ES2688193T3 - Comprimido de disgregación rápida en la cavidad oral - Google Patents
Comprimido de disgregación rápida en la cavidad oral Download PDFInfo
- Publication number
- ES2688193T3 ES2688193T3 ES04792383.4T ES04792383T ES2688193T3 ES 2688193 T3 ES2688193 T3 ES 2688193T3 ES 04792383 T ES04792383 T ES 04792383T ES 2688193 T3 ES2688193 T3 ES 2688193T3
- Authority
- ES
- Spain
- Prior art keywords
- weight
- parts
- saccharides
- mannitol
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 210000000214 mouth Anatomy 0.000 title claims abstract description 40
- 239000007898 rapid-disintegration tablet Substances 0.000 title claims description 23
- 239000000203 mixture Substances 0.000 claims abstract description 111
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 87
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 65
- 229930195725 Mannitol Natural products 0.000 claims abstract description 64
- 239000000594 mannitol Substances 0.000 claims abstract description 64
- 235000010355 mannitol Nutrition 0.000 claims abstract description 64
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 47
- 239000008011 inorganic excipient Substances 0.000 claims abstract description 31
- 238000001694 spray drying Methods 0.000 claims abstract description 22
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims abstract description 14
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 14
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract description 14
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 14
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- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 7
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 7
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims abstract description 7
- 239000011575 calcium Substances 0.000 claims abstract description 7
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 7
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- 235000010449 maltitol Nutrition 0.000 claims abstract description 7
- 239000000845 maltitol Substances 0.000 claims abstract description 7
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims abstract description 7
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- 239000005715 Fructose Substances 0.000 claims abstract description 5
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- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims abstract description 5
- 239000007864 aqueous solution Substances 0.000 claims abstract description 5
- 229960002737 fructose Drugs 0.000 claims abstract description 5
- 239000011148 porous material Substances 0.000 claims abstract description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 4
- 150000002484 inorganic compounds Chemical class 0.000 claims abstract description 4
- 229910010272 inorganic material Inorganic materials 0.000 claims abstract description 4
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 4
- -1 aroma Substances 0.000 claims description 20
- 239000002831 pharmacologic agent Substances 0.000 claims description 18
- 229920002678 cellulose Polymers 0.000 claims description 17
- 239000001913 cellulose Substances 0.000 claims description 17
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 16
- 229960000913 crospovidone Drugs 0.000 claims description 15
