ES2573957T3 - Sal de piperazina y procedimiento de preparación de la misma - Google Patents

Sal de piperazina y procedimiento de preparación de la misma Download PDF

Info

Publication number
ES2573957T3
ES2573957T3 ES09797145.1T ES09797145T ES2573957T3 ES 2573957 T3 ES2573957 T3 ES 2573957T3 ES 09797145 T ES09797145 T ES 09797145T ES 2573957 T3 ES2573957 T3 ES 2573957T3
Authority
ES
Spain
Prior art keywords
preparation procedure
piperazine salt
piperazine
salt
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09797145.1T
Other languages
English (en)
Spanish (es)
Inventor
Lászl CZIBULA
Éva ÁGAINÉ CSONGOR
Katalin Nogradi
Bálint JUHASZ
Ferenc Sebok
János Galambos
István VAGO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Nyrt
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Application granted granted Critical
Publication of ES2573957T3 publication Critical patent/ES2573957T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES09797145.1T 2008-12-17 2009-12-17 Sal de piperazina y procedimiento de preparación de la misma Active ES2573957T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0800763 2008-12-17
HU0800763A HU230067B1 (hu) 2008-12-17 2008-12-17 Új piperazin só és eljárás előállítására
PCT/HU2009/000108 WO2010070369A1 (en) 2008-12-17 2009-12-17 Piperazine salt and a process for the preparation thereof

Publications (1)

Publication Number Publication Date
ES2573957T3 true ES2573957T3 (es) 2016-06-13

Family

ID=89988672

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09797145.1T Active ES2573957T3 (es) 2008-12-17 2009-12-17 Sal de piperazina y procedimiento de preparación de la misma

Country Status (22)

Country Link
US (1) US8569496B2 (https=)
EP (1) EP2358690B1 (https=)
JP (1) JP5735923B2 (https=)
CN (1) CN102256953B (https=)
AU (1) AU2009329294B2 (https=)
BR (1) BRPI0923007B8 (https=)
CA (1) CA2743924C (https=)
DK (1) DK2358690T3 (https=)
EA (1) EA019024B1 (https=)
ES (1) ES2573957T3 (https=)
GE (1) GEP20125711B (https=)
HR (1) HRP20160726T1 (https=)
HU (2) HU230067B1 (https=)
IL (1) IL212639A0 (https=)
MX (1) MX2011006591A (https=)
NZ (1) NZ592907A (https=)
PL (1) PL2358690T3 (https=)
PT (1) PT2358690E (https=)
SI (1) SI2358690T1 (https=)
TW (1) TWI448455B (https=)
UA (1) UA104163C2 (https=)
WO (1) WO2010070369A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
CA2715760C (en) * 2008-02-21 2017-06-13 Mitsubishi Tanabe Pharma Corporation Solid preparation for oral administration of cariprazine hydrochloride
RS53866B1 (sr) 2008-07-16 2015-08-31 Richter Gedeon Nyrt. Farmaceutske formulacije koje sadrže ligande dopaminskih receptora
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
ITMI20131693A1 (it) 2013-10-14 2015-04-15 Chemo Res S L Derivati della 1,4-cicloesilammina e loro preparazione
CN104496854B (zh) * 2015-01-06 2017-09-22 上海医药工业研究院 3‑环己基‑1,1‑二甲基脲类化合物及其制备方法和应用
HU231173B1 (hu) 2016-07-08 2021-06-28 Richter Gedeon Nyrt. Ipari eljárás cariprazine előállítására
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
CN111269199B (zh) * 2018-12-05 2022-04-08 浙江京新药业股份有限公司 一种卡利拉嗪的制备方法
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
CN111892556A (zh) * 2019-05-06 2020-11-06 北京万全德众医药生物技术有限公司 新的卡利拉嗪制备方法
CN110372557B (zh) * 2019-08-06 2021-05-18 上海勋和医药科技有限公司 环己烷胺类d3/d2受体部分激动剂
CN114539185B (zh) * 2020-11-24 2024-12-24 上海新礼泰药业有限公司 一种卡利拉嗪及其中间体的制备方法
HUP2100108A1 (hu) 2021-03-12 2022-09-28 Richter Gedeon Nyrt Eljárás és berendezés gyógyászatilag alkalmazható piperazin származékok folyamatos áramú, áramlásos konszekutív redukálással történõ elõállítására
CN119874636A (zh) * 2025-01-16 2025-04-25 鲁南制药集团股份有限公司 一种卡利拉嗪的制备方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957921A (en) 1989-12-06 1990-09-18 Warner-Lambert Company Substituted cyclohexanols as central nervous system agents
US5047406A (en) 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
ES2293638T3 (es) 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
WO1997011070A1 (en) 1995-09-22 1997-03-27 Warner-Lambert Company Substituted cyclohexylamines as central nervous system agents
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
BR9909277A (pt) 1998-03-31 2001-10-16 Acadia Pharm Inc Compostos com atividade em receptores muscarìnicos
SE9802208D0 (sv) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
JP2000191570A (ja) * 1998-12-24 2000-07-11 Sumitomo Chem Co Ltd ヒドロキシフェニルプロパノール類の製造法
US6489341B1 (en) 1999-06-02 2002-12-03 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
PL364640A1 (en) 2001-02-27 2004-12-13 Ortho-Mcneil Pharmaceutical, Inc. Carbamate compounds for use in preventing or treating bipolar disorder
US6566550B2 (en) 2001-06-21 2003-05-20 Pfizer Inc Substituted aromatic ethers as inhibitors of glycine transport
HU227543B1 (en) * 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
SE0200301D0 (sv) 2002-02-01 2002-02-01 Axon Biochemicals Bv Thio-carbostyril derivative
US6833459B2 (en) * 2002-04-26 2004-12-21 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of thiazole intermediate
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
DE102004047517A1 (de) 2004-09-28 2006-03-30 Merck Patent Gmbh Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid
HUP0500170A3 (en) 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
GT200600414A (es) 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
JP2008001633A (ja) * 2006-06-22 2008-01-10 Showa Denko Kk テトラヒドロピランを溶媒とする塩化アルミニウム存在下での水素化ホウ素化合物による還元反応
HUP0600809A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HU230748B1 (hu) 2007-05-11 2018-02-28 Richter Gedeon Nyrt Új piperazin só és előállítási eljárása
EP2155200B1 (en) 2007-05-11 2016-12-07 Richter Gedeon Nyrt. Crystalline form of a carbamoyl-cyclohexane derivative
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
HUP0700369A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
HUP0700370A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania
AR070513A1 (es) 2007-08-01 2010-04-14 Lundbeck & Co As H Uso de abridores de canales de potasio kcnq para reducir los sintomas o tratar desordenes o afecciones en las cuales se encuentra anulado el sis-tema dopaminergico como por ejemplo esquizofrenia y trastorno depresivo mayor
US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
CA2715760C (en) 2008-02-21 2017-06-13 Mitsubishi Tanabe Pharma Corporation Solid preparation for oral administration of cariprazine hydrochloride
RS53866B1 (sr) 2008-07-16 2015-08-31 Richter Gedeon Nyrt. Farmaceutske formulacije koje sadrže ligande dopaminskih receptora
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives

