ES2733712T3 - Métodos para tratar la espondilitis anquilosante utilizando anticuerpos anti-IL-17 - Google Patents

Métodos para tratar la espondilitis anquilosante utilizando anticuerpos anti-IL-17 Download PDF

Info

Publication number
ES2733712T3
ES2733712T3 ES16163440T ES16163440T ES2733712T3 ES 2733712 T3 ES2733712 T3 ES 2733712T3 ES 16163440 T ES16163440 T ES 16163440T ES 16163440 T ES16163440 T ES 16163440T ES 2733712 T3 ES2733712 T3 ES 2733712T3
Authority
ES
Spain
Prior art keywords
patient
secukinumab
antagonist
approximately
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES16163440T
Other languages
English (en)
Spanish (es)
Inventor
Shepard Mpofu
Hanno Richards
Karthinathan Thangavelu
Matthias Machacek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44906168&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2733712(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2733712T3 publication Critical patent/ES2733712T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
ES16163440T 2010-11-05 2011-11-04 Métodos para tratar la espondilitis anquilosante utilizando anticuerpos anti-IL-17 Active ES2733712T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41053310P 2010-11-05 2010-11-05

Publications (1)

Publication Number Publication Date
ES2733712T3 true ES2733712T3 (es) 2019-12-02

Family

ID=44906168

Family Applications (3)

Application Number Title Priority Date Filing Date
ES16163440T Active ES2733712T3 (es) 2010-11-05 2011-11-04 Métodos para tratar la espondilitis anquilosante utilizando anticuerpos anti-IL-17
ES21180656T Active ES3030036T3 (en) 2010-11-05 2011-11-04 Pharmaceutical compositions comprising secukinumab
ES20187001T Pending ES2804624T1 (es) 2010-11-05 2011-11-04 Métodos de tratamiento de artritis psoriásica usando antagonistas de IL-17

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES21180656T Active ES3030036T3 (en) 2010-11-05 2011-11-04 Pharmaceutical compositions comprising secukinumab
ES20187001T Pending ES2804624T1 (es) 2010-11-05 2011-11-04 Métodos de tratamiento de artritis psoriásica usando antagonistas de IL-17

Country Status (30)