- 239000002245 particle Substances 0.000 claims description 15
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 15
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 15
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 11
- JAUGGEIKQIHSMF-UHFFFAOYSA-N dialuminum;dimagnesium;dioxido(oxo)silane;oxygen(2-);hydrate Chemical group O.[O-2].[O-2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O JAUGGEIKQIHSMF-UHFFFAOYSA-N 0.000 claims description 8
- 239000012736 aqueous medium Substances 0.000 claims description 7
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 6
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims description 6
- GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 claims description 6
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003355076 | 2003-10-15 | ||
| JP2003355076 | 2003-10-15 | ||
| JP2004236594 | 2004-08-16 | ||
| JP2004236594 | 2004-08-16 | ||
| PCT/JP2004/015151 WO2005037254A1 (ja) | 2003-10-15 | 2004-10-14 | 口腔内速崩壊性錠剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2688193T3 true ES2688193T3 (es) | 2018-10-31 |
Family
ID=34467754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04792383.4T Expired - Lifetime ES2688193T3 (es) | 2003-10-15 | 2004-10-14 | Comprimido de disgregación rápida en la cavidad oral |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8647668B2 (en:Method) |
| EP (1) | EP1674083B1 (en:Method) |
| JP (1) | JP4726628B2 (en:Method) |
| KR (1) | KR101159617B1 (en:Method) |
| ES (1) | ES2688193T3 (en:Method) |
| IN (2) | IN234086B (en:Method) |
| WO (1) | WO2005037254A1 (en:Method) |
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| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US8349361B2 (en) * | 2003-10-15 | 2013-01-08 | Fuji Chemical Industry Co., Ltd. | Composition for rapid disintegrating tablet in oral cavity |
| TWI358407B (en) * | 2005-06-22 | 2012-02-21 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersibl |
| IL169678A (en) | 2005-07-14 | 2010-11-30 | Innova Sa | Sweetener compositions |
| JP5074190B2 (ja) * | 2005-09-02 | 2012-11-14 | 富士化学工業株式会社 | 口腔内速崩壊性錠剤 |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| KR101324898B1 (ko) * | 2006-03-31 | 2013-11-04 | 루비콘 리서치 피브이티. 엘티디. | 구강 붕해 정제 |
| BRPI0713371A2 (pt) * | 2006-06-27 | 2012-03-13 | Daiichi Sankyo Company, Limited | método para a produção de um produto medicamentoso contendo olmesartan medoxomil, e, produto medicamentoso contendo olmesartan medoxomil |
| ES2531929T3 (es) * | 2006-12-20 | 2015-03-20 | Teva Women's Health, Inc. | Formas de dosificación solidas que se disgregan en la boca que comprenden progestina y métodos para hacer y usar las mismas |
| WO2008079342A2 (en) * | 2006-12-21 | 2008-07-03 | Mallinckrodt Inc. | Composition of and method for preparing orally disintegrating tablets |
| ES2302650B1 (es) * | 2007-01-11 | 2009-02-16 | Tedec-Meiji Farma, S.A. | Composicion de rapida desintegracion en la cavidad bucal. |
| PT2572705T (pt) | 2007-10-01 | 2017-11-08 | Lesvi Laboratorios Sl | Comprimidos orodispersíveis |
| WO2009088229A2 (ko) * | 2008-01-09 | 2009-07-16 | Lg Household & Health Care Ltd. | 고형의 구강 위생 조성물 및 이의 제조방법 |
| JP2011513194A (ja) * | 2008-02-29 | 2011-04-28 | 大塚製薬株式会社 | 口腔内崩壊錠 |
| WO2010057188A2 (en) * | 2008-11-17 | 2010-05-20 | L. Perrigo Company | Fast-acting, dietary supplement containing compositions and methods of producing the compositions |
