ES2637286T3 - Tratamiento oral de la enfermedad inflamatoria intestinal - Google Patents
Tratamiento oral de la enfermedad inflamatoria intestinal Download PDFInfo
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- ES2637286T3 ES2637286T3 ES12746034.3T ES12746034T ES2637286T3 ES 2637286 T3 ES2637286 T3 ES 2637286T3 ES 12746034 T ES12746034 T ES 12746034T ES 2637286 T3 ES2637286 T3 ES 2637286T3
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- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
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- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
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- GCHPUFAZSONQIV-UHFFFAOYSA-N isovaline Chemical compound CCC(C)(N)C(O)=O GCHPUFAZSONQIV-UHFFFAOYSA-N 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000014380 magnesium carbonate Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
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- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
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- 229920005989 resin Polymers 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 238000012552 review Methods 0.000 description 1
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- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
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- 239000007787 solid Substances 0.000 description 1
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- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
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- 239000008107 starch Substances 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
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- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1729—Cationic antimicrobial peptides, e.g. defensins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Marine Sciences & Fisheries (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11173351 | 2011-07-08 | ||
| EP11173351 | 2011-07-08 | ||
| US201161506437P | 2011-07-11 | 2011-07-11 | |
| US201161506437P | 2011-07-11 | ||
| PCT/EP2012/063137 WO2013007596A2 (en) | 2011-07-08 | 2012-07-05 | Oral treatment of inflammatory bowel disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2637286T3 true ES2637286T3 (es) | 2017-10-11 |
Family
ID=47506622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12746034.3T Active ES2637286T3 (es) | 2011-07-08 | 2012-07-05 | Tratamiento oral de la enfermedad inflamatoria intestinal |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9217021B2 (enExample) |
| EP (1) | EP2729159B1 (enExample) |
| JP (2) | JP6219277B2 (enExample) |
| ES (1) | ES2637286T3 (enExample) |
| WO (1) | WO2013007596A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2750727A1 (en) | 2008-07-18 | 2010-01-21 | Novozymes Adenium Biotech A/S | Treatment of inflammatory bowel diseases with mammal beta defensins |
| US9217021B2 (en) | 2011-07-08 | 2015-12-22 | Defensin Therapeutics Aps | Oral treatment of inflammatory bowel disease |
| KR101590452B1 (ko) | 2015-05-20 | 2016-02-02 | 중앙대학교 산학협력단 | 펩타이드 defb124를 유효성분으로 포함하는 면역증강 및 암 예방 또는 치료용 약학적 조성물 |
| WO2017027411A1 (en) * | 2015-08-07 | 2017-02-16 | The Regents Of The University Of California | Compositions and methods for inhibiting pro-inflammatory cytokine gene expression |
| JP6890135B2 (ja) * | 2016-01-26 | 2021-06-18 | ディフェンシン セラピューティクス エーピーエス | 腸内微生物叢を調節するための方法 |
| KR102465341B1 (ko) * | 2016-04-29 | 2022-11-09 | 디펜신 테라퓨틱스 에이피에스 | 간, 담관 및 췌장 장애의 치료 |
| EP3552632B1 (en) | 2016-12-07 | 2023-07-12 | Stelic Institute & Co., Inc. | Medicinal composition for treating and preventing inflammatory bowel disease |
| AU2017376400A1 (en) | 2016-12-13 | 2019-06-20 | Novozymes A/S | Methods for treating inflammatory conditions of the lungs |
| US20200316172A1 (en) * | 2017-11-10 | 2020-10-08 | Defensin Therapeutics Aps | Maturation of mucosal defense and gut/lung function in the preterm infant |