Country Link
US (10) US9744234B2 (cg-RX-API-DMAC7.html)
EP (6) EP4116325A1 (cg-RX-API-DMAC7.html)
JP (8) JP2014503482A (cg-RX-API-DMAC7.html)
KR (5) KR20160067984A (cg-RX-API-DMAC7.html)
CN (2) CN103189074A (cg-RX-API-DMAC7.html)
AU (1) AU2011325134B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013011176A2 (cg-RX-API-DMAC7.html)
CA (2) CA2813849C (cg-RX-API-DMAC7.html)
CL (1) CL2013001213A1 (cg-RX-API-DMAC7.html)
CY (1) CY1121802T1 (cg-RX-API-DMAC7.html)
DE (1) DE20187001T1 (cg-RX-API-DMAC7.html)
DK (2) DK3111954T3 (cg-RX-API-DMAC7.html)
ES (3) ES2733712T3 (cg-RX-API-DMAC7.html)
FI (1) FI3757126T3 (cg-RX-API-DMAC7.html)
HR (2) HRP20251174T1 (cg-RX-API-DMAC7.html)
HU (1) HUE044038T2 (cg-RX-API-DMAC7.html)
IL (4) IL311014A (cg-RX-API-DMAC7.html)
LT (2) LT3111954T (cg-RX-API-DMAC7.html)
MA (1) MA34647B1 (cg-RX-API-DMAC7.html)
MX (1) MX362591B (cg-RX-API-DMAC7.html)
PH (1) PH12013500890A1 (cg-RX-API-DMAC7.html)
PL (1) PL3111954T3 (cg-RX-API-DMAC7.html)
PT (2) PT3111954T (cg-RX-API-DMAC7.html)
RS (1) RS67377B1 (cg-RX-API-DMAC7.html)
RU (1) RU2582937C2 (cg-RX-API-DMAC7.html)
SG (2) SG189138A1 (cg-RX-API-DMAC7.html)
SI (1) SI3111954T1 (cg-RX-API-DMAC7.html)
TR (1) TR201909531T4 (cg-RX-API-DMAC7.html)
TW (3) TWI616204B (cg-RX-API-DMAC7.html)
WO (1) WO2012059598A2 (cg-RX-API-DMAC7.html)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ603570A (en) 2010-05-20 2014-12-24 Ablynx Nv Biological materials related to her3
EP4116325A1 (en) 2010-11-05 2023-01-11 Novartis AG Methods of treating rheumatoid arthritis using il-17 antagonists
UA117218C2 (uk) 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
DK2771022T3 (da) 2011-10-11 2020-09-28 Viela Bio Inc Cd40l-specifikke tn3-afledte skeletter (scaffolds) og fremgangsmåder til anvendelse deraf
US9284283B2 (en) 2012-02-02 2016-03-15 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating IL-17
US20140004131A1 (en) 2012-05-04 2014-01-02 Novartis Ag Antibody formulation
WO2014155278A2 (en) 2013-03-26 2014-10-02 Novartis Ag Methods of treating autoimmune diseases using il-17 antagonists
US9688769B2 (en) 2013-10-22 2017-06-27 Novimmune S.A. Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of TLR4 ligands and other biomarkers
EP3101035B1 (en) * 2014-01-28 2021-10-06 Beijing Hanmi Pharmaceutical Co., Ltd. Bifunctional fusion protein, preparation method therefor, and use thereof
CN106456756B (zh) 2014-05-13 2021-04-23 免疫医疗有限公司 用于治疗非小细胞肺癌的抗-b7-h1和抗-ctla-4抗体
JP2017521479A (ja) 2014-05-15 2017-08-03 ラニ セラピューティクス, エルエルシー ポリペプチドおよび/またはタンパク質を含む固体塊の薬学的組成物およびそれを製造するための方法
US11548940B2 (en) * 2014-05-15 2023-01-10 Rani Therapeutics, Llc Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
FR3021976B1 (fr) * 2014-06-06 2018-11-02 Hospices Civils De Lyon Marqueur biologique permettant d'evaluer le niveau pro-inflammatoire dependant de la contribution fonctionnelle de l'il-17 chez un individu
US20160002326A1 (en) * 2014-06-10 2016-01-07 Abbvie Inc. Compositions and methods for treating rheumatoid arthritis
NL2013007B1 (en) * 2014-06-16 2016-07-05 Ablynx Nv Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
CA2960754A1 (en) * 2014-09-10 2016-03-17 Novartis Ag Use of il-17 antagonists to inhibit the progression of structural damage in psoriatic arthritis patients
