KR20110119670A - 토실레이트 전구체로부터 18ｆ―방사성표지된 스티릴피리딘의 합성 및 그로부터의 안정한 약제학적 조성물 - Google Patents

토실레이트 전구체로부터 18ｆ―방사성표지된 스티릴피리딘의 합성 및 그로부터의 안정한 약제학적 조성물 Download PDF

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KR20110119670A
KR20110119670A KR1020117017636A KR20117017636A KR20110119670A KR 20110119670 A KR20110119670 A KR 20110119670A KR 1020117017636 A KR1020117017636 A KR 1020117017636A KR 20117017636 A KR20117017636 A KR 20117017636A KR 20110119670 A KR20110119670 A KR 20110119670A
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radiopharmaceutical composition
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radiopharmaceutical
compound
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Korean (ko)
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타일러 베네덤
제프 골딩
나다니엘 림
웨이 장
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애비드 라디오파마슈티컬스, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020117017636A 2008-12-31 2009-12-29 토실레이트 전구체로부터 18ｆ―방사성표지된 스티릴피리딘의 합성 및 그로부터의 안정한 약제학적 조성물 Ceased KR20110119670A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14188508P 2008-12-31 2008-12-31
US61/141,885 2008-12-31

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KR20110119670A true KR20110119670A (ko) 2011-11-02

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Country Link
US (1) US20100172836A1 (https=)
EP (1) EP2381967B1 (https=)
JP (1) JP5717650B2 (https=)
KR (1) KR20110119670A (https=)
CN (1) CN102271716B (https=)
AU (1) AU2009335049B2 (https=)
BR (1) BRPI0923890A2 (https=)
CA (1) CA2748705C (https=)
CO (1) CO6341578A2 (https=)
CR (1) CR20110410A (https=)
CY (1) CY1118658T1 (https=)
DK (1) DK2381967T3 (https=)
DO (1) DOP2011000210A (https=)
EA (1) EA023014B1 (https=)
EC (1) ECSP11011242A (https=)
ES (1) ES2620402T3 (https=)
HN (1) HN2011001810A (https=)
HR (1) HRP20170453T1 (https=)
HU (1) HUE033649T2 (https=)
IL (1) IL213674A (https=)
LT (1) LT2381967T (https=)
MA (1) MA33004B1 (https=)
MX (1) MX2011007063A (https=)
MY (1) MY162312A (https=)
NZ (1) NZ593848A (https=)
PE (1) PE20120007A1 (https=)
PL (1) PL2381967T3 (https=)
PT (1) PT2381967T (https=)
RS (1) RS55674B1 (https=)
SG (1) SG172439A1 (https=)
SI (1) SI2381967T1 (https=)
TN (1) TN2011000318A1 (https=)
UA (1) UA105914C2 (https=)
WO (1) WO2010078370A1 (https=)
ZA (1) ZA201104824B (https=)

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WO2017014599A1 (ko) * 2015-07-22 2017-01-26 주식회사 씨코헬스케어 [18f]플루오로-도파의 방사화학적 순도를 안정화시키는 조성물 및 이의 제조방법

