ES2670416T3 - Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento de cáncer - Google Patents
Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento de cáncer Download PDFInfo
- Publication number
- ES2670416T3 ES2670416T3 ES15724351.0T ES15724351T ES2670416T3 ES 2670416 T3 ES2670416 T3 ES 2670416T3 ES 15724351 T ES15724351 T ES 15724351T ES 2670416 T3 ES2670416 T3 ES 2670416T3
- Authority
- ES
- Spain
- Prior art keywords
- quinolin
- methyl
- imidazo
- pyridin
- oxan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
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- 238000011282 treatment Methods 0.000 title claims description 68
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- 150000001875 compounds Chemical class 0.000 claims abstract description 242
- 150000003839 salts Chemical class 0.000 claims abstract description 176
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 95
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 73
- 239000001257 hydrogen Substances 0.000 claims abstract description 64
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 64
- 229910052731 fluorine Chemical group 0.000 claims abstract description 33
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract description 16
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims abstract description 16
- 125000003566 oxetanyl group Chemical group 0.000 claims abstract description 14
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims abstract description 14
- 125000002393 azetidinyl group Chemical group 0.000 claims abstract description 12
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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| US201461990232P | 2014-05-08 | 2014-05-08 | |
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| PCT/GB2015/051312 WO2015170081A1 (en) | 2014-05-08 | 2015-05-05 | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
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| GB201516504D0 (en) * | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| GB201519406D0 (en) * | 2015-11-03 | 2015-12-16 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| GB201519568D0 (en) * | 2015-11-05 | 2015-12-23 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| ES2906813T3 (es) * | 2016-02-15 | 2022-04-20 | Astrazeneca Ab | Métodos que comprenden una dosificación intermitente fija de cediranib |
| US20190099421A1 (en) * | 2016-03-21 | 2019-04-04 | Astrazeneca Ab | Cinnolin-4-amine compounds and their use in treating cancer |
| MX2018012255A (es) * | 2016-04-07 | 2019-02-07 | Astrazeneca Ab | Oxido de n, n-dimetil-3-[[5-(3-metil-2-oxo-1-tetrahidropiran-4-il- imidazo[4,5-c]quinolin-8-il)-2-piridil]oxi]propan-1-amina como modulador de cinasa atm (ataxia telangiectasia mutada) para el tratamiento del cancer. |
| GB201608227D0 (en) * | 2016-05-11 | 2016-06-22 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| CN110177791B (zh) | 2016-12-20 | 2022-07-12 | 阿斯利康(瑞典)有限公司 | 氨基-三唑并吡啶化合物及其在治疗癌症中的用途 |
| KR102660196B1 (ko) * | 2017-01-09 | 2024-04-24 | 임팩트 테라퓨틱스 (상하이), 인코포레이티드 | 치환된 축합 헤테로아릴기 화합물인 키나제 억제제 및 이의 응용 |
| CN106798741A (zh) * | 2017-02-07 | 2017-06-06 | 宫英 | 一种治疗抑郁症的药物组合物 |
| CN106692147A (zh) * | 2017-02-07 | 2017-05-24 | 李明英 | 一种治疗男性不育的药物组合物 |
| CN106822123A (zh) * | 2017-02-09 | 2017-06-13 | 王艳苓 | 一种治疗心脑血管疾病的药物组合物 |
| CN110312717B (zh) * | 2017-02-27 | 2022-04-12 | 上海瑛派药业有限公司 | 取代的稠合杂芳三环化合物作为激酶抑制剂及其应用 |
| JOP20190209A1 (ar) * | 2017-03-16 | 2019-09-12 | Astrazeneca Ab | مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان |
| WO2019057757A1 (en) | 2017-09-20 | 2019-03-28 | Astrazeneca Ab | 1,3-DIHYDROIMIDAZO [4,5-C] CINNOLIN-2-ONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER |
| WO2019201283A1 (en) * | 2018-04-20 | 2019-10-24 | Xrad Therapeutics, Inc. | Dual atm and dna-pk inhibitors for use in anti-tumor therapy |
