWZQRICWSADMH-SEHXZECUSA-N 0.000 claims description 9
- NKDFYOWSKOHCCO-UHFFFAOYSA-N beta-ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C)(O)C(O)CCC(C)(O)C)CCC33O)C)C3=CC(=O)C21 NKDFYOWSKOHCCO-UHFFFAOYSA-N 0.000 claims description 9
- 235000015872 dietary supplement Nutrition 0.000 claims description 6
- 229930182490 saponin Natural products 0.000 claims description 3
- 150000007949 saponins Chemical class 0.000 claims description 3
- 235000017709 saponins Nutrition 0.000 claims description 3
- 206010033307 Overweight Diseases 0.000 abstract description 13
- 208000008589 Obesity Diseases 0.000 abstract description 6
- 235000020824 obesity Nutrition 0.000 abstract description 6
- 230000003247 decreasing effect Effects 0.000 abstract description 3
- 241000699670 Mus sp. Species 0.000 description 37
- 235000005911 diet Nutrition 0.000 description 30
- 230000037213 diet Effects 0.000 description 30
- 230000000694 effects Effects 0.000 description 14
- 210000001789 adipocyte Anatomy 0.000 description 11
- 235000013339 cereals Nutrition 0.000 description 9
- 238000009826 distribution Methods 0.000 description 8
- 238000009825 accumulation Methods 0.000 description 7
- 238000000605 extraction Methods 0.000 description 7
- 210000000579 abdominal fat Anatomy 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 235000020940 control diet Nutrition 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 150000002061 ecdysteroids Chemical class 0.000 description 6
- 208000024172 Cardiovascular disease Diseases 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 208000004611 Abdominal Obesity Diseases 0.000 description 4
- DCEFCUHVANGEOE-UHFFFAOYSA-N Ecdysterone Natural products CC(CC(C)(C)O)C(O)C(C)(O)C1CCC2(O)C3=CC(=O)C4CC(O)C(O)CC4(C)C3CCC12C DCEFCUHVANGEOE-UHFFFAOYSA-N 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 210000000577 adipose tissue Anatomy 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 235000013376 functional food Nutrition 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- 238000002483 medication Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 230000004584 weight gain Effects 0.000 description 4
- 235000019786 weight gain Nutrition 0.000 description 4
- 206010065941 Central obesity Diseases 0.000 description 3
- 235000015493 Chenopodium quinoa Nutrition 0.000 description 3
- 208000032928 Dyslipidaemia Diseases 0.000 description 3
- 208000017170 Lipid metabolism disease Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 230000000923 atherogenic effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000002354 daily effect Effects 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 201000010063 epididymitis Diseases 0.000 description 3
- 230000002710 gonadal effect Effects 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 3
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 244000300264 Spinacia oleracea Species 0.000 description 2
- 235000009337 Spinacia oleracea Nutrition 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000010411 cooking Methods 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000003862 health status Effects 0.000 description 2
- 235000009200 high fat diet Nutrition 0.000 description 2
- 201000001421 hyperglycemia Diseases 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 235000021590 normal diet Nutrition 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- INLFWQCRAJUDCR-IQVMEADQSA-N (1R,2S,4S,5'S,6R,7S,8R,9S,12S,13S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane] Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CCCCC4CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@H](C)CO1 INLFWQCRAJUDCR-IQVMEADQSA-N 0.000 description 1
