ES2500067T3 - Compuesto bicíclico y uso del mismo para fines médicos - Google Patents

Compuesto bicíclico y uso del mismo para fines médicos Download PDF

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Publication number
ES2500067T3
ES2500067T3 ES10804397.7T ES10804397T ES2500067T3 ES 2500067 T3 ES2500067 T3 ES 2500067T3 ES 10804397 T ES10804397 T ES 10804397T ES 2500067 T3 ES2500067 T3 ES 2500067T3
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ES
Spain
Prior art keywords
medical purposes
bicyclic compound
bicyclic
compound
medical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10804397.7T
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English (en)
Inventor
Tohru Kambe
Toru Maruyama
Shinsaku Yamane
Satoshi Nakayama
Kousuke Tani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2500067T3 publication Critical patent/ES2500067T3/es
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Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/902—Method of implanting
    • Y10S623/905—Eye

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)
  • Image Processing (AREA)

Abstract

3S,5aR,6R,7R,8aS)-6-[(1E,3R)-4-(2,5-Difluorofenoxi)-3-hidroxi-1-buten-14]-7-hidroxioctahidro-2Hciclopenta[ b]oxepin-3-il}butanoato de 2-propanilo o un solvato del mismo.

Description

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Claims (1)

  1. imagen1
ES10804397.7T 2009-07-28 2010-07-27 Compuesto bicíclico y uso del mismo para fines médicos Active ES2500067T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009175246 2009-07-28
JP2009175246 2009-07-28
PCT/JP2010/062587 WO2011013651A1 (ja) 2009-07-28 2010-07-27 二環式化合物およびその医薬用途

Publications (1)

Publication Number Publication Date
ES2500067T3 true ES2500067T3 (es) 2014-09-30

Family

ID=43529306

Family Applications (2)

Application Number Title Priority Date Filing Date
ES10804397.7T Active ES2500067T3 (es) 2009-07-28 2010-07-27 Compuesto bicíclico y uso del mismo para fines médicos
ES13003505.8T Active ES2567328T3 (es) 2009-07-28 2010-07-27 Compuesto bicíclico y uso del mismo para fines médicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES13003505.8T Active ES2567328T3 (es) 2009-07-28 2010-07-27 Compuesto bicíclico y uso del mismo para fines médicos

Country Status (21)

