JP7005043B2 - 網膜保護組成物 - Google Patents
網膜保護組成物 Download PDFInfo
- Publication number
- JP7005043B2 JP7005043B2 JP2020117981A JP2020117981A JP7005043B2 JP 7005043 B2 JP7005043 B2 JP 7005043B2 JP 2020117981 A JP2020117981 A JP 2020117981A JP 2020117981 A JP2020117981 A JP 2020117981A JP 7005043 B2 JP7005043 B2 JP 7005043B2
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- Prior art keywords
- retinal
- present
- lutein
- shows
- composition
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Images
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
(a)葛、稲、及びココヤシから選ばれる少なくとも1種の植物素材
(b)アルギニン、フェニルアラニン、セリン、トレオニン、トリプトファン、及びチロシンから選ばれる少なくとも1種のアミノ酸
(c)没食子酸、及びクロロゲン酸から選ばれる少なくとも1種のポリフェノール
(d)ビタミンB1、ビタミンD3、ビオチン、ビタミンK、カルシウム、マンガン、亜鉛、鉄、モリブデン、及びクロムから選ばれる少なくとも1種のビタミン・ミネラル類
本発明に用いられるルテインは、植物の葉、花、果実等に存在するカロテノイドの一種であり、植物由来のものを用いることができる。例えば、ルテインを多く含むマリーゴールド由来のものを使用することができる。また、合成により製造されたものを用いることもできる。
(a)植物素材
本発明の網膜保護組成物においては、ルテインと共に、有効成分として、葛、稲、及びココヤシから選ばれる少なくとも1種の植物素材を用いることが好ましい。
本発明の網膜保護組成物においては、ルテインと共に、有効成分として、アルギニン、フェニルアラニン、セリン、トレオニン、トリプトファン、及びチロシンから選ばれる少なくとも1種のアミノ酸(塩を含む)を用いることが好ましい。塩としては、例えば、ナトリウム塩、塩酸塩等を挙げることができる。
本発明の網膜保護組成物においては、ルテインと共に、有効成分として、没食子酸、及びクロロゲン酸から選ばれる少なくとも1種のポリフェノールを用いることが好ましい。
本発明の網膜保護組成物においては、ルテインと共に、有効成分として、ビタミンB1、ビタミンD3、ビオチン、ビタミンK、カルシウム、マンガン、亜鉛、鉄、モリブデン、及びクロムから選ばれる少なくとも1種のビタミン・ミネラル類を用いることが好ましい。なお、本発明のミネラル類としてのカルシウム、マンガン、亜鉛、鉄、モリブデン、及びクロムは、これらの金属を含む化合物の形態を含む。
[実施例1]
1.細胞培養
(1)37℃、5%CO2インキュベーター内で、75cm2フラスコを用いて、ヒト網膜色素上皮細胞(ARPE-19)を培養した。培地はDMEM培地とF-12HAM培地を1:1で混合し、FBSが10%となるように調製したものを用いた。
(2)トリプシン処理により浮遊させた細胞を、75cm2フラスコから96well plateの各wellに1.0×104cells/wellの細胞密度で播種した。
(3)37℃、5%CO2インキュベーター内で72時間前培養した。
(4)各wellより培地を除去後、所定濃度に調製した被験物質含有培地を200μLずつ添加し、CO2インキュベーター内で20時間培養した。
(1)20時間培養後、培養した細胞から培地を除去し、CellAmpTM Direct RNA Prep Kit for RT-PCR(Real Time)(Takara製)を用いて、RNAを回収し、N=3のサンプルを混合して1つのRNAサンプルとした。
(2)検量線を作成するため、1つのサンプルを3倍、9倍希釈した。One Step SYBR(登録商標) PrimeScriptTM RT-PCR Kit II(Perfect Real Time)(Takara製)を用いてPCRを実施した。プライマーはTGFβ1(QIAGEN製)とRPLP0(QIAGEN製)を使用した。
(3)1倍、3倍、9倍希釈したサンプルから作成した検量線を用いて、各サンプルにおける遺伝子発現量を算出した。解析は相対定量により行い、RPLP0(ハウスキーピング遺伝子)を内部標準としてmRNA量を補正した。
米ぬかについては、市販品を用いた。
ココナッツについては、市販のココナッツミルクを乾燥後、油分を除いたものを用いた。
ヨモギについては、生葉の微粉砕末を用いた。
マキベリーについては、市販品の果実の乾燥粉末を用いた。
下記成分からなるタブレット(200mg)を製造した。
ビルベリー抽出物 60mg
ブルーベリー抽出物 50mg
ステアリン酸カルシウム 5mg
アルギニン 1.5mg
フェニルアラニン 1.5mg
トリプトファン 1mg
クロロゲン酸 1mg
ビタミンB1 0.5mg
ビタミンK 0.5mg
塩化カルシウム 0.5mg
グルコン酸亜鉛 0.5mg
セルロース 残部
下記混合物をソフトカプセルに封入し、カプセル剤を製造した。
ルテイン(マリーゴールド抽出物) 30%(ルテインとして20mg)
紅花油 50%
ミツロウ 10%
葛の花エキス 2%
ブルーベリーエキス 1%
水溶性β-カロテン末 0.2%
ヘマトコッカス藻色素 0.2%
ビタミンB12 0.01%
ビオチン 0.01%
没食子酸 0.01%
ビタミンE 0.01%
塩化鉄 0.01%
下記成分を混合して常法により顆粒剤(3000mg)を製造した。
松樹皮抽出物 50mg
ココナッツミルク 200mg
アスパルテーム 500mg
チロシン 50mg
トレオニン 50mg
トリプトファン 30mg
クロロゲン酸 20mg
ビタミンB1 5mg
ビタミンK 5mg
塩化カルシウム 2mg
グルコン酸銅 1mg
デキストリン 残部
下記成分からなる液剤(125mL)を製造した。
ビルベリー抽出物 150mg
カシス抽出物 50mg
米ぬか抽出物 25mg
ビタミンC 10mg
クエン酸 5mg
アルギニン 1.5mg
フェニルアラニン 1.5mg
トリプトファン 1mg
ビタミンB1 0.5mg
ビタミンK 0.5mg
塩化カルシウム 0.5mg
グルコン酸亜鉛 0.5mg
水 残部
Claims (1)
- ルテインを有効成分とする網膜保護用組成物であって、さらに、アルギニン、フェニルアラニン、トレオニン及びトリプトファンから選ばれる少なくとも1種のアミノ酸を含有することを特徴とする網膜保護用組成物。
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JP2010105972A (ja) | 2008-10-31 | 2010-05-13 | Nippon Menaade Keshohin Kk | 水溶性カロテノイド組成物 |
JP2013078318A (ja) | 2006-06-08 | 2013-05-02 | Iams Co | 眼の健康を増進するための少なくとも一つのポリフェノールの使用 |
JP2014140366A (ja) | 2012-12-28 | 2014-08-07 | Kao Corp | 小麦ふすま加工品 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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JP2010502597A (ja) | 2006-08-29 | 2010-01-28 | アトゥクリトーイェ・アクチアニェルノーイェ・アブシェーストゥヴォ・ザヴォートゥ・エカロギチェスコーイ・テェフニーキ・イ・エカピターニャ・“ディオートゥ” | 眼疾患治療剤 |
JP2010105972A (ja) | 2008-10-31 | 2010-05-13 | Nippon Menaade Keshohin Kk | 水溶性カロテノイド組成物 |
JP2014140366A (ja) | 2012-12-28 | 2014-08-07 | Kao Corp | 小麦ふすま加工品 |
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Title |
---|
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