| CN110386932A (zh) | 2018-04-20 | 2019-10-29 | 艾科思莱德制药公司 | 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂 |
| US12226414B2 (en) * | 2018-09-14 | 2025-02-18 | Suzhou Zanrong Pharma Limited | 1-isopropyl-3-methyl-8-(pyridin-3-yl)-1,3-dihydro-2H-imidazo[4,5-c] cinnolin-2-one as selective modulators of ataxia telangiectasia mutated (ATM) kinase and uses thereof |
| AU2019360608A1 (en) * | 2018-10-15 | 2021-06-03 | Merck Patent Gmbh | Combination therapy utilizing DNA alkylating agents and ATR inhibitors |
| CR20210504A (es) * | 2019-03-05 | 2022-02-08 | Astrazeneca Ab | Compuestos tricíclicos condensados útiles como agentes anticancerígenos |
| TW202102497A (zh) * | 2019-03-29 | 2021-01-16 | 瑞典商阿斯特捷利康公司 | 化合物及它們在治療癌症中之用途 |
| CN111909147B (zh) * | 2019-05-10 | 2021-07-20 | 山东轩竹医药科技有限公司 | Dna-pk抑制剂 |
| US20220259211A1 (en) * | 2019-07-10 | 2022-08-18 | Impact Therapeutics (Shanghai), Inc | Substituted pyrazoloquinazolinone compounds and application thereof |
| CN119080781A (zh) * | 2019-09-12 | 2024-12-06 | 上海瑛派药业有限公司 | 取代的咪唑并喹喔啉化合物及其应用 |
| CN115003672A (zh) * | 2020-01-09 | 2022-09-02 | 南京明德新药研发有限公司 | 喹啉并咪唑类化合物及其应用 |
| WO2021146127A1 (en) * | 2020-01-13 | 2021-07-22 | Zhanggui Wu | Use of n2-quincline or isoquinoline substituted purine derivatives in cancer treatment |
| TW202216209A (zh) * | 2020-06-24 | 2022-05-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物及atm抑制劑之組合 |
| EP3992191A1 (en) | 2020-11-03 | 2022-05-04 | Deutsches Krebsforschungszentrum | Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors |
| CN117015534A (zh) * | 2021-02-03 | 2023-11-07 | 艾科思莱德制药公司 | 用于癌症疗法的双重atm和dna-pk抑制剂以及免疫治疗剂的组合 |
| WO2022193166A1 (en) * | 2021-03-17 | 2022-09-22 | Suzhou Zanrong Pharma Limited | Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof |
| JP2025503055A (ja) * | 2022-01-26 | 2025-01-30 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | ヒドラジン基含有化合物 |
| TW202446421A (zh) | 2023-04-10 | 2024-12-01 | 日商第一三共股份有限公司 | 抗ｂ７－ｈ３抗體－藥物結合物與ａｔｒ抑制劑或ａｔｍ抑制劑之組合 |
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| GB0211649D0 (en) * | 2002-05-21 | 2002-07-03 | Novartis Ag | Organic compounds |
| WO2005054237A1 (en) | 2003-11-21 | 2005-06-16 | Novartis Ag | 1h-imidazoquinoline derivatives as protein kinase inhibitors |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| PE20090717A1 (es) * | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| WO2010003025A1 (en) | 2008-07-01 | 2010-01-07 | Genentech, Inc. | Bicyclic heterocycles as mek kinase inhibitors |
| ES2614130T3 (es) * | 2008-09-30 | 2017-05-29 | Pfizer Inc. | Compuestos de imidazo[1,5]naftiridina, su uso farmacéutico y composiciones |
| TW201041888A (en) * | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| CN102803259A (zh) * | 2009-06-04 | 2012-11-28 | 诺瓦提斯公司 | 用于治疗增殖性疾病的1H-咪唑并[4,5-c]喹啉酮化合物 |
| EP2438064A1 (en) | 2009-06-04 | 2012-04-11 | Novartis AG | 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES |
| AU2010299820A1 (en) * | 2009-09-28 | 2012-04-19 | F. Hoffmann-La Roche Ag | Benzoxepin PI3K inhibitor compounds and methods of use |
| GB0919423D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| CN102199152A (zh) | 2010-03-25 | 2011-09-28 | 高大新 | 杂环咪唑类磷脂激酶抑制剂 |
| CN102372711B (zh) * | 2010-08-18 | 2014-09-17 | 山东轩竹医药科技有限公司 | 咪唑并喹啉类PI3K和mTOR双重抑制剂 |
| WO2012026233A1 (ja) | 2010-08-26 | 2012-03-01 | 日立建機株式会社 | 建設機械 |
| DE102010035744A1 (de) | 2010-08-28 | 2012-03-01 | Merck Patent Gmbh | Imidazolonylchinoline |
| CN102399218A (zh) * | 2010-09-16 | 2012-04-04 | 和记黄埔医药（上海）有限公司 | 一类并合三杂环及其作为pi3k抑制剂的用途 |
| KR20140014104A (ko) | 2010-12-06 | 2014-02-05 | 피라말 엔터프라이지즈 리미티드 | 치환된 이미다조퀴놀린 유도체 |
| US20140287931A1 (en) | 2011-04-04 | 2014-09-25 | Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis | Methods and compositions for predicting resistance to anticancer treatment |
| JP6042060B2 (ja) * | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
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