ES2626013T3 - Derivados de GLP-1 - Google Patents
Derivados de GLP-1 Download PDFInfo
- Publication number
- ES2626013T3 ES2626013T3 ES12805429.3T ES12805429T ES2626013T3 ES 2626013 T3 ES2626013 T3 ES 2626013T3 ES 12805429 T ES12805429 T ES 12805429T ES 2626013 T3 ES2626013 T3 ES 2626013T3
- Authority
- ES
- Spain
- Prior art keywords
- amino
- hydroxypropanoyl
- acetyl
- glp
- carboxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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Landscapes
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- Cardiology (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11180265 | 2011-09-06 | ||
| EP11180265 | 2011-09-06 | ||
| US201161532323P | 2011-09-08 | 2011-09-08 | |
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| JP6250034B2 (ja) | 2012-05-08 | 2017-12-20 | ノヴォ ノルディスク アー／エス | 二重アシル化されたｇｌｐ−１誘導体 |
| EP2846824B1 (en) * | 2012-05-08 | 2017-04-05 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| GEP201706762B (en) | 2013-05-28 | 2017-10-25 | Takeda Pharmaceuticals Co | Peptide compound |
| EP3129041B1 (en) * | 2014-04-07 | 2019-06-12 | Novo Nordisk A/S | Double-acylated glp-1 compounds |
| JP2018012644A (ja) * | 2014-11-26 | 2018-01-25 | 武田薬品工業株式会社 | ペプチド化合物 |
| KR102778218B1 (ko) * | 2016-04-28 | 2025-03-10 | 노보 노르디스크 에이/에스 | 심혈관 병태에서의 세마글루타이드 |
| WO2017204219A1 (ja) | 2016-05-24 | 2017-11-30 | 武田薬品工業株式会社 | ペプチド化合物 |
| CN109248323B (zh) * | 2017-07-14 | 2023-09-08 | 杭州先为达生物科技有限公司 | 酰化的glp-1衍生物 |
| JP6633777B2 (ja) | 2017-08-24 | 2020-01-22 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１組成物及びその使用 |
| DK3774862T3 (da) | 2018-04-05 | 2022-09-05 | Sun Pharmaceutical Ind Ltd | Nye GLP-1-analoger |
| CN113214382B (zh) * | 2018-04-19 | 2024-01-19 | 杭州先为达生物科技股份有限公司 | 酰化的glp-1衍生物 |
| WO2021136223A1 (en) | 2019-12-31 | 2021-07-08 | Beijing Ql Biopharmaceutical Co., Ltd. | Fusion proteins of glp-1 and gdf15 and conjugates thereof |
| CN119874775A (zh) | 2020-02-07 | 2025-04-25 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| AU2021208601B2 (en) | 2020-02-18 | 2025-06-05 | Novo Nordisk A/S | Glp-1 compositions and uses thereof |
| CN113292646B (zh) * | 2020-05-29 | 2022-05-13 | 东莞云璟生物技术有限公司 | Glp-1/胰高血糖素双重激动剂融合蛋白 |
| WO2022028572A1 (en) | 2020-08-06 | 2022-02-10 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| KR20230083294A (ko) | 2020-09-30 | 2023-06-09 | 베이징 큐엘 바이오파마슈티컬 컴퍼니 리미티드 | 폴리펩타이드 접합체 및 사용 방법 |
| CN115850438B (zh) * | 2021-12-28 | 2023-05-12 | 北京惠之衡生物科技有限公司 | 一种长效glp-1衍生物 |
| CN119137124A (zh) | 2022-03-09 | 2024-12-13 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| CN114891090B (zh) * | 2022-03-11 | 2022-10-25 | 北京惠之衡生物科技有限公司 | 一种酰化的长效glp-1衍生物 |
| WO2023179542A1 (en) | 2022-03-21 | 2023-09-28 | Gasherbrum Bio , Inc. | 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes |
| CA3252113A1 (en) | 2022-03-30 | 2023-10-05 | Beijing Ql Biopharmaceutical Co., Ltd. | Liquid pharmaceutical compositions of polypeptide conjugates and their methods of use |
