ES2580173T3 - Combinaciones sinérgicas de carotenoides y polifenoles - Google Patents
Combinaciones sinérgicas de carotenoides y polifenoles Download PDFInfo
- Publication number
- ES2580173T3 ES2580173T3 ES10731120.1T ES10731120T ES2580173T3 ES 2580173 T3 ES2580173 T3 ES 2580173T3 ES 10731120 T ES10731120 T ES 10731120T ES 2580173 T3 ES2580173 T3 ES 2580173T3
- Authority
- ES
- Spain
- Prior art keywords
- therapeutic composition
- lutein
- pge2
- peritonitis
- lycopene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000021466 carotenoid Nutrition 0.000 title abstract 2
- 150000001747 carotenoids Chemical class 0.000 title abstract 2
- 150000008442 polyphenolic compounds Chemical class 0.000 title 1
- 235000013824 polyphenols Nutrition 0.000 title 1
- 239000011885 synergistic combination Substances 0.000 title 1
- QRYRORQUOLYVBU-VBKZILBWSA-N carnosic acid Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 abstract 4
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 abstract 4
- 235000012680 lutein Nutrition 0.000 abstract 3
- 239000001656 lutein Substances 0.000 abstract 3
- 229960005375 lutein Drugs 0.000 abstract 3
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 abstract 3
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- 230000001225 therapeutic effect Effects 0.000 abstract 3
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 abstract 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 2
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 abstract 2
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 abstract 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 abstract 2
- 235000013734 beta-carotene Nutrition 0.000 abstract 2
- 239000011648 beta-carotene Substances 0.000 abstract 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 abstract 2
- 229960002747 betacarotene Drugs 0.000 abstract 2
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract 2
- 229960002986 dinoprostone Drugs 0.000 abstract 2
- 235000012661 lycopene Nutrition 0.000 abstract 2
- 239000001751 lycopene Substances 0.000 abstract 2
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 abstract 2
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- 206010034674 peritonitis Diseases 0.000 abstract 2
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 abstract 2
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 abstract 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 abstract 2
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 abstract 1
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- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 abstract 1
- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 abstract 1
- QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 abstract 1
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- Physical Education & Sports Medicine (AREA)
Abstract
Una composición terapéutica para su uso en el tratamiento de afecciones inflamatorias en el que los iones superóxido, el NO, el TNF-alfa y/o la PGE2 actúan como modulador o mediador de dicha afección mediante la inhibición o la reducción de la producción de iones superóxido, NO, TNF-alfa y/o PGE2 en un sujeto humano, en donde la afección que se va a tratar se selecciona entre el grupo que consiste en artritis reumatoide, síndrome de insuficiencia respiratoria en el adulto (ARDS), asma, rinitis, fibrosis pulmonar idiopática, peritonitis, inflamación cardiovascular, isquemia miocárdica, lesión por reperfusión, ateroesclerosis, septicemia, traumatismo, diabetes tipo II, retinopatía, psoriasis, inflamación gastrointestinal, cirrosis, peritonitis y enfermedad inflamatoria intestinal, y enfermedades neurodegenerativas, incluyendo la enfermedad de Alzheimer; comprendiendo dicha composición terapéutica ácido carnósico y dos o más carotenoides seleccionados entre el grupo que consiste en luteína, licopeno y beta-caroteno, en donde la zeaxantina comprende hasta el 15 % del contenido de luteína, y en donde dichos componentes están presentes en los siguientes intervalos de peso: licopeno : luteína : beta-caroteno : ácido carnósico : 0,1-1,0 : 0,1-1,0 : 0,1-1,0 : 0,1-1,0 y en donde cada uno de los agentes activos en dicha composición terapéutica se ha de administrar en una cantidad diaria en el intervalo de 1 a 5 mg.
Description
Claims (1)
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PCT/IL2010/000045 WO2010082205A1 (en) | 2009-01-19 | 2010-01-19 | Synergistic combinations of carotenoids and polyphenols |
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PL2381935T3 (pl) | 2016-11-30 |
JP2012515198A (ja) | 2012-07-05 |
AU2010205367A1 (en) | 2011-08-11 |
JP5778584B2 (ja) | 2015-09-16 |
CN105193777A (zh) | 2015-12-30 |
EP3085365A3 (en) | 2017-01-04 |
EP3085365A2 (en) | 2016-10-26 |
JP2015205882A (ja) | 2015-11-19 |
US20120071550A1 (en) | 2012-03-22 |
CN105193777B (zh) | 2019-06-28 |
BRPI1005154A2 (pt) | 2018-02-06 |
EP2381935A1 (en) | 2011-11-02 |
RU2563991C2 (ru) | 2015-09-27 |
CA2749202A1 (en) | 2010-07-22 |
CN102355894A (zh) | 2012-02-15 |
EP2381935A4 (en) | 2013-03-13 |
AU2010205367B2 (en) | 2015-06-18 |
CN102355894B (zh) | 2016-06-15 |
WO2010082205A1 (en) | 2010-07-22 |
RU2011134652A (ru) | 2013-02-27 |
EP2381935B1 (en) | 2016-06-01 |
US20170035713A1 (en) | 2017-02-09 |
CA2749202C (en) | 2019-11-26 |
US20220079901A1 (en) | 2022-03-17 |
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