ES2679673T3 - Sistema para iontoforesis ocular con amortiguación - Google Patents
Sistema para iontoforesis ocular con amortiguación Download PDFInfo
- Publication number
- ES2679673T3 ES2679673T3 ES09837075.2T ES09837075T ES2679673T3 ES 2679673 T3 ES2679673 T3 ES 2679673T3 ES 09837075 T ES09837075 T ES 09837075T ES 2679673 T3 ES2679673 T3 ES 2679673T3
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- therapeutic substance
- membrane
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- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000011095 buffer preparation Methods 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229940023913 cation exchange resins Drugs 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000000412 dendrimer Substances 0.000 description 1
- 229920000736 dendritic polymer Polymers 0.000 description 1
- 230000036576 dermal application Effects 0.000 description 1
- 229960004833 dexamethasone phosphate Drugs 0.000 description 1
- VQODGRNSFPNSQE-CXSFZGCWSA-N dexamethasone phosphate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COP(O)(O)=O)(O)[C@@]1(C)C[C@@H]2O VQODGRNSFPNSQE-CXSFZGCWSA-N 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- KCFYHBSOLOXZIF-UHFFFAOYSA-N dihydrochrysin Natural products COC1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 KCFYHBSOLOXZIF-UHFFFAOYSA-N 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005370 electroosmosis Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- LUJQXGBDWAGQHS-UHFFFAOYSA-N ethenyl acetate;phthalic acid Chemical compound CC(=O)OC=C.OC(=O)C1=CC=CC=C1C(O)=O LUJQXGBDWAGQHS-UHFFFAOYSA-N 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
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- 235000019253 formic acid Nutrition 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical compound NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000012432 intermediate storage Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate group Chemical group C(C(=C)C)(=O)[O-] CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 229920002717 polyvinylpyridine Polymers 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000029219 regulation of pH Effects 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229920001897 terpolymer Polymers 0.000 description 1
- 125000001302 tertiary amino group Chemical group 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
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- 230000000699 topical effect Effects 0.000 description 1
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- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0444—Membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Electrotherapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US141994P | 1999-07-01 | ||
| US14199408P | 2008-12-31 | 2008-12-31 | |
| US18060209P | 2009-05-22 | 2009-05-22 | |
| US180602P | 2009-05-22 | ||
| PCT/US2009/069580 WO2010078246A1 (en) | 2008-12-31 | 2009-12-28 | System and method for ocular iontophoresis with buffering |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2679673T3 true ES2679673T3 (es) | 2018-08-30 |
Family
ID=42310178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09837075.2T Active ES2679673T3 (es) | 2008-12-31 | 2009-12-28 | Sistema para iontoforesis ocular con amortiguación |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9180292B2 (https=) |
| EP (1) | EP2370155B1 (https=) |
| JP (1) | JP5723293B2 (https=) |
| CN (1) | CN102341146B (https=) |
| AU (1) | AU2009332951B2 (https=) |
| CA (1) | CA2750149C (https=) |
| ES (1) | ES2679673T3 (https=) |
| IL (1) | IL213796A0 (https=) |
| MX (1) | MX2011006925A (https=) |