Country Link
US (9) US8614340B2 (es)
EP (2) EP2653468B1 (es)
JP (3) JP5652397B2 (es)
KR (1) KR101768235B1 (es)
CN (1) CN102498105B (es)
AU (1) AU2010279183B2 (es)
BR (1) BR112012001797B1 (es)
CA (1) CA2767083C (es)
DK (2) DK2460801T3 (es)
ES (2) ES2500067T3 (es)
HK (1) HK1170487A1 (es)
HU (1) HUE028874T2 (es)
IL (1) IL217342A (es)
MX (1) MX2012000889A (es)
NZ (1) NZ597626A (es)
PL (2) PL2460801T3 (es)
PT (1) PT2460801E (es)
RU (1) RU2540330C2 (es)
TW (1) TWI466877B (es)
WO (1) WO2011013651A1 (es)
ZA (1) ZA201200797B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5652397B2 (ja) 2009-07-28 2015-01-14 小野薬品工業株式会社 二環式化合物およびその医薬用途
JP5907077B2 (ja) 2011-01-27 2016-04-20 小野薬品工業株式会社 二環式化合物およびその医薬用途
JP5835236B2 (ja) 2011-01-27 2015-12-24 小野薬品工業株式会社 二環式化合物およびその医薬用途
US9944217B2 (en) 2013-02-11 2018-04-17 Ferno-Washington, Inc. Equipment mounting system
US9890146B2 (en) 2014-02-27 2018-02-13 Ono Pharmaceutical Co., Ltd. Compound having selective EP2 agonist activity
EP3327018B1 (en) 2015-07-23 2020-11-25 ONO Pharmaceutical Co., Ltd. 2-(octahydrocyclopenta[b]pyran-2-yl)1,3-thiazole-4-carboxylic acid derivatives and related compounds as ep2 agonists with intraocular pressure lowering activity
CN112679495B (zh) * 2016-04-01 2023-03-28 里科瑞尔姆Ip控股有限责任公司 雌激素受体调节剂
JP6954282B2 (ja) * 2016-06-30 2021-10-27 小野薬品工業株式会社 二環式化合物の製造方法
WO2019124488A1 (ja) 2017-12-21 2019-06-27 参天製薬株式会社 セペタプロストとＲｈｏキナーゼ阻害剤との組み合わせ医薬
WO2019124489A1 (ja) * 2017-12-21 2019-06-27 参天製薬株式会社 セペタプロストとｅｐ２アゴニストとの組み合わせ医薬
MX2020006429A (es) * 2017-12-21 2020-09-17 Ono Pharmaceutical Co Agente terapeutico para el glaucoma que comprende un agonista de fp y un bloqueador beta.
CN111689982B (zh) * 2019-03-15 2023-04-07 博瑞生物医药（苏州）股份有限公司 艾日布林中间体及其制备方法
AU2019466972B2 (en) * 2019-09-19 2023-07-06 Polyactiva Pty Ltd Biodegradable drug-polymer conjugate
US11608319B2 (en) 2019-12-31 2023-03-21 Industrial Technology Research Institute Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and method for performing an in vivo related application that benefits from the inhibition of a kinase
WO2021145356A1 (ja) * 2020-01-15 2021-07-22 参天製薬株式会社 近視の治療、近視の予防および／または近視の進行抑制のための医薬組成物
CN115768433A (zh) * 2020-08-13 2023-03-07 参天制药株式会社 含有司培前列素的医药制剂
TW202404569A (zh) * 2022-04-22 2024-02-01 日商參天製藥股份有限公司 含有賽佩普斯特(Sepetaprost)之眼科用組合物

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US425417A (en) * 1890-04-15 Wall-paper exhibitor
JPS5411311B2 (es) 1973-08-11 1979-05-14
IL51189A (en) 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
FR2344285A1 (fr) * 1976-03-19 1977-10-14 Roussel Uclaf Nouvelles lactones derivees du cyclopentanol, leur procede de preparation et leur application comme medicaments
FI71138C (fi) 1976-12-31 1986-11-24 Erba Farmitalia Foerfarande foer framstaellning av terapeutiskt aktiva bisykliska prostaglandiner
US4209615A (en) * 1977-04-19 1980-06-24 The Upjohn Company Phenyl-substituted 9-deoxy-6,9α-epoxymethano-PG analogs
US4490537A (en) * 1977-04-19 1984-12-25 The Upjohn Company Enlarged-hetero-ring prostacyclin analogs
CA1184906A (en) 1977-04-19 1985-04-02 Roy A. Johnson 9-deoxy-5,9-epoxy-prostaglandins
US4490548A (en) * 1977-04-19 1984-12-25 The Upjohn Company Enlarged-hetero-ring prostacyclin analogs
US4169841A (en) * 1977-04-19 1979-10-02 The Upjohn Company Alkenyl-substituted 9-deoxy-6,9-α-epoxymethano-PG analogs
JPS5573678A (en) 1978-11-29 1980-06-03 Ono Pharmaceut Co Ltd Simultated compound of thio-prostaglandin i1, its preparation and drug composition containing it as active ingredient
DE2947526A1 (de) 1978-11-29 1980-06-12 Ono Pharmaceutical Co Prostacyclin-analoge
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JP4332316B2 (ja) 1999-10-15 2009-09-16 スキャンポ・アーゲー 二環式化合物組成物およびその安定化方法
JP5037780B2 (ja) 2003-05-23 2012-10-03 三菱化学株式会社 活性エネルギー線硬化性組成物及びハードコートフィルム
US7906552B2 (en) * 2004-08-10 2011-03-15 Allergan, Inc. Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents
BRPI0713587A2 (pt) * 2006-06-20 2012-10-23 Allergan Inc descrição de compostos terapêuticos da invenção
JP5573678B2 (ja) 2008-12-10 2014-08-20 コニカミノルタ株式会社 有機エレクトロルミネッセンス素子の製造方法、有機エレクトロルミネッセンス素子
JP5384959B2 (ja) 2009-01-28 2014-01-08 セミコンダクター・コンポーネンツ・インダストリーズ・リミテッド・ライアビリティ・カンパニー 電子回路
JP5652397B2 (ja) * 2009-07-28 2015-01-14 小野薬品工業株式会社 二環式化合物およびその医薬用途
CN102336754B (zh) 2010-07-15 2017-04-12 浙江奥翔药业股份有限公司 恩替卡韦的合成方法及其中间体化合物
JP5907077B2 (ja) 2011-01-27 2016-04-20 小野薬品工業株式会社 二環式化合物およびその医薬用途
JP5835236B2 (ja) * 2011-01-27 2015-12-24 小野薬品工業株式会社 二環式化合物およびその医薬用途
WO2016022879A1 (en) * 2014-08-07 2016-02-11 Georgia-Pacific Chemicals Llc Strengthening resins for paper products

