JP6219277B2 - 炎症性腸疾患の経口治療 - Google Patents

炎症性腸疾患の経口治療 Download PDF

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Publication number
JP6219277B2
JP6219277B2 JP2014519502A JP2014519502A JP6219277B2 JP 6219277 B2 JP6219277 B2 JP 6219277B2 JP 2014519502 A JP2014519502 A JP 2014519502A JP 2014519502 A JP2014519502 A JP 2014519502A JP 6219277 B2 JP6219277 B2 JP 6219277B2
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defensin
disease
beta
human
seq
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Japanese (ja)
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JP2014523906A5 (enExample
JP2014523906A (ja
Inventor
ローセンキレ ケーア，タニャ マリーア
ローセンキレ ケーア，タニャ マリーア
アナスン，ビアギデ
ブレンク，カロリーネ スィディールマン
ブレンク，カロリーネ スィディールマン
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Defensin Therapeutics ApS
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Defensin Therapeutics ApS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1729—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014519502A 2011-07-08 2012-07-05 炎症性腸疾患の経口治療 Expired - Fee Related JP6219277B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11173351 2011-07-08
EP11173351.5 2011-07-08
US201161506437P 2011-07-11 2011-07-11
US61/506,437 2011-07-11
PCT/EP2012/063137 WO2013007596A2 (en) 2011-07-08 2012-07-05 Oral treatment of inflammatory bowel disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017008251A Division JP6251827B2 (ja) 2011-07-08 2017-01-20 炎症性腸疾患の経口治療

Publications (3)

Publication Number Publication Date
JP2014523906A JP2014523906A (ja) 2014-09-18
JP2014523906A5 JP2014523906A5 (enExample) 2015-08-20
JP6219277B2 true JP6219277B2 (ja) 2017-10-25

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Family Applications (2)

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JP2014519502A Expired - Fee Related JP6219277B2 (ja) 2011-07-08 2012-07-05 炎症性腸疾患の経口治療
JP2017008251A Expired - Fee Related JP6251827B2 (ja) 2011-07-08 2017-01-20 炎症性腸疾患の経口治療

Family Applications After (1)

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JP2017008251A Expired - Fee Related JP6251827B2 (ja) 2011-07-08 2017-01-20 炎症性腸疾患の経口治療

Country Status (5)

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US (3) US9217021B2 (enExample)
EP (1) EP2729159B1 (enExample)
JP (2) JP6219277B2 (enExample)
ES (1) ES2637286T3 (enExample)
WO (1) WO2013007596A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102159233A (zh) 2008-07-18 2011-08-17 诺维信阿德宁生物技术公司 使用哺乳动物β防御素的炎性肠病的治疗
JP6219277B2 (ja) 2011-07-08 2017-10-25 ディフェンシン セラピューティクス アンパルトセルスカブＤｅｆｅｎｓｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ａｐｓ 炎症性腸疾患の経口治療
KR101590452B1 (ko) 2015-05-20 2016-02-02 중앙대학교 산학협력단 펩타이드 defb124를 유효성분으로 포함하는 면역증강 및 암 예방 또는 치료용 약학적 조성물
US20170035845A1 (en) * 2015-08-07 2017-02-09 The Regents Of The University Of California Compositions and Methods for Inhibiting Pro-Inflammatory Cytokine Gene Expression
ES2871117T3 (es) * 2016-01-26 2021-10-28 Defensin Therapeutics Aps Procedimientos para modular la microbiota intestinal
PL3448409T3 (pl) * 2016-04-29 2026-02-23 Defensin Therapeutics Aps Leczenie chorób wątroby, dróg żółciowych i trzustki defensynami
JP7129912B2 (ja) * 2016-12-07 2022-09-02 株式会社ステリック再生医科学研究所 慢性疾患の治療及び予防用医薬組成物
CA3045079A1 (en) 2016-12-13 2018-06-21 Defensin Therapeutics Aps Methods for treating inflammatory conditions of the lungs
KR20200095472A (ko) * 2017-11-10 2020-08-10 디펜신 테라퓨틱스 에이피에스 조산아에서의 점막 방어 및 장/폐 기능의 성숙화
KR20200097251A (ko) * 2017-11-24 2020-08-18 디펜신 테라퓨틱스 에이피에스 디펜신에 의한 이식편 대 숙주 질환의 예방 및 치료
KR102244161B1 (ko) 2018-08-31 2021-04-26 주식회사 나이벡 다중의 질환 바이오마커의 기능 및 발현을 억제하는 펩타이드의 신규한 용도
KR102742007B1 (ko) * 2018-10-09 2024-12-12 유니버시티 오브 서던 캘리포니아 양이온성 마크로사이클릭 펩티드의 전신 전달성, 내약성, 및 효능을 향상시키기 위한 조성물 및 방법(compositions and methods for enhancing systemic deliverability, tolerability, and efficacy of cationic macrocyclic peptides)

