ES2581840T3 - Pirazolilaminoquinazolina ópticamente activa y composiciones farmacéuticas y métodos de uso de la misma - Google Patents

Pirazolilaminoquinazolina ópticamente activa y composiciones farmacéuticas y métodos de uso de la misma Download PDF

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Publication number
ES2581840T3
ES2581840T3 ES11758009.2T ES11758009T ES2581840T3 ES 2581840 T3 ES2581840 T3 ES 2581840T3 ES 11758009 T ES11758009 T ES 11758009T ES 2581840 T3 ES2581840 T3 ES 2581840T3
Authority
ES
Spain
Prior art keywords
acid
rucl2
methyl
optically active
quinazolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11758009.2T
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English (en)
Spanish (es)
Inventor
Mark W. Holladay
Eduardo Setti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ambit Bioscience Corp
Original Assignee
Ambit Bioscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambit Bioscience Corp filed Critical Ambit Bioscience Corp
Application granted granted Critical
Publication of ES2581840T3 publication Critical patent/ES2581840T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3833—Chiral chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES11758009.2T 2010-09-01 2011-08-31 Pirazolilaminoquinazolina ópticamente activa y composiciones farmacéuticas y métodos de uso de la misma Active ES2581840T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37928610P 2010-09-01 2010-09-01
US37928010P 2010-09-01 2010-09-01
US379286P 2010-09-01
US379280P 2010-09-01
PCT/US2011/049895 WO2012030913A1 (en) 2010-09-01 2011-08-31 An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
ES2581840T3 true ES2581840T3 (es) 2016-09-07

Family

ID=45698050

Family Applications (2)

Application Number Title Priority Date Filing Date
ES11758009.2T Active ES2581840T3 (es) 2010-09-01 2011-08-31 Pirazolilaminoquinazolina ópticamente activa y composiciones farmacéuticas y métodos de uso de la misma
ES11758010.0T Active ES2579942T3 (es) 2010-09-01 2011-08-31 Pirazolilaminoquinazolina ópticamente activa y composiciones farmacéuticas y métodos de uso de la misma

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES11758010.0T Active ES2579942T3 (es) 2010-09-01 2011-08-31 Pirazolilaminoquinazolina ópticamente activa y composiciones farmacéuticas y métodos de uso de la misma

Country Status (9)

Country Link
US (5) US8912324B2 (enExample)
EP (2) EP2611796B1 (enExample)
JP (2) JP5932794B2 (enExample)
AR (2) AR082875A1 (enExample)
AU (2) AU2011296078B2 (enExample)
CA (2) CA2809994A1 (enExample)
ES (2) ES2581840T3 (enExample)
TW (2) TW201305143A (enExample)
WO (2) WO2012030913A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2581840T3 (es) * 2010-09-01 2016-09-07 Ambit Biosciences Corporation Pirazolilaminoquinazolina ópticamente activa y composiciones farmacéuticas y métodos de uso de la misma
EP2611792B1 (en) * 2010-09-01 2017-02-01 Ambit Biosciences Corporation Hydrobromide salts of a pyrazolylaminoquinazoline
US9611253B2 (en) 2012-02-29 2017-04-04 Ambit Biosciences Corporation Solid forms comprising optically active pyrazolylaminoquinazoline, compositions thereof, and uses therewith
DK3179992T3 (da) 2014-08-11 2022-07-11 Acerta Pharma Bv Terapeutisk kombination af en btk-inhibitor, en pd-1-inhibitor og/eller en pd-l1-inhibitor
DK3179991T3 (da) 2014-08-11 2021-12-06 Acerta Pharma Bv Terapeutiske kombinationer af en btk-inhibitor og en bcl-2-inhibitor
WO2016024232A1 (en) 2014-08-11 2016-02-18 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor and/or a cdk 4/6 inhibitor
WO2024032527A1 (zh) * 2022-08-08 2024-02-15 石药集团中奇制药技术（石家庄）有限公司 一种含有三环杂芳基的化合物的用途
WO2024201533A1 (en) * 2023-03-31 2024-10-03 Sava Healthcare Limited A parenteral composition of cinnamic acid
CN118239990B (zh) * 2024-05-28 2025-03-14 北京元延医药科技股份有限公司 不对称氢化催化合成药物的稀有贵金属和手性膦的配合物

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Also Published As

Publication number Publication date
JP2013536853A (ja) 2013-09-26
US20150141443A1 (en) 2015-05-21
JP5933554B2 (ja) 2016-06-15
AU2011296074A1 (en) 2013-03-28
US8952020B2 (en) 2015-02-10
EP2611795B1 (en) 2016-05-04
WO2012030913A1 (en) 2012-03-08
ES2579942T3 (es) 2016-08-17
US20120053193A1 (en) 2012-03-01
EP2611796B1 (en) 2016-04-20
WO2012030917A1 (en) 2012-03-08
US9295672B2 (en) 2016-03-29
CA2809993A1 (en) 2012-03-08
AU2011296078A1 (en) 2013-03-28
AU2011296078B2 (en) 2015-06-18
US8703943B2 (en) 2014-04-22
US20120053194A1 (en) 2012-03-01
EP2611796A1 (en) 2013-07-10
AU2011296074B2 (en) 2015-06-18
TW201305143A (zh) 2013-02-01
CA2809994A1 (en) 2012-03-08
US8912324B2 (en) 2014-12-16
EP2611795A1 (en) 2013-07-10
AR082875A1 (es) 2013-01-16
US20140194449A1 (en) 2014-07-10
AR082874A1 (es) 2013-01-16
TW201302732A (zh) 2013-01-16
US20150353528A1 (en) 2015-12-10
JP5932794B2 (ja) 2016-06-08
JP2013536854A (ja) 2013-09-26

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