| EP3713590B1 (en) * | 2017-11-24 | 2025-05-07 | Defensin Therapeutics ApS | Human beta 2 defensin for use in the prevention and treatment of graft-versus-host-disease |
| KR102244161B1 (ko) * | 2018-08-31 | 2021-04-26 | 주식회사 나이벡 | 다중의 질환 바이오마커의 기능 및 발현을 억제하는 펩타이드의 신규한 용도 |
| BR112021006643A8 (pt) * | 2018-10-09 | 2022-12-06 | B Schaal Justin | Composições e métodos para aumentar capacidade de distribuição sistêmica, tolerância e eficácia de peptídeos macrocíclicos catiônicos |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| DE19824484A1 (de) * | 1998-06-02 | 1999-12-09 | Bayer Ag | Festkörperreiche Polyurethandispersionen mit hoher Applikationssicherheit |
| DE19957043A1 (de) | 1999-11-26 | 2001-06-07 | Forssmann Wolf Georg | Neue Defensine |
| US7338936B2 (en) | 2000-11-28 | 2008-03-04 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
| US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| FR2841556B1 (fr) | 2002-07-01 | 2007-07-20 | Centre Nat Rech Scient | Peptides ayant des proprietes antimicrobiennes et les compositions les contenant notamment pour la conservation des aliments |
| US20060115480A1 (en) | 2002-12-19 | 2006-06-01 | Yitzchak Hillman | Disease treatment via antimicrobial peptide inhibitors |
| US20070207209A1 (en) | 2004-08-27 | 2007-09-06 | Murphy Christopher J | Trophic factor combinations for nervous system treatment |
| GB0514482D0 (en) | 2005-07-14 | 2005-08-17 | Ares Trading Sa | Protein |
| WO2007081486A2 (en) * | 2005-12-15 | 2007-07-19 | Ventria Bioscience | Oral administration of defensins to treat intestinal diseases |
| CA2676483A1 (en) | 2006-01-24 | 2007-08-02 | University Of Maryland Biotechnology Institute | Surface-layer protein coated microspheres and uses thereof |
| JP5491396B2 (ja) | 2007-09-11 | 2014-05-14 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | 治療剤としてのデフェンシンペプチドの使用 |
| CA2750727A1 (en) * | 2008-07-18 | 2010-01-21 | Novozymes Adenium Biotech A/S | Treatment of inflammatory bowel diseases with mammal beta defensins |
| NZ590469A (en) | 2008-07-18 | 2012-08-31 | Novozymes Adenium Biotech As | Treatment of rheumatoid arthritis with human beta defensins (1-4) |
| AU2009272680A1 (en) | 2008-07-18 | 2010-01-21 | Novozymes Adenium Biotech A/S | Treatment of inflammatory diseases with mammal beta defensins |
| JP5468007B2 (ja) * | 2008-09-10 | 2014-04-09 | 旭硝子株式会社 | 新規なプロスタグランジンｉ２誘導体 |
| JP2011121887A (ja) * | 2009-12-09 | 2011-06-23 | En Otsuka Pharmaceutical Co Ltd | 炎症性腸疾患用アミノ酸組成物 |
| JP4620169B1 (ja) | 2010-01-28 | 2011-01-26 | 株式会社三和化学研究所 | 有機酸重合体を有効成分とするクローン病の予防又は治療剤 |
| US9217021B2 (en) | 2011-07-08 | 2015-12-22 | Defensin Therapeutics Aps | Oral treatment of inflammatory bowel disease |
| US20130052213A1 (en) | 2011-08-19 | 2013-02-28 | Novozymes A/S | Novel immunomodulatory peptide |
-
2012
- 2012-07-05 US US14/131,364 patent/US9217021B2/en active Active
- 2012-07-05 EP EP12746034.3A patent/EP2729159B1/en active Active
- 2012-07-05 ES ES12746034.3T patent/ES2637286T3/es active Active
- 2012-07-05 JP JP2014519502A patent/JP6219277B2/ja active Active
- 2012-07-05 WO PCT/EP2012/063137 patent/WO2013007596A2/en not_active Ceased
- 2012-07-06 US US13/542,747 patent/US20130172235A1/en not_active Abandoned
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2015
- 2015-11-16 US US14/942,307 patent/US9833495B2/en active Active
-
2017
- 2017-01-20 JP JP2017008251A patent/JP6251827B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2729159A2 (en) | 2014-05-14 |
| JP6219277B2 (ja) | 2017-10-25 |
| EP2729159B1 (en) | 2017-05-24 |
| US20130172235A1 (en) | 2013-07-04 |
| JP2014523906A (ja) | 2014-09-18 |
| US9217021B2 (en) | 2015-12-22 |
| JP6251827B2 (ja) | 2017-12-20 |
| US20140213521A1 (en) | 2014-07-31 |
| US20160129081A1 (en) | 2016-05-12 |
| WO2013007596A3 (en) | 2013-04-04 |
| WO2013007596A2 (en) | 2013-01-17 |
| JP2017105796A (ja) | 2017-06-15 |
| US9833495B2 (en) | 2017-12-05 |
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