ES2727486T3 - Anticuerpos de la familia anti-DR5, anticuerpos de la familia anti-DR5 biespecíficos o multivalentes y métodos de uso de los mismos - Google Patents
Anticuerpos de la familia anti-DR5, anticuerpos de la familia anti-DR5 biespecíficos o multivalentes y métodos de uso de los mismos Download PDFInfo
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- ES2727486T3 ES2727486T3 ES13734785T ES13734785T ES2727486T3 ES 2727486 T3 ES2727486 T3 ES 2727486T3 ES 13734785 T ES13734785 T ES 13734785T ES 13734785 T ES13734785 T ES 13734785T ES 2727486 T3 ES2727486 T3 ES 2727486T3
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305821.6A EP2684896A1 (en) | 2012-07-09 | 2012-07-09 | Anti-DR5 family antibodies, bispecific or multivalent anti-DR5 family antibodies and methods of use thereof |
| US201261669866P | 2012-07-10 | 2012-07-10 | |
| PCT/EP2013/064466 WO2014009358A1 (en) | 2012-07-09 | 2013-07-09 | Anti-dr5 family antibodies, bispecific or multivalent anti-dr5 family antibodies and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2727486T3 true ES2727486T3 (es) | 2019-10-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13734785T Active ES2727486T3 (es) | 2012-07-09 | 2013-07-09 | Anticuerpos de la familia anti-DR5, anticuerpos de la familia anti-DR5 biespecíficos o multivalentes y métodos de uso de los mismos |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US9611327B2 (OSRAM) |
| EP (3) | EP2684896A1 (OSRAM) |
| JP (1) | JP6457386B2 (OSRAM) |
| CN (1) | CN104619725B (OSRAM) |
| BR (1) | BR112015000449B1 (OSRAM) |
| CA (1) | CA2878790C (OSRAM) |
| DK (1) | DK2877491T3 (OSRAM) |
| ES (1) | ES2727486T3 (OSRAM) |
| IL (2) | IL236651B (OSRAM) |
| IN (1) | IN2015DN00143A (OSRAM) |
| PL (1) | PL2877491T3 (OSRAM) |
| PT (1) | PT2877491T (OSRAM) |
| SG (2) | SG11201500177PA (OSRAM) |
| SI (1) | SI2877491T1 (OSRAM) |
| WO (1) | WO2014009358A1 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3750918A1 (en) | 2015-01-20 | 2020-12-16 | IGM Biosciences, Inc. | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
| EP3048116A1 (en) * | 2015-01-23 | 2016-07-27 | International-Drug-Development-Biotech | Anti-dr5 antibodies with enhanced apoptosis potency |
| CN107250161A (zh) | 2015-01-26 | 2017-10-13 | 宏观基因有限公司 | 包含dr5‑结合结构域的多价分子 |
| EP3112381A1 (en) * | 2015-07-01 | 2017-01-04 | FONDAZIONE IRCCS Istituto Nazionale dei Tumori | Bispecific antibodies for use in cancer immunotherapy |
| EP3322734B1 (en) | 2015-07-16 | 2020-09-09 | Inhibrx, Inc. | Multivalent and multispecific dr5-binding fusion proteins |
| MA43365A (fr) * | 2015-12-01 | 2018-10-10 | Genmab Bv | Anticorps anti-dr5 et procédés d'utilisation de ceux-ci |
| CN106397594B (zh) * | 2016-10-25 | 2019-06-04 | 中国药科大学 | 一种全人源的抗人死亡受体5的激动剂单链抗体及应用 |
| KR20190070977A (ko) | 2016-11-01 | 2019-06-21 | 젠맵 비. 브이 | 폴리펩티드 변이체 및 그의 용도 |
| EP3360898A1 (en) | 2017-02-14 | 2018-08-15 | Boehringer Ingelheim International GmbH | Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer |
| MX2019009346A (es) | 2017-02-10 | 2019-10-02 | Genmab Bv | Variantes de polipeptidos y usos de los mismos. |
| KR101926834B1 (ko) | 2017-03-21 | 2018-12-07 | 동아에스티 주식회사 | 항-dr5 항체 및 그의 용도 |
| US20200247897A1 (en) | 2017-06-07 | 2020-08-06 | Genmab B.V. | Therapeutic antibodies based on mutated igg hexamers |
| WO2019145455A1 (en) | 2018-01-24 | 2019-08-01 | Genmab B.V. | Polypeptide variants and uses thereof |
| KR20200123782A (ko) * | 2018-02-26 | 2020-10-30 | 아이쥐엠 바이오사이언스 인코포레이티드 | 암치료를 위해 화학치료제와 병용된 다중결합 항-dr5 결합분자의 용도 |
| MA52485A (fr) | 2018-05-03 | 2021-03-10 | Genmab Bv | Combinaisons de variants d'anticorps et utilisations associées |
| US12247075B2 (en) * | 2018-12-26 | 2025-03-11 | Imcheck Therapeutics Sas | BTN3A binding proteins and uses thereof |
| MA55881A (fr) | 2019-05-09 | 2022-03-16 | Genmab Bv | Schémas posologiques pour une combinaison d'anticorps anti-dr5 destinés à être utilisés dans le traitement du cancer |
| JP2023500701A (ja) | 2019-11-06 | 2023-01-10 | ジェンマブ ビー．ブイ． | 抗体変種の組み合わせおよびその使用 |
