ES2637286T3 - Tratamiento oral de la enfermedad inflamatoria intestinal - Google Patents
Tratamiento oral de la enfermedad inflamatoria intestinal Download PDFInfo
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- ES2637286T3 ES2637286T3 ES12746034.3T ES12746034T ES2637286T3 ES 2637286 T3 ES2637286 T3 ES 2637286T3 ES 12746034 T ES12746034 T ES 12746034T ES 2637286 T3 ES2637286 T3 ES 2637286T3
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- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 150000002411 histidines Chemical class 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 102000046699 human CD14 Human genes 0.000 description 1
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- 230000005764 inhibitory process Effects 0.000 description 1
- GCHPUFAZSONQIV-UHFFFAOYSA-N isovaline Chemical compound CCC(C)(N)C(O)=O GCHPUFAZSONQIV-UHFFFAOYSA-N 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000014380 magnesium carbonate Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
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- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 238000012552 review Methods 0.000 description 1
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- 230000007017 scission Effects 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
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- 239000007787 solid Substances 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
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- 239000010935 stainless steel Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
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- 239000011345 viscous material Substances 0.000 description 1
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- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1729—Cationic antimicrobial peptides, e.g. defensins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Marine Sciences & Fisheries (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11173351 | 2011-07-08 | ||
| EP11173351 | 2011-07-08 | ||
| US201161506437P | 2011-07-11 | 2011-07-11 | |
| US201161506437P | 2011-07-11 | ||
| PCT/EP2012/063137 WO2013007596A2 (en) | 2011-07-08 | 2012-07-05 | Oral treatment of inflammatory bowel disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2637286T3 true ES2637286T3 (es) | 2017-10-11 |
Family
ID=47506622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12746034.3T Active ES2637286T3 (es) | 2011-07-08 | 2012-07-05 | Tratamiento oral de la enfermedad inflamatoria intestinal |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9217021B2 (enExample) |
| EP (1) | EP2729159B1 (enExample) |
| JP (2) | JP6219277B2 (enExample) |
| ES (1) | ES2637286T3 (enExample) |
| WO (1) | WO2013007596A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102159233A (zh) | 2008-07-18 | 2011-08-17 | 诺维信阿德宁生物技术公司 | 使用哺乳动物β防御素的炎性肠病的治疗 |
| JP6219277B2 (ja) | 2011-07-08 | 2017-10-25 | ディフェンシン セラピューティクス アンパルトセルスカブＤｅｆｅｎｓｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ａｐｓ | 炎症性腸疾患の経口治療 |
| KR101590452B1 (ko) | 2015-05-20 | 2016-02-02 | 중앙대학교 산학협력단 | 펩타이드 defb124를 유효성분으로 포함하는 면역증강 및 암 예방 또는 치료용 약학적 조성물 |
| US20170035845A1 (en) * | 2015-08-07 | 2017-02-09 | The Regents Of The University Of California | Compositions and Methods for Inhibiting Pro-Inflammatory Cytokine Gene Expression |
| ES2871117T3 (es) * | 2016-01-26 | 2021-10-28 | Defensin Therapeutics Aps | Procedimientos para modular la microbiota intestinal |
| PL3448409T3 (pl) * | 2016-04-29 | 2026-02-23 | Defensin Therapeutics Aps | Leczenie chorób wątroby, dróg żółciowych i trzustki defensynami |
| JP7129912B2 (ja) * | 2016-12-07 | 2022-09-02 | 株式会社ステリック再生医科学研究所 | 慢性疾患の治療及び予防用医薬組成物 |
| CA3045079A1 (en) | 2016-12-13 | 2018-06-21 | Defensin Therapeutics Aps | Methods for treating inflammatory conditions of the lungs |
| KR20200095472A (ko) * | 2017-11-10 | 2020-08-10 | 디펜신 테라퓨틱스 에이피에스 | 조산아에서의 점막 방어 및 장/폐 기능의 성숙화 |