- JQNVCUBPURTQPQ-UHFFFAOYSA-N (25R)-Inokosterone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C)(O)C(O)CCC(CO)C)CCC33O)C)C3=CC(=O)C21 JQNVCUBPURTQPQ-UHFFFAOYSA-N 0.000 description 1
- 241000427159 Achyranthes Species 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 241000241550 Cyathula Species 0.000 description 1
- UPEZCKBFRMILAV-JNEQICEOSA-N Ecdysone Natural products O=C1[C@H]2[C@@](C)([C@@H]3C([C@@]4(O)[C@@](C)([C@H]([C@H]([C@@H](O)CCC(O)(C)C)C)CC4)CC3)=C1)C[C@H](O)[C@H](O)C2 UPEZCKBFRMILAV-JNEQICEOSA-N 0.000 description 1
- 240000008620 Fagopyrum esculentum Species 0.000 description 1
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- JQNVCUBPURTQPQ-FTWMDKANSA-N Inokosterone Natural products O=C1[C@H]2[C@@](C)([C@@H]3C([C@@]4(O)[C@@](C)([C@H]([C@@](O)([C@@H](O)CC[C@H](CO)C)C)CC4)CC3)=C1)C[C@H](O)[C@H](O)C2 JQNVCUBPURTQPQ-FTWMDKANSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010022489 Insulin Resistance Diseases 0.000 description 1
- 240000003183 Manihot esculenta Species 0.000 description 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 101100010166 Mus musculus Dok3 gene Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- UPEZCKBFRMILAV-UHFFFAOYSA-N alpha-Ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C(O)CCC(C)(C)O)C)CCC33O)C)C3=CC(=O)C21 UPEZCKBFRMILAV-UHFFFAOYSA-N 0.000 description 1
- 230000001195 anabolic effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 230000000879 anti-atherosclerotic effect Effects 0.000 description 1
- 230000000433 anti-nutritional effect Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 229940125708 antidiabetic agent Drugs 0.000 description 1
- 239000003524 antilipemic agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 210000000576 arachnoid Anatomy 0.000 description 1
- 235000004251 balanced diet Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- KTUQUZJOVNIKNZ-UHFFFAOYSA-N butan-1-ol;hydrate Chemical compound O.CCCCO KTUQUZJOVNIKNZ-UHFFFAOYSA-N 0.000 description 1
- 229940124571 cholagogue Drugs 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000013409 condiments Nutrition 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000020805 dietary restrictions Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- UPEZCKBFRMILAV-JMZLNJERSA-N ecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@H]([C@H](O)CCC(C)(C)O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 UPEZCKBFRMILAV-JMZLNJERSA-N 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 239000002031 ethanolic fraction Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000004153 glucose metabolism Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000000055 hyoplipidemic effect Effects 0.000 description 1
- 235000021233 hypercaloric diet Nutrition 0.000 description 1
- 208000006575 hypertriglyceridemia Diseases 0.000 description 1
- 230000000871 hypocholesterolemic effect Effects 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- JQNVCUBPURTQPQ-XDWLXSIGSA-N inokosterone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@](C)(O)[C@H](O)CCC(CO)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 JQNVCUBPURTQPQ-XDWLXSIGSA-N 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 210000001596 intra-abdominal fat Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 229940127017 oral antidiabetic Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/168—Steroids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/184—Hormones
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Animal Husbandry (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Alternative & Traditional Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0759478A FR2924346B1 (fr) | 2007-11-30 | 2007-11-30 | Utilisation de phytoecdysones dans la preparation d'une composition pour agir sur le syndrome metabolique. |