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US9987379B2 (en) * 2008-09-30 2018-06-05 Case Western Reserve University Molecular probes for imaging of myelin
SG185782A1 (en) 2010-06-04 2013-01-30 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
TWI504414B (zh) * 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
WO2011151282A1 (en) * 2010-06-04 2011-12-08 Bayer Pharma Aktiengesellschaft Method for production of f-18 labeled amyloid beta ligand
EP2699157B1 (en) * 2011-04-21 2018-03-14 The Regents of The University of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
BR112013032610B1 (pt) * 2011-06-21 2022-05-31 Life Molecular Imaging Sa Formulações de estilbeno fluorado adequadas para imagiologia pet, e seus métodos de preparação, obtenção e filtração estéril
EP2768790A1 (en) 2011-10-19 2014-08-27 Piramal Imaging SA IMPROVED METHOD FOR PRODUCTION OF F-18 LABELED Aß LIGANDS
CN102432529B (zh) * 2011-11-14 2014-03-26 江苏省原子医学研究所 一种苯乙烯基吡啶二硫二氮衍生物的制备方法
US20150004100A1 (en) * 2011-12-15 2015-01-01 Ge Healthcare Limited Heterocyclic compounds as imaging probes of tau pathology
CN102526765B (zh) * 2011-12-31 2014-07-30 郑州泰基鸿诺药物科技有限公司 一种Aβ斑块显像剂及其制备方法
CN103965105A (zh) * 2013-01-29 2014-08-06 中山大学 苯乙烯基喹啉衍生物及其在治疗阿尔茨海默病症中的应用
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
CA3003884C (en) * 2015-11-13 2020-04-21 Eli Lilly And Company Azetidine derivatives for tau imaging
WO2017156303A1 (en) * 2016-03-09 2017-09-14 Case Western Reserve University Radioligands for myelin
CN107198780A (zh) * 2016-03-18 2017-09-26 南京江原安迪科正电子研究发展有限公司 放射性药物组合物及其制备方法、应用
CN106018575B (zh) * 2016-05-05 2018-10-19 江苏省原子医学研究所 一种PET显像剂前体TsOP-(+)-DTBZ及其光学异构体的分离测定方法
US10695450B2 (en) * 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
JP2019534284A (ja) * 2016-11-08 2019-11-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 臨床設定用［ｆ−１８］ｆｄｄｎｐの複数ドーズ合成方法
TW201906818A (zh) * 2017-05-31 2019-02-16 美商５１１製藥公司 新穎氘取代之正子發射斷層掃描（ｐｅｔ）顯影劑及其藥理應用
EP3743115A1 (en) * 2018-01-24 2020-12-02 AC Immune SA Diagnostic compositions for pet imaging, a method for manufacturing the diagnostic composition and its use in diagnostics
CN111499570B (zh) * 2019-01-31 2023-05-16 中国医学科学院放射医学研究所 一种av-45中间体的合成方法
CN111499544B (zh) * 2019-01-31 2022-12-02 中国医学科学院放射医学研究所 一种一锅法制备N-Boc-N-甲基-4-氨基苯乙烯的合成方法
WO2020202831A1 (ja) * 2019-03-29 2020-10-08 国立研究開発法人量子科学技術研究開発機構 放射性医薬の製造方法及び放射性医薬
CN115400232A (zh) * 2021-05-26 2022-11-29 汉中汉核医疗科技有限公司 一种放射性药物合成方法
CN115403434A (zh) * 2021-05-26 2022-11-29 汉中汉核医疗科技有限公司 一种放射性药物的合成方法
CN113582885B (zh) * 2021-08-30 2023-04-21 南京克米斯璀新能源科技有限公司 一种烷基磺酸钠的生产方法
CN114805190A (zh) * 2022-06-08 2022-07-29 吉林大学第一医院 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法
WO2024107620A1 (en) * 2022-11-14 2024-05-23 Eli Lilly And Company Polymorphic forms of florbetapir precursor av-105
CN119080714A (zh) * 2024-09-12 2024-12-06 四川大学 一种偶氮苯磺酸酯化合物及其制备方法和应用、放射性探针的制备方法

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JP2007525211A (ja) * 2004-01-19 2007-09-06 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド パーキンソン病の診断検査
EP2213652B1 (en) * 2004-12-17 2014-10-22 The Trustees of The University of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
PL1999109T3 (pl) * 2006-03-30 2012-05-31 Univ Pennsylvania Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017014599A1 (ko) * 2015-07-22 2017-01-26 주식회사 씨코헬스케어 [18f]플루오로-도파의 방사화학적 순도를 안정화시키는 조성물 및 이의 제조방법

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MX2011007063A (es) 2011-12-16
BRPI0923890A2 (pt) 2015-07-28
CR20110410A (es) 2011-12-08
AU2009335049A1 (en) 2011-07-21
IL213674A0 (en) 2011-07-31
EP2381967A1 (en) 2011-11-02
RS55674B1 (sr) 2017-06-30
PT2381967T (pt) 2017-02-24
TN2011000318A1 (en) 2012-12-17
HRP20170453T1 (hr) 2017-06-02
DOP2011000210A (es) 2011-09-15
ES2620402T3 (es) 2017-06-28
ECSP11011242A (es) 2011-10-31
HK1162951A1 (en) 2012-09-07
CN102271716B (zh) 2014-11-19
IL213674A (en) 2016-04-21
PE20120007A1 (es) 2012-01-16
JP5717650B2 (ja) 2015-05-13
JP2012514007A (ja) 2012-06-21
MY162312A (en) 2017-05-31
MA33004B1 (fr) 2012-01-02
SI2381967T1 (sl) 2017-03-31
WO2010078370A1 (en) 2010-07-08
EA201170911A1 (ru) 2011-12-30
CA2748705A1 (en) 2010-07-08
DK2381967T3 (en) 2017-03-27
LT2381967T (lt) 2017-04-25
US20100172836A1 (en) 2010-07-08
ZA201104824B (en) 2013-01-30
EA023014B1 (ru) 2016-04-29
PL2381967T3 (pl) 2017-06-30
EP2381967A4 (en) 2013-01-02
NZ593848A (en) 2013-09-27
HUE033649T2 (en) 2017-12-28
CY1118658T1 (el) 2017-07-12
CN102271716A (zh) 2011-12-07
EP2381967B1 (en) 2017-01-18
HN2011001810A (es) 2013-08-12
UA105914C2 (uk) 2014-07-10
CO6341578A2 (es) 2011-11-21
CA2748705C (en) 2017-05-02
AU2009335049B2 (en) 2015-07-16
SG172439A1 (en) 2011-07-28

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