| WO (1) | WO2010078246A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240167531A1 (en) * | 2019-11-14 | 2024-05-23 | Siemens Gamesa Renewable Energy A/S | Damper for a wind turbine |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2679673T3 (es) * | 2008-12-31 | 2018-08-30 | Eyegate Pharmaceuticals, Inc. | Sistema para iontoforesis ocular con amortiguación |
| ES2590127T3 (es) * | 2011-01-12 | 2016-11-18 | Sooft Italia S.P.A. | Administración corneal de agentes de entrecruzamiento por iontoforesis para el tratamiento de queratocono y composiciones oftálmicas relacionadas |
| AU2012307090B2 (en) * | 2011-09-09 | 2016-06-16 | International Scientific Pty Ltd | Method and device for transdermal delivery of substances |
| ITVE20130043A1 (it) * | 2013-07-31 | 2015-02-01 | I A C E R S R L | Dispositivo perfezionato oftalmologico per il trattamento di malattie corneali quali il cheratocono. |
| ES2672327T3 (es) * | 2014-01-27 | 2018-06-13 | Opia Technologies | Dispositivo de iontoforesis ocular |
| MX2017009193A (es) | 2015-01-22 | 2017-12-12 | Eyegate Pharmaceuticals Inc | Lente de contacto iontoforetica. |
| US11787783B2 (en) | 2016-12-13 | 2023-10-17 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| WO2018107200A1 (en) | 2016-12-13 | 2018-06-21 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| US12239527B2 (en) * | 2019-03-04 | 2025-03-04 | Tohoku University | Method of absorbing or discharging water of ophthalmic medical device and ophthalmic medical device |
| IT201900010341A1 (it) | 2019-06-27 | 2020-12-27 | Vision Eng Italy Srl | Dispositivo, sistema e metodo di trattamento di un tessuto corneale |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US551880A (en) | 1895-12-24 | Theodore b | ||
| SU654254A2 (ru) | 1977-02-07 | 1979-03-30 | В. Н. Серов | Устройство дл лечени глаз |
| SU995783A1 (ru) | 1980-07-21 | 1983-02-15 | Омский Государственный Ордена Трудового Красного Знамени Медицинский Институт Им.М.И.Калинина | Устройство дл электрофореза лекарственных веществ в ткани глаза |
| US4678466A (en) | 1981-06-25 | 1987-07-07 | Rosenwald Peter L | Internal medication delivery method and vehicle |
| SU1342500A1 (ru) | 1982-03-09 | 1987-10-07 | Омский государственный медицинский институт им.М.И.Калинина | Способ лечени глаукомы |
| US5053000A (en) | 1985-11-13 | 1991-10-01 | Imperial Chemical Industries Plc | Ocular treatment |
| US4752285B1 (en) | 1986-03-19 | 1995-08-22 | Univ Utah Res Found | Methods and apparatus for iontophoresis application of medicaments |
| IL86076A (en) | 1988-04-14 | 1992-12-01 | Inventor S Funding Corp Ltd | Transdermal drug delivery device |
| US4955378A (en) | 1988-05-02 | 1990-09-11 | University Of South Florida | Apparatus and methods for performing electrofusion at specific anatomical sites |
| JPH04507202A (ja) | 1989-03-17 | 1992-12-17 | カンデラ・レーザー・コーポレーシヨン | 非攻撃的強膜切開レーザー装置および方法 |
| US5174304A (en) | 1990-02-16 | 1992-12-29 | Latina Mark A | Electrocycloablation apparatus and method |
| JPH07501238A (ja) | 1991-08-26 | 1995-02-09 | ラットガーズ，ザ・ステート・ユニバーシティ・オブ・ニュージャージー | 電離療法装置及び方法 |
| US5533971A (en) | 1993-09-03 | 1996-07-09 | Alza Corporation | Reduction of skin irritation during electrotransport |
| US5420109A (en) | 1993-11-12 | 1995-05-30 | Houghten Pharmaceuticals, Inc. | Cytokine restraining agents |
| US5472436A (en) | 1994-07-26 | 1995-12-05 | Fremstad; Daria A. | Ocular appliance for delivering medication |
| AUPM982694A0 (en) | 1994-12-02 | 1995-01-05 | University Of Queensland, The | Iontophoresis method and apparatus |
| US5980497A (en) * | 1996-03-15 | 1999-11-09 | Yavitz; Edward Q. | Membrane shield for eyes |
| JP3459724B2 (ja) * | 1996-03-17 | 2003-10-27 | 久光製薬株式会社 | イオントフォレーシス用電極デバイス |
| US5676648A (en) | 1996-05-08 | 1997-10-14 | The Aps Organization, Llp | Iontophoretic drug delivery apparatus and method for use |
| JPH1072374A (ja) * | 1996-06-20 | 1998-03-17 | Hisamitsu Pharmaceut Co Inc | イオントフォレーシス用薬物投与組成物 |