Family Cites Families (23)

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US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
DE4343591A1 (de) 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
DE19824484A1 (de) * 1998-06-02 1999-12-09 Bayer Ag Festkörperreiche Polyurethandispersionen mit hoher Applikationssicherheit
DE19957043A1 (de) 1999-11-26 2001-06-07 Forssmann Wolf Georg Neue Defensine
US7338936B2 (en) 2000-11-28 2008-03-04 House Ear Institute Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
US20080194481A1 (en) 2001-12-21 2008-08-14 Human Genome Sciences, Inc. Albumin Fusion Proteins
FR2841556B1 (fr) 2002-07-01 2007-07-20 Centre Nat Rech Scient Peptides ayant des proprietes antimicrobiennes et les compositions les contenant notamment pour la conservation des aliments
US20060115480A1 (en) 2002-12-19 2006-06-01 Yitzchak Hillman Disease treatment via antimicrobial peptide inhibitors
US20070207209A1 (en) 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
GB0514482D0 (en) 2005-07-14 2005-08-17 Ares Trading Sa Protein
WO2007081486A2 (en) 2005-12-15 2007-07-19 Ventria Bioscience Oral administration of defensins to treat intestinal diseases
WO2007087557A2 (en) 2006-01-24 2007-08-02 University Of Maryland Biotechnology Institute Surface-layer protein coated microspheres and uses thereof
WO2009046833A1 (en) 2007-09-11 2009-04-16 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
MX2011000569A (es) 2008-07-18 2011-02-23 Novozymes Adenium Biotech As Tratamiento de enfermedades inflamatorias con beta-defensinas de mamifero.
CN102159233A (zh) 2008-07-18 2011-08-17 诺维信阿德宁生物技术公司 使用哺乳动物β防御素的炎性肠病的治疗
MX2011000567A (es) 2008-07-18 2011-02-23 Novozymes Adenium Biotech As Tratamiento de artritis reumatoide con beta-defensinas de mamifero.
DK2343292T3 (da) * 2008-09-10 2014-11-03 Asahi Glass Co Ltd Nyt prostaglandin 12-derivat
JP2011121887A (ja) * 2009-12-09 2011-06-23 En Otsuka Pharmaceutical Co Ltd 炎症性腸疾患用アミノ酸組成物
JP4620169B1 (ja) 2010-01-28 2011-01-26 株式会社三和化学研究所 有機酸重合体を有効成分とするクローン病の予防又は治療剤
JP6219277B2 (ja) 2011-07-08 2017-10-25 ディフェンシン セラピューティクス アンパルトセルスカブＤｅｆｅｎｓｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ａｐｓ 炎症性腸疾患の経口治療
WO2013026794A1 (en) 2011-08-19 2013-02-28 Novozymes Novel immunomodulatory peptide

Also Published As

Publication number Publication date
ES2637286T3 (es) 2017-10-11
US9217021B2 (en) 2015-12-22
JP2017105796A (ja) 2017-06-15
US9833495B2 (en) 2017-12-05
EP2729159B1 (en) 2017-05-24
WO2013007596A3 (en) 2013-04-04
JP6251827B2 (ja) 2017-12-20
US20130172235A1 (en) 2013-07-04
WO2013007596A2 (en) 2013-01-17
EP2729159A2 (en) 2014-05-14
JP2014523906A (ja) 2014-09-18
US20160129081A1 (en) 2016-05-12
US20140213521A1 (en) 2014-07-31

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