Also Published As

Publication number Publication date
EP2358690B1 (en) 2016-03-30
AU2009329294A1 (en) 2010-06-24
CN102256953A (zh) 2011-11-23
UA104163C2 (ru) 2014-01-10
TW201035056A (en) 2010-10-01
EA201170810A1 (ru) 2011-12-30
SI2358690T1 (sl) 2016-07-29
US20110275816A1 (en) 2011-11-10
US8569496B2 (en) 2013-10-29
HUE029667T2 (en) 2017-04-28
HRP20160726T1 (hr) 2016-07-15
BRPI0923007B8 (pt) 2021-10-26
JP2012512239A (ja) 2012-05-31
BRPI0923007B1 (pt) 2021-08-17
CA2743924C (en) 2015-03-31
PL2358690T3 (pl) 2016-10-31
EA019024B1 (ru) 2013-12-30
EP2358690A1 (en) 2011-08-24
DK2358690T3 (en) 2016-07-18
BRPI0923007A2 (pt) 2015-08-11
MX2011006591A (es) 2011-07-12
AU2009329294B2 (en) 2014-04-10
HUP0800763A2 (en) 2010-11-29
NZ592907A (en) 2013-05-31
HU0800763D0 (en) 2009-03-02
CA2743924A1 (en) 2010-06-24
PT2358690E (pt) 2016-06-03
GEP20125711B (en) 2012-12-10
HU230067B1 (hu) 2015-06-29
CN102256953B (zh) 2016-06-01
JP5735923B2 (ja) 2015-06-17
WO2010070369A8 (en) 2011-04-28
WO2010070369A1 (en) 2010-06-24
IL212639A0 (en) 2011-07-31
TWI448455B (zh) 2014-08-11