| DE69804921T2 (de) | 1997-10-28 | 2002-11-07 | Mecanismos Auxiliares Industriales, S.A. M.A.I.S.A. | Anschlusselement für eine Leiterplatte |
| FR2773320B1 (fr) * | 1998-01-05 | 2000-03-03 | Optisinvest | Dispositif pour le transfert intraoculaire de produits actifs par iontophorese |
| EP1150741A1 (en) | 1999-02-10 | 2001-11-07 | GMP Drug Delivery, Inc. | Iontophoresis, electroporation and combination patches for local drug delivery |
| TW539564B (en) | 1999-05-25 | 2003-07-01 | Iomed Inc | Methods and apparatus for ocular iontophoresis |
| US20030023228A1 (en) * | 2001-07-20 | 2003-01-30 | Parkinson Thomas M. | Ocular iontophoretic device and method for using the same |
| FR2830766B1 (fr) | 2001-10-12 | 2004-03-12 | Optis France Sa | Dispositif de delivrance de medicaments par iontophorese transpalpebrale |
| WO2004066980A2 (en) | 2003-01-24 | 2004-08-12 | Control Delivery Systems, Inc. | Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors |
| US20050197618A1 (en) | 2004-03-03 | 2005-09-08 | Iomed, Inc. | Improved buffer gel for iontophoresis electrodes |
| FR2869531B1 (fr) | 2004-04-30 | 2006-07-14 | Optis France Sa Sa | Dispositif de iontophorese oculaire diminuant les irritations |
| AU2005247122C1 (en) | 2004-04-30 | 2012-02-02 | Eyegate Pharma S.A. | Irritation-reducing ocular iontophoretic device |
| KR20080066712A (ko) | 2005-09-30 | 2008-07-16 | 티티아이 엘뷰 가부시키가이샤 | 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법 |
| US8099162B2 (en) * | 2005-11-29 | 2012-01-17 | Eyegate Pharma, S.A.S. | Ocular iontophoresis device |
| US8321008B2 (en) * | 2005-11-30 | 2012-11-27 | Nitric Biotherapeutics, Inc. | Combination cartridge and device for electrokinetic delivery of medicament to a treatment site |
| US8062783B2 (en) | 2006-12-01 | 2011-11-22 | Tti Ellebeau, Inc. | Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices |
| EP2249921B1 (en) * | 2008-02-25 | 2020-06-17 | Eyegate Pharmaceuticals, Inc. | Enhanced delivery of dexamethasone phosphate to ocular tissues through iontophoresis |
| ES2679673T3 (es) * | 2008-12-31 | 2018-08-30 | Eyegate Pharmaceuticals, Inc. | Sistema para iontoforesis ocular con amortiguación |
-
2009
- 2009-12-28 ES ES09837075.2T patent/ES2679673T3/es active Active
- 2009-12-28 JP JP2011544556A patent/JP5723293B2/ja active Active
- 2009-12-28 EP EP09837075.2A patent/EP2370155B1/en not_active Not-in-force
- 2009-12-28 US US13/141,810 patent/US9180292B2/en not_active Expired - Fee Related
- 2009-12-28 CA CA2750149A patent/CA2750149C/en not_active Expired - Fee Related
- 2009-12-28 WO PCT/US2009/069580 patent/WO2010078246A1/en not_active Ceased
- 2009-12-28 AU AU2009332951A patent/AU2009332951B2/en not_active Ceased
- 2009-12-28 MX MX2011006925A patent/MX2011006925A/es active IP Right Grant
- 2009-12-28 CN CN200980157719.3A patent/CN102341146B/zh not_active Expired - Fee Related
-
2011
- 2011-06-28 IL IL213796A patent/IL213796A0/en unknown
-
2015
- 2015-11-02 US US14/930,193 patent/US9539141B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240167531A1 (en) * | 2019-11-14 | 2024-05-23 | Siemens Gamesa Renewable Energy A/S | Damper for a wind turbine |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2370155A1 (en) | 2011-10-05 |
| US9539141B2 (en) | 2017-01-10 |
| CA2750149C (en) | 2018-02-27 |
| EP2370155A4 (en) | 2012-12-26 |
| CN102341146A (zh) | 2012-02-01 |
| EP2370155B1 (en) | 2018-07-04 |
| IL213796A0 (en) | 2011-07-31 |
| US20160120696A1 (en) | 2016-05-05 |
| US9180292B2 (en) | 2015-11-10 |
| CN102341146B (zh) | 2015-09-23 |
| MX2011006925A (es) | 2011-07-28 |
| AU2009332951A1 (en) | 2011-07-14 |
| US20110301526A1 (en) | 2011-12-08 |
| WO2010078246A1 (en) | 2010-07-08 |
| CA2750149A1 (en) | 2010-07-08 |
| AU2009332951B2 (en) | 2015-06-11 |
| JP5723293B2 (ja) | 2015-05-27 |
| JP2012513875A (ja) | 2012-06-21 |
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