EP3209320B1 (en) * 2014-10-22 2023-03-08 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
AR103173A1 (es) * 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
AR103172A1 (es) * 2014-12-22 2017-04-19 Novartis Ag Reducción selectiva de residuos de cisteina en anticuerpos il-17
EP3265107B1 (en) 2015-03-02 2024-10-02 180 Therapeutics LP Method of treating a localized fibrotic disorder using a tnf receptor 2 antagonist
EP3167892A1 (en) 2015-11-10 2017-05-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for preventing or treating imflammatory bowel diseases
US20190330328A1 (en) * 2015-10-19 2019-10-31 Christian Mann Methods of treating non-radiographic axial spondyloarthritis using interleukin-17 (il-17) antagonists
EP3504648A1 (en) * 2016-08-23 2019-07-03 CSL Behring GmbH Method of preventing acute attacks of hereditary angioedema associated with c1 esterase inhibitor deficiency
CA3080665A1 (en) * 2017-11-02 2019-05-09 Novartis Ag Method of treating tendinopathy using interleukin-17 (il-17) antagonists
GB201719447D0 (en) * 2017-11-23 2018-01-10 Ucb Biopharma Sprl Pharmaceutical composition
CN119746057A (zh) * 2018-05-09 2025-04-04 诺华股份有限公司 卡那吉努单抗的用途
MX2021003514A (es) * 2018-09-26 2021-05-27 Viela Bio Inc Antagonista del ligando del grupo de diferenciacion 40 (cd40l) y usos del mismo.
WO2020154252A1 (en) * 2019-01-22 2020-07-30 Genentech, Inc. Methods of treating rheumatoid arthritis, chronic spontaneous urticaria, and systemic lupus erythematosis using an inhibitor of bruton's tyrosine kinase
JOP20210229A1 (ar) 2019-02-18 2023-01-30 Lilly Co Eli صيغة جسم مضاد علاجي
KR102169901B1 (ko) * 2019-05-17 2020-10-26 연세대학교 산학협력단 Dna 메틸화를 이용한 면역 항암 요법의 치료 반응에 관한 정보 제공 방법 및 이를 이용한 키트
CN110179746A (zh) 2019-05-17 2019-08-30 通化东宝生物科技有限公司 一种稳定的苏金单抗注射剂及其制备方法
KR20220044315A (ko) * 2019-08-05 2022-04-07 에벨로 바이오사이언시즈, 인크. 프레보텔라 히스티콜라를 사용한 건선 및 아토피성 피부염을 치료하기 위한 조성물 및 방법
BR112022004941A2 (pt) 2019-09-20 2022-06-28 Novartis Ag Métodos para tratar doenças autoimunes com o uso de antagonistas de interleucina-17 (il-17)
TW202120546A (zh) 2019-11-19 2021-06-01 瑞士商諾華公司 使用介白素-17(il-17)拮抗劑治療狼瘡性腎炎之方法
CN112915201B (zh) * 2019-12-06 2023-06-27 珠海市丽珠单抗生物技术有限公司 包含抗il-17抗体的液体制剂
WO2021146850A1 (en) * 2020-01-20 2021-07-29 Tsinghua University A critical role of febrile temperature in regulating interleukin (il) -17 producing cells via smad4
WO2022113105A1 (en) * 2020-11-25 2022-06-02 Dr. Reddy's Laboratories Limited Stable therapeutic protein formulation and methods of making the same
TW202241505A (zh) * 2021-01-04 2022-11-01 大陸商江蘇恆瑞醫藥股份有限公司 抗il-17抗體治療自體免疫性疾病和炎症的方法
WO2022184114A1 (zh) * 2021-03-03 2022-09-09 苏州盛迪亚生物医药有限公司 抗il-17抗体治疗自身免疫性疾病和炎症的方法
KR102339377B1 (ko) * 2021-03-29 2021-12-13 김지혜 사용자 맞춤형 문화 예술 컨텐츠 제공 방법 및 장치
CN117500834A (zh) * 2021-06-21 2024-02-02 百时美施贵宝公司 使用蔗糖、甘露糖醇和甘氨酸来减少高浓度冻干生物制剂药物产品的重构时间
CN114306594A (zh) * 2021-12-21 2022-04-12 华中科技大学同济医学院附属协和医院 地舒单抗在制备治疗膝关节骨性关节炎的药物中的应用
EP4654999A1 (en) 2023-01-27 2025-12-03 Fresenius Kabi Deutschland GmbH Biopharmaceutical composition
EP4406553A1 (en) 2023-01-27 2024-07-31 Fresenius Kabi Deutschland GmbH Stable secukinumab biopharmaceutical composition
WO2025071335A1 (ko) * 2023-09-27 2025-04-03 삼성바이오에피스 주식회사 항-il-17 항체의 안정한 액상 제형

