AR096440A1 - Compuesto peptídico agonista del receptor del péptido similar al glucagón tipo i (glp-1) y del péptido insulinotrópico dependiente de glucosa (gip) - Google Patents
Compuesto peptídico agonista del receptor del péptido similar al glucagón tipo i (glp-1) y del péptido insulinotrópico dependiente de glucosa (gip)Info
- Publication number
- AR096440A1 AR096440A1 ARP140102090A ARP140102090A AR096440A1 AR 096440 A1 AR096440 A1 AR 096440A1 AR P140102090 A ARP140102090 A AR P140102090A AR P140102090 A ARP140102090 A AR P140102090A AR 096440 A1 AR096440 A1 AR 096440A1
- Authority
- AR
- Argentina
- Prior art keywords
- peptide
- leu
- lys
- ala
- glp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente proporciona un compuesto peptídico que ejerce una acción de activación sobre los receptores del GLP-1 y los receptores del GIP, así como el uso del compuesto peptídico como medicamento destinado a la profilaxis o el tratamiento de la obesidad o la diabetes. Reivindicación 1: Un péptido caracterizado porque comprende una secuencia parcial representada por la fórmula (1): P¹-Tyr-Aib-Glu-Gly-Thr-aMePhe-Thr-Ser-Asp-Tyr-A¹¹-A¹²-A¹³-Leu-Asp-A¹⁶-A¹⁷-Ala-Gln-A²⁰-Glu-Phe-Val-Lys-Trp-Leu-Leu-Lys-A²⁹ (1) en donde P¹ es un grupo representado por la fórmula: -RA¹, -CO-RA¹, -CO-ORA¹, -CO-CORA¹, -SO-RA¹, -SO₂-RA¹, -SO₂-ORA¹, -CO-NRA²RA³, -SO₂-NRA²RA³ o -C(=NRA¹)-NRA²RA³ en donde RA¹, RA² y RA³ son cada uno de forma independiente un átomo de hidrógeno, un grupo hidrocarburo opcionalmente sustituido o un grupo heterocíclico opcionalmente sustituido; A¹¹ es Aib o Ala; A¹² es Ala, Ile, Lys, Phe o Pya(4); A¹³ es Aib, Cha, Leu, aMePhe o aMeTyr; A¹⁶ es Lys o Ser; A¹⁷ es Gln o Ile; A²⁰ es Ala o Ser; y A²⁹ es Gln o Gly; o una sal de él.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013111893 | 2013-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR096440A1 true AR096440A1 (es) | 2015-12-30 |
Family
ID=50942304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140102090A AR096440A1 (es) | 2013-05-28 | 2014-05-27 | Compuesto peptídico agonista del receptor del péptido similar al glucagón tipo i (glp-1) y del péptido insulinotrópico dependiente de glucosa (gip) |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US9200051B2 (es) |
| EP (1) | EP3004155B1 (es) |
| JP (2) | JP6429799B2 (es) |
| KR (1) | KR102229051B1 (es) |
| CN (1) | CN105209485B (es) |
| AP (1) | AP2015008781A0 (es) |
| AR (1) | AR096440A1 (es) |
| AU (1) | AU2014272500B2 (es) |
| CA (1) | CA2908581C (es) |
| CL (1) | CL2015003031A1 (es) |
| CY (1) | CY1124790T1 (es) |
| DK (1) | DK3004155T3 (es) |
| DO (1) | DOP2015000261A (es) |
| EA (2) | EA035813B1 (es) |
| EC (1) | ECSP15044389A (es) |
| ES (1) | ES2900744T3 (es) |
| GE (1) | GEP201706762B (es) |
| HK (1) | HK1216757A1 (es) |
| HR (1) | HRP20212014T1 (es) |
| HU (1) | HUE057361T2 (es) |
| IL (1) | IL242005B (es) |
| LT (1) | LT3004155T (es) |
| MA (1) | MA38472B1 (es) |
| MX (2) | MX2015015464A (es) |
| MY (1) | MY172744A (es) |
| PE (1) | PE20151770A1 (es) |
| PH (1) | PH12015502391A1 (es) |
| PL (1) | PL3004155T3 (es) |
| PT (1) | PT3004155T (es) |
| SG (1) | SG11201507934PA (es) |
| SI (1) | SI3004155T1 (es) |
| TN (1) | TN2015000451A1 (es) |
| TW (1) | TWI638831B (es) |
| UA (1) | UA118558C2 (es) |
| UY (1) | UY35589A (es) |
| WO (1) | WO2014192284A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2900744T3 (es) | 2013-05-28 | 2022-03-18 | Takeda Pharmaceuticals Co | Compuesto de péptidos |
