ES2620402T3 - Sintesis de estirilpiridinas radiomarcadas con 18F a partir de precursores de tosilato y composiciones farmacéuticas estables de las mismas - Google Patents
Sintesis de estirilpiridinas radiomarcadas con 18F a partir de precursores de tosilato y composiciones farmacéuticas estables de las mismas Download PDFInfo
- Publication number
- ES2620402T3 ES2620402T3 ES09837135.4T ES09837135T ES2620402T3 ES 2620402 T3 ES2620402 T3 ES 2620402T3 ES 09837135 T ES09837135 T ES 09837135T ES 2620402 T3 ES2620402 T3 ES 2620402T3
- Authority
- ES
- Spain
- Prior art keywords
- ethoxy
- pyridin
- vinyl
- methyl
- fluoroethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14188508P | 2008-12-31 | 2008-12-31 | |
| US141885P | 2008-12-31 | ||
| PCT/US2009/069741 WO2010078370A1 (en) | 2008-12-31 | 2009-12-29 | Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2620402T3 true ES2620402T3 (es) | 2017-06-28 |
Family
ID=42310197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09837135.4T Active ES2620402T3 (es) | 2008-12-31 | 2009-12-29 | Sintesis de estirilpiridinas radiomarcadas con 18F a partir de precursores de tosilato y composiciones farmacéuticas estables de las mismas |
Country Status (35)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2910945B1 (en) * | 2008-09-30 | 2018-07-18 | Case Western Reserve University | Molecular probes for imaging of myelin |
| SG185782A1 (en) | 2010-06-04 | 2013-01-30 | Piramal Imaging Sa | Method for production of f-18 labeled amyloid beta ligands |
| AU2011260420A1 (en) | 2010-06-04 | 2013-01-10 | Piramal Imaging Sa | Method for production of F-18 labeled amyloid beta ligand |
| TWI504414B (zh) | 2010-06-04 | 2015-10-21 | Bayer Schering Pharma Ag | 生產Ｆ－１８標記之Ａβ配位體之方法 |
| CN106729771A (zh) * | 2011-04-21 | 2017-05-31 | 加利福尼亚大学董事会 | 官能化磁性纳米颗粒及在淀粉样沉积物和神经原纤维缠结成像中用途 |
| ES2683818T3 (es) * | 2011-06-21 | 2018-09-28 | Piramal Imaging Sa | Formulaciones de estilbeno fluorado aceptables para la formación de imágenes mediante PET |
| US20140243533A1 (en) | 2011-10-19 | 2014-08-28 | Piramal Imaging Sa | Method for production of f-18 labeled a-beta ligands |
| CN102432529B (zh) * | 2011-11-14 | 2014-03-26 | 江苏省原子医学研究所 | 一种苯乙烯基吡啶二硫二氮衍生物的制备方法 |
| EP2791113A1 (en) * | 2011-12-15 | 2014-10-22 | GE Healthcare UK Limited | Heterocyclic compounds as imaging probes of tau pathology |
| CN102526765B (zh) * | 2011-12-31 | 2014-07-30 | 郑州泰基鸿诺药物科技有限公司 | 一种Aβ斑块显像剂及其制备方法 |
| CN103965105A (zh) * | 2013-01-29 | 2014-08-06 | 中山大学 | 苯乙烯基喹啉衍生物及其在治疗阿尔茨海默病症中的应用 |
| CN103645254B (zh) * | 2013-11-28 | 2015-01-07 | 江苏省原子医学研究所 | 一种Aβ斑块显像剂前体AV45的含量分析方法 |
| WO2017014599A1 (ko) * | 2015-07-22 | 2017-01-26 | 주식회사 씨코헬스케어 | [18f]플루오로-도파의 방사화학적 순도를 안정화시키는 조성물 및 이의 제조방법 |
| CA3003884C (en) * | 2015-11-13 | 2020-04-21 | Eli Lilly And Company | Azetidine derivatives for tau imaging |
| US10765763B2 (en) | 2016-03-09 | 2020-09-08 | Case Western Reserve University | Radioligands for myelin |
| CN107198780A (zh) * | 2016-03-18 | 2017-09-26 | 南京江原安迪科正电子研究发展有限公司 | 放射性药物组合物及其制备方法、应用 |
| CN106018575B (zh) * | 2016-05-05 | 2018-10-19 | 江苏省原子医学研究所 | 一种PET显像剂前体TsOP-(+)-DTBZ及其光学异构体的分离测定方法 |
| US10695450B2 (en) * | 2016-07-26 | 2020-06-30 | Laboratoires Cyclopharma | Synthesis of a radioactive agent composition |
| ES2929277T3 (es) * | 2016-11-08 | 2022-11-28 | Univ California | Métodos para la síntesis multidosis de [F-18]FDDNP para contextos clínicos |
| TW201906818A (zh) | 2017-05-31 | 2019-02-16 | 美商５１１製藥公司 | 新穎氘取代之正子發射斷層掃描（ｐｅｔ）顯影劑及其藥理應用 |
| IL275990B2 (en) * | 2018-01-24 | 2024-08-01 | Ac Immune Sa | Diagnostic preparations for PET imaging, a method for producing a diagnostic preparation and its use in diagnostics |
