JP6219277B2 - 炎症性腸疾患の経口治療 - Google Patents
炎症性腸疾患の経口治療 Download PDFInfo
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- JP6219277B2 JP6219277B2 JP2014519502A JP2014519502A JP6219277B2 JP 6219277 B2 JP6219277 B2 JP 6219277B2 JP 2014519502 A JP2014519502 A JP 2014519502A JP 2014519502 A JP2014519502 A JP 2014519502A JP 6219277 B2 JP6219277 B2 JP 6219277B2
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1729—Cationic antimicrobial peptides, e.g. defensins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| PCT/EP2012/063137 WO2013007596A2 (en) | 2011-07-08 | 2012-07-05 | Oral treatment of inflammatory bowel disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| SG172709A1 (en) | 2008-07-18 | 2011-07-28 | Novozymes Adenium Biotech As | Treatment of inflammatory bowel diseases with mammal beta defensins |
| JP6219277B2 (ja) | 2011-07-08 | 2017-10-25 | ディフェンシン セラピューティクス アンパルトセルスカブＤｅｆｅｎｓｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ａｐｓ | 炎症性腸疾患の経口治療 |
| KR101590452B1 (ko) | 2015-05-20 | 2016-02-02 | 중앙대학교 산학협력단 | 펩타이드 defb124를 유효성분으로 포함하는 면역증강 및 암 예방 또는 치료용 약학적 조성물 |
| US20170035845A1 (en) * | 2015-08-07 | 2017-02-09 | The Regents Of The University Of California | Compositions and Methods for Inhibiting Pro-Inflammatory Cytokine Gene Expression |
| BR112018015170A2 (pt) * | 2016-01-26 | 2018-12-18 | Defensin Therapeutics Aps | métodos para tratamento de doenças, para promoção de crescimento magro, para tratamento ou normalização de uma microbiota disbiótica no intestino, para aumentar riqueza gênica da microbiota intestinal, para aumentar número de filos da microbiota intestinal, para aumentar produção de ácidos graxos de cadeia curta da microbiota intestinal/metaboloma, para aumentar número de bactérias, para diminuir número de bactérias, defensina a, defensina ss, ou um fragmento bioativo das mesmas, e, defensina a e/ou defensina ss e/ou um glp-1/análogo de glp-1. |
| CN109414474B (zh) * | 2016-04-29 | 2024-07-02 | 诺维信公司 | 肝脏、胆道和胰腺障碍的治疗 |
| JP7129912B2 (ja) * | 2016-12-07 | 2022-09-02 | 株式会社ステリック再生医科学研究所 | 慢性疾患の治療及び予防用医薬組成物 |
| MX2019006848A (es) | 2016-12-13 | 2019-10-07 | Defensin Therapeutics Aps | Metodos para tratar condiciones inflamatorias de los pulmones. |
| MX2020004863A (es) * | 2017-11-10 | 2020-10-14 | Defensin Therapeutics Aps | Maduracion de la defensa de la mucosa y/o funcion intestinal/pulmonar en el bebe prematuro. |
| PL3713590T3 (pl) * | 2017-11-24 | 2025-09-15 | Defensin Therapeutics Aps | Ludzka beta 2 defensyna do stosowania w zapobieganiu i leczeniu choroby przeszczep przeciwko gospodarzowi |
| KR102244161B1 (ko) * | 2018-08-31 | 2021-04-26 | 주식회사 나이벡 | 다중의 질환 바이오마커의 기능 및 발현을 억제하는 펩타이드의 신규한 용도 |
| CN113164390A (zh) * | 2018-10-09 | 2021-07-23 | 达特·特兰 | 用于增强阳离子大环肽的全身递送能力、耐受性和效力的组合物和方法 |
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| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| DE19824484A1 (de) * | 1998-06-02 | 1999-12-09 | Bayer Ag | Festkörperreiche Polyurethandispersionen mit hoher Applikationssicherheit |
| DE19957043A1 (de) | 1999-11-26 | 2001-06-07 | Forssmann Wolf Georg | Neue Defensine |
| US7338936B2 (en) | 2000-11-28 | 2008-03-04 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
| US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
| FR2841556B1 (fr) | 2002-07-01 | 2007-07-20 | Centre Nat Rech Scient | Peptides ayant des proprietes antimicrobiennes et les compositions les contenant notamment pour la conservation des aliments |
| NZ540506A (en) | 2002-12-19 | 2008-09-26 | Yitzchak Hillman | Disease treatment via antimicrobial peptide inhibitors |
| US20070207209A1 (en) | 2004-08-27 | 2007-09-06 | Murphy Christopher J | Trophic factor combinations for nervous system treatment |
| GB0514482D0 (en) | 2005-07-14 | 2005-08-17 | Ares Trading Sa | Protein |
| WO2007081486A2 (en) | 2005-12-15 | 2007-07-19 | Ventria Bioscience | Oral administration of defensins to treat intestinal diseases |
| US8895062B2 (en) | 2006-01-24 | 2014-11-25 | University Of Maryland, Baltimore | Surface-layer protein coated microspheres and uses thereof |
| KR20100071985A (ko) | 2007-09-11 | 2010-06-29 | 몬도바이오테크 래보래토리즈 아게 | 치료제로서의 데펜신 펩티드의 용도 |
| AP2011005537A0 (en) | 2008-07-18 | 2011-02-28 | Novozymes Adenium Biotech As | Treatment of inflammatory diseases with mammal beta defensins. |
| SG172709A1 (en) | 2008-07-18 | 2011-07-28 | Novozymes Adenium Biotech As | Treatment of inflammatory bowel diseases with mammal beta defensins |
| US8232248B2 (en) | 2008-07-18 | 2012-07-31 | Novozymes Adenium Biotech A/S | Treatment of rheumatoid arthritis with mammal beta defensins |
| DK2343292T3 (da) * | 2008-09-10 | 2014-11-03 | Asahi Glass Co Ltd | Nyt prostaglandin 12-derivat |
| JP2011121887A (ja) * | 2009-12-09 | 2011-06-23 | En Otsuka Pharmaceutical Co Ltd | 炎症性腸疾患用アミノ酸組成物 |
| JP4620169B1 (ja) * | 2010-01-28 | 2011-01-26 | 株式会社三和化学研究所 | 有機酸重合体を有効成分とするクローン病の予防又は治療剤 |
| JP6219277B2 (ja) | 2011-07-08 | 2017-10-25 | ディフェンシン セラピューティクス アンパルトセルスカブＤｅｆｅｎｓｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ａｐｓ | 炎症性腸疾患の経口治療 |
| US20130052213A1 (en) | 2011-08-19 | 2013-02-28 | Novozymes A/S | Novel immunomodulatory peptide |
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| WO2013007596A2 (en) | 2013-01-17 |
| US20130172235A1 (en) | 2013-07-04 |
| JP6251827B2 (ja) | 2017-12-20 |
| JP2014523906A (ja) | 2014-09-18 |
| JP2017105796A (ja) | 2017-06-15 |
| ES2637286T3 (es) | 2017-10-11 |
| EP2729159A2 (en) | 2014-05-14 |
| US9833495B2 (en) | 2017-12-05 |
| US20140213521A1 (en) | 2014-07-31 |
| EP2729159B1 (en) | 2017-05-24 |
| US20160129081A1 (en) | 2016-05-12 |
| WO2013007596A3 (en) | 2013-04-04 |
| US9217021B2 (en) | 2015-12-22 |
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