BR112015031679A2 - conjugado de peptídeo-resina e seu uso - Google Patents

conjugado de peptídeo-resina e seu uso

Info

Publication number
BR112015031679A2
BR112015031679A2 BR112015031679A BR112015031679A BR112015031679A2 BR 112015031679 A2 BR112015031679 A2 BR 112015031679A2 BR 112015031679 A BR112015031679 A BR 112015031679A BR 112015031679 A BR112015031679 A BR 112015031679A BR 112015031679 A2 BR112015031679 A2 BR 112015031679A2
Authority
BR
Brazil
Prior art keywords
peptide
natural
amino acid
optionally protected
unnatural amino
Prior art date
Application number
BR112015031679A
Other languages
English (en)
Other versions
BR112015031679B1 (pt
BR112015031679A8 (pt
Inventor
Gatos Dimitrios
Barlos Kleomenis
Barlos Kostas
Original Assignee
Chemical & Biopharmaceutical Laboratories Of Patras S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemical & Biopharmaceutical Laboratories Of Patras S A filed Critical Chemical & Biopharmaceutical Laboratories Of Patras S A
Publication of BR112015031679A2 publication Critical patent/BR112015031679A2/pt
Publication of BR112015031679A8 publication Critical patent/BR112015031679A8/pt
Publication of BR112015031679B1 publication Critical patent/BR112015031679B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

a presente invenção refere-se a um conjugado de peptídeo-resina de fórmula (2), em que: pr1 é selecionado de h, alquila, arila, aralquila, acila, aroíla e um grupo de proteção; y é uma ligação direta; ou um resíduo de aminoácido natural ou não natural opcionalmente protegido; ou um peptídeo compreendendo de 2 a 200 resíduos de aminoácido naturais ou não naturais, cada um dos quais é opcionalmente protegido; dia é um diaminoácido natural ou não natural; a é uma resina polimérica conjugada com a função amino da cadeia lateral do diaminoácido; x é um resíduo de aminoácido natural ou não natural opcionalmente protegido; ou um peptídeo compreendendo de 2 a 15 resíduos de aminoácido naturais ou não naturais, cada um dos quais é opcionalmente protegido; r1 e r2 são cada um independentemente selecionado de h, alquila, arila, aralquila, nh2, nh-co-nh2. outros aspectos da invenção referem-se a um processo de preparação do conjugado de peptídeo-resina de fórmula (2), e seu uso na preparação de peptídeos.
BR112015031679-4A 2013-06-19 2014-06-19 Método para a preparação de um peptídeo contendo arginina ou homo-arginina BR112015031679B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1310921-0 2013-06-19
GBGB1310921.0A GB201310921D0 (en) 2013-06-19 2013-06-19 Peptide-resin conjugate and use thereof
PCT/IB2014/062430 WO2014203193A1 (en) 2013-06-19 2014-06-19 Peptide-resin conjugate and use thereof

Publications (3)

Publication Number Publication Date
BR112015031679A2 true BR112015031679A2 (pt) 2017-07-25
BR112015031679A8 BR112015031679A8 (pt) 2021-06-29
BR112015031679B1 BR112015031679B1 (pt) 2024-03-05

Family

ID=48914802

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015031679-4A BR112015031679B1 (pt) 2013-06-19 2014-06-19 Método para a preparação de um peptídeo contendo arginina ou homo-arginina

Country Status (10)

Country Link
US (1) US20160137689A1 (pt)
EP (1) EP3010930B1 (pt)
CN (1) CN105408344B (pt)
AU (1) AU2014282839B9 (pt)
BR (1) BR112015031679B1 (pt)
CA (1) CA2915439C (pt)
ES (1) ES2753407T3 (pt)
GB (1) GB201310921D0 (pt)
HK (1) HK1217022A1 (pt)
WO (1) WO2014203193A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3088418A1 (en) * 2015-04-28 2016-11-02 Vallaurix Pte. Ltd. Pharmaceutical compound
EP3802559A1 (en) * 2018-06-05 2021-04-14 DSM IP Assets B.V. Methods for the synthesis of arginine-containing peptides
CN110041407B (zh) * 2019-02-26 2022-10-28 南京肽业生物科技有限公司 一种基于Fmoc二肽的合成醋酸德舍瑞林的方法
JP2020169141A (ja) * 2019-04-04 2020-10-15 株式会社日立製作所 樹脂との密着性に優れたペプチドならびにそれを用いた生体適合機能材料
CN115038711B (zh) * 2021-01-04 2023-05-02 湖北健翔生物制药有限公司 一种阿托西班的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006501150A (ja) * 2002-05-03 2006-01-12 アベシア・リミテッド ペプチド合成のためのプロセス
WO2006045503A1 (en) 2004-10-19 2006-05-04 Lonza Ag Method for solid phase peptide synthesis
PT1987052E (pt) 2006-02-08 2011-07-25 Lonza Ag Síntese de péptidos tipo glucagina
CA2665559A1 (en) 2006-10-05 2008-04-10 Lonza Ag Method for peptide synthesis
KR101046846B1 (ko) * 2006-10-12 2011-07-06 동국제약 주식회사 고체상 합성법을 이용한 펩타이드의 제조방법
CN102127146B (zh) * 2010-12-24 2013-04-24 深圳翰宇药业股份有限公司 一种制备醋酸阿托西班的方法
WO2013098802A2 (en) * 2011-12-29 2013-07-04 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Solid phase peptide synthesis via side chain attachment
CN102653555B (zh) * 2012-05-18 2015-04-22 深圳翰宇药业股份有限公司 一种固相制备戈舍瑞林的方法

Also Published As

Publication number Publication date
CA2915439C (en) 2021-11-09
CN105408344A (zh) 2016-03-16
AU2014282839A1 (en) 2016-01-21
ES2753407T3 (es) 2020-04-08
AU2014282839B9 (en) 2019-12-19
EP3010930B1 (en) 2019-09-18
US20160137689A1 (en) 2016-05-19
BR112015031679B1 (pt) 2024-03-05
CA2915439A1 (en) 2014-12-24
AU2014282839B2 (en) 2019-12-12
CN105408344B (zh) 2020-08-11
EP3010930A1 (en) 2016-04-27
WO2014203193A1 (en) 2014-12-24
HK1217022A1 (zh) 2016-12-16
GB201310921D0 (en) 2013-07-31
BR112015031679A8 (pt) 2021-06-29

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/06/2014, OBSERVADAS AS CONDICOES LEGAIS