| PCT/FR2008/052088 WO2009071804A2 (fr) | 2007-11-30 | 2008-11-19 | Utilisation de phytoecdysones dans la preparation d'une composition pour agir sur le syndrome metabolique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2747932T3 true ES2747932T3 (es) | 2020-03-12 |
Family
ID=39473912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08856497T Active ES2747932T3 (es) | 2007-11-30 | 2008-11-19 | Uso de fitoecdisonas en la preparación de una composición para actuar sobre el síndrome metabólico |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8236359B2 (https=) |
| EP (1) | EP2217255B1 (https=) |
| JP (1) | JP2011504921A (https=) |
| CN (1) | CN102231986B (https=) |
| AU (1) | AU2008332981B2 (https=) |
| BR (1) | BRPI0820455B8 (https=) |
| CA (1) | CA2706821A1 (https=) |
| ES (1) | ES2747932T3 (https=) |
| FR (1) | FR2924346B1 (https=) |
| PL (1) | PL2217255T3 (https=) |
| RU (1) | RU2491083C2 (https=) |
| WO (1) | WO2009071804A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2982489B1 (fr) * | 2011-11-10 | 2013-12-27 | Inst Biophytis Sas | Phytoecdysones pour leur utilisation dans la stabilisation du poids apres un regime amaigrissant |
| FR2983733B1 (fr) | 2011-12-13 | 2017-12-22 | Inst Biophytis Sas | Phytoecdysones pour leur utilisation dans l'amelioration de la qualite musculaire de mammiferes obeses et/ou sarcopeniques |
| US10441594B2 (en) * | 2013-12-06 | 2019-10-15 | Rutgers, The State University Of New Jersey | Methods of making quinoa leachates and uses thereof |
| CN103837615B (zh) * | 2014-02-15 | 2015-05-20 | 青岛农业大学 | 一种应用高效液相色谱法同时测定植物蜕皮激素类物质的方法 |
| FR3078252B1 (fr) * | 2018-02-28 | 2020-08-14 | Biophytis | Phytoecdysones pour leur utilisation dans la prevention de la perte de force musculaire lors d’une immobilisation |
| RU2764439C1 (ru) * | 2021-04-09 | 2022-01-17 | Федеральное государственное бюджетное учреждение науки "Федеральный исследовательский центр питания, биотехнологии и безопасности пищи" | Способ получения экстракта из зерен киноа, обогащенного фитоэкдистероидами |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS632928A (ja) * | 1986-06-20 | 1988-01-07 | Japan Bio Kenkyusho:Kk | 鎮痛剤 |
| JPH04124135A (ja) * | 1990-09-14 | 1992-04-24 | Veritas:Kk | 抗糖尿病薬 |
| JP3862295B2 (ja) * | 1993-09-30 | 2006-12-27 | 独立行政法人理化学研究所 | 抗肥満剤 |
| JP4676040B2 (ja) * | 1997-07-31 | 2011-04-27 | 株式会社林原生物化学研究所 | 組成物 |
| JP3873097B2 (ja) * | 1997-11-06 | 2007-01-24 | 独立行政法人理化学研究所 | 抗肥満剤及び脂質代謝改善剤 |
| JP3858055B2 (ja) * | 2000-02-29 | 2006-12-13 | 独立行政法人理化学研究所 | 抗肥満剤及び脂質代謝改善剤 |
| CN1280010A (zh) * | 2000-06-12 | 2001-01-17 | 昆明制药股份有限公司 | 一种治疗糖尿病的口服药物及其生产方法 |
| WO2004016092A1 (en) * | 2002-08-14 | 2004-02-26 | Bionutrigen Co., Ltd | Powder or extracts of plant leaves with anti-obesity effects and anti-obesity food comprising them |
| CN1557324A (zh) * | 2004-01-13 | 2004-12-29 | 秋 陈 | 蜕皮甾酮在制备治疗胰岛素抵抗药物中的应用 |
| JP4124135B2 (ja) | 2004-02-13 | 2008-07-23 | 株式会社デンソー | ガスセンサ |
| GB2420066A (en) * | 2004-11-23 | 2006-05-17 | Nor Feed As | Feed additive derived from plant material originating from quinoa (Chenopodium quinoa) |
| RU2290185C1 (ru) * | 2005-07-26 | 2006-12-27 | Дмитрий Николаевич Мясников | Композиция для нормализации липидного обмена и снижения массы тела и способ её получения |
| US8377915B2 (en) * | 2006-05-09 | 2013-02-19 | Rutgers, The State University Of New Jersey | Methods for treating or preventing disorders using ecdysteroid compositions |
| CN101011436A (zh) * | 2007-01-20 | 2007-08-08 | 苏州大学 | 牛膝总甾酮的医药用途 |
-
2007
- 2007-11-30 FR FR0759478A patent/FR2924346B1/fr active Active
-
2008