| CN111499544B (zh) * | 2019-01-31 | 2022-12-02 | 中国医学科学院放射医学研究所 | 一种一锅法制备N-Boc-N-甲基-4-氨基苯乙烯的合成方法 |
| CN111499570B (zh) * | 2019-01-31 | 2023-05-16 | 中国医学科学院放射医学研究所 | 一种av-45中间体的合成方法 |
| CN113766952B (zh) * | 2019-03-29 | 2023-09-08 | 国立研究开发法人量子科学技术研究开发机构 | 放射性药品的制造方法及放射性药品 |
| CN115400232A (zh) * | 2021-05-26 | 2022-11-29 | 汉中汉核医疗科技有限公司 | 一种放射性药物合成方法 |
| CN115403434A (zh) * | 2021-05-26 | 2022-11-29 | 汉中汉核医疗科技有限公司 | 一种放射性药物的合成方法 |
| CN113582885B (zh) * | 2021-08-30 | 2023-04-21 | 南京克米斯璀新能源科技有限公司 | 一种烷基磺酸钠的生产方法 |
| CN114805190A (zh) * | 2022-06-08 | 2022-07-29 | 吉林大学第一医院 | 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法 |
| WO2024107620A1 (en) * | 2022-11-14 | 2024-05-23 | Eli Lilly And Company | Polymorphic forms of florbetapir precursor av-105 |
| CN119080714A (zh) * | 2024-09-12 | 2024-12-06 | 四川大学 | 一种偶氮苯磺酸酯化合物及其制备方法和应用、放射性探针的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005067391A2 (en) * | 2004-01-19 | 2005-07-28 | Technion Research & Development Foundation Ltd. | Diagnostic test for parkinson's disease |
| SG194363A1 (en) * | 2004-12-17 | 2013-11-29 | Univ Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
| HRP20120135T1 (hr) * | 2006-03-30 | 2012-03-31 | The Trustees Of The University Of Pennsylvania | Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova |
-
2009
- 2009-12-29 RS RS20170117A patent/RS55674B1/sr unknown
- 2009-12-29 US US12/648,869 patent/US20100172836A1/en not_active Abandoned
- 2009-12-29 AU AU2009335049A patent/AU2009335049B2/en active Active
- 2009-12-29 HR HRP20170453TT patent/HRP20170453T1/hr unknown
- 2009-12-29 BR BRPI0923890-5A patent/BRPI0923890A2/pt active Search and Examination
- 2009-12-29 KR KR1020117017636A patent/KR20110119670A/ko not_active Ceased
- 2009-12-29 JP JP2011543721A patent/JP5717650B2/ja active Active
- 2009-12-29 PE PE2011001294A patent/PE20120007A1/es not_active Application Discontinuation
- 2009-12-29 UA UAA201109307A patent/UA105914C2/uk unknown
- 2009-12-29 DK DK09837135.4T patent/DK2381967T3/en active
- 2009-12-29 NZ NZ593848A patent/NZ593848A/xx unknown
- 2009-12-29 PT PT98371354T patent/PT2381967T/pt unknown
- 2009-12-29 SI SI200931600A patent/SI2381967T1/sl unknown
- 2009-12-29 EP EP09837135.4A patent/EP2381967B1/en active Active
- 2009-12-29 PL PL09837135T patent/PL2381967T3/pl unknown
- 2009-12-29 CN CN200980153414.5A patent/CN102271716B/zh active Active
- 2009-12-29 EA EA201170911A patent/EA023014B1/ru not_active IP Right Cessation
- 2009-12-29 MA MA34065A patent/MA33004B1/fr unknown
- 2009-12-29 LT LTEP09837135.4T patent/LT2381967T/lt unknown
- 2009-12-29 ES ES09837135.4T patent/ES2620402T3/es active Active
- 2009-12-29 HU HUE09837135A patent/HUE033649T2/en unknown
- 2009-12-29 MY MYPI2011003056A patent/MY162312A/en unknown
- 2009-12-29 MX MX2011007063A patent/MX2011007063A/es active IP Right Grant
- 2009-12-29 SG SG2011048055A patent/SG172439A1/en unknown
- 2009-12-29 WO PCT/US2009/069741 patent/WO2010078370A1/en not_active Ceased
- 2009-12-29 CA CA2748705A patent/CA2748705C/en active Active
-
2011
- 2011-06-20 IL IL213674A patent/IL213674A/en active IP Right Grant
- 2011-06-24 TN TN2011000318A patent/TN2011000318A1/fr unknown
- 2011-06-29 ZA ZA2011/04824A patent/ZA201104824B/en unknown
- 2011-06-29 HN HN2011001810A patent/HN2011001810A/es unknown
- 2011-06-29 DO DO2011000210A patent/DOP2011000210A/es unknown
- 2011-07-11 CO CO11086470A patent/CO6341578A2/es active IP Right Grant
- 2011-07-29 CR CR20110410A patent/CR20110410A/es unknown
- 2011-07-29 EC EC2011011242A patent/ECSP11011242A/es unknown
-
2017
- 2017-02-24 CY CY20171100253T patent/CY1118658T1/el unknown
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