ES2660438T3 - Captura in vitro y análisis de células tumorales circulantes - Google Patents
Captura in vitro y análisis de células tumorales circulantes Download PDFInfo
- Publication number
- ES2660438T3 ES2660438T3 ES13789770.8T ES13789770T ES2660438T3 ES 2660438 T3 ES2660438 T3 ES 2660438T3 ES 13789770 T ES13789770 T ES 13789770T ES 2660438 T3 ES2660438 T3 ES 2660438T3
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- epcam
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- cells
- seprase
- tumor cells
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- 210000005266 circulating tumour cell Anatomy 0.000 description 25
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96466—Cysteine endopeptidases (3.4.22)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261724753P | 2012-11-09 | 2012-11-09 | |
| US201261724753P | 2012-11-09 | ||
| PCT/EP2013/073381 WO2014072465A1 (en) | 2012-11-09 | 2013-11-08 | In vitro capture and analysis of circulating tumor cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2660438T3 true ES2660438T3 (es) | 2018-03-22 |
Family
ID=49582733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13789770.8T Active ES2660438T3 (es) | 2012-11-09 | 2013-11-08 | Captura in vitro y análisis de células tumorales circulantes |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9250242B2 (enExample) |
| EP (1) | EP2919910B1 (enExample) |
| JP (1) | JP6404824B2 (enExample) |
| CN (1) | CN104781007B (enExample) |
| CA (1) | CA2891028C (enExample) |
| ES (1) | ES2660438T3 (enExample) |
| WO (1) | WO2014072465A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10155988B2 (en) * | 2010-04-07 | 2018-12-18 | Board Of Regents, The University Of Texas System | Methods of detecting tumor cells |
| TWI539158B (zh) * | 2010-06-08 | 2016-06-21 | 維里德克斯有限責任公司 | 使用血液中之循環黑色素瘤細胞預測黑色素瘤病患之臨床結果的方法。 |
| WO2012170560A2 (en) | 2011-06-06 | 2012-12-13 | Cornell University | Microfluidic device for extracting, isolating, and analyzing dna from cells |
| WO2013049636A1 (en) | 2011-09-30 | 2013-04-04 | The Regents Of The University Of Michigan | System for detecting rare cells |
| US10130946B2 (en) | 2011-09-30 | 2018-11-20 | The Regents Of The University Of Michigan | System for detecting rare cells |
| US10073024B2 (en) | 2012-10-29 | 2018-09-11 | The Regents Of The University Of Michigan | Microfluidic device and method for detecting rare cells |
| WO2014072465A1 (en) | 2012-11-09 | 2014-05-15 | Roche Diagnostics Gmbh | In vitro capture and analysis of circulating tumor cells |
| EP2799872B1 (en) * | 2013-05-01 | 2017-10-18 | F. Hoffmann-La Roche AG | Selective release of sub-group of biological units |
| US9709556B2 (en) | 2013-12-11 | 2017-07-18 | Analiza, Inc. | Devices and methods for determining and/or isolating circulating cancer cells |
| US20150160246A1 (en) | 2013-12-11 | 2015-06-11 | Analiza, Inc. | Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells |
| ES2970741T3 (es) * | 2014-08-25 | 2024-05-30 | Creatv Microtech Inc | Utilización de biomarcadores celulares circulantes en la sangre para la detección y el diagnóstico de enfermedades y métodos para aislarlos |
| US10829804B2 (en) | 2015-03-23 | 2020-11-10 | The University Of North Carolina At Chapel Hill | Method for identification and enumeration of nucleic acid sequences, expression, splice variant, translocation, copy, or DNA methylation changes using combined nuclease, ligase, polymerase, terminal transferase, and sequencing reactions |
