ES2713428T3 - Inmunoensayo de canalización de oxígeno luminiscente utilizando tres anticuerpos y métodos de producción y uso de los mismos - Google Patents

Inmunoensayo de canalización de oxígeno luminiscente utilizando tres anticuerpos y métodos de producción y uso de los mismos Download PDF

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Publication number
ES2713428T3
ES2713428T3 ES15767906T ES15767906T ES2713428T3 ES 2713428 T3 ES2713428 T3 ES 2713428T3 ES 15767906 T ES15767906 T ES 15767906T ES 15767906 T ES15767906 T ES 15767906T ES 2713428 T3 ES2713428 T3 ES 2713428T3
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antibody
binding fragment
analyte
binding
antibodies
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ES15767906T
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English (en)
Spanish (es)
Inventor
Jay J Li
David J Ledden
Eric Scott Cowden
Donglai Lu
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Siemens Healthcare Diagnostics Inc
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Siemens Healthcare Diagnostics Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
ES15767906T 2014-03-26 2015-03-24 Inmunoensayo de canalización de oxígeno luminiscente utilizando tres anticuerpos y métodos de producción y uso de los mismos Active ES2713428T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461970596P 2014-03-26 2014-03-26
PCT/US2015/022209 WO2015148479A1 (en) 2014-03-26 2015-03-24 Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof

Publications (1)

Publication Number Publication Date
ES2713428T3 true ES2713428T3 (es) 2019-05-21

Family

ID=54196294

Family Applications (2)

Application Number Title Priority Date Filing Date
ES15767906T Active ES2713428T3 (es) 2014-03-26 2015-03-24 Inmunoensayo de canalización de oxígeno luminiscente utilizando tres anticuerpos y métodos de producción y uso de los mismos
ES18199087T Active ES2884930T3 (es) 2014-03-26 2015-03-24 Inmunoensayo de canalización de oxígeno luminiscente utilizando tres anticuerpos y métodos de producción y uso de los mismos

Family Applications After (1)

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ES18199087T Active ES2884930T3 (es) 2014-03-26 2015-03-24 Inmunoensayo de canalización de oxígeno luminiscente utilizando tres anticuerpos y métodos de producción y uso de los mismos

Country Status (11)

