BRPI0912171B8 - composto ativador de receptor de glicocorticoide, e, composição - Google Patents
composto ativador de receptor de glicocorticoide, e, composiçãoInfo
- Publication number
- BRPI0912171B8 BRPI0912171B8 BRPI0912171A BRPI0912171A BRPI0912171B8 BR PI0912171 B8 BRPI0912171 B8 BR PI0912171B8 BR PI0912171 A BRPI0912171 A BR PI0912171A BR PI0912171 A BRPI0912171 A BR PI0912171A BR PI0912171 B8 BRPI0912171 B8 BR PI0912171B8
- Authority
- BR
- Brazil
- Prior art keywords
- glucocorticoid receptor
- formula
- lower alkyl
- composition
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 102000003676 Glucocorticoid Receptors Human genes 0.000 title 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 title 1
- 230000003213 activating effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- XKBGEVHKVFIMLY-UHFFFAOYSA-N 2,2,4-trimethyl-6-phenyl-1h-quinoline Chemical compound C1=C2C(C)=CC(C)(C)NC2=CC=C1C1=CC=CC=C1 XKBGEVHKVFIMLY-UHFFFAOYSA-N 0.000 abstract 1
- JFUAWXPBHXKZGA-IBGZPJMESA-N 4-fluoro-2-[(4r)-5,5,5-trifluoro-4-hydroxy-2-methyl-4-(1h-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol Chemical compound C([C@@](O)(CC=1NC2=CN=CC=C2C=1)C(F)(F)F)C(C)(C)C1=CC(F)=CC=C1O JFUAWXPBHXKZGA-IBGZPJMESA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 229940124750 glucocorticoid receptor agonist Drugs 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008-127414 | 2008-05-12 | ||
JP2008124714 | 2008-05-12 | ||
PCT/JP2009/058801 WO2009139361A1 (ja) | 2008-05-12 | 2009-05-12 | 置換オキシ基を有する2,2,4-トリメチル-6-フェニル-1,2-ジヒドロキノリン誘導体からなるグルココルチコイド受容体アゴニスト |
Publications (4)
Publication Number | Publication Date |
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BRPI0912171A2 BRPI0912171A2 (pt) | 2017-10-31 |
BRPI0912171A8 BRPI0912171A8 (pt) | 2017-12-12 |
BRPI0912171B1 BRPI0912171B1 (pt) | 2020-11-03 |
BRPI0912171B8 true BRPI0912171B8 (pt) | 2021-05-25 |
Family
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Family Applications (1)
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BRPI0912171A BRPI0912171B8 (pt) | 2008-05-12 | 2009-05-12 | composto ativador de receptor de glicocorticoide, e, composição |
Country Status (16)
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US (1) | US8426406B2 (pt) |
EP (1) | EP2319835B1 (pt) |
JP (1) | JP5635743B2 (pt) |
KR (1) | KR20110010634A (pt) |
CN (2) | CN102089283B (pt) |
AU (1) | AU2009247250B2 (pt) |
BR (1) | BRPI0912171B8 (pt) |
CA (1) | CA2724055C (pt) |
EA (1) | EA019091B1 (pt) |
ES (1) | ES2574987T3 (pt) |
GE (1) | GEP20146061B (pt) |
MX (1) | MX2010012303A (pt) |
MY (1) | MY158747A (pt) |
TW (1) | TWI510240B (pt) |
UA (1) | UA102101C2 (pt) |
WO (1) | WO2009139361A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20090086539A (ko) | 2006-11-14 | 2009-08-13 | 산텐 세이야꾸 가부시키가이샤 | (치환 페닐 또는 치환 복소환) 카르보닐옥시 저급 알킬기와 에스테르 구조를 도입한 페닐기를 치환기로서 갖는 신규 1,2-디히드로퀴놀린 유도체 |
WO2012108455A1 (ja) * | 2011-02-09 | 2012-08-16 | 参天製薬株式会社 | 3-ヒドロキシ-6H-ベンゾ[c]クロメン-6-オン誘導体およびその製造方法 |
WO2013108921A1 (ja) * | 2012-01-20 | 2013-07-25 | 参天製薬株式会社 | 1,2-ジヒドロキノリン誘導体またはその塩の工業的製造方法およびその製造中間体 |
WO2014156220A1 (ja) * | 2013-03-28 | 2014-10-02 | アイシン精機株式会社 | 周辺監視装置、及びプログラム |
CN107922356A (zh) | 2015-08-25 | 2018-04-17 | 参天制药株式会社 | [4‑(1,3,3‑三甲基‑2‑氧代‑3,4‑二氢‑1h‑喹喔啉‑7‑基)苯氧基]乙基氧基化合物或其盐 |
KR102619458B1 (ko) | 2017-06-16 | 2023-12-29 | 학교법인 도시샤 | mTOR 인히비터를 포함하는, 눈의 증상, 장해 또는 질환을 치료 또는 예방하기 위한 의약 및 그 응용 |
EP3639855A4 (en) | 2017-06-16 | 2021-03-17 | The Doshisha | COMPOUNDS HAVING CASPASE INHIBITORING ACTIVITY, PHARMACEUTICAL AGENT CONTAINING THEM FOR THE TREATMENT OR PREVENTION OF SYMPTOMS, DISORDERS OR DISEASES OF CORNEAL ENDOTHELIUM, AND APPLICATION OF SUCH PHARMACEUTICAL AGENT |
KR101933217B1 (ko) | 2017-12-28 | 2018-12-27 | (주) 에빅스젠 | 피부 염증 억제용 펩티드 및 이를 포함하는 피부 염증 예방 또는 치료용 조성물 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
