CN102341146B - 具有缓冲的眼用离子电渗用体系和方法 - Google Patents

具有缓冲的眼用离子电渗用体系和方法 Download PDF

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Publication number
CN102341146B
CN102341146B CN200980157719.3A CN200980157719A CN102341146B CN 102341146 B CN102341146 B CN 102341146B CN 200980157719 A CN200980157719 A CN 200980157719A CN 102341146 B CN102341146 B CN 102341146B
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CN
China
Prior art keywords
layer
buffer
delivery device
therapeutic substance
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980157719.3A
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English (en)
Chinese (zh)
Other versions
CN102341146A (zh
Inventor
P.莫斯勒米
M.曼佐
W.舒伯特
W.伊索姆
R.皮埃尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kiora Pharmaceuticals Inc
Original Assignee
EyeGate Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EyeGate Pharmaceuticals Inc filed Critical EyeGate Pharmaceuticals Inc
Publication of CN102341146A publication Critical patent/CN102341146A/zh
Application granted granted Critical
Publication of CN102341146B publication Critical patent/CN102341146B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0444—Membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN200980157719.3A 2008-12-31 2009-12-28 具有缓冲的眼用离子电渗用体系和方法 Expired - Fee Related CN102341146B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14199408P 2008-12-31 2008-12-31
US61/141994 2008-12-31
US18060209P 2009-05-22 2009-05-22
US61/180602 2009-05-22
PCT/US2009/069580 WO2010078246A1 (en) 2008-12-31 2009-12-28 System and method for ocular iontophoresis with buffering

Publications (2)

Publication Number Publication Date
CN102341146A CN102341146A (zh) 2012-02-01
CN102341146B true CN102341146B (zh) 2015-09-23

Family

ID=42310178

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980157719.3A Expired - Fee Related CN102341146B (zh) 2008-12-31 2009-12-28 具有缓冲的眼用离子电渗用体系和方法

Country Status (10)

Country Link
US (2) US9180292B2 (https=)
EP (1) EP2370155B1 (https=)
JP (1) JP5723293B2 (https=)
CN (1) CN102341146B (https=)
AU (1) AU2009332951B2 (https=)
CA (1) CA2750149C (https=)
ES (1) ES2679673T3 (https=)
IL (1) IL213796A0 (https=)
MX (1) MX2011006925A (https=)
WO (1) WO2010078246A1 (https=)

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ES2679673T3 (es) * 2008-12-31 2018-08-30 Eyegate Pharmaceuticals, Inc. Sistema para iontoforesis ocular con amortiguación
ES2590127T3 (es) * 2011-01-12 2016-11-18 Sooft Italia S.P.A. Administración corneal de agentes de entrecruzamiento por iontoforesis para el tratamiento de queratocono y composiciones oftálmicas relacionadas
AU2012307090B2 (en) * 2011-09-09 2016-06-16 International Scientific Pty Ltd Method and device for transdermal delivery of substances
ITVE20130043A1 (it) * 2013-07-31 2015-02-01 I A C E R S R L Dispositivo perfezionato oftalmologico per il trattamento di malattie corneali quali il cheratocono.
ES2672327T3 (es) * 2014-01-27 2018-06-13 Opia Technologies Dispositivo de iontoforesis ocular
MX2017009193A (es) 2015-01-22 2017-12-12 Eyegate Pharmaceuticals Inc Lente de contacto iontoforetica.
US11787783B2 (en) 2016-12-13 2023-10-17 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
WO2018107200A1 (en) 2016-12-13 2018-06-21 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
US12239527B2 (en) * 2019-03-04 2025-03-04 Tohoku University Method of absorbing or discharging water of ophthalmic medical device and ophthalmic medical device
IT201900010341A1 (it) 2019-06-27 2020-12-27 Vision Eng Italy Srl Dispositivo, sistema e metodo di trattamento di un tessuto corneale
JP7392142B2 (ja) * 2019-11-14 2023-12-05 シーメンス ガメサ リニューアブル エナジー エー／エス 風力タービン用のダンパ

Citations (4)

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US5980497A (en) * 1996-03-15 1999-11-09 Yavitz; Edward Q. Membrane shield for eyes
US6330471B1 (en) * 1996-03-17 2001-12-11 Hisamitsu Pharmaceutical Co., Ltd. Iontophoresis electrode device
US20050197618A1 (en) * 2004-03-03 2005-09-08 Iomed, Inc. Improved buffer gel for iontophoresis electrodes
US20070123814A1 (en) * 2005-11-29 2007-05-31 Eyegate Pharmasa Ocular iontophoresis device

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SU995783A1 (ru) 1980-07-21 1983-02-15 Омский Государственный Ордена Трудового Красного Знамени Медицинский Институт Им.М.И.Калинина Устройство дл электрофореза лекарственных веществ в ткани глаза
US4678466A (en) 1981-06-25 1987-07-07 Rosenwald Peter L Internal medication delivery method and vehicle
SU1342500A1 (ru) 1982-03-09 1987-10-07 Омский государственный медицинский институт им.М.И.Калинина Способ лечени глаукомы
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US5676648A (en) 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use
JPH1072374A (ja) * 1996-06-20 1998-03-17 Hisamitsu Pharmaceut Co Inc イオントフォレーシス用薬物投与組成物
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EP2249921B1 (en) * 2008-02-25 2020-06-17 Eyegate Pharmaceuticals, Inc. Enhanced delivery of dexamethasone phosphate to ocular tissues through iontophoresis
ES2679673T3 (es) * 2008-12-31 2018-08-30 Eyegate Pharmaceuticals, Inc. Sistema para iontoforesis ocular con amortiguación

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980497A (en) * 1996-03-15 1999-11-09 Yavitz; Edward Q. Membrane shield for eyes
US6330471B1 (en) * 1996-03-17 2001-12-11 Hisamitsu Pharmaceutical Co., Ltd. Iontophoresis electrode device
US20050197618A1 (en) * 2004-03-03 2005-09-08 Iomed, Inc. Improved buffer gel for iontophoresis electrodes
US20070123814A1 (en) * 2005-11-29 2007-05-31 Eyegate Pharmasa Ocular iontophoresis device

Also Published As

Publication number Publication date
EP2370155A1 (en) 2011-10-05
US9539141B2 (en) 2017-01-10
CA2750149C (en) 2018-02-27
ES2679673T3 (es) 2018-08-30
EP2370155A4 (en) 2012-12-26
CN102341146A (zh) 2012-02-01
EP2370155B1 (en) 2018-07-04
IL213796A0 (en) 2011-07-31
US20160120696A1 (en) 2016-05-05
US9180292B2 (en) 2015-11-10
MX2011006925A (es) 2011-07-28
AU2009332951A1 (en) 2011-07-14
US20110301526A1 (en) 2011-12-08
WO2010078246A1 (en) 2010-07-08
CA2750149A1 (en) 2010-07-08
AU2009332951B2 (en) 2015-06-11
JP5723293B2 (ja) 2015-05-27
JP2012513875A (ja) 2012-06-21

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Granted publication date: 20150923

Termination date: 20201228