Country Link
US (3) US20170176419A1 (https=)
EP (2) EP3123151B1 (https=)
JP (1) JP6596440B2 (https=)
CN (1) CN106662532B (https=)
AU (1) AU2015236288A1 (https=)
CA (1) CA2942281C (https=)
DK (2) DK3123151T3 (https=)
ES (2) ES2713428T3 (https=)
IL (1) IL247630A0 (https=)
MX (1) MX377772B (https=)
WO (1) WO2015148479A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018107012A1 (en) 2016-12-09 2018-06-14 Abbott Point Of Care Inc. Crossover analytical systems and methods using an immunosensor and magnetic immunosensor
US10928388B2 (en) 2016-12-09 2021-02-23 Abbott Point Of Care Inc. Combined immunoassay and magnetic immunoassay methods for extended range of sensitivity
US10935511B2 (en) 2016-12-09 2021-03-02 Abbott Point Of Care Inc. Ameliorated crosstalk immunoassay test device for determining a concentration of an analyte
EP3552016A1 (en) 2016-12-09 2019-10-16 Abbott Point of Care Inc. Extended range immunoassay devices with immunosensor and magnetic immunosensor
US10514379B2 (en) * 2016-12-09 2019-12-24 Abbott Point Of Care Inc. Dual range cardiac troponin immunoassay devices and methods using immunosensor and magnetic immunosensor
WO2018107007A1 (en) 2016-12-09 2018-06-14 Abbott Point Of Care Inc. Combined immunoassay and magnetic immunoassay systems and devices for extended range of sensitivity
WO2019167128A1 (ja) * 2018-02-27 2019-09-06 株式会社 島津製作所 サンドイッチ型免疫測定法
JP7434144B2 (ja) * 2018-02-27 2024-02-20 株式会社島津製作所 ＡＰＰ６６９－ｘのＮ末端を特異的に認識する抗体、及び免疫測定法
US12140596B2 (en) 2018-07-30 2024-11-12 Siemens Healthcare Diagnostics Inc. Kits, microfluidics devices, and methods for performing biotin assays
WO2020068548A1 (en) * 2018-09-25 2020-04-02 Siemens Healthcare Diagnostics Inc. Compositions, kits, and methods for multiplex assays to correct for biotin interference in target analyte measurements
WO2021041607A1 (en) * 2019-08-29 2021-03-04 Siemens Healthcare Diagnostics Inc. Device and method to evaluate a fluid sample on a single-use multianalyte consumable
CN113125416B (zh) * 2019-12-31 2025-08-22 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光检测方法及其应用
CN113125704B (zh) * 2019-12-31 2025-08-22 科美博阳诊断技术(上海)有限公司 一种均相化学发光测定试剂盒及其应用
CN113125418A (zh) * 2019-12-31 2021-07-16 科美诊断技术股份有限公司 一种均相化学发光检测方法及其应用
CN113125706B (zh) * 2019-12-31 2025-07-08 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光测定试剂盒及其应用
CN113125415B (zh) * 2019-12-31 2025-08-22 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光检测方法及其应用
CN113125731B (zh) * 2019-12-31 2025-09-16 科美博阳诊断技术(上海)有限公司 一种竞争性均相化学发光测定试剂盒及其应用
US20230152336A1 (en) * 2020-04-24 2023-05-18 Siemens Healthcare Diagnostics Inc. Calibration and quality control reagents for use with immunoassays for antibodies and methods of production and use thereof
CN111781385B (zh) * 2020-08-19 2023-07-18 武汉生之源生物科技股份有限公司 一种NT-proBNP检测试剂盒及其制备方法
CN114544978A (zh) * 2022-03-04 2022-05-27 美康生物科技股份有限公司 一种igf-1检测试剂盒及其制备方法和检测方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
NO164622C (no) * 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
EP0542810A1 (en) 1990-08-02 1993-05-26 B.R. Centre Limited Methods for the production of proteins with a desired function
EP0984281B1 (en) * 1991-05-22 2007-01-03 Dade Behring Marburg GmbH A homogeneous assay for determining analyte
US5340716A (en) 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US6251581B1 (en) * 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
GB9326238D0 (en) * 1993-12-23 1994-02-23 Sinvent As Method of assay
US7285418B2 (en) * 1996-06-25 2007-10-23 Hytest Ltd. Method and kit for the diagnosis of troponin I
US6248546B1 (en) * 1998-03-09 2001-06-19 Diagnostic Systems Laboratories, Inc. Assay of IGFBP complex
US6703248B1 (en) * 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
DE10064827A1 (de) * 2000-12-22 2002-06-27 Dade Behring Marburg Gmbh Nachweisverfahren
US6551788B1 (en) * 2001-11-28 2003-04-22 Beckman Coulter, Inc. Particle-based ligand assay with extended dynamic range
US6764819B2 (en) * 2002-07-16 2004-07-20 Emp Biotech Gmbh Method for chemiluminescent detection
DE112004001863T5 (de) * 2003-10-03 2006-09-07 Scantibodies Laboratory, Inc., Santee Verfahren und Verwendung von Bindungskomponenten zur Verbesserung der Testspezifität
EP1794282A4 (en) * 2004-09-20 2011-03-23 Boston Microfluidics MICROFLUIDIC DEVICE FOR DETECTION OF SOLUBLE MOLECULES
US20060263907A1 (en) * 2005-04-29 2006-11-23 Zweig Stephen E Fluorescence lateral flow immunoassay
US8124015B2 (en) * 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
GB2436616A (en) * 2006-03-29 2007-10-03 Inverness Medical Switzerland Assay device and method
DK2064549T3 (da) * 2006-09-21 2013-02-04 Nestec Sa Antistof-baserede arrays til detektion af flere signaltransducere i sjældne cirkulerende celler
CN101675075B (zh) * 2007-03-01 2014-06-18 西福根有限公司 重组抗表皮生长因子受体抗体组合物
US7790401B2 (en) * 2007-08-06 2010-09-07 Siemens Healthcare Diagnostics Methods for detection of immunosuppressant drugs
US20090170218A1 (en) * 2008-01-02 2009-07-02 Dade Behring Inc. Methods for detection of cyclosporin a
WO2011087813A2 (en) * 2009-12-22 2011-07-21 University Of Washington Capillarity-based devices for performing chemical processes and associated systems and methods
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US10088490B2 (en) * 2010-08-20 2018-10-02 Siemens Healthcare Diagnostics Inc. Assay for analytes using multiple receptors
CN102565381B (zh) * 2010-12-08 2014-06-18 中国科学院生态环境研究中心 导电微粒子介导电化学发光信号的免疫检测方法
JP6226872B2 (ja) 2011-11-22 2017-11-08 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． キャリブレーションおよび／またはクオリティ・コントロール溶液として再構成用の乾燥試薬を含むデバイスとその製造および使用方法
WO2014152165A1 (en) * 2013-03-15 2014-09-25 Siemens Healthcare Diagnostics Inc. Luminescent oxygen channeling immunoassays utilizing electrochemical discharge of singlet oxygen and methods of production and use thereof
DK2972245T3 (da) 2013-03-15 2020-09-07 Siemens Healthcare Diagnostics Inc Heterogene luminescerende oxygenkanaliserende immunoassays
WO2014151590A1 (en) 2013-03-15 2014-09-25 Siemens Healthcare Diagnostics Inc. Heterogeneous luminescent oxygen channeling immunoassays and methods of production and use thereof
WO2014151450A1 (en) 2013-03-15 2014-09-25 Siemens Healthcare Diagnostics Inc. Microfluidic distributing device
CN105722859B (zh) * 2013-07-25 2021-05-07 西托姆克斯治疗公司 多特异性抗体、多特异性可活化抗体及其使用方法
US20160320415A1 (en) * 2013-12-16 2016-11-03 Xen Biofluidx, Inc. Fast reconstituting reagent pellets

Also Published As

Publication number Publication date
MX377772B (es) 2025-03-11
US20210231647A1 (en) 2021-07-29
CA2942281A1 (en) 2015-10-01
EP3123151A1 (en) 2017-02-01
EP3123151A4 (en) 2017-03-22
JP6596440B2 (ja) 2019-10-23
IL247630A0 (en) 2016-11-30
CN106662532B (zh) 2019-12-13
DK3483593T3 (da) 2021-07-19
ES2884930T3 (es) 2021-12-13
JP2017508971A (ja) 2017-03-30
AU2015236288A1 (en) 2016-09-15
EP3123151B1 (en) 2018-11-28
EP3483593A1 (en) 2019-05-15
CN106662532A (zh) 2017-05-10
US20260104406A1 (en) 2026-04-16
US12366571B2 (en) 2025-07-22
CA2942281C (en) 2023-03-14
US20170176419A1 (en) 2017-06-22
MX2016011809A (es) 2017-05-10
DK3123151T3 (en) 2019-03-18
WO2015148479A1 (en) 2015-10-01
EP3483593B1 (en) 2021-04-28

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