- 2008-11-19 EP EP08856497.6A patent/EP2217255B1/fr active Active
- 2008-11-19 BR BRPI0820455A patent/BRPI0820455B8/pt active IP Right Grant
- 2008-11-19 CN CN200880118514.XA patent/CN102231986B/zh active Active
- 2008-11-19 JP JP2010535430A patent/JP2011504921A/ja active Pending
- 2008-11-19 RU RU2010126625/15A patent/RU2491083C2/ru active
- 2008-11-19 CA CA2706821A patent/CA2706821A1/fr not_active Abandoned
- 2008-11-19 ES ES08856497T patent/ES2747932T3/es active Active
- 2008-11-19 AU AU2008332981A patent/AU2008332981B2/en active Active
- 2008-11-19 US US12/745,315 patent/US8236359B2/en active Active
- 2008-11-19 PL PL08856497T patent/PL2217255T3/pl unknown
- 2008-11-19 WO PCT/FR2008/052088 patent/WO2009071804A2/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008332981B2 (en) | 2014-06-12 |
| CN102231986B (zh) | 2014-01-22 |
| AU2008332981A2 (en) | 2010-07-22 |
| EP2217255A2 (fr) | 2010-08-18 |
| FR2924346A1 (fr) | 2009-06-05 |
| CA2706821A1 (fr) | 2009-06-11 |
| BRPI0820455A2 (pt) | 2015-09-29 |
| AU2008332981A1 (en) | 2009-06-11 |
| RU2010126625A (ru) | 2012-01-10 |
| BRPI0820455B8 (pt) | 2021-05-25 |
| BRPI0820455B1 (pt) | 2020-09-24 |
| CN102231986A (zh) | 2011-11-02 |
| JP2011504921A (ja) | 2011-02-17 |
| EP2217255B1 (fr) | 2019-07-03 |
| RU2491083C2 (ru) | 2013-08-27 |
| WO2009071804A2 (fr) | 2009-06-11 |
| PL2217255T3 (pl) | 2020-06-01 |
| FR2924346B1 (fr) | 2010-02-19 |
| WO2009071804A3 (fr) | 2010-04-22 |
| US20110033561A1 (en) | 2011-02-10 |
| US8236359B2 (en) | 2012-08-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6652891B2 (en) | Co-enzyme Q10 dietary supplement | |
| JP2013501778A (ja) | チアシード及びマカを含む健康補助食品、飼料、薬学組成物並びにその製造方法 | |
| JP2017186354A (ja) | 真性糖尿病および他の代謝不均衡の治療または予防のための方法 | |
| MXPA04006166A (es) | Composiciones que incorporan al acido (-)-hidroxicitrico. al cromo y al acido gimnemico y metodos relacionados para promover un peso corporal adecuado y mejorar los factores relacionados con la salud. | |
| CN101579120A (zh) | 一种具有减肥功能的营养食品及其制备方法 | |
| ES2747932T3 (es) | Uso de fitoecdisonas en la preparación de una composición para actuar sobre el síndrome metabólico | |
| JP2008174539A (ja) | 紫色の馬鈴薯を使用した肥満患者用の健康機能食品 | |
| KR20130063074A (ko) | 당뇨병과 당뇨합병증의 혈당 혈압 저하작용 조성물 | |
| KR101731859B1 (ko) | 진피 추출물을 포함하는 이상 체중 감소 증상의 예방 또는 치료용 조성물 | |
| US8623432B2 (en) | Effects of Dichrostachys glomerata on various cardiovascular risk factors and metabolic syndrome | |
| CN103181557A (zh) | 具有减肥功能的营养食品及其制备方法 | |
| KR100450055B1 (ko) | 두과 식물을 주성분으로 함유하는 체질개선용 식품 조성물및 그로부터 제조되는 식품 | |
| KR101154182B1 (ko) | 방광과체질에 처방되는 변비개선용 천연음료 조성물 | |
| Parekar et al. | Molecular mechanisms of secondary metabolites as antidiabetic agents | |
| Premakumari et al. | Effect of supplementation of wheat germ, wheat bran and wheat grass to subjects with specific health issues | |
| KR20070002445A (ko) | Ｈｇｄｓｊ201 생약 복합제 추출물을 포함하는 비만의예방 및 치료용 조성물 | |
| US20140178507A1 (en) | Weight management composition | |
| JP2014172901A (ja) | 脂肪吸収抑制剤 | |
| JP2006306797A (ja) | むくみの予防及び／又は治療用組成物 | |
| US20100040704A1 (en) | Composition and method for weight reduction | |
| Cure et al. | Click on the image below to launch the video Moringa Documentary-the'miracle'tree-click on the image below to launch video. Treatment/Alternative Treatments/Herbal Medicines/Moringa Tree Moringa Tree: Side Effects & Uses for Cancer Treatment Moringa tree extracts contain high levels of antioxidants that may be beneficial in the treatment of cancer. Studies show moringa tree extracts reduce cancer cell growth. Some mesothelioma survivors claim the herbal supplement has helped them. | |
| KR20100101326A (ko) | 체질에 따라 처방되는 변비개선용 천연음료 조성물 | |
| KR20130048584A (ko) | 수리취 식이섬유를 포함하는 변비 개선용 조성물 |