ES2574987T3 - Agonista del receptor de glucocorticoides que comprende derivados de 2,2,4-trimetil-6-fenil-1,2-dihidroquinolina que tiene un grupo oxi sustituido - Google Patents

Agonista del receptor de glucocorticoides que comprende derivados de 2,2,4-trimetil-6-fenil-1,2-dihidroquinolina que tiene un grupo oxi sustituido Download PDF

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ES2574987T3
ES2574987T3 ES09746568.6T ES09746568T ES2574987T3 ES 2574987 T3 ES2574987 T3 ES 2574987T3 ES 09746568 T ES09746568 T ES 09746568T ES 2574987 T3 ES2574987 T3 ES 2574987T3
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carbon atoms
group
eczema
substituent
dermatitis
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Masatomo Kato
Miwa Takai
Takahiro Matsuyama
Tatsuji Kurose
Yumi Hagiwara
Mamoru Matsuda
Toshiyuki Mori
Kenji Imoto
Atsuyoshi Dota
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Ayumi Pharmaceutical Corp
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Ayumi Pharmaceutical Corp
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  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)

Abstract

Un compuesto representado por la fórmula (1) o una de sus sales, para usar en la prevención o tratamiento de una enfermedad: en donde R1 representa las fórmulas (2a), (3a), (4a) o (5a); R2 representa -(CO)-R8, -(CO)O-R9, -(SO)-R10, -(SO2)-R11 o -(CO)NR12R13; R2-O- es sustituyente en la posición 4 o 5 del anillo de benceno A; R3 representa un grupo alquilo que tiene de 1 a 8 átomos de carbono, preferiblemente de 1 a 6 átomos de carbono; R4, R5, R6 o R7 representa un átomo de halógeno, un grupo alquilo que tiene de 1 a 8 átomos de carbono, preferiblemente de 1 a 6 átomos de carbono, que puede tener un sustituyente, un grupo alquenilo que tiene de 2 a 8 átomos de carbono, preferiblemente de 2 a 6 átomos de carbono, un grupo alquinilo que tiene de 2 a 8 átomos de carbono, preferiblemente de 2 a 6 átomos de carbono, un grupo alcoxi que tiene de 1 a 8 átomos de carbono, preferiblemente de 1 a 6 átomos de carbono, un grupo nitro o un grupo formilo m, n, p o q representa 0,1 o 2; en el caso en el que m, n, p o q es 2, cada R4, R5, R6 o R7 pueden ser iguales o diferentes; R8, R9, R10 o R11 representa un grupo alquilo que tiene de 1 a 8 átomos de carbono, preferiblemente de 1 a 6 átomos de carbono, que puede tener un sustituyente, un grupo alquenilo que tiene de 2 a 8 átomos de carbono, preferiblemente de 2 a 6 átomos de carbono, un grupo cicloalquilo que tiene de 3 a 10 átomos de carbono, preferiblemente de 3 a 8 átomos de carbono, un grupo arilo que puede tener un sustituyente o un grupo heterocíclico que puede tener un sustituyente; R12 y R13 pueden ser iguales o diferentes y representan un átomo de hidrógeno, un grupo alquilo que tiene de 1 a 8 átomos de carbono, preferiblemente de 1 a 6 átomos de carbono, que puede tener un sustituyente, un grupo arilo que puede tener un sustituyente o un grupo heterocíclico, en donde la enfermedad se selecciona del grupo que consiste en una enfermedad inflamatoria ocular y una dermatitis seleccionada del grupo que consiste en eczema agudo, eczema subagudo, eczema crónico, dermatitis de contacto, eczema numular, dermatitis por autosensibilización, eczema infantil, liquen simple crónico de Vidal, dermatitis seborreica, queratodermia tiloidea palmar progresiva, eczema genital/anal, eczema/dermatitis del conducto auditivo externo o pabellón auditivo, eczema/dermatitis alrededor de vestíbulo nasal y aleta de la nariz, prurigo, urticaria, psoriasis, acrodermatitis, nerpetiformis impétigo, síndrome de Reiter, pustulosis palmoplantar, liquen plano, eritema, púrpura anafilactoide, enfermedad de Weber-Christian, síndrome oculocutáneo, enfermedad de Reynaud, alopecia areata, pénfigo, dermatitis herpetiforme de Dühring, epidermolisis bullosa hereditaria, herpes zoster, eritrodermia, lupus miliaris disseminates faciei, angitis alérgica, pitiriasis liquenoide et varioliforme aguda, pioderma ulcerosa crónica y esclerema neonatal.
ES09746568.6T 2008-05-12 2009-05-12 Agonista del receptor de glucocorticoides que comprende derivados de 2,2,4-trimetil-6-fenil-1,2-dihidroquinolina que tiene un grupo oxi sustituido Active ES2574987T3 (es)

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CA2724055A1 (en) 2009-11-19
CN102089283B (zh) 2015-11-25
UA102101C2 (ru) 2013-06-10
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CN105395550A (zh) 2016-03-16
EP2319835B1 (en) 2016-04-13
AU2009247250B2 (en) 2014-04-10
CA2724055C (en) 2016-08-02
WO2009139361A1 (ja) 2009-11-19
TWI510240B (zh) 2015-12-01
EP2319835A4 (en) 2011-12-28
MY158747A (en) 2016-11-15
BRPI0912171B1 (pt) 2020-11-03
MX2010012303A (es) 2011-03-30
EP2319835A1 (en) 2011-05-11
JP2009298775A (ja) 2009-12-24
US8426406B2 (en) 2013-04-23
US20110118260A1 (en) 2011-05-19
EA201071296A1 (ru) 2011-06-30
BRPI0912171A2 (pt) 2017-10-31
CN102089283A (zh) 2011-06-08
BRPI0912171A8 (pt) 2017-12-12
AU2009247250A1 (en) 2009-11-19
BRPI0912171B8 (pt) 2021-05-25
KR20110010634A (ko) 2011-02-01
GEP20146061B (en) 2014-03-25
CN105395550B (zh) 2018-07-17
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