ES2679370T3 - Polimorfismos de clorhidrato de N-[(R)-1-[(S)-1-(4-aminometil-bencilcarbamoil)-2-fenil-etilcarbamoil]-2-(4-etoxi-fhenil)-etil]-benzamida - Google Patents
Polimorfismos de clorhidrato de N-[(R)-1-[(S)-1-(4-aminometil-bencilcarbamoil)-2-fenil-etilcarbamoil]-2-(4-etoxi-fhenil)-etil]-benzamida Download PDFInfo
- Publication number
- ES2679370T3 ES2679370T3 ES13737357.7T ES13737357T ES2679370T3 ES 2679370 T3 ES2679370 T3 ES 2679370T3 ES 13737357 T ES13737357 T ES 13737357T ES 2679370 T3 ES2679370 T3 ES 2679370T3
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- Prior art keywords
- phenyl
- solid form
- ethoxy
- benzylcarbamoyl
- ethyl
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261668543P | 2012-07-06 | 2012-07-06 | |
| GB201212081 | 2012-07-06 | ||
| GB201212081A GB201212081D0 (en) | 2012-07-06 | 2012-07-06 | New polymorph |
| US201261668543P | 2012-07-06 | ||
| PCT/GB2013/051781 WO2014006414A1 (en) | 2012-07-06 | 2013-07-05 | Polymorphs of|n-[(r)-1 -[(s)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoy l]-2-(4-e|thoxy-phenyl)-ethyl]-benzamide hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2679370T3 true ES2679370T3 (es) | 2018-08-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13737357.7T Active ES2679370T3 (es) | 2012-07-06 | 2013-07-05 | Polimorfismos de clorhidrato de N-[(R)-1-[(S)-1-(4-aminometil-bencilcarbamoil)-2-fenil-etilcarbamoil]-2-(4-etoxi-fhenil)-etil]-benzamida |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9512065B2 (enExample) |
| EP (1) | EP2870137B8 (enExample) |
| JP (1) | JP6367187B2 (enExample) |
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| ES (1) | ES2679370T3 (enExample) |
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| TR (1) | TR201809681T4 (enExample) |
| WO (1) | WO2014006414A1 (enExample) |
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| GB2510407A (en) * | 2013-02-04 | 2014-08-06 | Kalvista Pharmaceuticals Ltd | Aqueous suspensions of kallikrein inhibitors for parenteral administration |
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| WO2017153567A1 (en) | 2016-03-10 | 2017-09-14 | Thrombogenics Nv | Posterior ocular fibrosis inhibition by antagonizing placental growth factor |
| DK3464271T3 (da) | 2016-05-31 | 2020-06-15 | Kalvista Pharmaceuticals Ltd | Pyrazolderivater som plasma-kallikreininhibitorer |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| GB201609603D0 (en) * | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| JP7291077B2 (ja) | 2016-12-16 | 2023-06-14 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｊａｋファミリーのキナーゼの低分子阻害物質 |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| WO2018140121A1 (en) | 2017-01-30 | 2018-08-02 | Janssen Biotech, Inc. | Anti-tnf antibodies, compositions, and methods for the treatment of active psoriatic arthritis |
| MX2019009377A (es) | 2017-02-07 | 2019-12-11 | Janssen Biotech Inc | Anticuerpos anti-tnf, composiciones y metodos para el tratamiento de la espondilitis anquilosante activa. |
| PT3716952T (pt) | 2017-11-29 | 2022-04-14 | Kalvista Pharmaceuticals Ltd | Formas de administração que incluem um inibidor de calicreína plasmática |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| UY38438A (es) | 2018-11-02 | 2020-05-29 | Biocryst Pharm Inc | Sales cristalinas de un inhibidor de calicreína plasmática |
| JP7805788B2 (ja) | 2019-05-23 | 2026-01-26 | ヤンセン バイオテツク，インコーポレーテツド | Ｉｌ－２３及びｔｎｆアルファに対する抗体の併用療法による炎症性腸疾患の治療方法 |
| EP4010333A1 (en) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| GB2591730A (en) | 2019-12-09 | 2021-08-11 | Kalvista Pharmaceuticals Ltd | New polymorphs |
| GB201918994D0 (en) * | 2019-12-20 | 2020-02-05 | Kalvista Pharmaceuticals Ltd | Treatments of diabetic macular edema and impaired visual acuity |
| IL298389A (en) | 2020-05-21 | 2023-01-01 | Janssen Biotech Inc | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