| WO2010077878A1 (en) * | 2008-12-15 | 2010-07-08 | Fleming And Company, Pharmaceuticals | Rapidly dissolving vitamin formulation and methods of using the same |
| ES2758624T3 (es) | 2009-02-12 | 2020-05-06 | Fuji Chem Ind Co Ltd | Composición de partículas desintegrantes y material de desintegración rápida moldeado por compresión que comprende la misma |
| KR101817361B1 (ko) | 2009-03-09 | 2018-01-11 | 에스피아이 파르마, 인크. | 고도 압착성 및 내구성 직접 압축성 부형제 및 부형제 시스템 |
| KR20120010228A (ko) * | 2009-04-09 | 2012-02-02 | 라이온 가부시키가이샤 | 복합체 및 그 제조 방법, 및 입상제 및 정제 |
| KR20120034643A (ko) | 2009-05-20 | 2012-04-12 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 유핵형 구강 내 붕괴 정 |
| EP2440210A4 (en) | 2009-06-12 | 2014-01-29 | Meritage Pharma Inc | METHOD FOR THE TREATMENT OF STOMACH DARM DISEASES |
| JP5753842B2 (ja) * | 2009-07-10 | 2015-07-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 水分含量の低い打錠補助剤およびその調製方法 |
| JP5674666B2 (ja) * | 2009-08-11 | 2015-02-25 | 富士化学工業株式会社 | 崩壊性粒子組成物及び口腔内速崩壊錠 |
| JP2011037767A (ja) * | 2009-08-11 | 2011-02-24 | Dainippon Sumitomo Pharma Co Ltd | 薬物および噴霧乾燥粒子を含有する口腔内速崩壊錠 |
| CN102548542B (zh) | 2009-08-11 | 2013-11-20 | 大日本住友制药株式会社 | 含有两种以上粒子的口腔速崩片 |
| US8900602B2 (en) | 2009-08-11 | 2014-12-02 | Fuji Chemical Industry Co., Ltd. | Disintegrating particle composition and orally rapidly disintegrating tablet |
| EP2515879A4 (en) * | 2009-12-22 | 2014-04-02 | Fmc Corp Inc | FINE PARTICLE CROSCARMELLOSIS AND USES THEREOF |
| JP2011173848A (ja) * | 2010-02-25 | 2011-09-08 | Taisho Pharm Ind Ltd | 口腔内速崩壊錠 |
| US20130052278A1 (en) * | 2010-03-11 | 2013-02-28 | Rich Vitamins Llc | Quick dissolve nutritional powder |
| US8722636B2 (en) * | 2011-01-31 | 2014-05-13 | New Market Pharmaceuticals, LLC | Animal treatments |
| WO2012119997A1 (de) * | 2011-03-09 | 2012-09-13 | Basf Se | Pharmazeutische formulierung für die herstellung von schnell zerfallenden tabletten |
| WO2013032310A1 (ko) * | 2011-09-02 | 2013-03-07 | 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 | 메게스트롤 속붕해정 및 이의 제조 방법 |
| EP2844230B8 (en) | 2012-05-02 | 2020-01-08 | NewMarket Pharmaceuticals LLC | Pharmaceutical compositions for direct systemic introduction |
| CN104487094B (zh) | 2012-07-20 | 2017-05-17 | 大塚制药株式会社 | 表面具有干燥油墨被膜的片剂、及用于喷墨打印机的油墨 |
| WO2014148520A1 (ja) * | 2013-03-21 | 2014-09-25 | 大正製薬株式会社 | 固形製剤 |
| US20160242439A1 (en) | 2014-04-04 | 2016-08-25 | Douxmatok Ltd | Method for producing sweetener compositions and sweetener compositions |
| US10207004B2 (en) | 2014-04-04 | 2019-02-19 | Douxmatok Ltd | Method for producing sweetener compositions and sweetener compositions |
| US10231476B2 (en) | 2014-04-04 | 2019-03-19 | Douxmatok Ltd | Sweetener compositions and foods, beverages, and consumable products made thereof |
| JP5897196B1 (ja) * | 2015-10-05 | 2016-03-30 | 大同化成工業株式会社 | 糖又は糖アルコール、膨潤型結合剤、崩壊剤及び高吸収性賦形剤を含む複合化造粒物及びその製造方法 |
| JP6606287B2 (ja) * | 2016-07-27 | 2019-11-13 | 沢井製薬株式会社 | 口腔内崩壊錠添加用組成物 |
| JP6651638B2 (ja) * | 2016-09-06 | 2020-02-19 | 沢井製薬株式会社 | 口腔内崩壊錠添加用組成物 |
| JP7719796B2 (ja) * | 2020-04-24 | 2025-08-06 | アストラゼネカ・アクチエボラーグ | 医薬製剤 |
| CA3198547A1 (en) | 2020-11-16 | 2022-05-19 | Mark RIDALL | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| JP7714271B1 (ja) * | 2023-08-30 | 2025-07-29 | 富士化学工業株式会社 | コプロセス添加剤 |