| CN114716533B (zh) * | 2022-04-12 | 2023-04-14 | 北京惠之衡生物科技有限公司 | 一种酰化的长效glp-1衍生物 |
| US20250250269A1 (en) | 2022-04-14 | 2025-08-07 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| JP2025538527A (ja) * | 2022-11-21 | 2025-11-28 | イーライ リリー アンド カンパニー | Ｇｉｐ／ｇｌｐ１デュアルアゴニストを調製するためのプロセス |
| US20240252410A1 (en) * | 2023-01-23 | 2024-08-01 | CrossChem Limited | Compounds for use in keratin treatment |
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| US5698522A (en) * | 1992-12-04 | 1997-12-16 | Abbott Laboratories | 6-position modified decapeptide LHRH antagonists |
| US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
| US5663907A (en) | 1996-04-25 | 1997-09-02 | Bright Microelectronics, Inc. | Switch driver circuit for providing small sector sizes for negative gate erase flash EEPROMS using a standard twin-well CMOS process |
| JP3149958B2 (ja) * | 1996-08-30 | 2001-03-26 | ノボ ノルディスク アクティーゼルスカブ | Ｇｌｐ―１誘導体 |
| AU2610699A (en) * | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | Derivatives of glp-1 analogs |
| IL138214A0 (en) | 1998-03-09 | 2001-10-31 | Zealand Pharmaceuticals As | Pharmacolgically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
| WO2002046227A2 (en) | 2000-12-07 | 2002-06-13 | Eli Lilly And Company | Glp-1 fusion proteins |
| MXPA06006746A (es) * | 2003-12-18 | 2006-08-18 | Novo Nordisk As | Analogos de glp-1 novedosos ligados a agentes similares a albumina. |
| CA2563379A1 (en) | 2004-03-31 | 2005-10-20 | Centocor, Inc. | Human glp-1 mimetibodies, compositions, methods and uses |
| EP2256130B1 (en) | 2005-02-02 | 2013-09-25 | Novo Nordisk A/S | Novel insulin derivatives |
| TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
| JP2011504871A (ja) | 2007-06-01 | 2011-02-17 | ノボ・ノルデイスク・エー／エス | 固体又は半固体担体中にペプチド薬剤を含む自然に分散可能なプレコンセントレイト |
| EP2190872B1 (en) | 2007-09-05 | 2018-03-14 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
| EP2190873B1 (en) | 2007-09-05 | 2015-07-22 | Novo Nordisk A/S | Truncated glp-1 derivatives and their therapeutical use |
| US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
| JP2013514322A (ja) * | 2009-12-16 | 2013-04-25 | ノヴォ ノルディスク アー／エス | 修飾されたｎ末端を有するｇｌｐ−１受容体アゴニスト化合物 |
| JP6231386B2 (ja) | 2010-11-09 | 2017-11-15 | ノヴォ ノルディスク アー／エス | リンカーを有する二重アシル化されたｇｌｐ−１誘導体 |
| EP2846824B1 (en) | 2012-05-08 | 2017-04-05 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| JP6250034B2 (ja) | 2012-05-08 | 2017-12-20 | ノヴォ ノルディスク アー／エス | 二重アシル化されたｇｌｐ−１誘導体 |
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| US9758560B2 (en) | 2017-09-12 |
| CN107266558A (zh) | 2017-10-20 |
| WO2013037690A1 (en) | 2013-03-21 |
| EP2753642B8 (en) | 2017-12-13 |
| US10308700B2 (en) | 2019-06-04 |
| JP2014529629A (ja) | 2014-11-13 |
| JP6126097B2 (ja) | 2017-05-10 |
| EP2753642B1 (en) | 2017-03-01 |
| US20170145069A1 (en) | 2017-05-25 |
| CN104039822A (zh) | 2014-09-10 |
| EP2753642A1 (en) | 2014-07-16 |
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