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US5696133A (en) * | 1994-12-22 | 1997-12-09 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
HUT78117A (hu) | 1994-12-22 | 1999-11-29 | Ligand Pharmaceuticals Incorporated | Szteroid receptor modulátor kinolin- és kondenzált kinolinszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények |
US6696459B1 (en) * | 1994-12-22 | 2004-02-24 | Ligand Pharmaceuticals Inc. | Steroid receptor modulator compounds and methods |
EP1201660B1 (en) | 2000-10-30 | 2005-08-31 | Pfizer Products Inc. | Glucocorticoid receptor modulators |
RU2315041C2 (ru) * | 2002-04-30 | 2008-01-20 | ЮСиБи, С.А. | Производные 2,6-хинолинила и 2,6-нафтила, фармацевтические композиции на их основе, их применение в качестве ингибиторов vla-4 и промежуточные соединения |
AU2003259747A1 (en) * | 2002-08-21 | 2004-03-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
BRPI0513119A (pt) * | 2004-07-14 | 2008-04-29 | Ligand Pharm Inc | compostos e métodos modulares de receptores intracelulares |
US20070072908A1 (en) * | 2005-06-08 | 2007-03-29 | Japan Tobacco Inc. | Heterocyclic compounds |
RU2383539C2 (ru) | 2005-06-08 | 2010-03-10 | Джапан Тобакко Инк. | Гетероциклические соединения |
CN101263119B (zh) | 2005-09-14 | 2014-04-09 | 参天制药株式会社 | 具有糖皮质激素受体结合活性的1,2-二氢喹啉衍生物 |
KR20090086539A (ko) | 2006-11-14 | 2009-08-13 | 산텐 세이야꾸 가부시키가이샤 | (치환 페닐 또는 치환 복소환) 카르보닐옥시 저급 알킬기와 에스테르 구조를 도입한 페닐기를 치환기로서 갖는 신규 1,2-디히드로퀴놀린 유도체 |
WO2008111632A1 (ja) * | 2007-03-13 | 2008-09-18 | Santen Pharmaceutical Co., Ltd. | 2,2,4-トリメチル-6-フェニル-1,2-ジヒドロキノリン誘導体からなるグルココルチコイド受容体アゴニスト |
-
2009
- 2009-05-12 CN CN200980127298.XA patent/CN102089283B/zh not_active Expired - Fee Related
- 2009-05-12 WO PCT/JP2009/058801 patent/WO2009139361A1/ja active Application Filing
- 2009-05-12 AU AU2009247250A patent/AU2009247250B2/en active Active
- 2009-05-12 JP JP2009115070A patent/JP5635743B2/ja active Active
- 2009-05-12 BR BRPI0912171A patent/BRPI0912171B8/pt not_active IP Right Cessation
- 2009-05-12 UA UAA201014842A patent/UA102101C2/ru unknown
- 2009-05-12 EP EP09746568.6A patent/EP2319835B1/en active Active
- 2009-05-12 MX MX2010012303A patent/MX2010012303A/es active IP Right Grant
- 2009-05-12 CA CA2724055A patent/CA2724055C/en not_active Expired - Fee Related
- 2009-05-12 GE GEAP200912027A patent/GEP20146061B/en unknown
- 2009-05-12 EA EA201071296A patent/EA019091B1/ru not_active IP Right Cessation
- 2009-05-12 TW TW098115620A patent/TWI510240B/zh active
- 2009-05-12 US US12/992,237 patent/US8426406B2/en active Active
- 2009-05-12 CN CN201510639475.XA patent/CN105395550B/zh not_active Expired - Fee Related
- 2009-05-12 KR KR1020107027931A patent/KR20110010634A/ko not_active Application Discontinuation
- 2009-05-12 ES ES09746568.6T patent/ES2574987T3/es active Active
- 2009-05-12 MY MYPI2010005303A patent/MY158747A/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW200950781A (en) | 2009-12-16 |
CA2724055A1 (en) | 2009-11-19 |
CN102089283B (zh) | 2015-11-25 |
UA102101C2 (ru) | 2013-06-10 |
EA019091B1 (ru) | 2014-01-30 |
CN105395550A (zh) | 2016-03-16 |
EP2319835B1 (en) | 2016-04-13 |
AU2009247250B2 (en) | 2014-04-10 |
ES2574987T3 (es) | 2016-06-23 |
CA2724055C (en) | 2016-08-02 |
WO2009139361A1 (ja) | 2009-11-19 |
TWI510240B (zh) | 2015-12-01 |
EP2319835A4 (en) | 2011-12-28 |
MY158747A (en) | 2016-11-15 |
BRPI0912171B1 (pt) | 2020-11-03 |
MX2010012303A (es) | 2011-03-30 |
EP2319835A1 (en) | 2011-05-11 |
JP2009298775A (ja) | 2009-12-24 |
US8426406B2 (en) | 2013-04-23 |
US20110118260A1 (en) | 2011-05-19 |
EA201071296A1 (ru) | 2011-06-30 |
BRPI0912171A2 (pt) | 2017-10-31 |
CN102089283A (zh) | 2011-06-08 |
BRPI0912171A8 (pt) | 2017-12-12 |
AU2009247250A1 (en) | 2009-11-19 |
KR20110010634A (ko) | 2011-02-01 |
GEP20146061B (en) | 2014-03-25 |
CN105395550B (zh) | 2018-07-17 |
JP5635743B2 (ja) | 2014-12-03 |
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