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| KR100256147B1 (ko) * | 1991-12-24 | 2000-08-01 | 오노다 마사요시 | 구강내 붕해성 제제 및 이의 제조방법 |
| JP3069458B2 (ja) | 1992-01-29 | 2000-07-24 | 武田薬品工業株式会社 | 口腔内崩壊型錠剤およびその製造法 |
| JPH05310558A (ja) * | 1992-05-07 | 1993-11-22 | Lion Corp | 固形製剤組成物 |
| CN1182838C (zh) * | 1994-01-31 | 2005-01-05 | 山之内制药株式会社 | 口溶性压制制剂及其制造方法 |
| DK0826376T3 (da) * | 1995-05-02 | 2007-04-16 | Taisho Pharmaceutical Co Ltd | Sammensætning til oral indgivelse |
| JP2003176242A (ja) | 1996-07-12 | 2003-06-24 | Dai Ichi Seiyaku Co Ltd | 速崩壊性圧縮成型物及びその製造法 |
| JP3961596B2 (ja) * | 1996-10-15 | 2007-08-22 | 富士化学工業株式会社 | 無機制酸剤含有速分散性造粒物、その製造方法及び用時懸濁内服制酸剤 |
| JP2000086537A (ja) | 1998-09-11 | 2000-03-28 | Fuji Chem Ind Co Ltd | 無機化合物糖類組成物、賦形剤、速崩壊性圧縮成型物及びその製造方法 |
| WO2000078292A1 (fr) * | 1999-06-18 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Preparations solides a desintegration rapide |
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| US20020001617A1 (en) * | 2000-05-26 | 2002-01-03 | Chang-Hyun Lee | Rapidly disintegrating tablet and process for the manufacture thereof |
| CA2424770A1 (en) | 2000-10-06 | 2003-04-03 | Takeda Chemical Industries, Ltd. | Solid pharmaceutical preparation |
| JP2002128661A (ja) * | 2000-10-20 | 2002-05-09 | Chugai Pharmaceut Co Ltd | 速崩壊錠剤の製造方法 |
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| US20040071772A1 (en) | 2001-03-06 | 2004-04-15 | Shoichi Narita | Preparations quickly disintegrating in oral cavity |
| JP3626483B2 (ja) * | 2001-05-10 | 2005-03-09 | 山之内製薬株式会社 | 口腔内速崩壊性錠剤およびその製造法 |
| PL361452A1 (en) * | 2001-07-27 | 2004-10-04 | Yamanouchi Pharmaceutical Co.Ltd. | Compositions containing sustained-release fine grains for tablets quickly disintegrable in the oral cavity and process for producing the same |
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| JP3841804B2 (ja) * | 2003-10-15 | 2006-11-08 | 富士化学工業株式会社 | 口腔内速崩壊性錠剤用の組成物 |
| US8340223B2 (en) | 2007-10-05 | 2012-12-25 | Nec Corporation | Receiver and wireless communication system equipped with the same |
| JP5271054B2 (ja) | 2008-11-26 | 2013-08-21 | 株式会社東芝 | 熱電変換材料の製造方法 |
-
2004
- 2004-10-14 EP EP04792383.4A patent/EP1674083B1/en not_active Expired - Lifetime
- 2004-10-14 ES ES04792383.4T patent/ES2688193T3/es not_active Expired - Lifetime
- 2004-10-14 US US10/576,257 patent/US8647668B2/en active Active
- 2004-10-14 JP JP2005514774A patent/JP4726628B2/ja not_active Expired - Lifetime
- 2004-10-14 WO PCT/JP2004/015151 patent/WO2005037254A1/ja active Application Filing
- 2004-10-14 KR KR1020067005250A patent/KR101159617B1/ko not_active Expired - Lifetime
- 2004-10-14 IN IN1274CH2006 patent/IN234086B/en unknown
-
2009
- 2009-01-09 IN IN167CH2009 patent/IN2009CH00167A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1674083B1 (en) | 2018-08-01 |
| IN2006CH01274A (en:Method) | 2007-06-29 |
| WO2005037254A1 (ja) | 2005-04-28 |
| IN2009CH00167A (en:Method) | 2009-06-05 |
| JP4726628B2 (ja) | 2011-07-20 |
| KR20070018776A (ko) | 2007-02-14 |
| US8647668B2 (en) | 2014-02-11 |
| EP1674083A1 (en) | 2006-06-28 |
| US20070275058A1 (en) | 2007-11-29 |
| EP1674083A4 (en) | 2007-03-07 |
| KR101159617B1 (ko) | 2012-06-27 |
| JPWO2005037254A1 (ja) | 2007-11-22 |
| IN234086B (en:Method) | 2009-05-29 |
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