| US10393726B2 (en) | 2015-03-23 | 2019-08-27 | The University Of North Carolina At Chapel Hill | Universal molecular processor for precision medicine |
| US10317406B2 (en) | 2015-04-06 | 2019-06-11 | The Regents Of The University Of Michigan | System for detecting rare cells |
| CN105259096B (zh) * | 2015-10-19 | 2018-01-12 | 武汉顺可达生物科技有限公司 | 磷酸锌纳米基底及其制备方法和在循环肿瘤细胞捕获与释放中的应用 |
| CN106868098A (zh) * | 2015-12-10 | 2017-06-20 | 益善生物技术股份有限公司 | 循环肿瘤细胞分型鉴定试剂盒 |
| WO2017156341A1 (en) | 2016-03-09 | 2017-09-14 | Beijing Percans Oncology Co. Ltd. | Tumor cell suspension cultures and related methods |
| WO2017188346A1 (ja) * | 2016-04-27 | 2017-11-02 | 国立大学法人 東京大学 | マイクロファイバーを用いた血中循環細胞の捕捉及び回収用材料及び当該材料を用いる方法 |
| WO2017199651A1 (ja) * | 2016-05-18 | 2017-11-23 | ソニー株式会社 | 生体物質分析装置、生体物質分析システム、生体物質選別方法、生体物質分析用プログラム及び細胞培養容器 |
| US11602747B2 (en) | 2016-05-22 | 2023-03-14 | Cornell University | Multifunctional microfluidic device for capturing target cells and analyzing genomic DNA isolated from the target cells while under flow conditions |
| CN107475354A (zh) * | 2016-06-08 | 2017-12-15 | 益善生物技术股份有限公司 | 前列腺癌组织溯源ctc分型鉴定试剂盒 |
| CN107475355A (zh) * | 2016-06-08 | 2017-12-15 | 益善生物技术股份有限公司 | 肺癌早期筛查试剂盒 |
| CN106366197B (zh) * | 2016-08-31 | 2021-03-30 | 上海美吉生物医药科技有限公司 | 一种HER2、EGFR、EpCAM、MUC1多重抗体免疫磁珠及其制备方法 |
| CN106434904A (zh) * | 2016-09-07 | 2017-02-22 | 上海交通大学医学院附属仁济医院 | 一种实时监控肝癌复发或转移的CD133、EpCAM和CK19联合检测试剂盒 |
| CN110291401B (zh) | 2016-12-14 | 2023-04-11 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| JPWO2018116465A1 (ja) * | 2016-12-22 | 2019-10-24 | 日立化成株式会社 | Ｈｅｒ２陽性癌細胞の検出方法 |
| CN106866820B (zh) * | 2017-02-17 | 2020-04-03 | 艾比玛特医药科技（上海）有限公司 | 一种用于捕获肿瘤细胞的抗人角蛋白18的单克隆抗体及其应用 |
| CN110573629B (zh) * | 2017-03-30 | 2024-08-13 | 伊利诺伊大学理事会 | 用于诊断早期胰腺癌的方法和试剂盒 |
| CN112088023B (zh) | 2018-01-05 | 2024-05-14 | 帕斯艾克斯公司 | 用于捕获和去除流体中的疾病物质的装置 |
| CN108344615B (zh) * | 2018-01-24 | 2020-10-23 | 杭州安弼晟生物科技有限公司 | 一种循环肿瘤细胞捕获系统及控制方法 |
| WO2019239431A1 (en) * | 2018-06-13 | 2019-12-19 | Tzar Management Technology Private Limited | Method for analysing pluripotent stem cell biomarkers, and implementations thereof |
| EP3870969A4 (en) * | 2018-10-24 | 2022-07-27 | Path Ex, Inc. | PROCESS FOR RECOVERING AND ISOLATION OF DISEASE MATERIAL FROM FLOWING MATERIAL |
| WO2020113173A1 (en) | 2018-11-28 | 2020-06-04 | Cornell University | Multiomic analysis of cell analytes using microfluidic systems |
| WO2020113192A1 (en) | 2018-11-28 | 2020-06-04 | Cornell University | Systems and methods for on-chip analysis of nucleic acids and for multiplexed analysis of cells |
| WO2020139211A1 (en) | 2018-12-28 | 2020-07-02 | Mikro Biyosistemler Elektronik Sanayi Ve Ticaret A.S. | A microfluidic device for selective capture of biological entities |
| CN110082529B (zh) * | 2019-03-11 | 2022-04-19 | 南方医科大学深圳医院 | 一种肿瘤细胞表面标志物及其应用 |
| CN112143732B (zh) * | 2019-06-28 | 2022-03-22 | 中国科学院苏州纳米技术与纳米仿生研究所 | 特异性识别N-cadherin的ssDNA适配体、其筛选方法及应用 |
| US12053569B2 (en) | 2019-09-04 | 2024-08-06 | The Regents Of The University Of Michigan | Indwelling intravascular aphaeretic system for in vivo enrichment of circulating tumor cells |
| US20230173487A1 (en) * | 2020-05-25 | 2023-06-08 | Tokyo Ohka Kogyo Co., Ltd. | Target particle separation method and system |