| JOP20200119A1 (ar) * | 2015-01-09 | 2017-06-16 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
| CN104846061A (zh) * | 2015-05-07 | 2015-08-19 | 中国药科大学 | 一种glp-1受体激动剂的受体亲和力测定方法 |
| CN105388239B (zh) * | 2015-12-18 | 2018-01-05 | 兆科药业（合肥）有限公司 | 一种多肽固相合成的监测方法 |
| US10501516B2 (en) | 2016-05-24 | 2019-12-10 | Takeda Pharmaceutical Company Limited | Peptide compound |
| US11285180B2 (en) | 2016-12-06 | 2022-03-29 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods of enhancing the potency of incretin-based drugs in subjects in need thereof |
| JOP20180028A1 (ar) * | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
| WO2019140030A1 (en) | 2018-01-12 | 2019-07-18 | Eli Lilly And Company | Combination therapy |
| CA3087733A1 (en) * | 2018-01-23 | 2019-08-01 | Gila Therapeutics, Inc. | Peptide yy pharmaceutical formulations, compositions, and methods |
| EP3788063B1 (en) | 2018-05-04 | 2023-08-09 | Novo Nordisk A/S | Gip derivatives and uses thereof |
| CN110818771B (zh) * | 2018-08-14 | 2023-01-17 | 陈铭 | 使用氨基酸离子液体的羰基硫介导多肽合成 |
| WO2020067557A2 (en) * | 2018-09-24 | 2020-04-02 | Takeda Pharmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
| WO2020067575A1 (en) * | 2018-09-24 | 2020-04-02 | Takeda Pharmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
| WO2021034815A1 (en) * | 2019-08-19 | 2021-02-25 | Eli Lilly And Company | Methods of making incretin analogs |
| WO2021066600A1 (ko) | 2019-10-04 | 2021-04-08 | 한미약품 주식회사 | 글루카곤, 및 glp-1 수용체 및 gip 수용체 이중 작용제를 포함하는 조성물 및 이의 치료학적 용도 |
| CN110684082B (zh) | 2019-10-08 | 2021-12-10 | 江苏诺泰澳赛诺生物制药股份有限公司 | Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途 |
| PE20230107A1 (es) * | 2020-03-25 | 2023-01-25 | Takeda Pharmaceuticals Co | Dosificacion qd de compuestos peptidicos agonistas del receptor de gip y sus usos |
| BR112023000229A2 (pt) | 2020-07-22 | 2023-01-31 | Novo Nordisk As | Composto, composição farmacêutica, e, peptídeo |
| JP2023534131A (ja) | 2020-07-22 | 2023-08-08 | ノヴォ ノルディスク アー／エス | 経口送達に好適なｇｌｐ－１受容体およびｇｉｐ受容体共作動薬 |
| CN117440964A (zh) | 2021-06-01 | 2024-01-23 | 南京知和医药科技有限公司 | 一种glp-1r和gipr双重靶向激动作用的多肽衍生物及其制备方法和用途 |
| TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
| WO2024012472A1 (zh) * | 2022-07-13 | 2024-01-18 | 杭州中美华东制药有限公司 | Glp-1/gip双激动剂及其制备方法和用途 |
| WO2024059674A1 (en) | 2022-09-15 | 2024-03-21 | Eli Lilly And Company | Gip and glp-1 dual agonist compounds |
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2014
- 2014-05-27 ES ES14729976T patent/ES2900744T3/es active Active
- 2014-05-27 AU AU2014272500A patent/AU2014272500B2/en active Active
- 2014-05-27 DK DK14729976.2T patent/DK3004155T3/da active
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- 2014-05-27 US US14/287,514 patent/US9200051B2/en active Active
- 2014-05-27 UY UY0001035589A patent/UY35589A/es not_active Application Discontinuation
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- 2014-05-27 CN CN201480026613.0A patent/CN105209485B/zh active Active
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- 2014-05-27 KR KR1020157032121A patent/KR102229051B1/ko active IP Right Grant
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2015
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- 2015-10-21 EC ECIEPI201544389A patent/ECSP15044389A/es unknown
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2016
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2018
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2021
- 2021-12-15 CY CY20211101100T patent/CY1124790T1/el unknown
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