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0565233A (ja) 1991-03-08 1993-03-19 Mitsui Toatsu Chem Inc モノクローナル抗体含有凍結乾燥製剤
US5250442A (en) * 1993-04-08 1993-10-05 Orestes Cabezas Method of treating rheumatoid arthritis using tetracycline
US6309636B1 (en) * 1995-09-14 2001-10-30 Cancer Research Institute Of Contra Costa Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
US20050147609A1 (en) 1998-05-15 2005-07-07 Genentech, Inc. Use of anti-IL-17 antibody for the treatment of cartilage damaged by osteoarthritis
JP2000186046A (ja) 1998-10-14 2000-07-04 Snow Brand Milk Prod Co Ltd 慢性関節リウマチ治療剤及び診断方法
IL143266A0 (en) 1998-11-27 2002-04-21 Darwin Discovery Ltd Transforming growth factor-beta binding proteins and pharmaceutical compositions for increasing bone mineral content utilizing the same
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
JP4159682B2 (ja) 1998-12-22 2008-10-01 株式会社クラレ 止血材
ES2338218T3 (es) 2001-07-25 2010-05-05 Facet Biotech Corporation Formulacion farmacologica liofilizada estable de anticuerpos igg daclizumab.
JP2005508992A (ja) 2001-11-09 2005-04-07 セントカー・インコーポレーテツド 凍結乾燥されたモノクローナル抗体組成物
AU2003223214B2 (en) 2002-03-01 2008-09-18 Celltech R & D, Inc. Methods to increase or decrease bone density
US20040023356A1 (en) 2002-06-14 2004-02-05 Robb Krumlauf Wise/Sost nucleic acid sequences and amino acid sequences
US6974701B2 (en) 2003-03-21 2005-12-13 Hemovations, Llc Erythrocyte sedimentation rate (ESR) test measurement instrument of unitary design and method of using the same
RS20050934A (sr) 2003-06-16 2008-04-04 Celltech R. & D. Inc., Antitela specifična za sklerostin i metode za povećanje mineralizacije kostiju
US8461155B2 (en) 2003-09-22 2013-06-11 University Of Connecticut Sclerostin and the inhibition of WNT signaling and bone formation
US8039642B2 (en) 2003-12-09 2011-10-18 Life Technologies Corporation Pyrenyloxysulfonic acid fluorescent agents
GB0417487D0 (en) * 2004-08-05 2004-09-08 Novartis Ag Organic compound
JP3936365B2 (ja) 2004-09-14 2007-06-27 ソニーケミカル&インフォメーションデバイス株式会社 機能素子実装モジュール及びその製造方法
DK2620450T3 (en) 2005-03-08 2019-02-04 Pfizer Prod Inc Antibody Compositions against CTLA-4
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
WO2007056188A1 (en) 2005-11-04 2007-05-18 President And Fellows Of Harvard College Synthesis of inhibitors of ftsz
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
US9084777B2 (en) 2005-12-28 2015-07-21 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing formulations
WO2007117749A2 (en) 2006-01-31 2007-10-18 Novartis Ag Il-17 antagonistic antibodies fpr treating cancer
TW200815469A (en) 2006-06-23 2008-04-01 Astrazeneca Ab Compounds
AU2007292890A1 (en) 2006-09-05 2008-03-13 Medarex, Inc. Antibodies to bone morphogenic proteins and receptors therefor and methods for their use
JPWO2008029908A1 (ja) 2006-09-07 2010-01-21 協和発酵キリン株式会社 抗体を含有する安定な凍結乾燥医薬製剤
UA99716C2 (ru) * 2006-10-02 2012-09-25 Кирин-Амген Инк. Антитело, которое специфично связывает человеческий il-17 рецептор а (il-17ra)
