ES2576959T3 - Peptidomiméticos fijados sobre plantilla como inhibidores del FPR1 - Google Patents
Peptidomiméticos fijados sobre plantilla como inhibidores del FPR1 Download PDFInfo
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- ES2576959T3 ES2576959T3 ES12768803.4T ES12768803T ES2576959T3 ES 2576959 T3 ES2576959 T3 ES 2576959T3 ES 12768803 T ES12768803 T ES 12768803T ES 2576959 T3 ES2576959 T3 ES 2576959T3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Compuesto de la fórmula general (I), ciclo[P1-P2-P3-P4-P5-P6-P7-P8-P9-P10-P11-P12-P13-P14-T1-T2] (I) en la que los elementos individuales T o P están conectados en cualquier dirección desde el punto de unión al carbonilo (C >= O) al nitrógeno (N) del elemento siguiente y en la que T1 es un D α-aminoácido de origen natural o no natural que contiene en total de 1 a 25 átomos de carbono y/o heteroátomos en una cadena lateral sencilla; T1 es un L α-aminoácido de origen natural o no natural que contiene en total de 1 a 25 átomos de carbono y/o heteroátomos en una cadena lateral sencilla; P1, P3, P12, P13 y P14 son independientemente Gly o un L α-aminoácido de origen natural o no natural que contiene en total de 1 a 25 átomos de carbono y/o heteroátomos en una cadena lateral sencilla; P2, P5 y P8 son independientemente un L α-aminoácido aromático de origen natural o no natural que contiene en total de 1 a 25 átomos de carbono y/o heteroátomos en una cadena lateral sencilla; P4 y P11 son L α-aminoácidos reticulantes de origen natural o no natural que contienen cada uno en total de 1 a 12 átomos de carbono y/o heteroátomos en una cadena lateral sencilla que, juntos, están uniendo P4 y P11 mediante interacciones covalentes o electrostáticas; P6 es Gly; P7 es un D α-aminoácido de origen natural o no natural que contiene en total de 1 a 25 átomos de carbono y/o heteroátomos en una cadena lateral sencilla; P9 es un L α-aminoácido alcohólico de origen natural o no natural que contiene en total de 1 a 25 átomos de carbono y/o heteroátomos en una cadena lateral sencilla; y P10 es un L α-aminoácido alifático de origen natural o no natural que contiene en total de 1 a 25 átomos de carbono y/o heteroátomos en una cadena lateral sencilla; o un tautómero o rotámero de los mismos, o una sal, o un hidrato o solvato de los mismos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11008121 | 2011-10-07 | ||
| EP11008121 | 2011-10-07 | ||
| PCT/EP2012/069412 WO2013050346A1 (en) | 2011-10-07 | 2012-10-02 | Template -fixed peptidomimetics as inhibitors of fpr1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2576959T3 true ES2576959T3 (es) | 2016-07-12 |
| ES2576959T9 ES2576959T9 (es) | 2017-05-29 |
Family
ID=46970289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12768803.4T Active ES2576959T3 (es) | 2011-10-07 | 2012-10-02 | Peptidomiméticos fijados sobre plantilla como inhibidores del FPR1 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9957297B2 (es) |
| EP (1) | EP2764010B9 (es) |
| JP (1) | JP6294227B2 (es) |
| CN (1) | CN103842373B (es) |
| AU (2) | AU2012320674A1 (es) |
| CA (1) | CA2848584C (es) |
| ES (1) | ES2576959T3 (es) |
| IL (1) | IL231756B (es) |
| MX (1) | MX349788B (es) |
| SG (1) | SG11201400354PA (es) |
| WO (1) | WO2013050346A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2132221T3 (pl) | 2007-02-28 | 2011-04-29 | Polyphor Ltd | Przyłączone do matrycy peptydomimetyki |