Also Published As

Publication number Publication date
PL2653468T3 (pl) 2016-08-31
US20210169842A1 (en) 2021-06-10
EP2653468A1 (en) 2013-10-23
IL217342A0 (en) 2012-02-29
US20120122964A1 (en) 2012-05-17
ZA201200797B (en) 2012-10-31
US20200093781A1 (en) 2020-03-26
KR20120038986A (ko) 2012-04-24
US10201520B2 (en) 2019-02-12
MX2012000889A (es) 2012-02-13
HUE028874T2 (en) 2017-01-30
JP2016188217A (ja) 2016-11-04
US10940134B2 (en) 2021-03-09
US20230190698A1 (en) 2023-06-22
US20180116995A1 (en) 2018-05-03
US11617733B2 (en) 2023-04-04
US20160287551A1 (en) 2016-10-06
DK2460801T3 (da) 2014-09-22
US8614340B2 (en) 2013-12-24
PT2460801E (pt) 2014-08-29
JP5652397B2 (ja) 2015-01-14
IL217342A (en) 2016-03-31
RU2540330C2 (ru) 2015-02-10
RU2012107109A (ru) 2013-09-10
EP2460801A1 (en) 2012-06-06
JP5935857B2 (ja) 2016-06-15
CN102498105B (zh) 2014-04-02
CA2767083A1 (en) 2011-02-03
BR112012001797A2 (pt) 2017-05-16
EP2460801B1 (en) 2014-06-25
US8962868B2 (en) 2015-02-24
NZ597626A (en) 2013-03-28
US20150112079A1 (en) 2015-04-23
DK2653468T3 (en) 2016-06-06
TWI466877B (zh) 2015-01-01
US9388157B2 (en) 2016-07-12
US9889114B2 (en) 2018-02-13
JPWO2011013651A1 (ja) 2013-01-07
EP2460801A4 (en) 2013-01-02
HK1170487A1 (en) 2013-03-01
ES2567328T3 (es) 2016-04-21
WO2011013651A1 (ja) 2011-02-03
AU2010279183B2 (en) 2015-10-29
BR112012001797B1 (pt) 2020-04-07
CN102498105A (zh) 2012-06-13
PL2460801T3 (pl) 2014-11-28
US20140073676A1 (en) 2014-03-13
JP6149975B2 (ja) 2017-06-21
AU2010279183A1 (en) 2012-02-02
JP2015052011A (ja) 2015-03-19
US20190111019A1 (en) 2019-04-18
KR101768235B1 (ko) 2017-08-14
EP2653468B1 (en) 2016-02-24
CA2767083C (en) 2017-05-16
TW201109311A (en) 2011-03-16

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