US7767206B2 (en) 2006-10-02 2010-08-03 Amgen Inc. Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
US20100036091A1 (en) 2006-11-10 2010-02-11 Amgen Inc. Antibody-based diagnostics and therapeutics
WO2008133722A2 (en) 2006-11-10 2008-11-06 Ucb Pharma S.A. Anti human sclerostin antibodies
BRPI0807205A2 (pt) 2007-02-02 2014-07-22 Novartis Ag Moduladores de ligantes esclerostina para tratamento de distúrbios relacionados ao osso
ES2446293T3 (es) 2007-03-20 2014-03-07 Eli Lilly & Company Anticuerpos anti-esclerostina
KR20090113340A (ko) 2007-03-22 2009-10-29 임클론 엘엘씨 안정한 항체 제제
JP5456658B2 (ja) 2007-03-30 2014-04-02 メディミューン,エルエルシー 抗体製剤
WO2008156865A2 (en) 2007-06-20 2008-12-24 Schering Corporation Joint destruction biomarkers for anti-il-17a therapy of inflammatory joint disease
US7720605B2 (en) 2007-06-22 2010-05-18 Weyerhaeuser Nr Company Identifying vegetation attributes from LiDAR data
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
AR068767A1 (es) 2007-10-12 2009-12-02 Novartis Ag Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina
BRPI0819688A2 (pt) 2007-12-14 2015-06-16 Amgen Inc Processo para tratamento de fratura óssea com anticorpos anti-esclerostina.
EP2297209A4 (en) 2008-06-03 2012-08-01 Abbott Lab IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF
US20090301682A1 (en) 2008-06-05 2009-12-10 Baker Hughes Incorporated Casting furnace method and apparatus
BRPI0915448A2 (pt) 2008-07-08 2015-11-10 Abbott Lab imunoglobulinas de domínio variável duplo para prostaglandina e2 e usos das mesmas
UA103499C2 (ru) 2008-09-29 2013-10-25 Рош Глікарт Аг Антитело против интерлейкина-17 (ил-17) человека и его применение
ES2719496T3 (es) 2008-11-12 2019-07-10 Medimmune Llc Formulación de anticuerpo
FR2938547B1 (fr) 2008-11-14 2012-11-16 Total Raffinage Marketing Liant synthetique clair
US20110256130A1 (en) 2008-12-01 2011-10-20 Joshua Robert Schultz Methods of treating inflammatory disorders
PE20160651A1 (es) 2009-03-05 2016-07-24 Abbvie Inc Proteinas de union a il-17
JP5537740B2 (ja) 2010-10-08 2014-07-02 ノバルティス アーゲー Il−17アンタゴニストを用いて乾癬を治療する方法
EP4116325A1 (en) 2010-11-05 2023-01-11 Novartis AG Methods of treating rheumatoid arthritis using il-17 antagonists
WO2012082573A1 (en) * 2010-12-13 2012-06-21 Novartis Ag Predictive methods and methods of treating arthritis using il-17 antagonists
RU2014125071A (ru) 2011-11-21 2015-12-27 Новартис Аг Способы лечения псориатического артрита (psa) с использованием антагонистов il-17 и аллелей ответа psa или отсутствия ответа psa
JP2015519311A (ja) 2012-04-20 2015-07-09 ノバルティス アーゲー Il−17アンタゴニストを用いて強直性脊椎炎を治療する方法
WO2014155278A2 (en) 2013-03-26 2014-10-02 Novartis Ag Methods of treating autoimmune diseases using il-17 antagonists
US20190330328A1 (en) 2015-10-19 2019-10-31 Christian Mann Methods of treating non-radiographic axial spondyloarthritis using interleukin-17 (il-17) antagonists
US11280479B2 (en) 2017-10-18 2022-03-22 The Sloan Company Sign box light module