| US10259847B2 (en) | 2014-09-30 | 2019-04-16 | Polyphor Ag | Beta-hairpin peptidomimetics |
| JP6873043B2 (ja) * | 2015-03-23 | 2021-05-19 | ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ | ベータ−ヘアピンペプチド模倣体 |
| CN109922818B (zh) * | 2016-09-06 | 2024-02-20 | 主线生物科学公司 | Cxcr4拮抗剂及使用方法 |
| CN111909238B (zh) * | 2017-06-29 | 2022-04-08 | 安徽省农业科学院农产品加工研究所 | 一种含有Ser-Cys的高锌螯合活性锌螯合肽及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7253146B2 (en) | 2001-02-23 | 2007-08-07 | Polyphor Ltd | Template-fixed peptidomimetics with antimicrobial activity |
| AU2002342618C1 (en) * | 2002-08-20 | 2008-10-30 | Polyphor Ltd. | Template-fixed peptidomimetics with antibacterial activity |
| WO2004096839A1 (en) | 2003-05-02 | 2004-11-11 | Polyphor Ag | Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity |
| KR100831633B1 (ko) * | 2004-02-04 | 2008-05-22 | 포항공과대학교 산학협력단 | Ｆｐｒ 계열 수용체 매개 신호전달에 대하여 길항작용 하는펩티드 |
| WO2006117011A1 (en) | 2005-05-02 | 2006-11-09 | Polyphor Ltd. | Dye conjugates of template-fixed peptidomimetics |
| PL2132221T3 (pl) * | 2007-02-28 | 2011-04-29 | Polyphor Ltd | Przyłączone do matrycy peptydomimetyki |
| US8883720B2 (en) | 2008-11-26 | 2014-11-11 | Polyphor Ag | Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity |
| WO2010127704A1 (en) | 2009-05-07 | 2010-11-11 | Polyphor Ag | Beta-hairpin peptidomimetics having cxcr4 antagonizing activity |
| NZ596868A (en) * | 2009-06-02 | 2014-04-30 | Nikan Pharmaceuticals Llc | Antagonism of human formyl peptide receptor for treatment of disease |
| WO2011066869A1 (en) | 2009-12-04 | 2011-06-09 | Polyphor Ag | Beta-hairpin peptidomimetics |
-
2012
- 2012-10-02 WO PCT/EP2012/069412 patent/WO2013050346A1/en active Application Filing
- 2012-10-02 CN CN201280048985.4A patent/CN103842373B/zh active Active
- 2012-10-02 ES ES12768803.4T patent/ES2576959T3/es active Active
- 2012-10-02 EP EP12768803.4A patent/EP2764010B9/en active Active
- 2012-10-02 US US14/349,683 patent/US9957297B2/en active Active
- 2012-10-02 CA CA2848584A patent/CA2848584C/en active Active
- 2012-10-02 MX MX2014003960A patent/MX349788B/es active IP Right Grant
- 2012-10-02 JP JP2014533851A patent/JP6294227B2/ja active Active
- 2012-10-02 SG SG11201400354PA patent/SG11201400354PA/en unknown
- 2012-10-02 AU AU2012320674A patent/AU2012320674A1/en not_active Abandoned
-
2014
- 2014-03-27 IL IL231756A patent/IL231756B/en active IP Right Grant
-
2017
- 2017-06-19 AU AU2017204122A patent/AU2017204122B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012320674A1 (en) | 2014-03-20 |
| CN103842373B (zh) | 2018-12-21 |
| CA2848584C (en) | 2020-03-24 |
| CN103842373A (zh) | 2014-06-04 |
| EP2764010B9 (en) | 2017-01-18 |
| SG11201400354PA (en) | 2014-09-26 |
| CA2848584A1 (en) | 2013-04-11 |
| US9957297B2 (en) | 2018-05-01 |
| MX349788B (es) | 2017-08-11 |
| IL231756A0 (en) | 2014-05-28 |
| IL231756B (en) | 2019-06-30 |
| NZ621974A (en) | 2015-06-26 |
| MX2014003960A (es) | 2014-05-14 |
| JP2014528958A (ja) | 2014-10-30 |
| EP2764010B1 (en) | 2016-03-16 |
| AU2017204122A1 (en) | 2017-07-06 |
| ES2576959T9 (es) | 2017-05-29 |
| JP6294227B2 (ja) | 2018-03-14 |
| EP2764010A1 (en) | 2014-08-13 |
| WO2013050346A1 (en) | 2013-04-11 |
| US20140287986A1 (en) | 2014-09-25 |
| AU2017204122B2 (en) | 2019-05-02 |
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