| MX2023010642A (es) | 2021-03-11 | 2023-11-28 | Janssen Pharmaceutica Nv | Lorpucitinib para uso en el tratamiento de trastornos mediados por jak. |
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| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| IT1223401B (it) * | 1987-12-02 | 1990-09-19 | Montedison Spa | Poliesteri aromatici liquido cristallini termotropici |
| GB9019558D0 (en) | 1990-09-07 | 1990-10-24 | Szelke Michael | Enzyme inhibitors |
| SE9301911D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptide derivatives |
| US5589467A (en) | 1993-09-17 | 1996-12-31 | Novo Nordisk A/S | 2,5',N6-trisubstituted adenosine derivatives |
| IL112795A (en) * | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them |
| US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
| JP4179878B2 (ja) * | 2001-02-02 | 2008-11-12 | 中外製薬株式会社 | ペプチド誘導体 |
| GB0205527D0 (en) | 2002-03-08 | 2002-04-24 | Ferring Bv | Inhibitors |
| DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
| NZ592039A (en) | 2003-08-27 | 2013-03-28 | Ophthotech Corp | Combination therapy for the treatment of ocular neovascular disorders |
| CA2561400A1 (en) * | 2004-04-02 | 2005-10-13 | Glaxo Group Limited | Chemical process and new crystalline form |
| US7453002B2 (en) * | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
| AU2005310229A1 (en) * | 2004-11-30 | 2006-06-08 | Mallinckrodt Inc. | Crystallization method for benzphetamine |
| NZ568595A (en) * | 2005-12-14 | 2010-04-30 | Bristol Myers Squibb Co | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor Xla inhibitors |
| WO2008016883A2 (en) | 2006-07-31 | 2008-02-07 | Activesite Pharmaceuticals, Inc. | Inhibitors of plasma kallikrein |
| DE102006050672A1 (de) * | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
| AU2010330743A1 (en) | 2009-12-18 | 2012-07-05 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| MX345259B (es) * | 2010-01-28 | 2017-01-23 | The Medicines Company (Leipzig) Gmbh | Inhibidores de serina proteasas similares a tripsina, y su preparación y uso. |
| JP2013121919A (ja) | 2010-03-25 | 2013-06-20 | Astellas Pharma Inc | 血漿カリクレイン阻害剤 |
| WO2012004678A2 (en) | 2010-07-07 | 2012-01-12 | The Medicines Company (Leipzig) Gmbh | Serine protease inhibitors |
| US9290485B2 (en) | 2010-08-04 | 2016-03-22 | Novartis Ag | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides |
| WO2012142308A1 (en) | 2011-04-13 | 2012-10-18 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| GB2494851A (en) | 2011-07-07 | 2013-03-27 | Kalvista Pharmaceuticals Ltd | Plasma kallikrein inhibitors |
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2012
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- 2013-07-05 ES ES13737357.7T patent/ES2679370T3/es active Active
- 2013-07-05 CA CA2878319A patent/CA2878319C/en active Active
- 2013-07-05 US US14/413,086 patent/US9512065B2/en not_active Expired - Fee Related
- 2013-07-05 PL PL13737357T patent/PL2870137T3/pl unknown
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- 2013-07-05 JP JP2015519357A patent/JP6367187B2/ja not_active Expired - Fee Related
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- 2013-07-05 EP EP13737357.7A patent/EP2870137B8/en active Active
- 2013-07-05 WO PCT/GB2013/051781 patent/WO2014006414A1/en not_active Ceased
Also Published As
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|---|---|
| TR201809681T4 (tr) | 2018-07-23 |
| CA2878319A1 (en) | 2014-01-09 |
| US9512065B2 (en) | 2016-12-06 |
| WO2014006414A1 (en) | 2014-01-09 |
| JP6367187B2 (ja) | 2018-08-01 |
| JP2015528798A (ja) | 2015-10-01 |
| HUE039775T2 (hu) | 2019-02-28 |
| EP2870137A1 (en) | 2015-05-13 |
| EP2870137B8 (en) | 2018-07-18 |
| US20150191421A1 (en) | 2015-07-09 |
| EP2870137B1 (en) | 2018-05-16 |
| PL2870137T3 (pl) | 2018-12-31 |
| GB201212081D0 (en) | 2012-08-22 |
| CA2878319C (en) | 2021-02-09 |
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