Similar Documents

Publication Publication Date Title
ES2573957T3 (es) Sal de piperazina y procedimiento de preparación de la misma
ES2500067T3 (es) Compuesto bicíclico y uso del mismo para fines médicos
CL2011000091A1 (es) Formulacion farmaceutica que comprende trans-1{4-[2-[4-(2,3-diclorofenil)-piperazin-1-il]etil]-ciclohexil}-3,3-dimetil-urea, en la cual la formulacion comprende menos del 1% de trans 4-[2-[4-(2,3-diclorofenil)-piperazin-1-il]etil]-ciclohexil-amina o una sal; uso en esquizofrenia, trastorno bipolar y mania aguda.
CY1119076T1 (el) Αλατα πιπεραζινης ως ανταγωνιστες των d3/d2
EA201171287A1 (ru) Жидкие составы солей 1-[2-(2,4-диметилфенилсульфанил)фенил]пиперазина
NO2017023I1 (no) Venetoklaks, dvs. 4-(4-{[2-(4-klorfenyl)-4,4-dimetylsykloheks-1-en-1-yl]metyl}piperazin-1-yl)-N-({3-nitro-4[{tetrahydro-2H-pyran-4-ylmetyl)amino]fenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloksy)benzamid
CY1119648T1 (el) Αλατα και κρυσταλλικες μορφες παραγοντα που προκαλει αποπτωση
SMT202400470T1 (it) 4-(4-(4-(((2-(2,6-diossopiperidin-3-il)-l-ossoisoindolin-4-il)ossi)metil)benzil)piperazin-l-il)-3-fluorobenzonitrile come composto antiproliferativo
CY1118553T1 (el) Κρυσταλλικη μορφη ενος παραγωγου καρβαμοϋλ-κυκλοεξανιου
CO6440532A2 (es) Sales de disacarina, ácido difumárico, ácido di-1-hidroxi-2-naftoico y ácido monobenzoico del 2-(4-((2-amino-4-metil-6-(pentilamino)pirimidin-5-il)fenil)acetato de 4-(dimetilamino)butilo
ES2525918T3 (es) Proceso para la fabricación de Nicorandil
UY34161A (es) 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil) carbamimidoil)pirazina-2-carboxamida, sus usos, y composiciones que la contienen
CU20140060A7 (es) 4-{4-[({[ 4- cloro-3-( trifluorometil) fenil] amino} carbonil) amino]-3- fluorofenoxi}-n-metilpiridina-2- carboxamida y su monohidrato
CL2015002309A1 (es) Proceso de fabricacion de vortioxetina.
HRP20120173T1 (en) 1- ¦[- (2, 4-dimethylphenylsulfanyl) -phenyl]piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment
CY1123766T1 (el) Trans-4-{2-[4-(2,3- διχλωροφαινυλ)-πιπepazin-1-yλ]-aiθyλ}- ν,ν-διμεθυλκαρβαμοϋλ-κυκλοεξυλαμινη για θεραπεια πρωταρχικων αρνητικων συμπτωματων σχιζοφρενειας
EA201290116A1 (ru) Новые композиции 1-[2-(2,4-диметилфенилсульфанил)фенил]пиперазина
CL2008000796A1 (es) Uso de 4-(2-(4-metilfenilsulfanil)fenil)piperidina y sales de adicion de acidos de la misma para el tratamiento del adhd, melancolia, depresion o sintomas residuales de la depresion; y dicho compuesto.
CY1118886T1 (el) Θεραπευτικες χρησεις της 1-[2-(2,4-διμεθυλ-φαινυλσουλφανυλ)φαινυλ]πιπεραζινης
ES2650914T3 (es) Sales de adición de ácidos de 5alfa-hidroxi-6beta-[2-(1H-imidazol-4-il)etilamino]colestan-3beta-ol
EA200901179A1 (ru) Замещённые тетрагидрохинолины
CO6630129A2 (es) Procedimiento para la preparación de 2-(ciclohexilmetil)-n-{2-[(2s)-1- metilpirrolidin-2-il]etil}-1,2,3,4-tetahidroisoquinolina-71sulfonamida
EA201301136A2 (ru) Новый способ синтеза (2e)-3-(3,4-диметоксифенил)проп-2-еннитрила, применение в синтезе ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
ES2585558T3 (es) Uso de sales de 3-carboxi-N-etil-N,N-dimetilpropan-1-aminio en el tratamiento de una enfermedad cardiovascular
ZA201801544B (en) 1-(4-(2-((1-(3,4-difluorophenyl)-1h-pyrazol-3-yl)methoxy)ethyl) piperazin-1-yl)ethanone salts