| JPWO2022009642A1 (enExample) * | 2020-07-06 | 2022-01-13 | ||
| CN112569362B (zh) * | 2020-12-23 | 2022-05-17 | 北京航空航天大学 | 一种通过打散ctc细胞团抑制肿瘤转移的方法 |
| CN112924363A (zh) * | 2021-01-22 | 2021-06-08 | 中国科学院苏州纳米技术与纳米仿生研究所 | 中间型循环肿瘤细胞作为肿瘤诊断和预后标志物及其应用 |
| EP4284911A4 (en) * | 2021-01-27 | 2025-01-08 | BioFluidica, Inc. | High efficiency capture of fetal cells from maternal samples |
| CN112730840B (zh) * | 2021-01-29 | 2023-10-17 | 章毅 | 鉴别cd44和cd24分子表型的方法 |
| CN114874989B (zh) * | 2022-04-11 | 2024-06-25 | 中国科学院苏州纳米技术与纳米仿生研究所 | 一种循环肿瘤细胞捕获方法 |
| WO2024021040A1 (zh) * | 2022-07-29 | 2024-02-01 | 曾繁根 | 细胞辨识方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999041613A1 (en) * | 1998-02-12 | 1999-08-19 | Immunivest | Methods and reagents for the rapid and efficient isolation of circulating cancer cells |
| US7785810B2 (en) * | 2000-09-09 | 2010-08-31 | The Research Foundation Of State University Of New York | Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof |
| AU2004286307A1 (en) * | 2003-10-31 | 2005-05-12 | Vitatex, Inc. | Blood test prototypes and methods for the detection of circulating tumor and endothelial cells |
| WO2008131048A2 (en) * | 2007-04-16 | 2008-10-30 | Cellpoint Diagnotics, Inc. | Devices and methods for diagnosing, prognosing, or theranosing a condition by enriching rare cells |
| US8889361B2 (en) | 2007-09-19 | 2014-11-18 | The Research Foundation For The State University Of New York | Gene expression signatures in enriched tumor cell samples |
| EP2223115B1 (en) | 2007-12-10 | 2011-09-14 | Roche Diagnostics GmbH | Seprase as a marker for cancer |
| US10429376B2 (en) | 2008-05-16 | 2019-10-01 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids |
| GR1006582B (el) | 2008-07-14 | 2009-11-03 | Ελενη Στυλιανου Μωυσιαδου | Προϊοντα καθαρισμου και απολυμανσης με φυσικα αβλαβη υλικα που εχουν βαση την ζαχαρη |
| US20100210989A1 (en) * | 2008-12-23 | 2010-08-19 | Janet Lesley Macpherson | Processing blood |
| EP2409151B1 (en) * | 2009-03-18 | 2018-07-11 | The Regents of The University of California | Device for capturing circulating cells |
| EP2995953B1 (en) | 2009-03-24 | 2017-11-29 | Biocept, Inc. | Devices and methods of cell capture and analysis |
| US20120077246A1 (en) | 2009-04-24 | 2012-03-29 | The Board Of Trustees Of The University Of Illinoi | Methods and Devices for Capturing Circulating Tumor Cells |
| SG10201600803SA (en) | 2011-02-03 | 2016-03-30 | Univ Northeastern | Methods and compositions for highly specific capture and release of biological materials |
| CN202279815U (zh) * | 2011-07-19 | 2012-06-20 | 西门子公司 | 循环肿瘤细胞捕获装置 |
| WO2014072465A1 (en) | 2012-11-09 | 2014-05-15 | Roche Diagnostics Gmbh | In vitro capture and analysis of circulating tumor cells |
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| CN104781007B (zh) | 2017-11-17 |
| CN104781007A (zh) | 2015-07-15 |
| US9952212B2 (en) | 2018-04-24 |
| JP6404824B2 (ja) | 2018-10-17 |
| WO2014072465A1 (en) | 2014-05-15 |
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| US20140134646A1 (en) | 2014-05-15 |
| EP2919910A1 (en) | 2015-09-23 |
| JP2015537210A (ja) | 2015-12-24 |
| US20160139116A1 (en) | 2016-05-19 |
| CA2891028A1 (en) | 2014-05-15 |
| EP2919910B1 (en) | 2017-12-20 |
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