Also Published As

Publication number Publication date
ES2804624T1 (es) 2021-02-08
CA2813849C (en) 2021-06-15
WO2012059598A2 (en) 2012-05-10
PH12013500890A1 (en) 2013-07-01
US20210177966A1 (en) 2021-06-17
FI3757126T3 (fi) 2025-10-12
IL262559B (en) 2022-06-01
SG10201505624VA (en) 2015-09-29
KR20180129991A (ko) 2018-12-05
TWI616204B (zh) 2018-03-01
US20230293683A1 (en) 2023-09-21
US20180008706A1 (en) 2018-01-11
TW201306864A (zh) 2013-02-16
CA2813849A1 (en) 2012-05-10
EP3111954B1 (en) 2019-04-03
JP6250109B2 (ja) 2017-12-20
JP2016065094A (ja) 2016-04-28
CN103189074A (zh) 2013-07-03
US20210128726A1 (en) 2021-05-06
MX2013005060A (es) 2013-06-28
TW201726170A (zh) 2017-08-01
TWI604851B (zh) 2017-11-11
KR20160067984A (ko) 2016-06-14
CA3116725A1 (en) 2012-05-10
US20190307880A1 (en) 2019-10-10
TR201909531T4 (tr) 2019-07-22
SG189138A1 (en) 2013-05-31
US20200276305A1 (en) 2020-09-03
LT3757126T (lt) 2025-12-10
JP2017002064A (ja) 2017-01-05
HRP20251174T1 (hr) 2025-11-21
PT3111954T (pt) 2019-07-10
TWI618543B (zh) 2018-03-21
DK3111954T3 (da) 2019-07-15
JP2019142912A (ja) 2019-08-29
CA3116725C (en) 2023-10-24
JP2025102772A (ja) 2025-07-08
SI3111954T1 (sl) 2019-08-30
US20230346926A1 (en) 2023-11-02
EP3757126B1 (en) 2025-09-03
EP3912640A1 (en) 2021-11-24
EP4116325A1 (en) 2023-01-11
IL282625A (en) 2021-06-30
JP6515168B2 (ja) 2019-05-15
IL225309B (en) 2021-05-31
CY1121802T1 (el) 2020-07-31
EP3111954A1 (en) 2017-01-04
IL311014A (en) 2024-04-01
JP2021104995A (ja) 2021-07-26
WO2012059598A3 (en) 2012-09-27
PT3757126T (pt) 2025-11-13
KR20180019247A (ko) 2018-02-23
US20130209480A1 (en) 2013-08-15
AU2011325134A1 (en) 2013-04-04
LT3111954T (lt) 2019-07-10
ES3030036T3 (en) 2025-06-26
MA34647B1 (fr) 2013-11-02
PL3111954T3 (pl) 2019-10-31
AU2011325134B2 (en) 2014-10-23
US10363307B2 (en) 2019-07-30
IL225309A0 (en) 2013-06-27
KR20140008305A (ko) 2014-01-21
CN104800844A (zh) 2015-07-29
JP2018065826A (ja) 2018-04-26
US11534491B2 (en) 2022-12-27
EP2635303A2 (en) 2013-09-11
HUE044038T2 (hu) 2019-09-30
MX362591B (es) 2019-01-25
DE20187001T1 (de) 2021-04-01
US12465635B2 (en) 2025-11-11
KR20150020734A (ko) 2015-02-26
US20250205332A1 (en) 2025-06-26
DK3757126T3 (da) 2025-09-29
JP2014503482A (ja) 2014-02-13
BR112013011176A2 (pt) 2020-09-01
CL2013001213A1 (es) 2014-03-28
RU2013125775A (ru) 2014-12-10
US20220193234A1 (en) 2022-06-23
EP3757126A1 (en) 2020-12-30
HRP20191162T1 (hr) 2019-10-04
US9744234B2 (en) 2017-08-29
EP3542820A1 (en) 2019-09-25
RS67377B1 (sr) 2025-11-28
TW201517917A (zh) 2015-05-16
EP3912640B1 (en) 2025-03-05
IL262559A (en) 2018-12-31
JP2023109910A (ja) 2023-08-08
RU2582937C2 (ru) 2016-04-27
JP6049843B2 (ja) 2016-12-21

Similar Documents

Publication Publication Date Title
ES2733712T3 (es) Métodos para tratar la espondilitis anquilosante utilizando anticuerpos anti-IL-17
AU2014259526B2 (en) Methods of treating ankylosing spondylitis using IL-17 antagonists
HK40010039A (en) Methods of treating psoriatic arthritis using il-17 antagonists
HK40040628A (en) Methods of treating psoriatic arthritis using il-17 antagonists
HK40035240A (en) Methods of treating psoriatic arthritis using il-17 antagonists
HK40083901A (en) Methods of treating rheumatoid arthritis using il-17 antagonists
HK40061520A (en) Pharmaceutical compositions comprising secukinumab
HK1229257B (en) Methods of treating ankylosing spondylitis using anti-il-17 antibodies
HK1229257A1 (en) Methods of treating ankylosing spondylitis using anti-il-17 antibodies