| JP2023534726A (ja) | 2020-07-23 | 2023-08-10 | ジェンマブ ビー．ブイ． | 多発性骨髄腫の治療に使用するための抗ｄｒ５抗体と免疫調節イミド薬との併用 |
| CN119546635A (zh) * | 2022-03-02 | 2025-02-28 | 瓦尔登生物科学股份有限公司 | 新颖的可溶性尿激酶纤溶酶原激活物受体(suPAR)结合分子及其用途 |
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| US4342566A (en) | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6284236B1 (en) | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
| EP1500702A1 (en) | 1996-04-01 | 2005-01-26 | Genentech, Inc. | APO-2LI and APO-3 apoptosis polypeptides from the TNFR1 familiy |
| EP1012274B2 (en) | 1997-01-28 | 2011-06-15 | Human Genome Sciences, Inc. | Death domain containing receptor 4 (dr4: death receptor 4), member of the tnf-receptor superfamily and binding to trail (ap0-2l) |
| US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
| US20050233958A1 (en) | 1997-03-17 | 2005-10-20 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
| EP1045906B1 (en) | 1998-01-15 | 2008-10-15 | Genentech, Inc. | Apo-2 ligand |
| WO1999037791A1 (en) | 1998-01-23 | 1999-07-29 | Vlaams Interuniversitair Instituut Voor Biotechnologie | Multipurpose antibody derivatives |
| ES2292236T3 (es) | 1998-04-02 | 2008-03-01 | Genentech, Inc. | Variantes de anticuerpos y sus fragmentos. |
| PT1192185E (pt) | 1999-06-09 | 2006-11-30 | Genentech Inc | Sinergismo de agonista do receptor de apo-2l e cpt-11 |
| US6444640B1 (en) | 1999-09-30 | 2002-09-03 | Ludwig Institute For Cancer Research | Compositions of trail and DNA damaging drugs and uses thereof |
| US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
| GB0020442D0 (en) | 2000-08-18 | 2000-10-04 | Nokia Networks Oy | Data transmission protocol |
| US20020155109A1 (en) | 2001-04-20 | 2002-10-24 | Lynch David H. | Bispecific antibodies that bind TRAIL-R1 and TRAIL-R2 |
| ES2437992T3 (es) | 2001-05-25 | 2014-01-15 | Human Genome Sciences, Inc. | Anticuerpos que se unen inmunoespecíficamente a los receptores de TRAIL |
| ATE433996T1 (de) | 2001-07-03 | 2009-07-15 | Genentech Inc | Humane dr4-antikörper und deren anwendungen |
| KR20070010046A (ko) | 2004-04-06 | 2007-01-19 | 제넨테크, 인크. | Ｄｒ5 항체 및 그의 용도 |
| CA2587766A1 (en) | 2004-11-10 | 2007-03-01 | Macrogenics, Inc. | Engineering fc antibody regions to confer effector function |
| CN101218251A (zh) | 2005-02-28 | 2008-07-09 | 森托科尔公司 | 异二聚体蛋白结合组合物 |
| CA2644903A1 (en) | 2006-03-10 | 2007-09-20 | Macrogenics, Inc. | Identification and engineering of antibodies with variant heavy chains and methods of using same |
| KR100847010B1 (ko) * | 2006-07-05 | 2008-07-17 | 아주대학교산학협력단 | 세포사멸 수용체 5 (ｄｒ5)에 특이적으로 결합하는 항체 및이를 포함하는 암 예방 또는 치료용 조성물 |
| WO2009002947A2 (en) | 2007-06-22 | 2008-12-31 | Affymax, Inc. | Compounds and peptides that bind the trail receptor |
| UA117901C2 (uk) * | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
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2012
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| SI2877491T1 (sl) | 2019-08-30 |
| HK1211044A1 (en) | 2016-05-13 |
| JP2015527992A (ja) | 2015-09-24 |
| EP2877491A1 (en) | 2015-06-03 |
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| BR112015000449A2 (OSRAM) | 2017-08-15 |
| IN2015DN00143A (OSRAM) | 2015-06-12 |
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| IL269527B (en) | 2021-12-01 |
| US20200332016A1 (en) | 2020-10-22 |
| JP6457386B2 (ja) | 2019-01-23 |
| CA2878790A1 (en) | 2014-01-16 |
| DK2877491T3 (da) | 2019-06-03 |
| EP2684896A1 (en) | 2014-01-15 |
| EP3575323A1 (en) | 2019-12-04 |
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| CA2878790C (en) | 2023-09-26 |
| CN104619725B (zh) | 2019-04-23 |
| IL236651A0 (en) | 2015-02-26 |
| IL236651B (en) | 2019-10-31 |
| PT2877491T (pt) | 2019-06-07 |
| SG11201500177PA (en) | 2015-03-30 |
| BR112015000449B1 (pt) | 2022-12-20 |
| US20170260281A1 (en) | 2017-09-14 |
| IL269527A (en) | 2019-11-28 |
| US9611327B2 (en) | 2017-04-04 |
| WO2014009358A1 (en) | 2014-01-16 |
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