| KR20200097251A (ko) * | 2017-11-24 | 2020-08-18 | 디펜신 테라퓨틱스 에이피에스 | 디펜신에 의한 이식편 대 숙주 질환의 예방 및 치료 |
| KR102244161B1 (ko) | 2018-08-31 | 2021-04-26 | 주식회사 나이벡 | 다중의 질환 바이오마커의 기능 및 발현을 억제하는 펩타이드의 신규한 용도 |
| KR102742007B1 (ko) * | 2018-10-09 | 2024-12-12 | 유니버시티 오브 서던 캘리포니아 | 양이온성 마크로사이클릭 펩티드의 전신 전달성, 내약성, 및 효능을 향상시키기 위한 조성물 및 방법(compositions and methods for enhancing systemic deliverability, tolerability, and efficacy of cationic macrocyclic peptides) |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| DE19824484A1 (de) * | 1998-06-02 | 1999-12-09 | Bayer Ag | Festkörperreiche Polyurethandispersionen mit hoher Applikationssicherheit |
| DE19957043A1 (de) | 1999-11-26 | 2001-06-07 | Forssmann Wolf Georg | Neue Defensine |
| US7338936B2 (en) | 2000-11-28 | 2008-03-04 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
| US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| FR2841556B1 (fr) | 2002-07-01 | 2007-07-20 | Centre Nat Rech Scient | Peptides ayant des proprietes antimicrobiennes et les compositions les contenant notamment pour la conservation des aliments |
| US20060115480A1 (en) | 2002-12-19 | 2006-06-01 | Yitzchak Hillman | Disease treatment via antimicrobial peptide inhibitors |
| US20070207209A1 (en) | 2004-08-27 | 2007-09-06 | Murphy Christopher J | Trophic factor combinations for nervous system treatment |
| GB0514482D0 (en) | 2005-07-14 | 2005-08-17 | Ares Trading Sa | Protein |
| WO2007081486A2 (en) | 2005-12-15 | 2007-07-19 | Ventria Bioscience | Oral administration of defensins to treat intestinal diseases |
| WO2007087557A2 (en) | 2006-01-24 | 2007-08-02 | University Of Maryland Biotechnology Institute | Surface-layer protein coated microspheres and uses thereof |
| WO2009046833A1 (en) | 2007-09-11 | 2009-04-16 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
| MX2011000569A (es) | 2008-07-18 | 2011-02-23 | Novozymes Adenium Biotech As | Tratamiento de enfermedades inflamatorias con beta-defensinas de mamifero. |
| CN102159233A (zh) | 2008-07-18 | 2011-08-17 | 诺维信阿德宁生物技术公司 | 使用哺乳动物β防御素的炎性肠病的治疗 |
| MX2011000567A (es) | 2008-07-18 | 2011-02-23 | Novozymes Adenium Biotech As | Tratamiento de artritis reumatoide con beta-defensinas de mamifero. |
| DK2343292T3 (da) * | 2008-09-10 | 2014-11-03 | Asahi Glass Co Ltd | Nyt prostaglandin 12-derivat |
| JP2011121887A (ja) * | 2009-12-09 | 2011-06-23 | En Otsuka Pharmaceutical Co Ltd | 炎症性腸疾患用アミノ酸組成物 |
| JP4620169B1 (ja) | 2010-01-28 | 2011-01-26 | 株式会社三和化学研究所 | 有機酸重合体を有効成分とするクローン病の予防又は治療剤 |
| JP6219277B2 (ja) | 2011-07-08 | 2017-10-25 | ディフェンシン セラピューティクス アンパルトセルスカブＤｅｆｅｎｓｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ａｐｓ | 炎症性腸疾患の経口治療 |
| WO2013026794A1 (en) | 2011-08-19 | 2013-02-28 | Novozymes | Novel immunomodulatory peptide |
-
2012
- 2012-07-05 JP JP2014519502A patent/JP6219277B2/ja not_active Expired - Fee Related
- 2012-07-05 WO PCT/EP2012/063137 patent/WO2013007596A2/en not_active Ceased
- 2012-07-05 EP EP12746034.3A patent/EP2729159B1/en active Active
- 2012-07-05 ES ES12746034.3T patent/ES2637286T3/es active Active
- 2012-07-05 US US14/131,364 patent/US9217021B2/en active Active
- 2012-07-06 US US13/542,747 patent/US20130172235A1/en not_active Abandoned
-
2015
- 2015-11-16 US US14/942,307 patent/US9833495B2/en not_active Expired - Fee Related
-
2017
- 2017-01-20 JP JP2017008251A patent/JP6251827B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9217021B2 (en) | 2015-12-22 |
| JP2017105796A (ja) | 2017-06-15 |
| US9833495B2 (en) | 2017-12-05 |
| EP2729159B1 (en) | 2017-05-24 |
| WO2013007596A3 (en) | 2013-04-04 |
| JP6219277B2 (ja) | 2017-10-25 |
| JP6251827B2 (ja) | 2017-12-20 |
| US20130172235A1 (en) | 2013-07-04 |
| WO2013007596A2 (en) | 2013-01-17 |
| EP2729159A2 (en) | 2014-05-14 |
| JP2014523906A (ja) | 2014-09-18 |
| US20160129081A1 (en) | 2016-05-12 |
| US20140213521A1 (en) | 2014-07-31 |
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