AR098739A1 - Análogos del péptido exendina-4 como agonistas duales del receptor de glp-1 / glp (péptido similar al glucagón tipo 1 / glucagón) - Google Patents

Análogos del péptido exendina-4 como agonistas duales del receptor de glp-1 / glp (péptido similar al glucagón tipo 1 / glucagón)

Info

Publication number
AR098739A1
AR098739A1 ARP140104638A ARP140104638A AR098739A1 AR 098739 A1 AR098739 A1 AR 098739A1 AR P140104638 A ARP140104638 A AR P140104638A AR P140104638 A ARP140104638 A AR P140104638A AR 098739 A1 AR098739 A1 AR 098739A1
Authority
AR
Argentina
Prior art keywords
ser
peptide
amino acid
glucagon
acid residue
Prior art date
Application number
ARP140104638A
Other languages
English (en)
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of AR098739A1 publication Critical patent/AR098739A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente se refiere a derivados de exendina-4 y a su uso médico, por ejemplo, en el tratamiento de trastornos del síndrome metabólico, que incluyen diabetes y obesidad, además de reducción de la ingesta excesiva de alimentos. Reivindicación 1: Un compuesto peptídico que tiene la fórmula (1): R¹-Z-R² (1) en donde Z es un resto de péptido que tiene la fórmula (2): His-X²-X³-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-GIn-Leu-Asp-Glu-Gln-X¹⁸-Ala-X²⁰-X²¹-Phe-Ile-Glu-Trp-Leu-lle-X²⁸-Gly-Gly-Pro-X³²-Ser-Gly-Ala-Pro-Pro-Pro-Ser (2) X² representa un residuo de aminoácido seleccionado de Ser, D-Ser y Aib, X³ representa un residuo de aminoácido seleccionado de Gln y His, X¹⁸ representa un residuo de aminoácido seleccionado de Arg y Lys, X²⁰ representa un residuo de aminoácido seleccionado de Lys, Gln, His y (S)MeLys, X²¹ representa un residuo de aminoácido seleccionado de Asp y Glu, X²⁸ representa un residuo de aminoácido seleccionado de Ser y Ala, X³² representa un residuo de aminoácido seleccionado de Ser y Val, R¹ representa NH₂, R² representa OH o NH₂, o una sal o solvato del mismo.
ARP140104638A 2013-12-13 2014-12-12 Análogos del péptido exendina-4 como agonistas duales del receptor de glp-1 / glp (péptido similar al glucagón tipo 1 / glucagón) AR098739A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13306715 2013-12-13

Publications (1)

Publication Number Publication Date
AR098739A1 true AR098739A1 (es) 2016-06-08

Family

ID=49882999

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140104638A AR098739A1 (es) 2013-12-13 2014-12-12 Análogos del péptido exendina-4 como agonistas duales del receptor de glp-1 / glp (péptido similar al glucagón tipo 1 / glucagón)

Country Status (5)

Country Link
US (1) US20170022260A9 (es)
EP (1) EP3080155A1 (es)
AR (1) AR098739A1 (es)
TW (1) TW201609800A (es)
WO (1) WO2015086731A1 (es)

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AU2013366691A1 (en) 2012-12-21 2015-07-09 Sanofi Exendin-4 derivatives
EP3080150B1 (en) 2013-12-13 2018-08-01 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／ｇｉｐ受體促效劑
TW201609796A (zh) 2013-12-13 2016-03-16 賽諾菲公司 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
TW201609797A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／升糖素受體促效劑
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
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TWI622596B (zh) 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
AU2016379403B2 (en) 2015-12-23 2020-03-12 The Johns Hopkins University Long-acting GLP-1r agonist as a therapy of neurological and neurodegenerative conditions
AR110300A1 (es) 2016-12-02 2019-03-13 Sanofi Sa Compuestos como agonistas peptídicos trigonales de los receptores de glp1 / glucagón / gip
AR110299A1 (es) 2016-12-02 2019-03-13 Sanofi Sa Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico
AR110301A1 (es) 2016-12-02 2019-03-13 Sanofi Sa Compuestos como agonistas peptídicos de receptores de glp1 / glucagón / gip
KR20200141469A (ko) 2018-04-05 2020-12-18 썬 파마슈티칼 인더스트리스 리미티드 신규한 glp-1 유사체
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Also Published As

Publication number Publication date
WO2015086731A1 (en) 2015-06-18
EP3080155A1 (en) 2016-10-19
TW201609800A (zh) 2016-03-16
US20170022260A9 (en) 2017-01-26
US20160168225A1 (en) 2016-06-16

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